Paul Jerome Lamont @PAULJLAMONT
Committed to solve Alzheimer's syndrome. 🇳🇿🇺🇸🇦🇺🇮🇹 Los Angeles, CA Joined December 2021-
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Tauopathy neurons make more lipids than they break down, forcing them to export the fat to microglia, triggering neuroinflammatory responses. A dearth of neuronal AMP kinase exacerbates the process. @UCSanDiego ow.ly/c3Sm50Rt1SU
@PAULJLAMONT @MitoPsychoBio by "the same" do you mean the effect of anorexia/starvation on the autonomic system (i.e., greater parasympathetic activity)? If so, I would think yes, but the effect would be smaller than in earlier life - but I do not know of any studies that test this.
Insulin is produced in the brain. mdpi.com/1422-0067/24/7…
Harnessing the immune modulatory capacity of skin stem cells may have broader applications beyond wound healing. Very Fascinating.
Harnessing the immune modulatory capacity of skin stem cells may have broader applications beyond wound healing. Very Fascinating.
Vitamin D regulates microbiome-dependent cancer immunity | Science science.org/doi/10.1126/sc…
Apolipoprotein E controls CLEC7A-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation nature.com/articles/s4159…
Exploring new perspectives in immunology: @CELL cell.com/cell/fulltext/…
Adaptive immune changes associate with clinical progression of Alzheimer’s disease …arneurodegeneration.biomedcentral.com/articles/10.11….
Dr. Grubb and colleagues recently published this review of the literature on autoimmunity in #POTS and #OH. They highlight the mounting evidence that autoimmunity plays a role in both conditions. See more details in comments below. Read the article at mdpi.com/2075-4426/14/4…
Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation jneuroinflammation.biomedcentral.com/articles/10.11…
PAPER ALERT! Human microglia are very temperamental and if you ever tried, you know they don't like to be transfected. But did you know that you can modulate them with ASOs? We show here the selective modulation of human microglia gene expression and function in vivo!
IgG3 antibodies ? Think about a merry goes around .
IgG3 antibodies ? Think about a merry goes around .
Interesting
This is remarkable
Is forgetting a bug or a feature? Can you delay it and remember longer? Our 🥶COOLEST paper to date (and our most poetic abstract…) Show LOVE ❤️and please SHARE! Thread (1/N)👇 biorxiv.org/content/10.110…
From today you can check your GFAP at the QUEST labs. A great step forward to understand neuro inflammation. Acknowledging the recent work done by @BellaverBruna @LabPascoal
From today you can check your GFAP at the QUEST labs. A great step forward to understand neuro inflammation. Acknowledging the recent work done by @BellaverBruna @LabPascoal
🚨 Check our comment in @Brain1878! We truly believe that understanding astrocyte reactivity ⭐️ is the key to bridge the gap in comprehending the diverse contexts of neurodegenerative diseases 🧠
🚨 Check our comment in @Brain1878! We truly believe that understanding astrocyte reactivity ⭐️ is the key to bridge the gap in comprehending the diverse contexts of neurodegenerative diseases 🧠
Happy to share that our paper investigating #sexhormones and #inflammation in males and females with #depression has been published in the Journal of Affective Disorders. Take a look! shorturl.at/bsw36 @ParianteLab @MondelliValeria @paola_DZN @PIXIELabKCL @SPILabKCL
Labcorp, Quest add new blood tests for Alzheimer's, brain damage. @erzimmer @BellaverBruna @zimmerneurolab 🔥 fiercebiotech.com/medtech/labcor…
What’s in our genome: 🧬~1% codes for cellular proteins 🧬~54% is transposable elements and other repeats, including 17% LINE1 and 10% Alu SINEs 🧬~45% is non-coding DNA of unknown origin (probably mostly ancient TEs) As always, superb talk by @KathleenHBurns at #ICTE2024
Neighson @NeighsonCR2VEL
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@smead2 @PhilAlz @SFAckley @MariaGlymour @VincentPlanche @nvillain_alz @AlbertoEspay @KasperKepp @kathy_y_liu @seb_walsh But how can the patient or doctor be “well informed” if they ignore the fact that on average the effect of the drug at 18/12 is about 50% of what might be noticeable? The risks are easy to understand and explain but the clinical meaningfulness of the benefits is really unclear.
We argue that "language should be prudently restrained" about mAbs in Alzheimer's to avoid overstatement and false hope. We cite @SFAckley @MariaGlymour @VincentPlanche @nvillain_alz @AlbertoEspay @KasperKepp @kathy_y_liu @seb_walsh @ProfRobHoward researchgate.net/publication/38…
I invite you and all the anti-vaxxers to my talk on May 16th. Spoiler to make you sad: I will show how vaccines actually help reduce neuroinflammation in the brain. Free and online here: unitetofight2024.world #UniteToFight2024
@DaniBeckman @Leah_Starz Can I see the full study which shows you’ve run proper control tests to differentiate between vaxxed and unvaxxed samples?
May 1st is also the day we mourn the death of a character who intensely dedicated his life to his career until the last second of it, and showed the world that Brazilians can also go beyond with love, passion, and determination. A symbol we have, Ayrton Senna.
If you haven't been following me for too long you might not know this: I actually ran a small-scale trial (n=10) of my cream diet last year, inspired by @mold_time's potato trial. Of the 10 participants, 7 finished, and lost an average of 9.6lbs in 30 days.…
@AdrianoAguzzi I like the sound of you being proven wrong. Keep fighting 💪❤️
All EV automakers planning to tap into Tesla’s public charging stations, are affected by Tesla eliminating most of its Supercharger group, cutting its staff by 500, which will slow the growth of the US network. That’s on top over 10% staff cuts in Tesla car manufacturing
No one should be collagen maxxing. Everyone should be glycine/methionine balancing. Glycine/methionine balancing is a powerful weapon of longevity. Glycine/methionine balance probably explains many of the discrepancies in whether animal foods or plant foods are better for our…
My blood continues to be full of bacteria despite massive i.v. antibiotics. We added clindamycin despite the risk of C.difficile. Bayesian inference tells me that this will end badly, but I'd be happy to be proven wrong.
In case anyone was wondering, the @GarminFitness wrist HR sensor isn’t super reliable on the 965.
@Drlipid @nationallipid @society_eas I’m doing my own vitamin D experiment this year because there seem to be real studies saying that many lab tests are shockingly inaccurate
@Drlipid @nationallipid @society_eas Here comes the FDA poised to ruin health in more ways.
@iam_emilyanne The cost of everything is absurd. Nothing is worth what we pay and then on top of this abysmal reality, everywhere you turn there's a fee, a tax, a surcharge... someone or some thing trying to take more from us
What happens with MICROGLIA during NEUROINFLAMATION? Microglia are the brain's dead cell removers. - M0 = resting - M1 = inflammatory - M2 = anti-inflammatory - Primed = They are easily and quickly pushed from this state to the inflammatory state. #MECFS youtu.be/XggO__DlALw?si…
One of the "systems" that gets thrown off kilter in #mecfs #longcovid is the parasympathetic nervous system - and the Vagus Nerve. Its not just part of the stress response system - it also plays a role in immune responses. Layering vagal interventions is the best way to manage…
@Alan_Couzens The secret is definitely getting a border collie.
@Alan_Couzens The best thing I ever did was abandon a 20 week training plan to racing mentality and embrace a life of Z1/Z2 focused on health.