Nikolas Karvelas, MD @NikKarvel
MD from @uoaofficial, studying cerebrovascular disease in @IcahnMountSinai 🧠 Also interested in: literature, archaeology, electronic music, mischief New York, USA Joined December 2023-
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This study provides Class II evidence that among those aged 65 years or older, statin initiation was associated with a reduced risk of #Alzheimer disease, especially in the presence of an APOE-e4 allele: bit.ly/3VWTQnT
Rare diseases pose a challenge for omics studies, which require hundreds of samples. With our work, we provide a novel framework for proteomics discovery, that uncovers central mechanisms of #CADASIL! 🔬 Congrats to lead author Jonah Keller, and the whole team! 🎉
Rare diseases pose a challenge for omics studies, which require hundreds of samples. With our work, we provide a novel framework for proteomics discovery, that uncovers central mechanisms of #CADASIL! 🔬 Congrats to lead author Jonah Keller, and the whole team! 🎉
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Read the three winning entries from the Brain essay competition, on the illusion of consciousness (tinyurl.com/ntdkbvuv), the origins of migraine stigma (tinyurl.com/mtkzu9f2), and a sci-fi view of the future of gene repair technology (tinyurl.com/2crc9m7d).
So grateful I had the chance to lead this work. Understanding the molecular basis of common pathologies (such as ePVS) is crucial for better diagnostics and therapies for cerebral small vessel disease. Thank you to @FannyElahi, the team and of course the #CADASIL community! 🧠
So grateful I had the chance to lead this work. Understanding the molecular basis of common pathologies (such as ePVS) is crucial for better diagnostics and therapies for cerebral small vessel disease. Thank you to @FannyElahi, the team and of course the #CADASIL community! 🧠
Interesting how the exact same amount of steps has been shown to ward off dementia! jamanetwork.com/journals/jaman…
Interesting how the exact same amount of steps has been shown to ward off dementia! jamanetwork.com/journals/jaman…
“Police cordon holding back Beatles fans outside the London Pavillion at the premiere of “Let It Be” (1970), illustrating the concept of inhibitory restraint around a seizure focus.” Very imaginative cover. You can’t just “let it be” when it comes to seizure activity!
“Police cordon holding back Beatles fans outside the London Pavillion at the premiere of “Let It Be” (1970), illustrating the concept of inhibitory restraint around a seizure focus.” Very imaginative cover. You can’t just “let it be” when it comes to seizure activity!
Honored to be involved in rare disease research (CADASIL) and serve this community! Rare diseases are not as rare as we think, even more so considering how underdiagnosed they are. Let’s make an impact this #RareDiseaseDay2024 #CADASIL
Honored to be involved in rare disease research (CADASIL) and serve this community! Rare diseases are not as rare as we think, even more so considering how underdiagnosed they are. Let’s make an impact this #RareDiseaseDay2024 #CADASIL
In this case series of 15 patients with severe autoimmune disease, selective deep depletion of B lymphocytes with CD19 CAR T-cell therapy was effective in achieving clinical remission. Read the full article: nej.md/3UMQcMH
What a beautiful view of the Empire State Building! People, monuments and buildings across America showed their support for heart health and wellbeing today. We wore red for YOU! Who do you Go Red for? #HeartMonth #WearRedDay #NationofLifesavers
Efficient enzyme-free isolation of brain-derived extracellular vesicles biorxiv.org/cgi/content/sh… #bioRxiv
Groundbreaking work! Excited to see how it will be translated in the context of neurological disease
Groundbreaking work! Excited to see how it will be translated in the context of neurological disease
Some scientists would rather share their toothbrush with a colleague than discuss their ideas. But those that do..
Sunday Punday @ImmunityCP you are on a roll
Severe intracerebral hemorrhage causes tissue compliance as an intracranial pressure compensatory mechanism in aged hypertensive rats @Psych_UAlberta @ualbertaScience @KalisvaartAnna @casswilkinson10 ahajrnls.org/3TEuQAN
Do you know the milestones of biomarker evolution in Alzheimer’s disease? Will we learn from this experience as we pivot toward Parkinson? Nice paper by Mankhong and colleagues mdpi.com/2227-9059/10/4… and discussion at Parkinsonsecrets.com
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5K Followers 1K Following Professor of Neurology & Cognitive Neuroscience @UniofOxford, Editor-in-Chief @Brain1878, Fellow @NewCollegeOxReduction of soluble Aβ42 or Aβ40 through solanezumab increased CSF NfL. "Binding soluble amyloid-β was associated with increased measures of neurodegeneration." Biomarker analysis of the DIAN-TU-001 study of dominantly inherited #Alzheimers @JAMANeuro jamanetwork.com/journals/jaman…
"Elisabeth Bik, expert in scientific integrity: ‘We need to slow down scientific publishing’ " | @MicrobiomDigest buff.ly/3UGvyh5
We are highlighting papers that have been published on #PredatoryPublishing. Please take a look by following the link. #ArticlesOnPredatoryPublishing @springerpub @Scopus buff.ly/3IPEUPr
Wow, a whole extra day if time is pressing .......... time passes .......... thinks .......... "No, we'll still pass, but thanks for the invite anyway"
We have taken a look at the Google Scholar profile of Kumba Digdowiseiso (following the @RetractionWatch article: buff.ly/4aTehGM). So far, in 2024, he has published (163 articles / 104 days) = 1.57 articles each day. Be interesting to see how this develops in 2024.
"We need to slow down scientific publishing," says Elisabeth Bik. english.elpais.com/science-tech/2…
This is definitive proof that you can never outgrow your mentor. Thank you Prof @ajlees for all your inspiration and guidance!
Yay! Three years after @raoult_didier @Pr_Chabriere_E and @IHU_Marseille filed a complaint against me for harassment and blackmail, the Marseille Procureur tells me today they could not find any grounds for criminal prosecution.
Parkinson's disease risk: the double whammy of lysosomal gene mutations and high exposure to pesticides nature.com/articles/s4153… @FogelLab @UCLANeurology
Landmark revisit Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction Macrophages pull together angiogenic sprouts to fuse!😍 @Joey_JMVieira @RuhrbergLab @BloodJournal 2010 ashpublications.org/blood/article/…
Q97: Which antihypertensive drugs have the best effect on white matter hyperintensities (WMH)? A: Angiotensin-converting enzyme inhibitors are 'most consistently associated with less WMH progression” bit.ly/3Y8HOFE Citing checklist: bit.ly/3SD8VHC
New #GraphicMedicine by Dr. Mom Grace Farris—"QI Parenting” ow.ly/uLb450Rp8yv
Cell cycle genes are re-activated in some #neurons as our brains age. @chow_heiman &co use bioinformatics to characterize the prevalence, nature & fate of these #CellCycle re-entry neurons, within the healthy #aging & diseased human brain. #PLOSBiology plos.io/4dbHoXt
Researchers revealed that diosgenin significantly improved #cardiac function in a myocardial infarction 💓 mouse model, reducing cardiac fibrosis and cell apoptosis while promoting #angiogenesis. 📖 @BBRCME | bit.ly/49QFsRz
#SARSCoV2 inside the synapse... Brain explants from individuals with or without COVID-19 were analyzed (high-throughput proteomic screens) and identified increase in the expression of three synaptic proteins — Bassoon; presynaptic fibronectin leucine-rich transmembrane-3 protein…
How #SARSCoV2 can disrupt brain synapses nature.com/articles/s4156… nature.com/articles/s4156… Increased expression of 3 synaptic proteins, and finding a drug that restores synaptic function @NatureMicrobiol
We found this article interesting and this is just one small quote. You can see the full article by following the link. #FJNSoundBite @ElsevierConnect @ELS_Dermatology buff.ly/3wxgXp7
Brain neurons re-entering the #cellCycle age quickly and shift to senescence, particularly in neurodegenerative disease @PLOS @PLOSBiology medicalxpress.com/news/2024-04-b…
A huge congratulations to Dr. Gan for receiving the 2024 Jessica M. and Natan Bibliowicz Award for Excellence in Mentoring Women Faculty! It is a pleasure to receive your guidance daily in our lab. @WeillCornell #WCMDiversityWeek diversity.weill.cornell.edu/about-us/diver…
The sign outside my office used to read: 'Ardem Patapoutian, PhD, Professor.' My title keeps changing... I have no idea who's behind it, but I kind of like it!