Niklas Mattsson-Carlgren @NiklasMattsson4
Research on Alzheimer's disease and other neurological diseases Sweden Joined August 2019-
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Check out this paper, a collaboration between Lund University and UCSF Memory and Aging Center, where we show that CSF biomarkers have very high accuracy for autopsy confirmed Alzheimer's disease n.neurology.org/content/98/11/… @OskarHansson9 @RabLab_UCSF @MultiparkL @biofinder_study
Enjoy this podcast episode about our recent Neurology paper on CSF biomarkers in autopsy confirmed neurodegenerative diseases! player.fm/series/neurolo… @biofinder_study @OskarHansson9 @RabLab_UCSF
Does #Abeta38 affect the risk of #AD ? @alzforum discusses interesting findings by Nicholas Cullen, @NiklasMattsson4, @SebastianPalmqv and @OskarHansson9. #neuroscience #biomarkers #alzheimersdisease @medfak_LU
Does #Abeta38 affect the risk of #AD ? @alzforum discusses interesting findings by Nicholas Cullen, @NiklasMattsson4, @SebastianPalmqv and @OskarHansson9. #neuroscience #biomarkers #alzheimersdisease @medfak_LU
Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and FTLD. Class II evidence. bit.ly/3K0hWFf @NiklasMattsson4 @grinberg_t @RikOssenkoppele @ajehrenberg @SalvoSpinaSF @JulioCRojas10 @relajoie @leoiacca @OskarHansson9 @AlbaLanguage @RabLab_UCSF
Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and FTLD. 101 patients w/ CSF & neuropath data. bit.ly/3K0hWFf @NiklasMattsson4 @grinberg_t @RikOssenkoppele @ajehrenberg @SalvoSpinaSF @JulioCRojas10 @relajoie @leoiacca @OskarHansson9 @RabLab_UCSF
Research in progress in one of our research groups. @NiklasMattsson4 @roman_sattarov #researchinprogress #phdlife #neuroscience #operetta #experimentalresearch #biomarkers #inducedneurons
Findings from @biofinder_study reveal genetic influence on longitudinal #cognitivedecline in early stages of #AD, partially mediated by #Abeta pathology. @SciReports @SebastianPalmqv @OskarHansson9 @NiklasMattsson4 @medfak_LU rdcu.be/czgt1
80 % of the world’s #HighlyCitedResearchers at #lunduniversity comes from MultiPark. Congratulations to @OskarHansson9 @sara_linse and @NiklasMattsson4. And to @BrundinPatrik, previously initiating MultiPark. @medfak_LU #Clarivate multipark.lu.se/article/majori…
In this new paper doi.org/10.15252/emmm.…, we show how changes in levels of soluble phosphorylated tau depend on deposition of both beta-amyloid and tau aggregates in the brain in Alzheimer's disease @biofinder_study @EmboMolMed
In this new paper doi.org/10.15252/emmm.…, we show how changes in levels of soluble phosphorylated tau depend on deposition of both beta-amyloid and tau aggregates in the brain in Alzheimer's disease @biofinder_study @EmboMolMed https://t.co/cXpUE2nbhA
Our recent paper shows that plasma pTau is mainly related to amyloid plaques in early disease and tau tangles in later disease stages. That is, soluble pTau is associated with both pathologies and not simply a marker of any of these pathologies per se. doi.org/10.15252/emmm.…
Great collaboration evaluating plasma pTau in two cohorts characterized using either neuropathology (Banner) or PET (BioFINDER). Especially thanks to @NiklasMattsson4. @MultiparkL @lunduniversity
Great collaboration evaluating plasma pTau in two cohorts characterized using either neuropathology (Banner) or PET (BioFINDER). Especially thanks to @NiklasMattsson4. @MultiparkL @lunduniversity
I am delighted to share our latest blood biomarker work published in @alzassociation. We investigated baseline & longitudinal #pTau, #NfL, #GFAP, #tTau, #Aβ to predict diagnosis & grey matter changes in individuals not predetermined by CSF/imaging. alz-journals.onlinelibrary.wiley.com/doi/full/10.10… 1/n
In this proteomics study rdcu.be/cdX7P we found evidence of accelerated inflammatory ageing in Alzheimer's disease, supporting the view that inflammatory pathways are critically involved in Alzheimer's disease @biofinder_study @LuWcmm @OskarHansson9
Very happy to present this work on Time Between Milestone Events in The Alzheimer's Disease Amyloid Cascade doi.org/10.1016/j.neur…. One key finding was that changes in tau started quite early. Perhaps DMTs must be initiated prior to significant Aβ pathology? @biofinder_study
Plasma phosphorylated tau (P-tau) correlate with imaging measures of brain atrophy over time in AD! Perhaps repeated blood tests can track atrophy, both in clinical practice and in drug trials, to find therapies that reduce degeneration? doi.org/10.1002/acn3.5…. @biofinder_study
In this paper, we demonstrate how plasma and CSF biomarkers can be used for individualized prognostication of cognitive decline due to Alzheimer's disease. We hope that this will improve patient management, help patients and families, and speed up drug trials for new therapies.
In this paper, we demonstrate how plasma and CSF biomarkers can be used for individualized prognostication of cognitive decline due to Alzheimer's disease. We hope that this will improve patient management, help patients and families, and speed up drug trials for new therapies.
Plasma P-tau depends on both beta-amyloid and tau pathology in Alzheimer's disease. Early in the disease, plasma P-tau may be increased in response to beta-amyloid pathology. In later disease stages, plasma P-tau is associated with tau aggregation in the neocortex.
Plasma P-tau depends on both beta-amyloid and tau pathology in Alzheimer's disease. Early in the disease, plasma P-tau may be increased in response to beta-amyloid pathology. In later disease stages, plasma P-tau is associated with tau aggregation in the neocortex. https://t.co/DzdhwtvHGC
Excellent review about #APOE ε2: "Protective mechanism and therapeutic implications for #Alzheimer’s disease", bit.ly/2TZWJTO. Can we develop therapies that mimic APOE ε2 effects to prevent/delay/cure AD?
New data from the @biofinder_study suggest that enlarged perivascular spaces, which previously have been implicated in AD+pathological #aging, are related to small vessel but not #Alzheimer disease or cognition:bit.ly/35vU7CA @GreenJournal @OskarHansson9 @NiklasMattsson4
You could pay every American $3,000 on the money that the wealthiest 0.0002% have *increased* their wealth by during the pandemic -__-
You could pay every American $3,000 on the money that the wealthiest 0.0002% have *increased* their wealth by during the pandemic -__-
Prof. Melissa E. Murr.. @DrNeuroChic
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467 Followers 228 Following Research center at University of Oslo. Our goal is to understand brain and cognitive changes throughout the entire lifespan, and how we can optimize them.Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and FTLD. 101 patients w/ CSF & neuropath data. bit.ly/3K0hWFf @NiklasMattsson4 @grinberg_t @RikOssenkoppele @ajehrenberg @SalvoSpinaSF @JulioCRojas10 @relajoie @leoiacca @OskarHansson9 @RabLab_UCSF
Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and FTLD. Class II evidence. bit.ly/3K0hWFf @NiklasMattsson4 @grinberg_t @RikOssenkoppele @ajehrenberg @SalvoSpinaSF @JulioCRojas10 @relajoie @leoiacca @OskarHansson9 @AlbaLanguage @RabLab_UCSF
Exciting #ADPD2022 day tomorrow for my first in-person conference again 🤩🎉! Join us at 8h30 for the Fluid Biomarkers 1 session for some @biofinder_study updates by @SebastianPalmqv and I, and other amazing speakers! Followed by a plenary by @OskarHansson9!
We hope you enjoyed the first day of AD/PD™ 2022! Let us know what you thought on social media using #ADPD2022 and join us again tomorrow!🤩 #visitbarcelona #alzheimers #parkinsons #ADPD2022 #neurodegenerative #alzheimersnews
Enjoying the first day of #ADPD2022 If you are interested in #astroglia in #Alzheimer's, do not miss our poster #144. We show that in early stages, higher plasma #GFAP levels are associated with higher glucose metabolism, as measured with FDG PET. #BarcelonaBeta @fpmaragall
Greatful for the opportunity to present my work at #ADPD2022 !
Research in progress in one of our research groups. @NiklasMattsson4 @roman_sattarov #researchinprogress #phdlife #neuroscience #operetta #experimentalresearch #biomarkers #inducedneurons
Findings from @biofinder_study reveal genetic influence on longitudinal #cognitivedecline in early stages of #AD, partially mediated by #Abeta pathology. @SciReports @SebastianPalmqv @OskarHansson9 @NiklasMattsson4 @medfak_LU rdcu.be/czgt1
80 % of the world’s #HighlyCitedResearchers at #lunduniversity comes from MultiPark. Congratulations to @OskarHansson9 @sara_linse and @NiklasMattsson4. And to @BrundinPatrik, previously initiating MultiPark. @medfak_LU #Clarivate multipark.lu.se/article/majori…
Our recent paper shows that plasma pTau is mainly related to amyloid plaques in early disease and tau tangles in later disease stages. That is, soluble pTau is associated with both pathologies and not simply a marker of any of these pathologies per se. doi.org/10.15252/emmm.…
Great collaboration evaluating plasma pTau in two cohorts characterized using either neuropathology (Banner) or PET (BioFINDER). Especially thanks to @NiklasMattsson4. @MultiparkL @lunduniversity
Our recent paper shows that plasma pTau is mainly related to amyloid plaques in early disease and tau tangles in later disease stages. That is, soluble pTau is associated with both pathologies and not simply a marker of any of these pathologies per se. doi.org/10.15252/emmm.…
NEW: @NiklasMattsson4, @OskarHansson9 et al. show that levels of soluble P-tau217 in #plasma reflect BOTH #amyloid and #tau pathology. Is P-tau involved in amyloid-dependent formation of neocortical tau tangles? bit.ly/2PQNFSJ @biofinder_study @MultiparkL @EmboMolMed
Great talk by @RikOssenkoppele at the #TN2 symposium, covering clinicoanatomical associations, patterns in atypical variants (including the behavioral variant 🙌🏻), diagnostic and prognostic values and the future of #tau #PET in the clinic!
In a phase IIb/III (truncated) clinical trial in preclinical #Alzheimer's disease, #Atabecestat (a nonselective oral β-secretase inhibitor) was associated with dose-related WORSENING of #cognitive (and #neuropsychiatric) symptoms. bit.ly/35WWZcA @JAMANeuro.
NEW: our longitudinal #Tau #PET study led by @ErikRubenSmith showed that females and younger individuals showed higher rate of tau accumulation, bit.ly/3qlAMO0. @Brain1878 @biofinder_study @NiklasMattsson4 @SebastianPalmqv @AntoineLeuzy @OskarHansson9
In a longitudinal PET study, Smith et al. show that tau accumulation rates are higher in females, younger Aβ-positive individuals, and those with higher baseline tau load. bit.ly/3qlwLJy
Big day! Today both Tessa Timmers and Emma Wolters (aka “the tau twins”) will defend their #PhD thesis on #tau #PET. @AlzheimerAms @PhilipAlz
Nya rön om biomarkörer för risk att utveckla #Alzheimers sjukdom. Forskarna har även utvecklat en app för riskbedömning #Forskning med stöd av Knut och Alice Wallenbergs Stiftelse #KAW100 @OskarHansson9 @NiklasMattsson4 @Lundsuni bit.ly/37h3RROv
Nya rön om biomarkörer för individens risk att utveckla #Alzheimers sjukdom från @OskarHansson9 och @NiklasMattsson4 vid @Lundsuni. Forskarna har även utvecklat en en app för riskbedömning. lu.se/artikel/valide… @biofinder_study @MultiparkL
App predicts risk of developing Alzheimer’s New findings: biomarkers can reveal an individual’s risk of developing #Alzheimers #Research supported by Knut and Alice Wallenberg Foundation #KAW100 @OskarHansson9 @NiklasMattsson4 @Lundsuni #dementia #medicine bit.ly/39ujDM7
App predicts risk of developing Alzheimer’s: bit.ly/3qdgshN #Alzheimers #medicine #dementia @NatureAging
@medfak_LU @OskarHansson9 @NiklasMattsson4 @Lundsuni @biofinder_study @MultiparkL Viktigt för våra patienter @skanesus @regionskane
WCMM Fellow Niklas Mattson-Carlgren has developed an AD risk assessment app together with Prof Oskar Hansson. @KAWstiftelsen @medfak_LU @lunduniversity @NiklasMattsson4
Nya rön om biomarkörer för individens risk att utveckla #Alzheimers sjukdom från @OskarHansson9 och @NiklasMattsson4 vid @Lundsuni. Forskarna har även utvecklat en en app för riskbedömning. lu.se/artikel/valide… @biofinder_study @MultiparkL