Daniel Kim @vervacity
Medical oncology fellow @MSKCancerCenter | previously @StanfordMedRes, @StanfordMSTP, @MITEECS | physician-scientist, full-stack genomics vervacity.github.io New York, NY Joined April 2010-
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Excited to share our paper out today in @ScienceMagazine! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4) science.org/doi/10.1126/sc…
Thrilled to share our new @NatureGenet paper! We mapped human skin at single-cell spatial resolution and found that anatomy is encoded in cell states and neighborhoods, led by PhD student @paularstrpo. Link: nature.com/articles/s4158… 1/9
Excited to share our study of T cell signaling, where we directed high-content, single-cell genetic screening to uncover how a single adapter protein orchestrates a complex cellular process essential for health. (1/14) biorxiv.org/content/10.110…
1) Super excited that COVET and ENVI by the gifted @DoronTheViking finally out in @NatureBiotech providing a powerful tool to analyze the rapidly accumulating spatial transcriptomics data. See x.com/dana_peer/stat… for the original BioRxiv tweetorial -->
The covariance environment defines cellular niches for spatial inference go.nature.com/4auQI72
We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in @Nature nature.com/articles/s4158…. Thread 👇(1/N)
Exciting news! Our latest research on "Cell type directed design of synthetic enhancers" has been published in @Nature. We've harnessed deep learning to design enhancers with cell-type specificity. Find our paper here: nature.com/articles/s4158…. Highlights below: [1/n]
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent immune response against a distant tumor. @yerinchen led the charge w/ help from @DjenetBousbaine, @VeinbachsA, @BelkaidLab. @ScienceMagazine 1/26 science.org/doi/10.1126/sc…
Absolutely overjoyed to share our incredible @StanfordMedRes #Match2023. So excited to welcome this amazing group of physicians and physician-scientists to the @StanfordDeptMed family. Welcome!!! 🥳🎉🍾 @HeartBobH @PoonamHosamani @WendyCaceresMD @StanfordChiefs @AJRogers_ICU
We published a paper "Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease" 1/ authors.elsevier.com/c/1gIGbL7PXiquv DOI: doi.org/10.1016/j.cell…
@anshulkundaje @midjourney_ai Congratulations!! Thanks for taking on a very clueless grad student all those years ago - I would never have done ML or become a comp bio person if it weren’t for my time in the lab.
though also i am truly excited for the possibilities. keep it coming, i cannot WAIT to use these tools!
i am definitely not the first and will definitely not be the last to say - plz slow down so simple humans like myself can keep up 😅
i'm on vacation now after a hectic season of fellowship apps, inpatient time, on-call nights, and finally catching up a little on #ML #science - and WOW we got crazy text generation #ChatGPT; image generation #dalle; and even PROTEIN GENERATION @UWproteindesign @generate_biomed
Was about to start the Road to Hana #Maui when we stopped to get the match results - so thrilled to be going to @MSKCancerCenter for Heme/Onc! So grateful to all my mentors and community @StanfordMedRes @anshulkundaje Paul Khavari #StanfordMSTP. Excited for this new adventure!
This morning at the Illumina Genomics Forum, we unveiled our fastest, most cost-efficient sequencing machine yet – the NovaSeq X series. This technology will slash the cost to $200 per human genome and provide a readout at twice the speed. @WIRED feature: wired.com/story/the-era-…
What are the rules of enhancer syntax? How flexible/constrained TF motif positions within enhancers are? How does the sequence context modulate the contribution of motifs to enhancer function? Excited to share our work together with @reiterfanny addressing these questions! 1/19
Enhancers display constrained sequence flexibility and context-specific modulation of motif function biorxiv.org/cgi/content/sh… #bioRxiv
Excited to share our work on using deep learning to predict enhancer activity from DNA sequence, learn cis-regulatory rules and the importance of TF motif instances, and design synthetic enhancers with desired activities. @reiterfanny @stark_lab (1/16) biorxiv.org/content/10.110…
The @stark_lab at the IMP has developed a deep learning model, DeepSTARR, which predicts the activity of enhancers from their DNA sequence with exceptional accuracy. Now published @NatureGenet. The paper 👇🏾 [1/n] nature.com/articles/s4158…
this tweet is dedicated to my patient for whom we finally got the properly sized catheter. i never expected to learn so much about hospital supply chains
an observation: in medicine we often extend ourselves to perform logistical miracles for our patients' care - which is great training for getting things done, but not gonna lie it's also kinda harrowing 😅 #internyear #medres #wheredidallthesegrayhairscomefrom
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