Eric Topol @EricTopol
physician-scientist, author, editor. Ground Truths: https://t.co/YhatcBT0hA scripps.edu/translational La Jolla, CA Joined November 2009-
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Followers693K
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Following587
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The gut microbiome and #LongCovid: "Gut microbiome-based multi-label machine learning accurately predicts upcoming long-term symptoms after acute COVID19." cell.com/cell-host-micr… @cellhostmicrobe by @Siew_C_Ng @CUHKMedicine and colleagues
The story of frequent persistence of #SARSCoV2 in multiple organs after mild Covid keeps getting stronger, and correlates (odds ratio >5) with symptoms of #LongCovid 🆕@TheLancetInfDis thelancet.com/journals/lanin…
Reupping for #EarthDay2024
Brain activation mapping in people with low and high BMI and ability to modify eating behaviors pnas.org/doi/10.1073/pn… @PNASNews
What if you could diagnosis most cancers cheaply and quickly from a dried serum spot like what's used for screening newborns? nature.com/articles/s4189… @naturesustainab
Owing to concerns for aspiration and delayed gastric emptying, GLP-1 drugs are recommended to be withheld before surgery. New data suggest this may not be necessary jamanetwork.com/journals/jama/… @JAMA_current @aadixit @stanfordanes
Unraveling the mechanism for #SARSCoV2 high complex mutation rate that can appear suddenly: RdRp template switching events nature.com/articles/s4156… @NatureMicrobiol @BCMFromtheLabs @bcmhouston
I tell my students the impact of GLP-1 based therapeutics is one of the most remarkable things I have seen in my career. This podcast from @EricTopol and @DanielJDrucker is a must-listen to get a sense of the revolution underway and how society at large will change as a result.
I tell my students the impact of GLP-1 based therapeutics is one of the most remarkable things I have seen in my career. This podcast from @EricTopol and @DanielJDrucker is a must-listen to get a sense of the revolution underway and how society at large will change as a result.
Great to see Prof Svetlana Mosjov recognized as a co-discoverer of GLP-1 time.com/6964971/joel-h… #TIME100 For a highly informative discussion of the unanticipated benefits of these drugs, and side effects, my recent Ground Truths w/ @DanielJDrucker (link in profile)
AJ Leonardi, MBBS, Ph.. @fitterhappierAJ
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220K Followers 2K Following We study antiviral immunity and viral disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII President of @ImmunologyAAI
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Here's a visual of the US H5N1 "Cattle clade", HA plus two internal genes. Strongly suggests to me there was single origin, at least for these sequences. Possibly in late 2023/early 2024.
Here is a link to 239 consensus genome sequences, assembled by @xrayfoo, from sequencing reads of 2.3.4.4b H5N1 influenza A virus from cattle and other species. github.com/andersen-lab/a…
Can AI rewrite our human genome? ⌨️🧬 Today, we announce the successful editing of DNA in human cells with gene editors fully designed with AI. Not only that, we've decided to freely release the molecules under the @ProfluentBio OpenCRISPR initiative. Lots to unpack👇
@EricTopol @NatureMicrobiol @BCMFromtheLabs @bcmhouston If you look closely, you can see examples of such TRS-related template-switching events in sequences every day. Just today one I hadn't noticed before showed up in a cluster of sequences from Japan. The match w/the TRS-L is good, especially if you fudge a bit by skipping a nuc.
@EricTopol @NatureMedicine Using AI to reduce bias and promote fairness is revolutionary. Thanks for sharing the links!
One way to enhance #PandemicPreparedness is to discover/repurpose drugs against novel pathogens. In our new manuscript, we repurpose an antibiotic that is currently broadly available and potentiates the innate immune system against respiratory viral infections. 👇
Repurposed: Intranasal administration of neomycin, an antibiotic, led to protection in mouse and hamster models vs Covid, and (neosporin) raised interferon expression in humans pnas.org/doi/10.1073/pn… @PNASNews @VirusesImmunity @tianyangmao @YaleIBIO
@EricTopol @NatureMicrobiol @BCMFromtheLabs @bcmhouston Congratulations @ChristopheHer16 and company!
@EricTopol @NatureMedicine Thank you for surfacing this issue Eric! 👏
@EricTopol @PNASNews @ThaisLaerkholmJ @CEBI_UCPH Our dust study resonate it clearly how airborne transmission occurs doi.org/10.1016/j.isci…
shop til you drop! never more true
A clever and unique study documents that much Covid transmission occurred via shopping in retail stores pnas.org/doi/10.1073/pn… @PNASNews @ThaisLaerkholmJ @CEBI_UCPH
@EricTopol @PNASNews @ThaisLaerkholmJ @CEBI_UCPH The CO2 at my grocery and drug stores is about 600. At the vet and doctor, over 2000.
@EricTopol @drkerrynphelps @PNASNews @ThaisLaerkholmJ @CEBI_UCPH Very interesting. I just came back from buying milk at the local retail store while wearing a fitted 3M with double straps. Unfortunately, very few people masking now. Thank you @EricTopol for posting. #RemainingNovid
@EricTopol @PNASNews @ThaisLaerkholmJ @CEBI_UCPH Thanks for sharing this important work! To add to this point, we can use indoor dust to measure the level of Covid transmission as well ⬇️ x.com/charinmodchang…
In summary, we found a link between SARS-CoV-2 RNA levels in dust and COVID-19 cases. Higher dust viral concentrations suggest higher community risk. Also, less movement = less virus in public spaces. doi.org/10.1016/j.isci… 6/6
Despite the compulsory hand sanitisers? Well what a surprise! #COVIDIsAirborne
A clever and unique study documents that much Covid transmission occurred via shopping in retail stores pnas.org/doi/10.1073/pn… @PNASNews @ThaisLaerkholmJ @CEBI_UCPH
@JillianMichaels Meanwhile people who do this for a living who have no financial incentive are promoting this drug for severely obese people. Not the vain person who wants to lose 50 pounds and is too lazy. Maybe bring a real expert on like @EricTopol
I tell my students the impact of GLP-1 based therapeutics is one of the most remarkable things I have seen in my career. This podcast from @EricTopol and @DanielJDrucker is a must-listen to get a sense of the revolution underway and how society at large will change as a result.
Great to see Prof Svetlana Mosjov recognized as a co-discoverer of GLP-1 time.com/6964971/joel-h… #TIME100 For a highly informative discussion of the unanticipated benefits of these drugs, and side effects, my recent Ground Truths w/ @DanielJDrucker (link in profile)
I was just named Data Journalist of the Year! I won the award for what the judges called "pioneering" work using satellites to cover war. Huge thanks go my colleagues at @TheEconomist who make my work possible. More here thepressawards.com/results-2024
Watch for this microplastics association to show up in the context of early onset rectal cancers (numbers of which are going through the roof).
Good succinct summary of the microplastic mess. Recent evidence of presence in arteries, clots, and GI tract and correlation with adverse health outcomes nature.com/articles/s4159… @NatureMedicine
April 19th update: Infection rates still declining to low numbers. We will find out by early May if the FLiRT mutations are able to reverse the trend. 🔸200,000 new infections/day 🔸~2.77 avg total infections per capita across the US 🔸1 in every 164 people currently infected
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