Jesse Engreitz @jengreitz
Assistant Professor @stanford Genetics and BASE Initiative. Mapping the regulatory code of the human genome to understand heart development and disease. engreitzlab.org Stanford via Broad/MIT/Harvard Joined August 2010-
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Our paper "A machine readable specification for genomics assays" is now published in Bioinformatics, @OUPBioinfo. In short, we present a lightweight file format and command-line tool to document the structure of sequencing reads. Coauthored with @XiChenUoM and @lpachter. Paper:…
Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158… I break the key findings down panel by panel in this thread: x.com/cureffi/status…
Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158… I break the key findings down panel by panel in this thread: x.com/cureffi/status… https://t.co/k6g7paLMdA
What a PERFFect day to share our new preprint! With @tsion_abay #BobStickels @MerilTakizawa @ChaligneRonan and @Satpathology, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n
Check out this new preprint/white paper from our friends at Entwine bio together with @vram142 and @ZaroLab. We and others have long been interested in sequence-to-function modeling in RNA, especially as it comes to splicing. biorxiv.org/content/10.110…
An Analysis presents a collection of non-coding CRISPRi screens from the ENCODE4 Functional Characterization Centers and establishes experimental guidelines for future screens identifying cis-regulatory elements. @ReillyLikesIt nature.com/articles/s4159…
Our new paper on non-coding CRISPRi screens to functionally characterize enhancers just came out in @naturemethods ! nature.com/articles/s4159…
We report a new CRISPR resource, Fragmid, in @CellGenomics today, let by the incomparable Abby McGee. Let's walk through it… cell.com/cell-genomics/…
Neurons and astrocytes closely coordinate their gene expression, in a program we call “SNAP” – a collaboration that we find to be central in protection from schizophrenia and cognitive aging. nature.com/articles/s4158…
We devised a human-mouse mixing experiment to identify RNA-protein contacts that could not have occurred in vivo. We find that many PRC2-RNA contacts are detected even when the RNA and protein are not expressed within the same cells, clearly establishing that there is a problem.
Online Now: Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo dlvr.it/T33rxh
Delighted to see this out. The work deepens our understanding of lncRNAs structure-function relationships, ultimately suggesting that RNAs functional element deriving from SINE may acquire similar folding and function, even without shared ancestor. doi.org/10.1038/s41467…
Delighted to present our work predicting cell type-specific epigenomic profiles whilst accounting for distal genetic effects. See below for a 🧵 with the details 1/15 biorxiv.org/content/10.110…
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology nature.com/articles/s4158… Wonderful paper just out @Nature from @EleZeggini and co.
Long non-coding RNAs comprise a large part of the genome, yet loss of one copy (haploinsufficiency) of a lncRNA is not known to cause a human disease. Read our preprint to learn how deletions of the lncRNA CHASERR cause a severe neurodevelopmental disorder.medrxiv.org/content/10.110…
Research from HMS, @BrighamWomens and the @broadinstitute, shows how genetic alterations can affect the biology of cells that line the walls of blood vessels to magnify heart disease risk bit.ly/3w6HWx4
Excited to open registration for the symposium 'Frontiers of Implemented Genomic Medicine' hosted by the @novonordiskfond Center @broadinstitute & Maria Rossing fr @Rigshospitalet. Such an exciting topic & truly exceptional group of speakers. Please share! broadinstitute.swoogo.com/frontiers2024
Our study is out @Nature. We identify non-lipid risk pathways for coronary artery disease using pooled CRISPR-interference for 2,285 genes at GWAS loci. With an amazing team we identified the genetic risk pathways for CAD that act in endothelial cells. nature.com/articles/s4158…
Anshul Kundaje (anshu.. @anshulkundaje
22K Followers 2K Following Genomics, Machine Learning, Statistics, Big Data and Football (Soccer, GGMU). Post: @anshulkundaje, Threads: anshulkundaje
Lior Pachter @lpachter
44K Followers 2K Following Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatter
Veera Rajagopal @doctorveera
17K Followers 4K Following MBBS, MD, PhD | GWAS storyteller | Scientist at Regeneron | Human genetics & drug discovery in Neuroscience & Psychiatry | He/Him
Arjun Raj @arjunrajlab
25K Followers 2K Following Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. https://t.co/fZAnUCqd12
Anne Carpenter, PhD @DrAnneCarpenter
21K Followers 2K Following Discovery in images. Enthralled by science. 5 kids. She. SAB Recursion, Quiver. Founder SyzOnc. https://t.co/CQCHnSAc9M
Patrick Hsu @pdhsu
30K Followers 3K Following co-founder @ArcInstitute, @BerkeleyBioE professor | researcher & investor in genome editing, biotech, AI | 🇨🇦 @harvard @broadinstitute @editasmed, Fast Grants
Manolis Kellis @manoliskellis
25K Followers 4K Following Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL, @BroadInstitute
Eric Fauman @Eric_Fauman
6K Followers 246 Following GWAS whisperer 'Nothing in biology makes sense except in the light of evolution' -Dobzhansky DMs open Executive Director, Integrative Biology @Pfizer
Mitch Guttman @mitchguttman
3K Followers 190 Following Molecular biologist interested in non-coding RNAs, nuclear organization, and gene regulation. Professor at Caltech
Pradeep Natarajan @pnatarajanmd
23K Followers 817 Following Dir of Preventive Cardiology @MassGeneralNews | Assoc Dir of Personalized Medicine @MassGenBrigham | Assoc Prof @harvardmed | Assoc Mem @broadinstitute
Cecilia Lindgren @ceclindgren
8K Followers 1K Following Director of Oxford Big Data Institute. Proud mom of 3. Co-chair of @icdabio. Wellcome Trust Investigator. Promoting equality in academia. Love 🦈. #🕷🕸💙
Benoit Bruneau @benoitbruneau
9K Followers 2K Following Cardiovascular disease researcher, developmental biologist, and Oakland resident. Je cherche a comprendre.
Anders Sejr Hansen @Anders_S_Hansen
4K Followers 2K Following Associate Professor @MITdeptofBE : https://t.co/uy48t7k949 Interested in understanding the relationship between 3D genome structure and function
Michael Love @mikelove
18K Followers 5K Following I'm not on twitter anymore, find my on Bluesky or Mastodon
Jian Ma @jmuiuc
7K Followers 1K Following Ray and Stephanie Lane Professor of Computational Biology at CMU School of Computer Science @CMUCompBio @SCSatCMU @CarnegieMellon
Vijay Sankaran @bloodgenes
10K Followers 3K Following Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist - @DFBC_PedCare, @BostonChildrens, @DanaFarber & @broadinstitute
Julia Joung @JuliaJoung
2K Followers 411 Following Postdoc in the lab of Jonathan Weissman @WhiteheadInst. PhD Feng Zhang lab | @MITdeptofBE | @broadinstitute
Jacob Schreiber @jmschreiber91
4K Followers 1K Following Post-doc @StanfordMed, studying genomics, machine learning, and fruit. Editor @StanfordAILab Blog, @JOSS_TheOJ. My code is like our genomes: most of it is junk.
Josh Tycko @JoshTycko
2K Followers 3K Following Postdoc at Harvard Med, Greenberg lab & BIDMC, Pollak lab aka DJ Fishing Expedition
Jason Sheltzer @JSheltzer
17K Followers 2K Following Assistant prof at @YaleMed. Interested in aneuploidy, mitotic kinases, drug targeting, CRISPR, and promoting diversity in science. Co-founder @MelioraTx.
Gunjan Dixit @Gunjan_D12
204 Followers 986 Following PhD student at the John Curtin School of Medical Research, ANU. #Bioinformatician
Sebastien « Seb » B.. @sbonnet2
1K Followers 654 Following #PAH #RVfailure #AHA #ATS #ERS #ESC #PVRI #PSG #Girondins #Foot #LetsgoOilers #Canada #Quebec #epigenetic #heartfailure #pulmonaryhypertension #coronarydisease
ana @anasaprieto
0 Followers 43 Following
Karl Heilbron @karlheilbron
173 Followers 276 Following
Kaijin Chen @KaijinChen
13 Followers 51 Following B.S. @ZJU_China. PhD student @Westlake_uni. Transcriptional activation | enhancer-promoter intereation | 3D genome
Elisabeth Bik @MicrobiomDigest
149K Followers 49K Following Science integrity consultant, PhD. #ImageForensics Previously @ Stanford and (gasp!) uBiome. She/her. elisabethbik.bsky https://t.co/V4MR7WVHiT 🇳🇱🇺🇸
Lucas Kampman @LucasKampman
11 Followers 88 Following Incoming class of '23, UW/Fred Hutch MCB PhD. Past: Corces Lab @GladstoneInst, Laura Kaufman Group @ChemColumbia, Hallatschek Lab @BerkeleyPhysics
Koushik @koushik_here
716 Followers 5K Following Machine Learning for biology | Deep Learning Data Scientist @Bayer4Crops | Prev: PhD @IowaStateU | he/him
Yujin Kim @yjkim_4869
6 Followers 36 Following Bioinformatician. Korea University. Interested in genomics, noncoding genome, package development, autism spectrum disorder and Alzheimer's disease.
noahalexander @noahale67781532
3 Followers 95 Following
Quinn Cowan @Quinn_Cowan_sci
194 Followers 297 Following Biochemistry PhD candidate in the @KomorLab @UCSanDiego 🧬🔬 Looking for postdoc positions 👀
stephen zhang @syzmath
566 Followers 1K Following applied mathematics grad student, misanthrope x(t) ~ @scimelb + @UBCmath + 𝒪(Δ t²) also death+black+tech+??? metal currently not upside down
Michael Herger @HergerMichael
26 Followers 255 Following Postdoc in the Genome Function Laboratory @TheCrick | Functional Genomics, Protein Engineering, Synthetic Biology
Anurag Das @anurag721
594 Followers 709 Following Neuro PhD @IowaStateU 🪰 Glia , metabolic organelles, circadian & Drosophila enthusiast. Driven to discover the unknown & generate new knowledge. ChelseaFC 💙
Albert Vilella @AlbertVilella
21K Followers 8K Following Next-Generation Sequencing, Single-Cell and Spatial Biology, Next-Generation Proteomics, Synthetic Biology, Compute Acceleration in Biotech.
Wector @Wector18
14 Followers 290 Following bioinformatics DNA damage DNA repair genomics RNA-seq multi-omics data data analysis machine learning
giovanni @lembo1993
2 Followers 58 Following
Han Yuan @HY3952
334 Followers 367 Following Computational biologist @Calico. Previously Ph.D in Leslie lab at @MSKCC. Study system biology and regulatory genomics.
Pariya Mohammadyari @pariya_mhmdyri
2 Followers 46 Following https://t.co/J3Q00McvRs in Medical Laboratory Science
Hani Goodarzi @genophoria
4K Followers 1K Following Core Investigator @arcinstitute | Associate Professor @Ucsf_Biochem @UCSFurology @UCSFCancer | {Computational, Cancer, RNA} biologist
Matteo Gianeselli, MD @MatteoGianesel2
91 Followers 392 Following PhD Student at @IcahnMountSinai |🫀passionate | physician-scientist wannabe | freediver🤿
Maria Pirra @pirra_maria
30 Followers 279 Following PhD student @ Italian Institute of Technology (IIT), interested in cell tracking, gene regulation and breast cancer🔬🧬
Digbijay Mahat @DigbijayMahat
993 Followers 467 Following Cancer Research Scientist working on single-cell transcriptomics at MIT |🇳🇵
maplecai @maplinecai
0 Followers 60 Following
Adib Miraki Feriz @Adib_m_
52 Followers 249 Following Computational Biologist at @mo_lotfollahi lab 🧬 ایرانی هستم.
Ethan Garvin @EthanRGarvin
52 Followers 77 Following
Peinan Hu @HuPeinan
22 Followers 129 Following PhD Candidate in CWRU, gene regulation, genome architecture.
Marathon.Beh @BehMarathon
8 Followers 316 Following Commissioning Editor, Frontiers in Bioscience-Elite /Frontiers in Bioscience-Scholar (PubMed Indexed), IMR Press
Yutong Zhu @YuutongZhu
0 Followers 3 Following
Ali Farhat @alifarhat40
150 Followers 2K Following MD/PhD Candidate @uicmstp (G3) | UCLA BioEngineering alum '19 🇺🇲🇱🇧
Oznur Tastan @TastanOznur
2K Followers 2K Following Associate Prof. @sabanciu; machine learning + computation biology. Prev. @MSFTResearch, Alumni @SCSatCMU @LTIatCMU and @sabanciu Views are my own.
Stephen Dorn @stphn_drn
199 Followers 403 Following MS student in Biomedical Data Science @UWMadison. Interested in statistical genetics and its applications to neurodegenerative disorders.
a @neutrlmilfhoteI
172 Followers 358 Following
Chinese Knot @Chinese__knot
24 Followers 90 Following PhD Candidate at Department of Systems Biology in Columbia; Genetics; Deep Learning; Variant Effect Prediction
Javed Chitaman @jchitaman
76 Followers 451 Following 🇹🇹 PhD Candidate at FSU. Some of my interests include 3D epigenomics, brain plasticity, and the Mets.
Wilson (Yuqin Wu) @Wilson79078233
542 Followers 4K Following PhD candidate at Monash BDI, study in Glucagon signalling in metabolic control (supervised by Dr Adam Rose, the head of Nutrient Metabolism and Signalling lab)
Steamed Bun Invasion .. @BaoZiInvasion
1K Followers 5K Following Neuroscience Masters student. I am disabled by Autism
Sissi @SissiCallofDuty
3 Followers 19 Following
Dr. Caf @STROMAMAJOKES
43 Followers 88 Following Just a caf trying to find its desmoplace in this world
Loïc Yengo @LoicYengo
1K Followers 159 Following Snow Fellow | Group Leader | Statistical Genomics Lab at the Institute for Molecular Bioscience | The University of Queensland
NING XIE | 谢宁 @XieNing_Ning
3 Followers 20 Following
Hannah Munby @hannah_munby
144 Followers 305 Following Evolutionary genomics + population genetics. Biology PhD student @ Columbia w/ Molly Przeworski. Previously Durbin group @geneticscam
Guido Barzaghi @BarzaghiGuido
425 Followers 1K Following PhD student at @EMBL with the Krebs and Zaugg labs. TF binding, TF cooperativity, Bioinformatics, SingleMoleculeFootprinting.
Tuomo Kiiskinen @i_am_dr_doom
217 Followers 538 Following MD-Ph.D | Helsinki-based Genomancer @FIMM_UH PostDoc /w @HannaMOllila. ER Doctor (self-employed) | The Last Warrior Poet
Ruby Michelle @Rubymich1234
430 Followers 5K Following
Anshul Kundaje (anshu.. @anshulkundaje
22K Followers 2K Following Genomics, Machine Learning, Statistics, Big Data and Football (Soccer, GGMU). Post: @anshulkundaje, Threads: anshulkundaje
David R. Liu @davidrliu
64K Followers 59 Following Professor at Harvard, Broad Institute, & HHMI. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1
Lior Pachter @lpachter
44K Followers 2K Following Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatter
Veera Rajagopal @doctorveera
17K Followers 4K Following MBBS, MD, PhD | GWAS storyteller | Scientist at Regeneron | Human genetics & drug discovery in Neuroscience & Psychiatry | He/Him
Arjun Raj @arjunrajlab
25K Followers 2K Following Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. https://t.co/fZAnUCqd12
Fabian Theis @fabian_theis
29K Followers 446 Following Computational biologist @HelmholtzMunich, prof @TU_Muenchen & associate PI @sangerinstitute. Dad of 4 and mountain lover. Department news, see @CompHealthMuc
Patrick Hsu @pdhsu
30K Followers 3K Following co-founder @ArcInstitute, @BerkeleyBioE professor | researcher & investor in genome editing, biotech, AI | 🇨🇦 @harvard @broadinstitute @editasmed, Fast Grants
Manolis Kellis @manoliskellis
25K Followers 4K Following Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL, @BroadInstitute
Eric Fauman @Eric_Fauman
6K Followers 246 Following GWAS whisperer 'Nothing in biology makes sense except in the light of evolution' -Dobzhansky DMs open Executive Director, Integrative Biology @Pfizer
Mitch Guttman @mitchguttman
3K Followers 190 Following Molecular biologist interested in non-coding RNAs, nuclear organization, and gene regulation. Professor at Caltech
Pradeep Natarajan @pnatarajanmd
23K Followers 817 Following Dir of Preventive Cardiology @MassGeneralNews | Assoc Dir of Personalized Medicine @MassGenBrigham | Assoc Prof @harvardmed | Assoc Mem @broadinstitute
Cecilia Lindgren @ceclindgren
8K Followers 1K Following Director of Oxford Big Data Institute. Proud mom of 3. Co-chair of @icdabio. Wellcome Trust Investigator. Promoting equality in academia. Love 🦈. #🕷🕸💙
Benoit Bruneau @benoitbruneau
9K Followers 2K Following Cardiovascular disease researcher, developmental biologist, and Oakland resident. Je cherche a comprendre.
Anders Sejr Hansen @Anders_S_Hansen
4K Followers 2K Following Associate Professor @MITdeptofBE : https://t.co/uy48t7k949 Interested in understanding the relationship between 3D genome structure and function
Michael Love @mikelove
18K Followers 5K Following I'm not on twitter anymore, find my on Bluesky or Mastodon
Jay Shendure @JShendure
14K Followers 332 Following Genomics technology developer. Developmental biology adult learner. Professor at @uwgenome @HHMINEWS @BrotmanBaty. He/him.
Vijay Sankaran @bloodgenes
10K Followers 3K Following Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist - @DFBC_PedCare, @BostonChildrens, @DanaFarber & @broadinstitute
Schübeler Lab @SchubelerLab
4K Followers 430 Following Studying gene regulation in chromatin @FMIscience
Julia Joung @JuliaJoung
2K Followers 411 Following Postdoc in the lab of Jonathan Weissman @WhiteheadInst. PhD Feng Zhang lab | @MITdeptofBE | @broadinstitute
Jacob Schreiber @jmschreiber91
4K Followers 1K Following Post-doc @StanfordMed, studying genomics, machine learning, and fruit. Editor @StanfordAILab Blog, @JOSS_TheOJ. My code is like our genomes: most of it is junk.
Nicky Whiffin @nickywhiffin
4K Followers 759 Following Associate Prof & Henry Dale Fellow @bdi_oxford @HumanGeneticsOx | Computational Rare Disease Genomics | Non-coding | @StAnnesCollege | @nickywhiffin.bsky.social
Hani Goodarzi @genophoria
4K Followers 1K Following Core Investigator @arcinstitute | Associate Professor @Ucsf_Biochem @UCSFurology @UCSFCancer | {Computational, Cancer, RNA} biologist
Jonathan Weissman's L.. @JswLab
9K Followers 4K Following Jonathan S. Weissman's lab at the @WhiteheadInst/@MIT. Account run by lab members.
David Garfield (@daga.. @dagarfield
2K Followers 1K Following Computational biology, regeneration, aging, and evolution at gRED (Genentech). The views expressed here are most definitely my own.
Fyodor Urnov @UrnovFyodor
15K Followers 533 Following Gene editor + Professor of Molecular Therapeutics @berkeleyMCB + Director of @igisci @danahercorp Beacon for CRISPR Cures.
Jure Leskovec @jure
43K Followers 377 Following Professor of #computerscience @Stanford; Co-founder at https://t.co/hhm1j5wP0f #machinelearning #graphs.
Sheila Teves @sheilat.. @sheilateves
4K Followers 2K Following Assistant Professor, Biochemistry Department, Transcription & Chromatin biology, Outdoor enthusiast, Dog lover (otters too), Occasional politics 🇵🇭🇺🇲🇨🇦
Paul de Bakker @Piwdb
3K Followers 936 Following head of disease portfolio, data & computational sciences @VertexPharma, ex-faculty @harvardmed @BrighamWomens @umcutrecht
Heard_Lab @heard_lab
2K Followers 331 Following
Patrick Ellinor @patrick_ellinor
3K Followers 621 Following Chief of Cardiology @MGHHeartHealth, Director, CV Disease Initiative @broadinstitute, CV research mixed w weekend projects around the house
Anton Goloborodko @go.. @golobor
2K Followers 2K Following Chromosomes, loops (and extrusion thereof), Hi-C, all that stuff. A group leader at @IMBA_Vienna.
Wu Lab @TingWu_Lab
2K Followers 316 Following We are the Ting Wu Lab, located in Boston at Harvard Medical School in the Department of Genetics. Managed by WuLab members
Cosmas Arnold @cosmas_arnold
26 Followers 87 Following
Bernardo Almeida @deAlmeida_BP
742 Followers 491 Following Research scientist at @instadeepai, interested in building computational models that can read the human genome and interpret it's variation
Chan Zuckerberg Biohu.. @czbiohub
16K Followers 440 Following Accelerating science & developing new technologies to help cure, prevent, or manage all disease. Locations: #CZBiohubSF, #CZBiohubCHI & #CZBiohubNY
george church @geochurch
55K Followers 23 Following Professor @Harvard @MIT @PGorg @WyssInstitute tech dev: #CRISPR #NGS #BRAINi
Doudna Lab @doudna_lab
71K Followers 88 Following News from Jennifer Doudna's lab at @UCBerkeley @igisci. Tweets from lab members and not Jennifer Doudna unless signed JD. Tweets represent personal views only.
Teichlab @teichlab
6K Followers 70 Following Using genomics & bioinformatics to decipher immunity @sangerinstitute @humancellatlas
Plath Lab @PlathLab
968 Followers 179 Following Twitter feed for the laboratory of Prof. Kathrin Plath @UCLA
Angelika Feldmann @angifeldmann
1K Followers 735 Following Junior Group Leader @DKFZ, „Mechanisms of Genome Control“, interests: gene regulation, 3D genome structure, chromatin #NewPI
Michael Montgomery @MichaelTMont
251 Followers 304 Following #firstgen PhD Candidate in the @jengreitz Lab @StanfordMed. Passionate about dissecting and reprogramming cell type-specific gene regulation.
Brunet Lab @BrunetLab
10K Followers 5K Following Aging lab @Stanford - Epigenomics and metabolism in #aging; Brain aging and rejuvenation; Neural stem cells; C. elegans; African #killifish
Jarod Rutledge, Ph.D. @JarodRutledge1
457 Followers 329 Following Scientific omnivore. Research in longevity, AI, neuroscience, genomics. A jack of all trades is a master of none, but often better than a master of one.
Fei Chen Lab @insitubiology
3K Followers 107 Following Fei Chen's lab at @BroadInstitute and @HSCRB | Spatial and temporal genomics | Tweets by lab members | Where is Fei?
Evan Macosko @macosko
3K Followers 362 Following Genomics technologist, Psychiatrist, Associate Professor, Massachusetts General Hospital @broadinstitute. Founder, Curio Bioscience
Stein Aerts @steinaerts
4K Followers 653 Following Computational biologist interested in deciphering the genomic regulatory code | Director https://t.co/tdfwR4ZJdY
Dr. Jean Fan @JEFworks
7K Followers 382 Following Assistant prof @JHUBME. Doing #singlecell #spatialtranscriptomics #bioinformatics. Founder @cuSTEMized. Editor @PLOSCompBiol. Alum @HarvardDBMI @blairmagnet.
Chan Zuckerberg Initi.. @ChanZuckerberg
26K Followers 461 Following Building technology, community-driven solutions and collaborative partnerships for a more inclusive, just and healthy future.
Alireza Karbalayghare.. @karbalayghareh
338 Followers 911 Following ML in Biology & Genomics. Postdoc at Sloan Kettering Institute @MSKCancerCenter, Dr. Christina Leslie Lab.
Impetus @impetusgrants
2K Followers 218 Following "Huge if true" aging science. Over $34M of research funded. Next round, questions, donations and other details - https://t.co/Mz3BjY7DdQ
Juliane Weller @JulianeWeller
452 Followers 638 Following Genome architect apprentice | @sangerinstitute and @cambridge_uni | SynBio, prime editing, high throughput screening, genomics and structural variants
brent richards @BrentRichards19
2K Followers 487 Following I'm a doctor and scientist trying to use human genetics to help my patients.
Mo Lotfollahi @mo_lotfollahi
7K Followers 1K Following I train neural networks and dogs to do cool things! ML for biology and drug discovery| Faculty @sangerinstitute.
William Goodyer, MD/P.. @Will_Goodyer
412 Followers 514 Following Pediatric Cardiologist & Electrophysiologist Physician-Scientist - Goodyer Lab: https://t.co/3noHGGkQlK Father. He/him/his. 🏳️🌈
evo-devo @Xiaojie_Qiu
3K Followers 2K Following Assistant Prof. @ Stanford BASE, Genetics & Computer Science (courtesy). Lead the predictive biology lab of ML & single cell/spatial genomics, focus on heart
Stegle Lab (EMBL & DK.. @StatGenomics
3K Followers 58 Following Pioneering AI in Molecular Biology and Cancer
Josh Tycko @JoshTycko
2K Followers 3K Following Postdoc at Harvard Med, Greenberg lab & BIDMC, Pollak lab aka DJ Fishing Expedition
Nicholas Mancuso @nmancuso_
2K Followers 3K Following Associate Professor @KECKSchool_USC @uscpphs @qcb_usc. Center for Genetic Epi. Genetics/Stats/ML. Husband and father. GA➡️CA. He/him. Views are mine.
Juleen R. Zierath @JuleenRZierath
8K Followers 93 Following Professor of Physiology, Lifelong Athlete, Member of Nobel Assembly @karolinskainst, KVA @ScienceAcad_swe, & @KeystoneSymp Board - Past EASD President @EASDnews
Martin Borch Jensen @MartinBJensen
6K Followers 473 Following Aging, Systems Biology, Gene Therapy. CSO @GordianBio, doing pooled therapeutic screens in vivo. Also @impetusgrants, https://t.co/KWEUni9245. Prev K99 Fellow @BuckInstitute
SheqLab @ShechnerLab
3K Followers 2K Following The Shechner lab in UW Pharmacology. We study Noncoding RNAs and cellular architecture. He/His/Him. All comments are my own. @ShechnerLab.mstdn.science
Max Staller @maxvstaller
995 Followers 274 Following PI at the Center for Computational Biology, UC Berkeley. Transcription factors. Rational protein mutagenesis. Experiments. Machine Learning. Simulations.
I don’t know if I’m more confused about Fisher Scientific selling jeans, or about this being the top search result for a typo in paraformaldehyde.
Very excited to see our work published in Nature Medicine today! A unique autoantibody signature found in some patients w MS - 5 years before onset. & the target of that autoimmune response bears remarkable similarity to many pathogens - including EBV. nature.com/articles/s4159…
Our paper "A machine readable specification for genomics assays" is now published in Bioinformatics, @OUPBioinfo. In short, we present a lightweight file format and command-line tool to document the structure of sequencing reads. Coauthored with @XiChenUoM and @lpachter. Paper:…
Great article by @ericschmidt about the work we are doing at the National Security Commission on Emerging Biotech @biotech_gov ! 🇺🇸🧬 AI models trained on large DNA datasets + labeled data about how that DNA performs in cells will have a "ChatGPT moment" once they hit a certain…
Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158… I break the key findings down panel by panel in this thread: x.com/cureffi/status…
Is having even more gene-disease associations still useful for picking drug targets? For which types of programs does it matter? Has pharma shifted focus towards genetically validated targets? New paper by me, @mnelsonxy, @DongCoco90417, & @jivecast doi.org/10.1101/2023.0…👇
scFLARE leads to a change in clinical practice in humans? 🤯 When we made our calcium integrator scFLARE in 2020 we hoped that it would be used by basic neuroscientists to help dissect neural circuitry but we never imagined that it might lead to a change in clinical practice in…
The choice of whether to use Seurat or Scanpy for single-cell RNA-seq analysis typically comes down to a preference of R vs. Python. But do they produce the same results? In biorxiv.org/content/10.110… w/ @Josephmrich et al. we take a close look. The results are 👀 1/🧵
In a pair of @biorxivpreprint preprints just posted w/ @sinabooeshaghi and @agalvezmerchan, we describe algorithms for an open data Commons Cell Atlas and demonstrate how a Human Commons Cell Atlas can be used for discovery. biorxiv.org/content/10.110… biorxiv.org/content/10.110… 1/🧵
What a PERFFect day to share our new preprint! With @tsion_abay #BobStickels @MerilTakizawa @ChaligneRonan and @Satpathology, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n
To sum things up, we think PERFF-seq bolsters the concept of ‘nucleic acid cytometry’, recently introduced in FIND-seq (from @icclarker, Adam Abate and colleagues), but now using cells/nuclei as the vessel for enrichments rather than droplet sorting. 15/n
Learn about biopharma from @Amgen folks — for free! Weekly webinars on Thursdays 3-5pm Eastern from April 4 to May 9. Hosted by @thebiotechclub. Register at thebiotechclub.us16.list-manage.com/track/click?u=…
Delivering and expressing a gene in cells is usually a messy (heterogeneous) process. The messiness interferes with research and applications such as gene therapy. In two new papers, we introduce a toolbox of synthetic miRNA-based control circuits that enable more precise, gene…
We're in an energy and climate crisis, it's paradoxical. Hydrocarbons are powerful and portable, but limited and environmentally costly. For Episode 36 of S³ @TerraformIndies goes in-depth and reveals how they're making natural gas from thin air.
🔴 SURPRISE : We're back every last tuesday of the month! Season 3 of The Lonely Pipette is starting next tuesday 26 of march. Stay tuned ✨ . . #podcast #AcademicChatter #AcademicChatter #research #mentor #tips #scientist #worklifebalance #teaser
@SashaGusevPosts We're doing a bunch of this in @IGVFConsortium . Will be releasing very efficient workflows for single cell / nuc RNA and ATAC for many platforms and designs (eg. various types of mux) by late 2024 latest.
Fourteen years ago today, I signed the Affordable Care Act into law. Afterwards, one Republican member of the House called the ACA the “most dangerous piece of legislation ever passed in Congress.” Another predicted the country would “never recover from it.” But then something…
I also gave a seminar on creating the fourth chapter of genomics to a very enthusiastic audience, and I ended the day by having dinner with the great Stanford genomics faculty. Thank you all for making me feel so welcome!
Check out this new preprint/white paper from our friends at Entwine bio together with @vram142 and @ZaroLab. We and others have long been interested in sequence-to-function modeling in RNA, especially as it comes to splicing. biorxiv.org/content/10.110…
An Analysis presents a collection of non-coding CRISPRi screens from the ENCODE4 Functional Characterization Centers and establishes experimental guidelines for future screens identifying cis-regulatory elements. @ReillyLikesIt nature.com/articles/s4159…
Our new paper on non-coding CRISPRi screens to functionally characterize enhancers just came out in @naturemethods ! nature.com/articles/s4159…
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