Daniele Focosi, MD PhD MSc @dfocosi
Hematologist, PhD in Virology, MSc in clinical trials, transfusion physician. Opinions are mine. Retweets/likes ≠ endorsements Focosi.MD Pisa, Toscana Joined October 2009-
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It seems as @WHO likes to stay behind the game. All times. 🤦♂️ @siamosolocani @RajlabN @CorneliusRoemer
It seems as @WHO likes to stay behind the game. All times. 🤦♂️ @siamosolocani @RajlabN @CorneliusRoemer
Dumb question. Has anyone tested the supplied water at #H5N1-affected US ranches? sciencedirect.com/science/articl… frontiersin.org/journals/micro… @LouiseHMoncla @thijskuiken @PeacockFlu @DuckSwabber @MichaelWorobey
Another interesting point to note, the sequence from the human specimen (from Texas) contains the adaptation signature mutation PB2 E627K but lacks that PB2 M631L prevalent in all the cattle sequences!
Another interesting point to note, the sequence from the human specimen (from Texas) contains the adaptation signature mutation PB2 E627K but lacks that PB2 M631L prevalent in all the cattle sequences!
Humans rarely learn from history.
Humans rarely learn from history.
Oh well. PS: I’m not concerned about transmission by milk, but rather about how widespread virus circulation is.
“No update on when genomic data will be uncloaked” and you are seriously “grateful”??
“No update on when genomic data will be uncloaked” and you are seriously “grateful”??
OK, I think we're close to decisive evidence that US bovine H5N1 had a single origin from birds, and that when related viruses from birds *have* been found, they are jumps from cattle back into birds. Grackles, blackbirds, chickens all show mammalian adaptation like PB2 M631L.
#IDTwitter. Our summary of the anti-Spike monoclonal antibody clinical pipeline, featuring #Evusheld2 (#AZD3152), #VYD222 (pemivibart, Pemgarda), REGN17092, AER-800, and more. With @ACasadevall1 & @Fabrizi66265683 @Janet_Handal @bjarijn @yunlong_cao clinicalmicrobiologyandinfection.com/article/S1198-…
The story of frequent persistence of #SARSCoV2 in multiple organs after mild Covid keeps getting stronger, and correlates (odds ratio >5) with symptoms of #LongCovid 🆕@TheLancetInfDis thelancet.com/journals/lanin…
New study. We compared the immune response of XBB and JN.1 in human infections to evaluate the necessity for #SARSCOV2 vaccine updates Results: JN.1 exposure induces higher neutralization against emerging mutants, including FLiRT (JN.1+346T+456L) and KP.3 biorxiv.org/content/10.110…
This should be urgently investigated by @CDCgov . We need maximum speed and transparency. @ACasadevall1
This should be urgently investigated by @CDCgov . We need maximum speed and transparency. @ACasadevall1
T. Ryan Gregory @TRyanGregory
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649 Followers 536 Following Deputato M5S eletto nel 2022. Ex-portavoce in Consiglio Regionale della Toscana. Medico.@Mike_Honey_ @dfocosi @yunlong_cao @RajlabN @SystemsVirology @BenjMurrell @SimonLoriereLab @EricTopol @LongDesertTrain @SolidEvidence @CorneliusRoemer @siamosolocani As expected JN.1. has been chosen. Sorry FLIRTs KP.2 etc who.int/news/item/26-0…
New study. We compared the immune response of XBB and JN.1 in human infections to evaluate the necessity for #SARSCOV2 vaccine updates Results: JN.1 exposure induces higher neutralization against emerging mutants, including FLiRT (JN.1+346T+456L) and KP.3 biorxiv.org/content/10.110…
@SolidEvidence @CiscoRucinski @dfocosi Yes sorry, typo on my part. Although he's using FLiRTTI (first "i" is lower-case), which is a bit cleaner IMO.
Safety of COVID-19 convalescent plasma: A definitive systematic review and meta-analysis of randomized controlled trials [Dec 29, 2023] Franchini et al. @dfocosi Transfusion onlinelibrary.wiley.com/doi/10.1111/tr… #COVID19CP @AABB @ACasadevall1 @jwsenefeld @DrMJoyner
couldn’t agree more…but let’s get diagnostic tests ready now
Bird flu is ravaging mammals worldwide & the pandemic clock is ticking. Convalescent plasma will again be our first-line therapy. H/t @ACasadevall1 @DrMJoyner @andrewpekosz @Fabrizi66265683 @PeacockFlu @thijskuiken @MarionKoopmans @bjarijn @Tuliodna onlinelibrary.wiley.com/doi/10.1002/rm…
Stiamo FLiRTando con una nuova ondata di Covid? Se lo sappiamo, se potremo difenderci è grazie, anche, a due grandi, che in silenzio, senza le luci dei riflettori di TV e media, cercano di proteggerci. Un enorme grazie a @siamosolocani e @dfocosi che da 4 anni lavorano per noi.
Are we FLiRTing with a new Covid wave? New data on age-specific Covid interactions and self-amplifying vaccines. In the new Ground Truths (link in profile). Thanks @JPWeiland @dfocosi @siamosolocani @BenjMurrell and so many others for continuing to keeping close 👀 on #SARSCoV2
Bravissimi @dfocosi e @siamosolocani! Un meritato riconoscimento al lavoro di "privati cittadini" che mettono a disposizione di tutti le proprie competenze e professionalità. Un plauso anche a @EricTopol che sa apprezzare il contributo fornito e non si ferma al titolo accademico.
@elonmusk if you want to update yourself a bit. no specific danger just viruses as usual.
Great work by @BenjMurrell out now with the new growth advantages of all the circulating variants: github.com/MurrellGroup/l… Perfectly matching the early warning (and tracking) of variant community especially @xz_keg @CorneliusRoemer @JosetteSchoenma @AlexJohnsonLi3 ..cont
@Mike_Honey_ @dfocosi @yunlong_cao @RajlabN @SystemsVirology @BenjMurrell @SimonLoriereLab @EricTopol @LongDesertTrain @SolidEvidence @CorneliusRoemer @siamosolocani 4. WHO will decide on vaccine composition today and most likely it'll be JN.1. indico.un.org/event/1009842/ deviating from this choice will make global coordination complicated. END thanks for not reading LOL.
@siamosolocani @dfocosi We're not the brightest species, sometimes, are we???
@mkarolian @Daniel_E_Park No, it did not. They only looked at medical records. There was no control group, so it's actually impossible to tell anything about the protection provided by vaccination here. The 95% figure is ludicrous. I don't see how you could conclude anything from this study.
For those following the @DrMJoyner vs. @MayoClinic here is an article covering yesterdays hearing. thecollegefix.com/mayo-clinic-ar…
@EricTopol 🎯 Our world's problems are mostly political & will never be swept away or fixed by some technological panacea. Just to give 1 example, there's more than enough food to satisfy every human's needs. People still go hungry for political reasons, not for want of technological fixes.
@dfocosi @RuteMPinto @SpyrosLytras @RajlabN @PeacockFlu @LongDesertTrain NP:Y52H is present in 2024 H5N1 seqs from southwestern USA states (CA, NM, TX) including mammals (Dairy Cattle, Skunk, and Human) based on GISAID deposits
Some thoughts on the H5N1 situation 🦆🐄🦠 First, the situation is very concerning. this virus does not trasmit h2h, but the more animals in close contact with humans it infects the more the chance of h2h becoming a possibility. Now onto the interesting mutations:
If I’m not wrong this sequence has NP:Y52H, a mutation which @RuteMPinto and @SpyrosLytras linked to immune evasion to BTN3A3, a restriction factor for human infection by avian influenzavirus. nature.com/articles/s4158… @RajlabN @PeacockFlu @LongDesertTrain
It is needed to say that Israel is commiting Genocide. No fear of speaking up , I hate Hamas i am a friend of Israel. As a friend i dont let friends to makes horrible mistakes.
@dfocosi @RuteMPinto @SpyrosLytras @RajlabN @PeacockFlu @LongDesertTrain Your link seems defective, here is a working one: pubmed.ncbi.nlm.nih.gov/37380775/