Raj Rajnarayanan @RajlabN
Assistant Dean of Research and Associate Professor, NYITCOM at Arkansas State University | My Tweets are my own nyit.edu/arkansas Jonesboro, AR Joined December 2018-
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Another interesting point to note, the sequence from the human specimen (from Texas) contains the adaptation signature mutation PB2 E627K but lacks that PB2 M631L prevalent in all the cattle sequences!
Another interesting point to note, the sequence from the human specimen (from Texas) contains the adaptation signature mutation PB2 E627K but lacks that PB2 M631L prevalent in all the cattle sequences!
#H5N1 updates This highlights the need for proactive action from @USDA , @CDCgov, @US_FDA and others Need broader testing of cattle in all states Strategically sequence samples from all states Establish a unit for rapid dissemination of info and transparent communication.
"Citizen Science" played* an important role in #SARSCoV2 lineage analysis as well... Citizen Science fills gaps at all levels from PH data analysis to trustworthy communication (*playing)
"Citizen Science" played* an important role in #SARSCoV2 lineage analysis as well... Citizen Science fills gaps at all levels from PH data analysis to trustworthy communication (*playing)
#H5N1 updates Welcome @USDA's testing/reporting requirement of HPAI in Cattle, along with testing cattle prior to interstate movement. >>I'd strongly recommend a period of quarantine and retesting before integrating them into the existing herd << aphis.usda.gov/sites/default/…
Strangely familiar, like a flashback to the early 2020s!
Many rapid COVID-19 + Flu A/B antigen tests detect H5N1. There are now a few FDA authorized CorDx is the most recent home/self multiplex (plus Sekisui and Osang) and a number of CLIA-waived devices too These are in US now if needed and can support surveillance testing
Many rapid COVID-19 + Flu A/B antigen tests detect H5N1. There are now a few FDA authorized CorDx is the most recent home/self multiplex (plus Sekisui and Osang) and a number of CLIA-waived devices too These are in US now if needed and can support surveillance testing
Excellent thread on current status of the North American #H5N1 Clade 2.3.4.4b #AvianFlu H/T @svscarpino
Excellent thread on current status of the North American #H5N1 Clade 2.3.4.4b #AvianFlu H/T @svscarpino
Timely data from @yunlong_cao group - JN.1 exposure induces higher neutralization against emerging mutants, including JN.1 #FLiRT lineages
Timely data from @yunlong_cao group - JN.1 exposure induces higher neutralization against emerging mutants, including JN.1 #FLiRT lineages
Timely analysis of the 239 sequences submitted by @USDA_APHIS @USDA H/T @MichaelWorobey
Timely analysis of the 239 sequences submitted by @USDA_APHIS @USDA H/T @MichaelWorobey
(1/2) @USDA published 239 genetic sequences of the U.S. H5N1 clade 2.3.4.4b influenza virus from samples associated with the ongoing highly pathogenic avian influenza outbreak in poultry/wild birds...
There's nothing like a genome sequence dump on a Sunday night. Sigh. #H5N1 #birdflu @USDA #cows statnews.com/2024/04/21/usd…
Everyone needs a break.. human or bot! (Bot evoked human emotions …as I watched it collapse after working 20 hours straight)
Everyone needs a break.. human or bot! (Bot evoked human emotions …as I watched it collapse after working 20 hours straight)
T. Ryan Gregory @TRyanGregory
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19K Followers 42 Following 🦠 The American Society for Virology #LoveVirology 🦠 @amersocvirology on Bluesky @amersocvirol on ThreadsArbitrary limitations imposed on some researchers by nameless GISAID authorities remains a problem. I have strict limits on my account. I have no idea why. I'm going to have to spend >30 hours mindlessly clicking buttons & checking boxes in order to do large-scale analysis. 1/9
I am a researcher studying viruses. I have contributed to the sequencing of more than a million genomes deposited in the GISAID database. Last week I found that my access to bulk downloads from GISAID had been cut off without cause or explanation. [1/3]
Cattle Veterinarians Express Unease, Confusion over U.S. Response to H5N1 Bird Flu - @RachelNuwer for @ThinkGlobalHlth - Vets say without basic information such as how cows contract the virus and how long they shed it once infected, it's difficult to issue precise instructions…
Many working on farms are migrant workers. They may lack access to healthcare and are scared to come forward for testing We need to engage communities & understand barriers so we can better facilitate care. We should also consider vaccination in persons at high risk for #H5N1
👀US-based vet said that there is underreporting of H5N1 infections in farm workers "every dairy that I've worked with has – with the exception of one – had sick human beings at the same time they had sick cows" bovinevetonline.com/news/industry/…
This I find curious: The milk data and the genetic sequence data suggest the #H5N1 #birdflu outbreaks in cows are far more widespread than has been recognized. And yet the last time @USDA confirmed a new outbreak was 4/19. How much testing is going on?aphis.usda.gov/livestock-poul…
Due to enormous and collaborative effort from the @nextstrain team, @hamesjadfield @trvrb and of course @USDA , we now have the USDA cattle sequences on Nextstrain: nextstrain.org/avian-flu/h5n1… visualized with new, 2-year builds.
Another team of scientists conclude the genetic sequences from the cows infected with #H5N1 #birdflu point to a single introduction of the virus into cows from wild birds, and then spread from herd to herd.
Due to enormous and collaborative effort from the @nextstrain team, @hamesjadfield @trvrb and of course @USDA , we now have the USDA cattle sequences on Nextstrain: nextstrain.org/avian-flu/h5n1… visualized with new, 2-year builds.
The discovery of #H5N1 #birdflu in a significant portion of commercially purchased milk suggests the outbreak in cows is much larger than we know, scientists who've been doing this work tell @MeganMolteni. statnews.com/2024/04/25/h5n…
Getting ready to fly again. PSA: I will wear a mask the entire time in the airport & during boarding (highest risk times). Once we are at high altitude, I will assess the sounds of those around me. ACH are high so the key is to make sure those close to you are not sick. (1/3)
“But every dairy that I've worked with has – with the exception of one – had sick human beings at the same time they had sick cows.” bovinevetonline.com/news/industry/…
It’s clear that “citizen science” is playing an important role in filling knowledge gaps. It would be great to see someone sequencing the samples from wastewater and watersheds that might be showing peaks of flu A in March/April. - @statnews statnews.com/2024/04/25/h5n…
1/n On this #WorldMalariaDay both malaria and hookworm are co-endemic in Africa to produce profound anemia in both children and pregnant women. We’re developing a hookworm anemia vaccine shown to be highly protective in clinical trials, possibly to combine with malaria vaccine
> 新たな変異株は登場していないので 新世代の組み換え体や亜系統の挙動がわからんので楽観視はできないと思います。 JN.1.* +FLiRTKP.2 XDQ*
【臨時】東京 新型コロナ再上昇⚠️ な、なんでやねん😿なんか増えてる。ちょうど去年と同じくらいになってきました。新たな変異株は登場していないので、去年みたいなGW明けの急拡大はないかと思いますが、若干心配ですね。
Very important to note here that qPCR positives are not the same as "virus particles." It's much easier to detect viral RNA by qPCR than it is to detect infectious virus or intact virus particles (as the article correctly notes). This finding does have some big implications:
#Breaking Testing conducted by the FDA on pasteurized commercially purchased milk has found genetic evidence of the H5N1 bird flu virus, the agency confirmed Tuesday. trib.al/5sU2zvO
@SecVilsack @USDA With full respect @SecVilsack, can you please authorize immediate release of all data collected to date on this widespread outbreak? All genomic data w/ metadata? All data on virus sampling from various farms, animals and the environment nearby (water, soil, farm animals,…
Glad to see this increased surveillance related to #H5N1 A few questions - how long before interstate transfer will a negative test be required - does this mean if the herd tests positive there can be no interstate movement (point two doesn’t make it sound that way)
USDA issues federal order to increase monitoring of H5N1 bird flu: • Negative test for lactating dairy cows before interstate travel • Other cows to be tested "based on scientific factors" • Mandatory reporting for all positive tests
This is the award I will be receiving on Sunday.... today.ucsd.edu/story/uc-san-d…
Excited and a bit nervous....looking forward to this event. Incredibly honored to be part of this ceremony.
This Sunday, 21 scientists will be honored for their outstanding achievements across a wide range of scientific disciplines & pursuits. Don't miss the Awards Ceremony at 2pm ET on April 28 at the #NAS161 annual meeting. Register for the webcast: ow.ly/5kbe50Rlbpr #NASaward