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Rick Bright @RickABright

Practical, Innovative, Hyper-focused on saving lives. Immunologist, Virologist, Pandemic Nemesis. Posts are mine. Washington, DC Joined January 2017
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Rick Bright retweeted
HelenBranswell Profile Picture

Helen Branswell 🇨🇦 @HelenBranswell

2 hours ago

New twist in the #H5N1 #birdflu in cows reporting saga. @USDA has upped the number of reported outbreaks to 36 in 9 states. The 2 newly reported outbreaks occurred in NM & were apparently confirmed on or before April 17, but only posted publicly today. What's up with that?

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Rick Bright @RickABright

7 hours ago

As an advisor to @cure345 Xchange challenge, I know first hand that @EveryCure AI-powered platform could change the way we approach repurposing of already approved drugs to find potential new treatments & cures for millions of patients who suffer from the most debilitating…

cure345 Profile Picture

We Will Cure @cure345

5 days ago

As an advisor to @cure345 Xchange challenge, I know first hand that @EveryCure AI-powered platform could change the way we approach repurposing of already approved drugs to find potential new treatments & cures for millions of patients who suffer from the most debilitating…

Rick Bright retweeted
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Katelyn Jetelina @dr_kkjetelina

a day ago

Interesting #H5N1 preprint on wastewater just dropped. medrxiv.org/content/10.110… Three take-homes: 1. Can H5 be detected in wastewater? Yes, one company (@Verily) now has an assay. It's 100% specific. Huge first step.

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Rick Bright @RickABright

22 hours ago

It’s not only they’re 2 shot vaccines, they’re made in eggs & cells w/ many limitations due to yield & immunogenicity. They will require additional of adjuvant and will take many months for supply ramp up. Vietnam waited 2 years for flu vaccine in the 2009 H1N1 pandemic. We…

rtnarch Profile Picture

Robert Nelsen @rtnarch

a day ago

It’s not only they’re 2 shot vaccines, they’re made in eggs & cells w/ many limitations due to yield & immunogenicity. They will require additional of adjuvant and will take many months for supply ramp up. Vietnam waited 2 years for flu vaccine in the 2009 H1N1 pandemic. We…

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Rick Bright @RickABright

22 hours ago

Excellent 🧵 by @celinegounder w/ critical data & outstanding questions. Great to follow her for updates.

celinegounder Profile Picture

Céline Gounder, MD, ScM, FIDSA 🇺🇦 @celinegounder

a day ago

Excellent 🧵 by @celinegounder w/ critical data & outstanding questions. Great to follow her for updates.

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Rick Bright @RickABright

22 hours ago

Very concerning again. I don’t think stockpile of oseltamivir/tamiflu is going to get us far in an H5N1 influenza outbreak in people. It’s highly susceptible to virus resistance w/ a single mutation & it’s modestly effective if given within first 1-2 days of infection. Without…

celinegounder Profile Picture

Céline Gounder, MD, ScM, FIDSA 🇺🇦 @celinegounder

a day ago

Very concerning again. I don’t think stockpile of oseltamivir/tamiflu is going to get us far in an H5N1 influenza outbreak in people. It’s highly susceptible to virus resistance w/ a single mutation & it’s modestly effective if given within first 1-2 days of infection. Without…

Rick Bright retweeted
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Céline Gounder, MD, ScM, FIDSA 🇺🇦 @celinegounder

a day ago

4/ What's concerning is that the PB2 E627K mutation appeared quickly: 🔸the virus mutated in this individual or 🔸there was evolutionary pressure selecting for this mutation from among sub-dominant species.

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Rick Bright @RickABright

23 hours ago

This is exactly what I’d expect from high path avian influenza H5N1 in many mammals. It’s a deadly virus. Any attempts to minimize the threat of this virus are irresponsible. This virus can change easily, can spread swiftly, and cause great harm. There has never been such…

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Tatiana Prowell, MD @tmprowell

a day ago

This is exactly what I’d expect from high path avian influenza H5N1 in many mammals. It’s a deadly virus. Any attempts to minimize the threat of this virus are irresponsible. This virus can change easily, can spread swiftly, and cause great harm. There has never been such…

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Rick Bright @RickABright

a day ago

“Expect the Unexpected” For #H5N1 virus, critical not to make assumptions based on seasonal flu. Insist on data & transparency. Great piece ⁦@HelenBranswell⁩ ⁦@thijskuiken⁩ ⁦@JurgenRicht⁩ Dr. Webby ⁦@florian_krammer⁩ @statnews⁩ statnews.com/2024/04/29/bir…

Rick Bright retweeted
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mark warling @markwarling3

2 days ago

Alex Witt Reports – 4/28/24 | 3PM topnewsshow.com/alex-witt-repo…

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Rick Bright @RickABright

2 days ago

We’ll never get in front of this outbreak, and learn for the next, if we neglect to test all exposed workers and all cattle. If we don’t find a way to do so soon, this has a great potential to worsen. Are there innovative low cost, rapid ways to test cattle?

thijskuiken Profile Picture

Thijs Kuiken @thijskuiken

2 days ago

We’ll never get in front of this outbreak, and learn for the next, if we neglect to test all exposed workers and all cattle. If we don’t find a way to do so soon, this has a great potential to worsen. Are there innovative low cost, rapid ways to test cattle?

Rick Bright retweeted
thijskuiken Profile Picture

Thijs Kuiken @thijskuiken

2 days ago

Out of 33 dairy farms in 8 U.S. states (+1 dairy farm in Colorado), 23 people have been tested for highly pathogenic avian influenza H5N1 by states. Less than 1 person per farm. This seems a clear answer to the question: “Are we testing enough for H5N1?” medpagetoday.com/special-report…

Rick Bright retweeted
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Eric Topol @EricTopol

3 days ago

@JohanSorensen83 @Nature @MichaelWorobey If it goes human-human transmission, you don't want to know. Hopefully we won't see that. But we're not ready for that worst case scenario.

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Rick Bright @RickABright

3 days ago

Detecting mutation in #H5N1 sequence from cow, associated w/ resistance neuraminidase inhibitor is significant concern; needs to be monitored very closely. Also imp to know if cows are being treated w/ drugs (was mutated sample collected before or after treatment)? The US SNS…

CoronaHeadsUp Profile Picture

CoronaHeadsUp @CoronaHeadsUp

3 days ago

Detecting mutation in #H5N1 sequence from cow, associated w/ resistance neuraminidase inhibitor is significant concern; needs to be monitored very closely. Also imp to know if cows are being treated w/ drugs (was mutated sample collected before or after treatment)? The US SNS…

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