Patrick Sanger, MD, PhD @PatrickSanger

UCSF trained internist. Practices Medicine 3.0. PhD in biomedical informatics, boarded in Internal Medicine and Clinical Informatics. healthspan.md San Francisco, CA Joined December 2013

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Patrick Sanger, MD, PhD @PatrickSanger

2 years ago

@lipo_fan @LowCarbEyeDoc @realDaveFeldman @JohnKastelein @stathitriadis @JesperLundbom @nicknorwitz Note that some studies included in this graphic represent only FH populations, primary prevention, secondary prevention etc. They all fall on the same regression line. academic.oup.com/eurheartj/arti…

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Patrick Sanger, MD, PhD @PatrickSanger

2 years ago

@lipo_fan @LowCarbEyeDoc @realDaveFeldman @JohnKastelein @stathitriadis @JesperLundbom @nicknorwitz Yes, but not due to uniquely pathologic mutations but rather cumulative lifetime exposure to ApoB. See the figure from Ference which to me conclusively demonstrates that it doesn’t matter how you raise or lower ApoB (with some unique exceptions eg niacin).

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Patrick Sanger, MD, PhD @PatrickSanger

2 years ago

@lipo_fan @LowCarbEyeDoc @realDaveFeldman @JohnKastelein @stathitriadis @JesperLundbom @nicknorwitz This illustration is misleading without context. FH carriers have a lifetime of exposure. From the abstract: “In an analysis of participants with serial lipid measurements over many years, FH mutation carriers had higher cumulative exposure to LDL cholesterol than noncarriers.”

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Patrick Sanger, MD, PhD @PatrickSanger

3 years ago

Has @mcuban and @costplusdrugs considered partnering with @valisure (or other high throughput analytical lab) to check every batch of generics to verify dosage of active ingredient and screen for contaminants? I would be directing all of my patients to @costplusdrugs if so!

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Patrick Sanger, MD, PhD @PatrickSanger

4 years ago

@Bob_Wachter Bob, recommend you try a more comfortable N95 such as 3M Aura or Kimberly Clark Pouch Style. I wear these all day and find them much more comfortable than KN95 (due to ear loops) or the old school rigid 3M.