Dr. Spencer Nadolsky @DrNadolsky
Obesity and Lipid Specialist Physician. Medical Director of WW. Co-Host of #DocsWhoLift Podcast podcasts.apple.com/us/podcast/doc… Start Here Joined August 2013-
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The new powerful GLP-1 medicines at doses used for #obesity are relatively new. Yet the class of GLP-1 medicines is now 19 years old, with Exenatide approved for #T2D April 28 2005. We have millions of treatment years for this class. Happy birthday Exenatide/GLP-1 medicines!
If I recruited people who started smoking 2-3 years ago a few packs per day who were otherwise really healthy and it showed they had very little plaque in their arteries, would we conclude that smoking is not a risk for heart disease?
@MichaelAlbertMD Individual variation in physiological parameters is limited by imprecision of measurements. Genes & environment affect parameter P shifting the BW equilibrium point. Appetite feedback control strength k also determined by genes & can be altered by drugs & surgery (& environment?)
When you start thinking of obesity as a chronic biological disease, this makes much more sense. It doesn't mean everyone with excess adiposity has the biological drivers and cannot lose weight without medicine or surgery btw.
When you start thinking of obesity as a chronic biological disease, this makes much more sense. It doesn't mean everyone with excess adiposity has the biological drivers and cannot lose weight without medicine or surgery btw.
This recent study by @KevinH_PhD is awesome. It investigates the impact of different weight loss methods on the "lipostat"-- the body fat regulatory system in the brain that opposes weight loss efforts. My plain language summary. doi.org/10.1002/oby.24…
Proud to hear from fellow obesity docs that our data from Sequence (now @ww_clinic_ ) was presented with great interest at the @OMAsocial conference. Great job @drard !!
I’d bet around 10% or so can come off and not regain most of their weight long term. It’s not the majority but they are out there. They don’t have the strong biological drivers of obesity.
I’d bet around 10% or so can come off and not regain most of their weight long term. It’s not the majority but they are out there. They don’t have the strong biological drivers of obesity.
Thanks for the feedback video game graphic captain monkey.
Here is another paper that will rattle the bones of the apoB (and hence LDL and cholesterol) deniers. Authors conclude the MR screen identified APOB & lipoproteins containing APOB as CAUSAL DETERMINANTS of healthspan, a finding that is concordant with recent observations…
Seed oils so deadly they improve all your metabolic markers when subbed for animal fat
Seed oils so deadly they improve all your metabolic markers when subbed for animal fat
The effects of replacing ghee with rapeseed oil on liver steatosis and enzymes, lipid profile, insulin resistance and anthropometric measurements in patients with non-alcoholic fatty liver disease: a randomised controlled clinical trial cambridge.org/core/journals/…
I had a choice between becoming bitter- or creating the type of healthcare I enjoyed. Starting a startup is hard and initially financially scary- but working for the system is certainly harder.
I had a choice between becoming bitter- or creating the type of healthcare I enjoyed. Starting a startup is hard and initially financially scary- but working for the system is certainly harder.
“Eating less” doesn’t mean you eat “junk food” all day just less of it. You could do that. But you could also be eating more satiating foods that help you eat fewer calories overall.
Spencer is correct: I did four years of reduced carb (not ketogenic) with 5 days of severe fasting once a month (not especially fun) with 30 minutes of daily aerobics. I did it for 4 years. I pretty rapidly lost 70 pounds and maintained that loss during that period. After…
Spencer is correct: I did four years of reduced carb (not ketogenic) with 5 days of severe fasting once a month (not especially fun) with 30 minutes of daily aerobics. I did it for 4 years. I pretty rapidly lost 70 pounds and maintained that loss during that period. After…
I don’t know who needs to hear this but: Keto Intermittent fasting Plant-based Carnivore Calorie counting All fall under CICO (calories in, calories out) When trying to lose weight, you have to eat fewer calories (eat less).
Does your method result in eating fewer calories (eating less) …yes or no?
Does your method result in eating fewer calories (eating less) …yes or no?
Bringing up baby and first trimester exposure to GLP-1RA-no evidence for harm #pregnancy @bmj_latest bmjopen.bmj.com/content/14/4/e…. #T2D #obesity
Layne Norton, PhD @BioLayne
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Gil Carvalho MD PhD�.. @NutritionMadeS3
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73K Followers 2K Following Health and Fitness minimalist. Follow me to build a strong, healthy body WITHOUT the gym. Join my free newsletter (10K+ subscribers)⬇️
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Congratulations to Dr. Nicholas Neuwald for an outstanding doctoral dissertation on the role of food switching on children’s eating behavior and obesity!
Remember, lean mass (muscle) loss during GLP1 RA treatment is normal -- it's like when you lose weight *any other way*. Resistance training (lifting weights) is almost always a good idea, and it's a great idea if you're losing weight.
@ceykoloji @DrNadolsky O yes. Make sure to exclude all previous smokers from the analysis. Otherwise you won’t uncover all the crazy benefits of smoking in lean mass puff puffs 😢
A ProPublica Report “Cigna tracks every minute that its staff doctors spend deciding whether to pay for health care. Dr. Debby Day said her bosses cared more about being fast than being right: “Deny, deny, deny. That’s how you hit your numbers,” Day said.” propublica.org/article/cigna-…
@WardWriting @DrNadolsky Lean Mass Hyper Ventilators??? 😂
@ethanjweiss @DrNadolsky We are not saying it’s safe! Just asking questions
@DrNadolsky This is something I have been dying to see data on..in this cohort maybe it doesn’t, rather they shift their fuel needs to carbon monoxide so actually it’s a sign of their health!
RCT or GTFO
If I recruited people who started smoking 2-3 years ago a few packs per day who were otherwise really healthy and it showed they had very little plaque in their arteries, would we conclude that smoking is not a risk for heart disease?
@DrNadolsky And eating a whole bag of Cheetos per day effectively reduced cigarette usage more than smoking cessation efforts by occupying their oral fixation and making an orange mess of their cigarettes and is therefore healthier 😂
@DrNadolsky I consider myself a lean mass chain smoker.
@KevinH_PhD @JohnSpeakman4 @sguyenet Looking forward to the science that helps us land these concepts. My job is knowledge translation, HCP training and patient care and all three of you have been very big contributors to this and the Canadian obesity guidelines. BTW I’m leaning upper and lower intervention points…
@MichaelAlbertMD @DrNadolsky Smoking is just the firetruck
@sguyenet @KevinH_PhD One thing important to note is at no point does he mention the word lipostat - which implicitly (or explicitly) has a set-point. His model is a control theory feedback model. NOT a lipostat model.
@JohnSpeakman4 @sguyenet Yeah, I prefer the term “equilibrium point” because it has less baggage that “set point” and “settling point” and can encompass environmental influences along with biological responses to perturbations
@lispmeister My calculations already factor in inflation
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