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alephh @alephh

Entrepreneur, self-improvement, strategy game coder, WW2/History buff, OMAD keto, avid book/research reader, quantum biology/physiology, minimalist,green voter☀ Electromagnetic Quantum Field Joined August 2007
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alephh @alephh

a week ago

Human longevity: regular sleep patterns —underwent polysomnography, 1-week actigraphic recording, electroencephalogram spectral analysis. Oldest old had strictly regular sleep-wake schedules, high HDL, low trigs... go to bed, wake-up at same circadian time ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Obstructive sleep apnoea vs Sudden death (22-study 42,099-patients systematic review & meta-analysis) —OSA associated with all-cause sudden death (RR=1.74; 1.44/2.1) & cardiovascular mortality (RR=1.94; 1.39/2.7) (older age significant contributing factor) ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Sleep-wake disturbances after stroke vs cardio-cerebrovascular events (CCE) or death — The four different sleep-wake-disturbances were associated with a higher risk for subsequent CCE, including death (odds ratio 1.80 per index unit; 1.19/2.72; p= 0.0056) pubmed.ncbi.nlm.nih.gov/36912423/

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alephh @alephh

a week ago

Genetic QT Score & Sleep Apnea vs Sudden Cardiac Death (UK Biobank) — Adjusted per 5-unit change in QTc-PRS for SCD was HR=1.64 (1.16/2.31; p=0.005) in those with sleep apnea and HR=1.04 (0.95/1.14; p=0.44) in those without sleep apnea (p-interaction=0.01) ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Pre-Existing Sleep Disorders vs Mortality in Breast Cancer (n=2,966) — Sleep disorder group had poorer survival rates (HR=1.51; 1.19/1.91; p<0.001) than the non-sleep disorder group in breast cancer. ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Weekend catch-up sleep (CUS) & sleep duration vs mortality in middle-aged adults —Stricter cutoffs: protective effect of short CUS with normal sleep (≥390 min) strengthened (HR=0.36), harmful effect of short CUS with short sleep (<330 min) emerged HR=1.84 ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Sleep duration in midlife and old age vs mortality over 48-year follow-up (n=2,504) —Mortality HR=1.20 for short vs normal sleep, but association vanished after adjustments. In old age, HR=1.41 & HR=1.19 for short sleep duration, HR=1.33 & HR=1.31 for long pubmed.ncbi.nlm.nih.gov/38471293/

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alephh @alephh

a week ago

Sleep duration vs mortality in chronic noncommunicable disease (n=14,171) —Compared with 7-8 h/d, sleeping over 8 h/d associated with higher all-cause mortality, HR=1.29 for hypertension, 1.23 high cholesterol, 1.44 for diabetes, 1.36 chronic renal failure ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Sleep disorders vs all-cause mortality in cancer survivors (NHANES 2005–2016) — Sleep disorders associated with a higher risk of all-cause mortality (HR=1.23; 1.06/1.42). After stratified by gender, the high HRs were observed in men (P<0.05), not in women. ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Single dose creatine improves cognitive performance, induces changes in cerebral high energy phosphates in sleep deprivation — Creatine 0.35 g/kg induces changes in PCr/Pi, ATP, tCr/tNAA, prevents pH drop, improves cognitive performance & processing speed ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

#longevity #aging #antiAging #lifespan #healthspan

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alephh @alephh

a week ago

Interplay Between Plasma Glycine and Branched-Chain Amino Acids Contributes to Hypertension & Coronary Heart Disease — BCAA/glycine ratio associated with a higher risk of hypertension & CHD (Q5 versus Q1 HR=1.196 (1.109/1.289] and HR=1.1226 (1.160/1.1296) pubmed.ncbi.nlm.nih.gov/38587181/

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alephh @alephh

a week ago

Effect of Glycine and N-Acetylcysteine on Oxidative Stress in Spinal Cord and Skeletal Muscle After Spinal Cord Injury — Glutathione and superoxide dismutase in spinal cord tissues elevated, whereas malondialdehyde was decreased in GlyNAC-treated animals pubmed.ncbi.nlm.nih.gov/37975960/

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alephh @alephh

a week ago

Genetic Insights into Glycine’s Protective Role Against CAD —2-step Mendelian randomization showed higher levels of glycine in blood were associated with less CAD in Europeans OR=0.84 (0.72/−0.98; P=.029) & East Asians OR=0.76 (0.66/−0.89; P=3.57×10^−4) ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Glycine & N-Acetylcysteine Improves Brain Glutathione Deficiency, Ox-Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation, Neurotrophic Factors to Reverse Cognitive Decline in Old Mice — GlyNAC improved/corrected brain defects ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Preliminary evidence of glycine as a biomarker of cardiovascular disease risk in obese kids —Major relationships (p<.01 for all) of GLY with visceral fat (r2=0.40), BCAA (r2=0.44), HOMA-IR (r2=0.33), 25(OH)D (r2=0.48), IL-6 (r2=0.46), adiponectin (r2=0.39) pubmed.ncbi.nlm.nih.gov/37516817/

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alephh @alephh

a week ago

Glycine vs physiological systems in adults (systematic review) — Nervous system had most positive effects: improved psychiatric symptoms from longer-term glycine in psychiatric populations... longer-term glycine improved sleep in healthy populations ncbi.nlm.nih.gov/pmc/articles/P…

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alephh @alephh

a week ago

Glycine vs pancreatic microcirculation in T1D —Restored biorhythmic contraction/relaxation, improved blood distribution patterns, reversed lower amplitudes of endothelial oscillators, reversed islet deterioration, inhibited IL-6/TNFα/IFN-γ/pro-MMP-9/VEGF-A pubmed.ncbi.nlm.nih.gov/37918522/

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alephh @alephh

a week ago

Glycine enhances glutathione availability in tissues of pigs with intrauterine growth restriction —Glycine increased GSH/GSSG in plasma, liver, jejunum, longissimus lumborum muscle, gastrocnemius muscle.. reduced TBARS in plasma, jejunum, muscles, pancreas pubmed.ncbi.nlm.nih.gov/38271555/

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alephh @alephh

a week ago

Glycine partially restores oxidative stress-associated glutathione deficiency in ageing cats — Feeding senior cats a balanced dry diet supplemented with 1.5 % free glycine for 12 weeks elevated initial erythrocyte glutathione & altered markers of ox-stress pubmed.ncbi.nlm.nih.gov/38418414/

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