Robert Nelsen @rtnarch

Jeff Bezos just funded a bet that AI got the brain wrong. Flourish landed $500M to build AI that runs on 50 watts instead of gigawatts. The pitch: neuroscientists and engineers working side-by-side to reverse-engineer actual neurons.

Here's an exclusive inside look at Flourish, a startup full of neuroscientists and AI researchers working together to make discoveries about the brain and use them to create a more efficient form of AI that learns like people do. wired.com/story/jeff-bez…

California’s election was 2 days ago… They’ve counted 56% of the votes.

We just decided to stop teaching everyone math, in the hopes that this would make society equal because everyone would be equally incompetent

Josh Kraushaar @JoshKraushaar

2 days ago

“At UC San Diego, the number of freshmen failing to meet high-school math standards grew nearly 30-fold between 2020 and 2025. By fall 2025, 1 of 12 entering students was placed into remedial math to learn material taught in elementary and middle school” wsj.com/opinion/the-un…

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The fact that California elections often can't be resolved for weeks is kind of insane and not common in other electoral systems around the world.

Re-tweeting. We need rapid policies that make USA companies more competitive and create a market mechanism that preserves patient options, while preventing harm to biotech innovation cycle.

Robert Nelsen @rtnarch

a week ago

We need an Innovation Review Voucher, where a USA innovator (not others) can apply, based on their innovation in a drug category or molecule, for super fast regulatory approval, AND a transferable and subdividable 3 year commercial exclusivity, which covers the structure and

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Up until the early 1990s, raw salmon was almost never eaten in Japan, especially not in sushi. Why? Japanese Pacific salmon was (and still is) often heavily infested with parasites, so tradition dictated that salmon be cooked (grilled or salted). Raw salmon was considered unsafe and was not part of sushi culture. In the 1980s, Norway faced a massive surplus of farmed Atlantic salmon and needed new markets. They launched a deliberate, long-term marketing campaign, often called "Project Japan", that lasted roughly a decade. Norway sent trade delegations and held tasting events, worked with Japanese importers, restaurants, and sushi chefs, promoted the safety and quality of their parasite-free farmed Atlantic salmon and ultimately introduced it first to conveyor-belt (kaiten) sushi restaurants, where it was cheaper and more accessible. The strategy worked incredibly well. By the mid-to-late 1990s, salmon had gone from virtually unknown in sushi to one of the most popular toppings in Japan. Today, salmon is often the #1 best-selling sushi item in the country, surpassing even tuna in many places. It’s one of the most successful examples of how a targeted national marketing campaign can completely reshape a country’s culinary habits. Norway essentially created the global phenomenon of salmon sushi.

On every metric, American kids are so much dumber than they were 5 years ago and we are grade inflating away the reality.

John Moscatiello @HookedonJohnics

3 weeks ago

They just gave up on pretending AP exams are “college level work”

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Stellar data from first-ever epigenome editing clinical trial by @tunetx_news [$COI: I own equity as a co-founder]. Invented at Sangamo by yours truly and colleagues in 2001, reduced to clinical practice 2026. "It's been a long time coming | but now it's here" (Springsteen).

Bill Maher asks how Mississippi is kicking California’s ass in education, and Texas is “blowing them away” in green energy for “way less money.” “Did you know that a black fourth grader in Mississippi is two and a half times as likely to be proficient in math and reading as one in California? Mississippi is kicking our ass in education and for way less money. We’re 37th in fourth-grade reading, they’re ninth.” “Texas is kicking our ass in green energy. The average time to get solar panels connected there is three to four months. About 1,000 days faster than it took me. Remember when I was trying to get my solar hooked up? It would have been quicker to build a windmill.” “Texas has passed California in solar and blows away California when it comes to wind and energy storage. How does a state with no pro-climate policies produce better climate results than a state where here, even though we have so much better bumper stickers on our Priuses?” “I’ll tell you why. Because you’re allowed to build there because every third person in Texas isn’t someone whose job it is to make sure nothing gets done.” “Democrats, these are your issues: education, race, the environment.” “And I say this with love: you’re losing to the Waffle House, car-on-the-lawn states.”

@RealEmirHan Rudd . . . Paul Rudd, in this scene from Anchorman regarding the cologne Sex Panther. Love the quote/line/delivery of “60% of the time it works every time”.

60 percent of the time ARCH companies work every time.

The p-tau217 breakthrough blood test replicated again, predicting Alzheimer's disease in a large cohort mean age 61. The cover of the new issue is telling @TheLancet thelancet.com/journals/lance…

For 63 years, medicine couldn’t lower lipoprotein(a). Now everyone is trying at once. Three Phase 3 trials. Over 32,000 patients. 35+ countries. Drugs hitting 80 to 94% Lp(a) reduction. The first results from 8,323 patients land this summer. But that’s the injectable chapter. Behind it: -> @EliLillyandCo is testing the first oral Lp(a) pill. No needle. Daily dose. 86% reduction in Phase 2. -> And behind that: gene editing. One infusion. Potentially permanent. -> @CRISPRTX cut Lp(a) by 73% in humans with a single dose (CTX320, Phase 1). -> @editasmed just showed ~90% reduction in primates by editing LDLR regulatory regions instead of the Lp(a) gene itself. -> @EliLillyandCo is developing its own one-time gene edit through Verve. 1 in 5 people carry elevated Lp(a). It’s over 90% genetic. Diet and exercise don’t touch it. 0.1% of Americans have ever been tested (Cleveland Clinic, 71 million records). One blood draw. $25. Once in your life.

The Wall Street Journal @WSJ

a week ago

Tens of millions of people in the U.S. have elevated Lp(a), an inherited and largely hidden driver of heart disease. A drug trial to address it is expected to report results soon. 🔗 on.wsj.com/49qpoIU

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This is a summary of ARCH’s investment strategy.

Mario Nawfal @MarioNawfal

a week ago

10/10 for attitude 😂

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@rtnarch Not to mention a very sizable nondilutive investment from @ARPA_H! Very exciting!!

Robert Nelsen @rtnarch

a week ago

ARCH founded Vaccine Company because we believed better vaccines could be created. Almost no one believed in the vision except the amazing Vaccine Company and ARCH team who stayed with it, and Luma Group, Pfizer Ventures, Wellcome Trust, and GHIC.

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It is getting harder to out-idiot CA and WA, but Oregon is still in the game with a late entrant.

KATU News @KATUNews

a week ago

An effort to criminalize the killing of animals for food in Oregon is a step closer to being on the November ballot. IP-28 would make it illegal to injure or kill animals and would effectively ban hunting, fishing and the breeding of animals. katu.com/news/local/ore…

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ARCH founded Vaccine Company because we believed better vaccines could be created. Almost no one believed in the vision except the amazing Vaccine Company and ARCH team who stayed with it, and Luma Group, Pfizer Ventures, Wellcome Trust, and GHIC.

Luciana Borio, MD @llborio

a week ago

Grateful to be part of this journey on behalf of #ARCH Venture Partners and proud of #Vaccine Company exceptional team. prnewswire.com/news-releases/…

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We need an Innovation Review Voucher, where a USA innovator (not others) can apply, based on their innovation in a drug category or molecule, for super fast regulatory approval, AND a transferable and subdividable 3 year commercial exclusivity, which covers the structure and close derivatives. Applications would be 90 day decisions, with a standard that a reasonable person would conclude that the technology was used or copied by the entity. In practice, this should prevent USA innovation from being decimated via less funding flowing in (which hurts patients in the long run), and if the commercial delay is critically important the vouchers are tradeable, and can be granted to more than one party at the discretion of the holder, so patients are protected. Prob have like ARPA H like structure or some new DOC panel to do it.

Peter Kolchinsky @PeterKolchinsky

2 weeks ago

The paradox of biotech protectionism: Why walling off China biotech weakens America US ban on Chinese biotech/trials would return pharma leadership to Europe, slow US patient access to new meds, & lead to US dependency protectionism claims to prevent. rapport.racap.com/all-stories/th…

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Human genetics has long supported the principle that the earlier, longer, and deeper we reduce LDL-C, the more atherosclerosis we can prevent. Now, Lilly/Verve report phase 1 results of a PCSK9 gene-editing therapy offering substantial long-term LDL lowering with a single infusion.

Crémieux @cremieuxrecueil

a week ago

Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!

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