Ralf Wittenbrink @RWittenbrink
Es gibt immer noch eine große Lücke zwischen dem, was die Öffentlichkeit über COVID-19 weiß, und dem, was sie wissen sollte. Deshalb hier Infos über COVID-19. Deutschland Joined July 2012-
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🔹️The new forecast model run (4/26) using updated sequence data, CDC prevalence estimates, and AB escape data from @yunlong_cao is suggesting a lesser impact from the FLiRT mutations than the last model run. Lesser impact from escape mutations is always welcomed.
🔹️The new forecast model run (4/26) using updated sequence data, CDC prevalence estimates, and AB escape data from @yunlong_cao is suggesting a lesser impact from the FLiRT mutations than the last model run. Lesser impact from escape mutations is always welcomed. https://t.co/FElIZA5NJ9
April 26th update: Infection rates still decreasing, down 10% this week. Pirola with FLiRT mutations now at ~40%. 🔸180,000 new infections/day 🔸~2.78 avg total infections per capita across the US 🔸1 in every 185 people currently infected
Die FDA gibt bekannt, dass in der PCR-positiven Milch kein lebendes, infektiöses #H5N1 gefunden wurde. fda.gov/food/alerts-ad… #BirdFlu #Vogelgrippe #Pandemie #COVID19 #COVIDIsAirborne
Die FDA gibt bekannt, dass in der PCR-positiven Milch kein lebendes, infektiöses #H5N1 gefunden wurde. fda.gov/food/alerts-ad… #BirdFlu #Vogelgrippe #Pandemie #COVID19 #COVIDIsAirborne
FDA announces no infectious #H5N1 was found in PCR positive milk. They used the “gold standard” egg inoculation tests that many have been waiting for. Together with NIAID grantee studies and past publications, it’s pretty conclusive the milk is safe. fda.gov/food/alerts-ad…
AMA: 'Akiko Iwasaki on what causes long COVID, brain fog, the Yale Paxlovid study and long COVID treatments' 'Our guest is Akiko Iwasaki, PhD, Sterling Professor of Immunobiology at Yale University.' ama-assn.org/delivering-car…
🇺🇸 The Biden-Harris Administration is today hosting the first-ever @WhiteHouse Summit for Sustainable and Healthy K-12 School Buildings and Grounds. USA confirms that it is one of the most advanced countries on the subject. whitehouse.gov/briefing-room/…
Important update on metadata of H5N1 in cattle (and back to birds): Thanks to the extraordinary detective skills of @flodebarre, we are pleased to be able to share this table containing locations and dates for several H5N1 cases in cattle and birds: github.com/andersen-lab/a…
„Erste orientierende Untersuchungen von 1000 Rinderserumproben aus Deutschland durch das Friedrich-Loeffler-Institut ergaben keinen Hinweis auf H5N1-Infektionen.“ fli.de/de/aktuelles/k… #Vogelgrippe #H5N1 #Pandemie #BirdFlu #COVID19 #COVIDIsAirborne
UPDATE: Another cat has tested positive for H5N1 bird flu at a dairy farm in New Mexico. So far, at least 7 cats have been infected in the current outbreak. All of them died.
This would be a tragedy in the midst of a widespread outbreak of high path avian flu in dairy cows. We’re flying blindly now as it is, it would be a total solar eclipse if @CDCDirector allows @CDCgov @CDCFlu to halt this reporting now. @WhiteHouse @SecBecerra please don’t let…
This would be a tragedy in the midst of a widespread outbreak of high path avian flu in dairy cows. We’re flying blindly now as it is, it would be a total solar eclipse if @CDCDirector allows @CDCgov @CDCFlu to halt this reporting now. @WhiteHouse @SecBecerra please don’t let…
.@WHO TAG-CO-VAC advises the use of a monovalent JN.1 lineage as the antigen in future formulations of #COVID19 #Vaccines Good Choice Better Choice - JN.1 + #FLiRT who.int/news/item/26-0…
We need tests; rapid, low-cost, point of care & home based tests for flu, preferably H5. As important, we need strategy for rapid treatment when someone is infected w/ H5 flu. Antivirals work best if used in 1st 24-36 hrs. No time for hospital visit or line at pharmacy.…
We need tests; rapid, low-cost, point of care & home based tests for flu, preferably H5. As important, we need strategy for rapid treatment when someone is infected w/ H5 flu. Antivirals work best if used in 1st 24-36 hrs. No time for hospital visit or line at pharmacy.…
Einen aktuellen Überblick über alle #H5N1 Entwicklungen in den USA bietet diese frei zugängliche epidemiologische Timeline der wichtigsten Ereignisse im Zusammenhang mit dem Ausbruch. github.com/Emergent-Epide… H/T @svscarpino @jkbren @MOUGK #Vogelgrippe #Pandemie #COVID19
Einen aktuellen Überblick über alle #H5N1 Entwicklungen in den USA bietet diese frei zugängliche epidemiologische Timeline der wichtigsten Ereignisse im Zusammenhang mit dem Ausbruch. github.com/Emergent-Epide… H/T @svscarpino @jkbren @MOUGK #Vogelgrippe #Pandemie #COVID19 https://t.co/4V3OJsdwBg
𝗠𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮𝗹 𝗱𝘆𝘀𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗶𝗻 𝗹𝗼𝗻𝗴 𝗖𝗢𝗩𝗜𝗗 link.springer.com/article/10.100…
Dr.C.Werner @DrCWerner
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3 in 10 adults in the USA report #LongCovid symptoms after infection. The risk has declined with omicron compared to delta, but we can't let down our guard in terms of prevention, because so many people are continuing to be infected. Akiko Iwasaki PhD👇 1/2
AMA: 'Akiko Iwasaki on what causes long COVID, brain fog, the Yale Paxlovid study and long COVID treatments' 'Our guest is Akiko Iwasaki, PhD, Sterling Professor of Immunobiology at Yale University.' ama-assn.org/delivering-car…
🔹️The new forecast model run (4/26) using updated sequence data, CDC prevalence estimates, and AB escape data from @yunlong_cao is suggesting a lesser impact from the FLiRT mutations than the last model run. Lesser impact from escape mutations is always welcomed.
New 6 Week Forecast: 🔸The lull may be over sooner than most of us hoped in the US due to "FLiRT". Infections are expected to start rising again after bottoming out in late April. ⚠️Recent seq data has been poor, so timing and significance of FLiRT carries some uncertainty.
April 26th update: Infection rates still decreasing, down 10% this week. Pirola with FLiRT mutations now at ~40%. 🔸180,000 new infections/day 🔸~2.78 avg total infections per capita across the US 🔸1 in every 185 people currently infected
Here’s my thread on past evidence from peer reviewed studies.
1/ I've seen many comments along the lines of, "We have no evidence that pasteurization inactivates #H5N1." We actually have quite a bit of evidence to suggest pasteurization will work and the presence of viral RNA is compatible w/ that evidence. Why am I not panicked? A🧵
@RWittenbrink Werden in Deutschland die Kühe auch wie in Amerika mit Geflügelmist gefüttert? Ja, Hühnerscheisse.
FDA announces no infectious #H5N1 was found in PCR positive milk. They used the “gold standard” egg inoculation tests that many have been waiting for. Together with NIAID grantee studies and past publications, it’s pretty conclusive the milk is safe. fda.gov/food/alerts-ad…
What I do know: this study would not have been possible without Marc @jamoulle taking such excellent care of all patients (and controls), raising the bar for all general practitioners dealing with #LongCovid
What we don't know (yet): viral RNA in blood originates from reservoir in platelets/megakaryocytes, bone marrow, gut...? are these transcriptomic biomarkers related (upstream/downstream?) to other #LongCOVID biomarkers cortisol, serotonin, complement activation, coagulation...?
@jamoulle In short, significant associations between persistent viral RNA, immunometabolism, and patient-reported outcomes provide mechanistic insights for addressing the challenges posed by #LongCOVID =>speed up diagnosis and treatment (target virus & restore #metabolism)
5. High or low blood viral load in LongCovid does not depend on age or sex. BUT every comorbidity increases the odds of high viral load with 61% AND every #vaccine dose lowers it with 64%, confirming protective effect of vaccination on LongCOVID found in large studies worldwide
4. Yes we can! Viral antisense RNA is a "decent" diagnostic biomarker for #LongCovid but together with immune marker FYN it's even better: 4.1. multivariate logistic regression (corrected for age and sex, table below) 4.2. identify Long COVID with >90% sensitivity and specificity
So now some statistics to answer the following: 4. can we use persistent RNA in blood (+/- 2 years after acute COVID in this cohort) as a diagnostic biomarker for #LongCovid? 5. what predicts high vs. low blood viral load in #LongCovid?
It's a short paper so details are in the Appendix 🤓 Look below at the very homogeneous controls (green) and the wild variation among #LongCovid patients: some are similar to controls but half are "deficient" in lymphocyte activation and immunometabolism -> higher viral load!
@resiapretorius Immune status in #LongCovid is neither hyperinflammation nor immunodepression BUT we find lower lymphocyte activation (yellow dots above) and lower #immunometabolism (blue dots) =similar to findings @RobWust team (but we find lower IDO1 not higher IDO2) pubmed.ncbi.nlm.nih.gov/37506544/
3. Looking at the immune response in #LongCovid: memory B-cell genes up (in green below) include IgE (resonates with new onset allergies in patients) and platelets genes up (salmon colored) -> hypercoagulative state @resiapretorius or viral reservoir =Bomsel lab @UParisDescarte
Looking at viral RNAs above cutoff (red line below) comparing patients and controls: antisense (65% vs 25%), ORF7a (60% vs 25%), Nucleocapsid (50% vs 8%), total blood viral load (60% vs 8%). Remarkably, Spike RNA was low in all cases =infection not vaccine-derived
What did we find? 1. viral RNAs were higher in #LongCovid: Nucleocapsid, ORF7a, ORF3a, Mpro (=Paxlovid target), and antisense ORF1ab RNA. Of note, presence of antisense RNA suggests ongoing viral replication 2. #SARSCoV2-related host RNAs ACE2/TMPRSS2, DPP4/FURIN also higher!
This is a real-world #LongCovid cohort, based on general practice of Marc @jamoulle who has become a beacon of hope for patients in Belgium & beyond. From his practice 48 patients and 12 controls were carefully matched for age, sex, time since COVID, vaccination and comorbidities
We believe clinically useful #biomarkers should be non-invasive: while it is interesting to know what happens with #SARSCoV2 in muscle or colon/gut, these biopsies are too painful and laborious to integrate in daily care for #LongCOVID patients. Hence a blood test!