LCAP (Long Covid Action Project) @LongCovidAP
LCAP is a united, diverse force of non-partisan individuals taking action to end the Long Covid crisis through awareness & government accountability. linktr.ee/longcovidactio… Washington, D.C. Joined January 2023-
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@2022onward @HELPCmteDems @GOPHELP Moonshot does too little, too slowly. I need antivirals now, not in 10 years or more. I helped write @LongCovidAP's legislation, based on what has successfully been implemented to research and care for people with HIV. x.com/amymitchellart…
@2022onward @HELPCmteDems @GOPHELP Moonshot does too little, too slowly. I need antivirals now, not in 10 years or more. I helped write @LongCovidAP's legislation, based on what has successfully been implemented to research and care for people with HIV. x.com/amymitchellart…
NEW: Sen. Bernie Sanders’ $10 billion long COVID research proposal received mixed reviews from patient-advocacy groups ahead of his April 23 comment deadline. But these recommendations could influence what Sanders includes in the final bill. My latest: dlvr.it/T5ywRm
4. Yes we can! Viral antisense RNA is a "decent" diagnostic biomarker for #LongCovid but together with immune marker FYN it's even better: 4.1. multivariate logistic regression (corrected for age and sex, table below) 4.2. identify Long COVID with >90% sensitivity and specificity
So now some statistics to answer the following: 4. can we use persistent RNA in blood (+/- 2 years after acute COVID in this cohort) as a diagnostic biomarker for #LongCovid? 5. what predicts high vs. low blood viral load in #LongCovid?
It's a short paper so details are in the Appendix 🤓 Look below at the very homogeneous controls (green) and the wild variation among #LongCovid patients: some are similar to controls but half are "deficient" in lymphocyte activation and immunometabolism -> higher viral load!
@JoshuaPribanic Antisense RNA is only found inside a cell with replicating virus, so yes
@johanvawe Thank you. @zeynep please see this answer & use studies at longcovidfacts.com to correct @NIHDirector about existence of SARS2 live virus detected via viral load tests, of which those w/in NIH confirmed to LCAP they have been using w/out data shown to public
@JoshuaPribanic @Julia_Daye @itsJalenB @corbett_jessica @jacksontom @microbeminded2 @LastBornPodcast @NIHDirector @NIH @NIHceal @HHSGov Excellent thread describing more details and the significance of this work from one of the authors of the study:
@JoshuaPribanic @Julia_Daye @itsJalenB @corbett_jessica @jacksontom @microbeminded2 @LastBornPodcast @NIHDirector @NIH @NIHceal @HHSGov Excellent thread describing more details and the significance of this work from one of the authors of the study:
📣 Speaker announcement 📣 A warm welcome for our next speaker! Johan Van Weyenbergh (@johanvawe ) joins #UniteToFight2024 ! We are very happy to have you with us on this journey! 🙏 #longcovid #mecfs
If you have time to read only one thread by a Long Covid researcher today, make this be the one!
If you have time to read only one thread by a Long Covid researcher today, make this be the one!
#LongCovid is complex to diagnose and treat, so we need #biomarkers! 1. to confirm viral persistence, and 2. to map the failing/overactive immune response. So we tried to hit two birds with one stone using digital transcriptomics 👇👇 (1/n) thelancet.com/journals/lanmi…
We believe clinically useful #biomarkers should be non-invasive: while it is interesting to know what happens with #SARSCoV2 in muscle or colon/gut, these biopsies are too painful and laborious to integrate in daily care for #LongCOVID patients. Hence a blood test!
Looking at viral RNAs above cutoff (red line below) comparing patients and controls: antisense (65% vs 25%), ORF7a (60% vs 25%), Nucleocapsid (50% vs 8%), total blood viral load (60% vs 8%). Remarkably, Spike RNA was low in all cases =infection not vaccine-derived
What did we find? 1. viral RNAs were higher in #LongCovid: Nucleocapsid, ORF7a, ORF3a, Mpro (=Paxlovid target), and antisense ORF1ab RNA. Of note, presence of antisense RNA suggests ongoing viral replication 2. #SARSCoV2-related host RNAs ACE2/TMPRSS2, DPP4/FURIN also higher!
This THE 🩸 transcriptomic viral load test we’ve been highlighting at LCAP & to the press since it came out - shouting for NIH to open access to its SARS2 transcriptomic viral load tests to people w/ Long Covid that’s in use behind closed doors #AntiviralsNow #ViralLoadTestsNow
This THE 🩸 transcriptomic viral load test we’ve been highlighting at LCAP & to the press since it came out - shouting for NIH to open access to its SARS2 transcriptomic viral load tests to people w/ Long Covid that’s in use behind closed doors #AntiviralsNow #ViralLoadTestsNow https://t.co/qgtsP1JNPU
I could use your help reaching my fundraising goal. Every single share and donation makes a difference. gofund.me/68d7140c
I just wrote @LongCovidAP's "Tell @SenSanders to Enact the HEAL Legislation Proposal for Long Covid" Get Loud! We need Long Covid legislation that creates: Viral Load Tests Now! #AntiviralsNow! $28B+ Now! Sign the letter! actionnetwork.org/letters/tell-b… #HELPHEALUS #SARS2
@Partikel007 @bfrde @InspekteurSan @BVerfG 🎬 Anbetracht der vielen offenen Fragen zur intrinsischen Virulenz und zukünftigen Langzeitfolgen durch wiederholte Exposition zu #SARSCoV2 und deren Persistence sollten Kindern, Vulnerablen, Patienten besonderer Infektionsschutz angedeiht werden 📽 x.com/joshuapribanic…
@Partikel007 @bfrde @InspekteurSan @BVerfG 🎬 Anbetracht der vielen offenen Fragen zur intrinsischen Virulenz und zukünftigen Langzeitfolgen durch wiederholte Exposition zu #SARSCoV2 und deren Persistence sollten Kindern, Vulnerablen, Patienten besonderer Infektionsschutz angedeiht werden 📽 x.com/joshuapribanic…
I just wrote @LongCovidAP's "Tell @SenSanders to Enact the HEAL Legislation Proposal for Long Covid" Get Loud! We need Long Covid legislation that creates: Viral Load Tests Now! #AntiviralsNow! $28B+ Now! Sign the letter! actionnetwork.org/letters/tell-b… #HELPHEALUS #SARS2
I just wrote @LongCovidAP's "Tell @SenSanders to Enact the HEAL Legislation Proposal for Long Covid" Get Loud! We need Long Covid legislation that creates: Viral Load Tests Now! #AntiviralsNow! $28B+ Now! Sign the letter! actionnetwork.org/letters/tell-b… #HELPHEALUS #SARS2
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ezRks @ez_rks
110 Followers 519 Following
Renate-new account�.. @Renate834601
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Long Covid Belgium @TooLongCovidBe
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4K Followers 4K Following Researcher in #HTLV #HIV #NTDs respiratory viruses and vaccine response. 'Nothing in #human #immunology makes sense outside the light of #clinical #evolution'
jellyrollblues #Covid.. @jlerollblues
6K Followers 6K Following father, retired scientist PhD, Covid modeler , liberal, artist, history buff, deadhead #NoRA #union #IChooseScience https://t.co/M6oCUBv5MI
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1K Followers 923 Following Sandusky Register scribe. Like: science fiction, Asian food, Robert Anton Wilson, civil liberties, 20th century Russian composers.Opinions mine, not Register's.
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Renee. Long Cvid 💀.. @LCaddams
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5K Followers 2K Following We advocate for people threatened by COVID-19 by promoting the multi-layered approach in mitigation measures. Let’s stay COVID-SMART.
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788 Followers 970 Following Editorial board member at The Star-Ledger. Parallel parking ace. Board opinions aren't always my own; sometimes they are the product of a debate that I lost.
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282 Followers 734 Following Proud mom of 2 amazing kids, wife and engineer! Lover of ⛷️🥾 🌳 🌸 📚 🎶 🌊 🧳 👯♂️ On a mission to spread kindness to everyone everyday! Long COVID ❤️ ✌️
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Association Winslow S.. @winslow_la
2K Followers 2K Following Citoyens, malades, CovidConcerné-es, médecins, humanistes vs le populisme sanitaire -winslowsp sur bsky - ➡️ Réhabiliter la santé publique https://t.co/qTk6KgyMEP
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2K Followers 3K Following Militante Santé Publique @solenntango.bsky.social Asso @winslow_la 🐘 338ppm Prof éthique, justice sociale, inegalités... LC / EP illness "in ffp2 we trust"@2022onward @HELPCmteDems @GOPHELP Moonshot does too little, too slowly. I need antivirals now, not in 10 years or more. I helped write @LongCovidAP's legislation, based on what has successfully been implemented to research and care for people with HIV. x.com/amymitchellart…
The comment period for @SenSanders #LongCOVID legislation ends sometime tomorrow April 23. Don't forget to personalize and send your @LongCovidAP letter. 🏥👩⚕️🧪 #healus #helphealus actionnetwork.org/letters/tell-b…
@The_BMC @RepPressley @HHSGov How much discussion was focused on SARS2 viral persistence, transcriptomic #ViralLoadTestsNow & #AntivirlalsNow? What was the discussion focussed on regarding #LongCovid?
@CockapooWinnie Shouldn’t someone have to give a reason at some point for this? It’s not like impulsively buying skittles at 7-11 and not explaining. This is serious stuff. I agree we definitely need more. The math doesn’t add up.
NEW: Sen. Bernie Sanders’ $10 billion long COVID research proposal received mixed reviews from patient-advocacy groups ahead of his April 23 comment deadline. But these recommendations could influence what Sanders includes in the final bill. My latest: dlvr.it/T5ywRm
Research Moving toward viral load test for #longcovid 👇#covid #bloid #fatigue #cough #depression #anxiety #copd #asthma
The #SARSCoV2 viral RNA signature in people with #LongCovid markedly differs vs controls thelancet.com/journals/lanmi… @LancetMicrobe Also linked to symptoms. Not only indicative of persistence, but also potential as a biomarker @johanvawe @jamoulle @KU_Leuven
4. Yes we can! Viral antisense RNA is a "decent" diagnostic biomarker for #LongCovid but together with immune marker FYN it's even better: 4.1. multivariate logistic regression (corrected for age and sex, table below) 4.2. identify Long COVID with >90% sensitivity and specificity
So now some statistics to answer the following: 4. can we use persistent RNA in blood (+/- 2 years after acute COVID in this cohort) as a diagnostic biomarker for #LongCovid? 5. what predicts high vs. low blood viral load in #LongCovid?
It's a short paper so details are in the Appendix 🤓 Look below at the very homogeneous controls (green) and the wild variation among #LongCovid patients: some are similar to controls but half are "deficient" in lymphocyte activation and immunometabolism -> higher viral load!
@JoshuaPribanic Antisense RNA is only found inside a cell with replicating virus, so yes
@johanvawe Thank you. @zeynep please see this answer & use studies at longcovidfacts.com to correct @NIHDirector about existence of SARS2 live virus detected via viral load tests, of which those w/in NIH confirmed to LCAP they have been using w/out data shown to public
@KevCTNC @Julia_Daye @itsJalenB @corbett_jessica @jacksontom @microbeminded2 @LastBornPodcast @NIHDirector @NIH @NIHceal @HHSGov It’s live SARS2 in 92% of those tested w/ Long Covid in the transcriptomic viral load study - see thread & researchers answer. Folks have been using word games to dodge this for over a year - we need #ViralLoadTestsNow #AntiviralsNow @SenSanders @NIHDirector @NIHDirector
@johanvawe Thank you. @zeynep please see this answer & use studies at longcovidfacts.com to correct @NIHDirector about existence of SARS2 live virus detected via viral load tests, of which those w/in NIH confirmed to LCAP they have been using w/out data shown to public
@JoshuaPribanic @Julia_Daye @itsJalenB @corbett_jessica @jacksontom @microbeminded2 @LastBornPodcast @NIHDirector @NIH @NIHceal @HHSGov Excellent thread describing more details and the significance of this work from one of the authors of the study:
#LongCovid is complex to diagnose and treat, so we need #biomarkers! 1. to confirm viral persistence, and 2. to map the failing/overactive immune response. So we tried to hit two birds with one stone using digital transcriptomics 👇👇 (1/n) thelancet.com/journals/lanmi…
Great Work!! Thank you! Viral Persistence!! We need Biomarkers!
#LongCovid is complex to diagnose and treat, so we need #biomarkers! 1. to confirm viral persistence, and 2. to map the failing/overactive immune response. So we tried to hit two birds with one stone using digital transcriptomics 👇👇 (1/n) thelancet.com/journals/lanmi…
📣 Speaker announcement 📣 A warm welcome for our next speaker! Johan Van Weyenbergh (@johanvawe ) joins #UniteToFight2024 ! We are very happy to have you with us on this journey! 🙏 #longcovid #mecfs
If you have time to read only one thread by a Long Covid researcher today, make this be the one!
#LongCovid is complex to diagnose and treat, so we need #biomarkers! 1. to confirm viral persistence, and 2. to map the failing/overactive immune response. So we tried to hit two birds with one stone using digital transcriptomics 👇👇 (1/n) thelancet.com/journals/lanmi…
#LongCovid is complex to diagnose and treat, so we need #biomarkers! 1. to confirm viral persistence, and 2. to map the failing/overactive immune response. So we tried to hit two birds with one stone using digital transcriptomics 👇👇 (1/n) thelancet.com/journals/lanmi…
We believe clinically useful #biomarkers should be non-invasive: while it is interesting to know what happens with #SARSCoV2 in muscle or colon/gut, these biopsies are too painful and laborious to integrate in daily care for #LongCOVID patients. Hence a blood test!
This is a real-world #LongCovid cohort, based on general practice of Marc @jamoulle who has become a beacon of hope for patients in Belgium & beyond. From his practice 48 patients and 12 controls were carefully matched for age, sex, time since COVID, vaccination and comorbidities
Looking at viral RNAs above cutoff (red line below) comparing patients and controls: antisense (65% vs 25%), ORF7a (60% vs 25%), Nucleocapsid (50% vs 8%), total blood viral load (60% vs 8%). Remarkably, Spike RNA was low in all cases =infection not vaccine-derived
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