Patrick Griffin @patrick_griffN
Postdoc @ Harvard HSCRB and the Broad Institute. Boston, MA Joined July 2012-
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Patrick Griffin retweeted
Infinite Epigenetics & True Diagnostics acquire @sinclairfriends lab spin-out, Tally, giving them access to DNAme IP to help bring down costs & accelerate epigenetics-informed health care Congrats to @L_Catterton, @melanie_goldey, @patrick_griffN, @gladyshev_lab & the entire team! 👏
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Patrick Griffin retweeted
It takes two (transcription factors) to tango Transcription factor collaboration enables precise T cell state engineering tinyurl.com/tcelltfs Excited to share our preprint with @JD_Buenrostro, @cgersbach, and an incredible team of collaborators as part of @IGVFConsortium 🧵
Patrick Griffin retweeted
Excited to share my postdoc work with @JD_Buenrostro now out in @Nature! "Epigenetic memory of colitis promotes tumour growth" nature.com/articles/s4158… We wanted to understand how transient inflammation can create a long-lived increase in cancer risk, even after full recovery 🧵
Patrick Griffin retweeted
First test of partial epigenetic reprogramming to reverse aging for two eye conditions (glaucoma and NAION) gets FDA go ahead @lifebiosciences Based on 2020 @Nature paper pubmed.ncbi.nlm.nih.gov/33268865/ endpoints.news/exclusive-fda-…
Patrick Griffin retweeted
Huge thanks to all co-authors and the inimitable @JD_Buenrostro for supporting this new direction - I got to think about evolution, engineering, chromatin biophysics, and modeling during the course of this project. For more, check out the preprint: biorxiv.org/content/10.110…
Patrick Griffin retweeted
Excited to share a short article I wrote describing: Slide-tags - which enables spatial single-nucleus sequencing, allowing us to dive deeper into the complexity of tissue organization. Grateful for the amazing team and support from @insitubiology and @macosko! #ToolsOfTheTrade
Slide-tags enables spatial single-nucleus sequencing go.nature.com/48x06XP #ToolsOfTheTrade by Andrew J. C. Russell @AndyRusss @broadinstitute @insitubiology @HSCRB
Patrick Griffin retweeted
The latest LLLM (large language of life) foundation model, with state-of-the art chronological age estimation, prediction of outcomes, and performance across different datasets and conditions
Patrick Griffin retweeted
Introducing IN SITU GENOME SEQUENCING, a new technology to resolve DNA sequence🧬 and structure🔬 A team effort with @Andrew_C_Payne, @PaulReginato, @eboyden3, @JD_Buenrostro, and Fei Chen science.sciencemag.org/content/early/… This is how it works: (1/8)
Patrick Griffin retweeted
Thrilled to see our ExIGS tool featured! A true testament to the power of collaboration. Huge congrats to the team for their hard work! 🧬@ajaylabade31 @z_chiang @CarolineComenho nature.com/articles/d4158…
Patrick Griffin retweeted
Grades of DNA methylation as the basis of epigenetic cell memory... must-read. biorxiv.org/content/10.110…
Patrick Griffin retweeted
T cells become exhausted and fail to control tumors in cancer patients. What if we could replicate T cell exhaustion in vitro and uncover the gene regulatory network driving exhaustion, enabling immuno-oncology drug discovery? With AstraZeneca, the Buenrostro lab addresses this gap (biorxiv.org/content/10.110…):
Patrick Griffin retweeted
Study Proposes Framework to Standardize Biomarkers of Aging and Accelerate Clinical Use @jpoganik Read more: buff.ly/3OMHMBo
Patrick Griffin retweeted
We are recruiting postdoctoral fellows in neurobiology and development to complement our group specializing in genomic technologies, epigenetics and machine learning. projects are very well funded and we are interested in co-mentorship. Please DM if interested in hearing more!
Patrick Griffin retweeted
Our latest paper is out - a new method called "TIME-Seq" to measure biological age for just a few dollars. Great work Patrick Griffin! @NatureAging Free download rdcu.be/dvDfc
@ThomasJGriffin0 @BlackHarePress Huge congrats brother! 💪
Patrick Griffin retweeted
Can we reverse aging? 7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, biorxiv.org/content/10.110… we used 🧬 screens to find new rejuvenation factors🧵1/8
Patrick Griffin retweeted
Delving into our newly released result, a thread:
Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma: A year-long functional tracking of in vivo partial reprogramming demonstrates safety and efficacy. Work from @margaretekarg @YuanchengLu @davidasinclair @bruce_ksander liebertpub.com/doi/10.1089/ce…
Patrick Griffin retweeted
Can we shield the epigenome from age-related changes, much like how SIRT6 defends the genome? Using a CRISPRi screening approach, @XiaoTianPhD seeks to identify genes involved in maintaining epigenome stability. His new lab @sbpdiscovery is recruiting for various roles!
Xiao is one of the most productive and kindest scientists I have ever met! Amazing opportunity
I am hiring multiple Postdoctoral Associates for my new lab at Sanford Burnham Prebys. We use a multidisciplinary approach (multi-omics, machine learning, long-lived species) to push the boundaries of aging research. Please see more details and apply here: sbpdiscovery.hrmdirect.com/employment/job…
Patrick Griffin retweeted
Congratulations HSCRB Associate Professor @jd_buenrostro for being been named a 2023 #MacFellow! @macfound macfound.org/fellows/class-…
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