kat @katclone

something new :) katkaj.substack.com Cambridge, MA Joined June 2020

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kat @katclone

10 hours ago

@OliviaHelenS Congrats Olivia!!!!! ☀️

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No one should be able to order a bioweapon through the mail. @IFP & @JoinFAI are proud to co-lead an open letter calling for mandatory DNA synthesis screening & recordkeeping. Signatories include: - Sam Altman, CEO & Co-Founder, OpenAI - Dario Amodei, CEO & Co-Founder, Anthropic - David Baker, Director, Institute for Protein Design; 2024 Nobel Prize in Chemistry recipient - Patrick Collison, CEO & Co-Founder, Stripe - Paul Graham, Founder, Y Combinator - Demis Hassabis, CEO, Google DeepMind; 2024 Nobel Prize in Chemistry recipient - Emily Leproust, CEO & Co-Founder, Twist Bioscience - Lawrence Lessig, Roy L. Furman Professor of Law and Leadership, Harvard Law School - Gerald W. Parker, former Special Assistant to the President for Biosecurity and Pandemic Response - Mustafa Suleyman, CEO, Microsoft AI - Alex Tabarrok, Professor of Economics, George Mason University - Alexandr Wang, Chief AI Officer, Meta; Founder, Scale AI - Christine E. Wormuth, President & CEO, Nuclear Threat Initiative; 25th Secretary of the Army Read the letter and see the full list of signatories: screendna.org Many DNA synthesis companies voluntarily screen orders to mitigate biosecurity risks, but no law requires them to do so. Leaders in AI, biotech, life sciences, national security, and the nucleic acid synthesis industry agree that Congress should act to strengthen safeguards against biological threats. @deanwball put it well in the WSJ: “If you’re synthesizing the stuff that yields biological life and viruses, we’re asking you to screen to see whether it is dangerous in some way. That seems like a reasonable thing for society to insist upon.”

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kat @katclone

a week ago

Before I leave end of June, would love to chat (esp if you’re working on) • preventative or (closer) to curative therapeutics • faster rna (better LNP, etc) or peptide (cell free?) therapeutic manufacturing • thinking about what experimental data we need to improve models

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kat @katclone

a week ago

ahhHHHHH @MIT PhDone!!!!!! I loved my time there. So many brilliant & kind people in a shared pursuit of helping humanity. I can’t wait to continue accelerating biology 🤍

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kat @katclone

a week ago

@ladanuzhna @MatthewMcAteer0 100%

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Alex Kesin @alexkesin

3 weeks ago

Keytruda transformed cancer care and made Merck more money than any drug in history. It was also discovered by accident, and nearly out-licensed in 2010 for pocket change. New Approved + exclusive interviews with the inventors and the Merck CMO who ran development:

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kat @katclone

4 weeks ago

@rrhoover Congrats Ryan!!!

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kat @katclone

a month ago

@algobaker Somehow yes

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kat @katclone

a month ago

THE DOG GOT A CHECKPOINT INHIBITOR

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kat @katclone

a month ago

I will say jokes aside moments like these end up often funneling more money and attention in a field that is worth having more funding Maybe in a clinical trial cancer vaccine would’ve helped dogs

kat @katclone

a month ago

THE DOG GOT A CHECKPOINT INHIBITOR

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kat @katclone

a month ago

I actually cannot believe how many times I’ve heard about the dog from every imaginable social circle 😹😹

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kat @katclone

a month ago

me after hearing ai cured dog cancer for the billionth time lol

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kat @katclone

a month ago

@tbpn @VictorWBoyd @alexkshieh @NDobroshinsky @ishangpta @antoni_kiszka @HighPriestOfSWO @G413N @needaubrey @samuelclcc @clairebookworm @clairebookworm Claire!!!! 🥳

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kat @katclone

2 months ago

begged my department and Bob to let me take his cancer bio class at mit as a neuro phd — best class, legend

Raghu Kalluri @rkalluriMDPhD

2 months ago

I had the great pleasure of spending a few hours this afternoon with Bob Weinberg at Whitehead/MIT, catching up on our 25 years of friendship and many conversations about science, life, and society. A legend and a scholar who has deeply shaped our understanding of cancer biology.

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Jacob Stern @JAC0BSTERN

2 months ago

Last August, @sytses and I traveled to Beijing for an experimental scan to look at a biomarker that’s specifically upregulated in his cancer. We were stunned. The whole experience — from international patient check-in, to preparation of the radiotracer, to injection, to imaging, to discussing the result with the physician, to leaving with a glossy printout of the whole-body scan — took two hours. This experience inspired me to return to China to understand in more depth what is happening there at the forefront of biotech and medicine. I recently spent a week visiting 5 cities across China's biotech ecosystem, meeting with companies, investigators, and research organizations. I came away impressed. What I found was a system and a community built for speed and pragmatic innovation that cares about helping patients. Interestingly, the investigator-initiated trial system in China seems to operate on a "marketplace of reputation," where trusted physicians and institutions can move promising therapies to patients quickly, with safety governed by local scientific and ethics committees and professional accountability rather than centralized bureaucracy. The implications are striking: medical tourism may soon invert, with patients flying to China for cutting-edge experimental treatments. And I hope that we in America can learn from the sensible steps the Chinese ecosystem has taken and speed up our own innovation cycle. Patients deserve it. Thanks very much to @jordanschneider and the team at ChinaTalk (especially Lily Ottinger and Nick Corvino) for publishing my thoughts on the trip. Link to post in comments.

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Citrini @citrini

2 months ago

Posting for two reasons: 1 being if any of you can help this guy out. 2 being to remind everyone that if AI can shorten (even by a little) the time it takes to get drugs like these to the people that need them, then the trillions on compute will have been well spent.

Christian Ruf @pinpulleddrmf

2 months ago

Veteran buried his eldest and it’s not looking good for his two others. Posting for any connections, help that can be made while they fight for time.

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“paula” @paularambles

2 months ago

fiscally american socially european

𓁹‿𓁹 @kitvolta

2 months ago

the trick to surviving is having a european approach to life with somehow an american work output

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kat @katclone

2 months ago

My phone died lol close enough

kat @katclone

2 months ago

BEAUTIFUL DAY FOR 20 MILE RUN AND WORK

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kat @katclone

2 months ago

BEAUTIFUL DAY FOR 20 MILE RUN AND WORK

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kat @katclone

2 months ago

@JohnSchloendorn Yeah single nuc seq would be fine too I think. Ideally looking for a provider that has benchmarked results to other preservation methods