The amazing group of people who support our research aimed at reversing aging in order to treat diseases and dramatically extend healthy lifespanfriendsofsinclairlab.com Boston, MAJoined September 2025
Congrats @lifebiosciences team. Big thanks to our investors. Well done Jerry McLaughlin, Michael Ringel, Amit Shashank, Sharon Rozenzweig-L, Ivan Kaplan, @Serenapoon & team. Go ER-100🤞
Not sure we qualify as “startup” after 8 yrs & being in the clinic 😉
endpoints.news/david-sinclair…
A major new paper reframes aging as a systems failure of epigenetic information. Not wear and tear but a software problem. This is what the Information Theory of Aging predicts and, if correct, means aging is reversible.
Let's dive in... 🧵
We built this demo in collaboration with a clinical pathology lab. It shows a single system doing real lab tasks: tool use, precision manipulation, and high level planning.
This was done in one take with no teleop and uses our skills based AI to enable generality while staying
Today’s guest on the Free Radicals podcast is @M_S_Ringel, COO @lifebiosciences and former Managing Director at @BCG.
Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he
Oh wow — so cool to see two of my favorite examples that I’ve been using in my talks for close to a decade (rockfish lifespans spectrum from 10 to 200 years and the black garden ant queen’s 30-year lifespan vs. the worker’s 1-year [rather than a month — I think Michael misspoke]) getting wider airtime as evidence that aging is a programmed adaptation. The more people making this case, the better!
Here’s a video with relevant excerpts:
Today’s guest on the Free Radicals podcast is @M_S_Ringel, COO @lifebiosciences and former Managing Director at @BCG.
Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he
Every week, I tell one of my students to increase the font size on their slides, especially numbers. Here’s how you know you’re good:
Take 5 steps back from your laptop or monitor. If you can still read every letter & number clearly, you’re probably good 👍
For 25 years, my team has been told we were wrong, by scientists, big pharma, the media, ethicists, and trolls. It hasn’t been easy
Looking back, it was 100% worth it
Here’s why you should believe in yourself… 🧵
According to ITOA, NAD declines with age, causing epigenetic changes & disease susceptibility
In 2010, we showed NAD-dependent enzyme, SIRT3, protects the heart 🐁
New study says NAD precursor NMN protects the heart via SIRT3 in mice fed a Western diet
Why's that important? 🧵
In 2006, we reported the longevity & metabolic benefits of resveratrol in mice
Now, after 40 human trials with 2,551 patients, resveratrol is reported to significantly lower insulin resistance, lipids, BP & inflammation
Discovery. Translation. Progress.
nature.com/articles/natur…
It FINALLY happened!!!!
The Rapamycin & Exercise clinical trial manuscript has been accepted
5 years in the making
Special thanks to @mkaeberlein, @LifespanNews, @vitadao, everyone who donated, and viewers of my channel.
Longevity’s strongest correlate is having a dependable partner.
We are creatures whose optimal biology requires tight social bonds, presumably because our ancestors’ survival once depended on them.
For optimal health, rebel against today’s antisocial society 💪
Very few factors significantly slow epigenetic aging.
Strong social connection is one of them.
The data keep pointing the same way: healthy relationships are a key to a long and healthy life.
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