Jamie Timmons @metapredict

NHS staff should be banned from wearing pro-Palestinian badges, report recommends. Good. About time. When did ANYONE think it was acceptable for NHS staff to wear ANY political insignia while at work? While we're at it, can we ban rainbow lanyards too? bbc.co.uk/news/articles/…

I’ve visited villages in Poland where Jews used to live. They took all the Jews away and murdered them. But all of the buildings are intact.

BREAKING: Israel to allow Hamas to do a “wee bit” of rape and murder after inspiring drum performance by the group ‘Absolute Fucking Retards For Palestine’.

@MariosGeorgakis @robbie_stats Each single cell profile is missing 50% or > of its genuine GE. The pattern not random. Why is this not just the influence of a biased filter? And loci to target choice remains "complicated". Tissue level can be deconvoluted & the transcriptomic assay is less compromised...

@agingroy @Stanford This will be, as it always in for muscle, a "just in mice" story.

This piece suggests that because a German hotel had had a bad week with fake bookings, they somehow, when they *meant* to say, “sorry can we just run an ID verification check?” said instead “No Jews allowed”. An easy mistake to make I guess. NARRATOR: This is not an easy mistake to make.

Tobias Huch @TobiasHuch

2 days ago

x.com/i/article/2061…

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@ClaudiaWebbe You are missing "liar" 🤥 from your profile of "achievements"

@harrybrossiter @changmyung1981 Ancient 😁 Certainly find the increasingly exotic functions ascribed to lactate hard to buy.....

This is a sharp critique that computational biologists must heed. Integrating 11k+ heterogeneous datasets requires aggressive batch correction, which can inflate predictive metrics. Plus, translating controlled rodent signatures to highly variable human tissues has clear limitations.

@nicolelampert There's a section of @CelticFC supporters, my team, that are sub-human terrorist supporters. The fact they can't see the ~equivalence between the history of the occupation of Ireland with repeat occupation and attacks on the home of the Jewish people baffles me.

Definitely more word salad. It's like Opus 4.8 was trained by an immunologist.

Arjun Raj @arjunrajlab

2 days ago

Maybe it’s just me, but I feel like Claude generates a lot more word salad these days…

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🚨 Should obesity always be considered a disease? A provocative new Nature Comment argues that the answer is no. Francesco Rubino, chair of the 2025 Lancet Commission on Clinical Obesity, challenges the growing movement to classify all obesity as a chronic disease. Instead, he proposes a more nuanced framework distinguishing clinical obesity from preclinical obesity, with major implications for diagnosis, treatment, health policy, and research. The central argument For years, obesity was viewed primarily as a risk factor for diabetes, cardiovascular disease, cancer, and premature mortality. More recently, advocacy groups and professional societies have increasingly promoted obesity as a chronic disease to reduce stigma and improve access to treatment. However, Rubino argues that this shift may oversimplify a highly heterogeneous condition. Two individuals with exactly the same BMI can have dramatically different health states: ✅ One may have preserved organ function and remain healthy for decades. ❌ Another may experience heart failure, respiratory impairment, metabolic dysfunction, and severe mobility limitations. Yet current classifications often place both under a single disease label. Clinical vs Preclinical Obesity The 2025 Lancet Commission proposed a distinction: 🔴 Clinical obesity Excess adiposity directly causes organ dysfunction Impairs daily activities Produces measurable physiological abnormalities Represents a true disease state 🟡 Preclinical obesity Excess adiposity is present Organ function remains preserved Future risk is elevated Disease has not yet developed This framework treats risk as risk and disease as disease. Why BMI alone is insufficient The article emphasizes that obesity differs from diseases such as diabetes or COVID-19. Classic diseases are usually defined through: Consistent symptoms Predictable clinical trajectories Shared biological mechanisms Obesity lacks this uniformity. BMI predicts population-level risk but often fails to predict: Individual prognosis Current health status Treatment response Underlying biology As a result, obesity cannot always be interpreted as a disease at the individual level. The biological argument Another key point: There is no single biological abnormality shared by all people with obesity. While genetics, environment, aging, sleep disruption, medications, and food environments contribute, obesity represents multiple biological pathways rather than one disease mechanism. The success of GLP-1 receptor agonists demonstrates that body weight is biologically modifiable—but not necessarily that every case of obesity constitutes disease. Policy implications The consequences are enormous. If every person with obesity were classified as having a chronic disease: Hundreds of millions could become eligible for lifelong treatment Health systems could face unsustainable costs Access criteria might become increasingly arbitrary Some individuals may receive therapies with limited clinical benefit relative to risk The author argues that treatment intensity should be proportional to demonstrated disease burden rather than BMI alone. Take-home message The debate is not whether obesity can be a disease. The debate is whether all obesity should be considered disease. Rubino argues that diagnostic precision matters: Clinical obesity = disease. Preclinical obesity = elevated risk, but not disease. Recognizing this distinction could improve patient-centered care, sharpen research, reduce overtreatment, and create more sustainable health policy. Reference Rubino F. Why obesity shouldn’t always be considered a disease. Nature. 2026;654:33–36. #Obesity #GLP1 #MetabolicHealth #Endocrinology #PublicHealth #PrecisionMedicine #ObesityMedicine #NatureJournal #Metabolism #HealthcarePolicy

@ggkuhnle I assume you mean by creating a minimum universal income 😉

@Jvnior Made up stuff by a racist 👋

Every word of this. Brendan O’Neill nails it yet again. 🎯🎯🎯 “Defamations against Israel fall from the mouth of every influencer here. Even a sports presenter, following the game with Qatar, could casually say on air that Israel is waging a ‘genocidal campaign’ in Gaza. Nothing to say about Qatar? The team we just played? Which funded the army of anti-Semites that killed more Jews in one day than anyone else has since the Nazis? Of course not. Israel is the all-consuming devil that stalks the fever dreams of Ireland’s pious. It is a substitute Satan in a post-Catholic land. You can’t even watch the footie here without being subjected to self-righteous homilies about the uniquely wicked nature of this far-off nation. It is relentless. It is exhausting.”

spiked @spikedonline

3 days ago

Israelophobia is rotting Ireland’s soul. The cultural elites have been completely conquered by the Euro-malady of anti-Zionism. They spend more time raging against the Jewish nation than they do fixing the Irish nation. It’s madness, says Brendan O’Neill buff.ly/JRXfe2l

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@pesottas Only when they can be distinguished. As we've seen this week even Harvard is pushing out junk assays for "aging".

@DrNeilStone No where is spotlessly clean, by definition.

Finally public! Dr @CharlesMBrenner joins University of Helsinki, SWAN network in Faculty of Medicine, also connected to @HiLIFE_helsinki and Faculty of Pharmacy. Warm welcome to Charlie, a leading figure in the field of redox metabolism. helsinki.fi/en/news/rare-d…

@pdhsu @brian_armstrong @zavaindar Bs. you don't even have an assay to define aging (clue; it's not a chronological age clock).