Alexander M. Wolf @AlexanderMWolf7
Scientist. Father of 5. Wrote "The tumor suppression theory of aging"&"Rodent diet aids and the fallacy of caloric restriction" Dettighofen Joined December 2021-
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@kemmishTree @dwarkesh_sp @jacobkimmel Not necessary. It's good entertainment, and there's value in that. But it's surprising how much money you can raise with a good story, no matter how bonkers it is to those with a little common sense.
@Madam_Mito @s66755 But thank you for reading it. Peto's paradox is well investigated. Proliferation is not uncoupled from aging because conserved aging pathways are those regulating the pace of aging. IGF1 determines not only proliferation, but also size and length of life in dogs, all else equal.
@Madam_Mito @s66755 Ok, but AFAIK, mice kept completely pathogen free still age normally. In humans, no research has connected pathogen load to aging. There are no known associations of immune deficiencies or bone marrow abnormalities with accelerated aging. It must be your imagination.
2 weeks ago, I presented the tumor suppression theory of aging at a conference, "The Evolution of Ageing: Traversing the interdisciplinary divide", held from September 30 – October 2, 2025 at Wasem Monastery, Ingelheim (close to Mainz), Germany (1/21)
@strygah @altos_labs @calico Both @altos_labs and @calico are very exclusive retirement homes where the superstars can retire in dignity without having to deliver anything or justify their actions or spending to outside scrutiny.
@Madam_Mito @s66755 This is not about malignancy surveillance. You can read it in detail here: researchgate.net/publication/40…
@mattwridley And the reason for that is because treating aging is fundamentally different from treating disease. In disease, something's wrong, and we can treat that. But there's nothing wrong in aging. Evolution optimized it. Treating aging is like treating stupidity. papers.ssrn.com/sol3/papers.cf…
@itsolelehmann The problem with living to 150 is that it would require treating aging, not just treating disease. Treating diseases is easy because there's something wrong that you can fix. But there's nothing wrong in aging. Treating aging is like treating stupidity. papers.ssrn.com/sol3/papers.cf…
@adamgries @EricTopol @VitalistBay @grok I'm not objecting to optimism. I'm objecting to dumbing everything down by declaring each irrelevant finding a breakthrough. And stifling serious research by turning what should be scientific meetings into fundraising parties for get-rich-quick-with-crackpot-antiaging schemes.
@adamgries @EricTopol @VitalistBay @grok And there is no such thing as "resetting aged DNA", because DNA is a digital storage medium that doesn't age. That doesn't mean that cloning isn't useful, it just means that there's no evidence that DNA "ages" or that cloning resets some hypothetical DNA aging.
@adamgries @EricTopol @VitalistBay @grok Your Grok answer illustrates that none of these work in humans, mostly because humans aren't fat enough. Or don't work at all (so far), like senolytics. Laron syndrome patients aren't long-lived. They're just small & suicidal. Cloning, parabiosis and reprogramming are jokes.
@Madam_Mito Childhood cancer survivors will disagree.
@drmichaellevin Chemotherapy can eliminate the mutated clone, and completely cure the disease. Success rates for childhood cancer are ~90%.
@Aging_Scientist @statto @longevityinit Laron dwarfism is the best example.
@realNathanCheng It's a psychosis. If it wouldn't be random, it might deviate from the expected outcome predicted by complete randomness. But it never, ever, behaves in any way different from the outcome predicted by complete randomness. LLM's are programmed to be nice to psychotic people.
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