Kaveh Daneshvar @kavehdaneshvar
Gene & RNA Therapies | Sr. Director of precision editing @Arbortx | Past: @Tome_bio, @FlagshipPioneer, and @Harvard kavehdaneshvar.com Cambridge, MA Joined January 2016-
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Today, Tome acquired Replace Therapeutics Inc., a private #biotechnology company developing a novel PGI method capable of inserting and deleting small #DNA sequences. Learn how this technology complements Tome’s integrase-mediated PGI (I-PGI): bit.ly/4aJbW1y #CRISPR
Thrilled to have been part of the Tome's journey since the early days! 🚀
🚨!!!Preprint Alert!!!🚨 I am super-delighted to share our work co-led with @adrianobolondi describing the discovery and characterization of a novel lncRNA, LNCSOX17, a key regulator of human definitive endoderm. #Meissner Lab @MPI_MolGen. A🧵1/11 biorxiv.org/content/10.110…
New preprint! How do you insert large genes efficiently + programmatically? CRISPR-based methods are programmable, integrases are efficient. Why not combine them? PASTE places short (~45bp) integrase landing sites that serve as beacons for insertion (up to 36kb)! @omarabudayyeh
New preprint! How do you insert large genes efficiently + programmatically? CRISPR-based methods are programmable, integrases are efficient. Why not combine them? PASTE places short (~45bp) integrase landing sites that serve as beacons for insertion (up to 36kb)! @omarabudayyeh
Any suggestions for a high-yield T7 IVT kit that makes 5'-capped, 3'-poylA tailed mRNA with modified nucleotides (e.g. 5mCTP, ψUTP) to avoid cell immune response?
I wonder what type of biases and discriminations this algorithm is going to reinforce. Also, reminds me of this good book on a related topic: goodreads.com/book/show/2818…
I wonder what type of biases and discriminations this algorithm is going to reinforce. Also, reminds me of this good book on a related topic: goodreads.com/book/show/2818…
Excited to share my work w/@CarolynBertozzi describing the discovery of glycoRNA today @CellCellPress. Since our @biorxivpreprint we uncovered an unexpected twist: glycoRNAs are on the surface of cells+some Siglec receptors have RNA-dependent cell binding authors.elsevier.com/a/1d4xcL7PXe%7…
Glad to share our latest paper on a new role of RNA in homologous recombination. Thanks to members of my team and our collaborators! RNA transcripts stimulate homologous recombination by forming DR-loops | Nature nature.com/articles/s4158…
My boomer parents can't identify spam emails. My zoomer kids can't identify junk mail. Gen X FTW!
Our pre-print is alive! We showed that KSHV-encoded polyadenylated nuclear (PAN) lncRNA is m6A modified by using 2nd and 3rd gen seq, identified frequency of m6A by a new method - SLAP, its structural impact, and related methylome biorxiv.org/cgi/content/sh…
ChIRP-MS of #SARSCoV2 + RBP KOs + #Mitochondria KO screen in 7 viruses Many RBPs and Mito factors work as host-protective during RNA virus infections! @CellCellPress w/@juliabelk @Satpathology @CarolynBertozzi @WilenLab Carette @HowardYChang Horvath zpr.io/RzWuK
Come work with us in a highly collaborative biotech venture ecosystem! I am hiring a Ph.D. scientist with expertise in molecular biology & protein biochemistry. We're developing new therapeutic modalities targeting RNA. tinyurl.com/y7fdov8z
Hopping transposable elements generating diversity in transcription factors! Very interesting paper and thread.
Hopping transposable elements generating diversity in transcription factors! Very interesting paper and thread.
Excellent work by @DewaeleShanna in our lab demonstrating the importance of #lncRNA SAMMSON for uveal melanoma cell survival. Preprint out now 👇 biorxiv.org/content/10.110…
Three days to register for my graduate course on RNA Therapeutics. Open to scientists, innovators, and students who want to learn about the progress in RNA-focused drug development. Syllabus: tinyurl.com/y3o3z73a Registration: tinyurl.com/y3zl2798
Does a single nucleotide change in the sequence of approved mRNA vaccines trigger a new clinical trial?
Oded Rechavi @OdedRechavi
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21 Followers 47 FollowingGolnar Rezagholi @GRezagholi
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27 Followers 225 Following ❤️💜💙🧡💚🤍🤎🖤💛 16 - left/right 🏳️🌈🏳️🌈🏳️🌈🏳️🌈 - likes 10somes - hate smal pneis - Joe 2024 - Dubai porta potty - Dm for full nude - 8K Ultra HDAnja Hess @anjuhess
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1K Followers 2K Following Husband & Dad. CEO @mybenthos🇺🇸 Global Biomedical Expertise in 🧬🫀🫁 🩸via @MountSinaiNYC @nyuniversity🇺🇸@BakerResearchAu🇦🇺@HAYA_lncRNA🇨🇭Dad Jokes @Dadsaysjokes
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1K Followers 741 Following Assist. Prof. at Saitama Univ. 😋💕☕️🍫 https://t.co/OHJVWBFqWNNovartis @Novartis
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2K Followers 838 Following building a Home for Scientist Leaders @wilbe_science, board @stemfromdanceRoni Wright @RoniHGwright
704 Followers 2K Following Cancer Researcher working on chromatin and gene regulation. Passionate about gender equality, women and mothers in science.#CRG #UICBarcelona #mothersinsciکتابفروشی د.. @bahmanbooks
5K Followers 1 Following تهران، خ ۱۶ آذر، خ ادوارد براون، پلاک ۷ ۶۶۹۸۱۰۲۴ ارسال به همهجای دنیا سفارش در تلگرام: https://t.co/bQ2xI5ozUH مدیر: بهمن دارالشفایی @bahmandaroshafaHassan Rashidi @hr_RegenMed
549 Followers 1K Following A hardcore & passionate stem cell biologist, interested in painful history of mankind & anti war. Views are mine.Maryam R-Sarmazdeh @sarmazdehlab
800 Followers 1K Following Biomol Eng-Syn bio-Protein Eng and Design-Educator-PI-Graduate Program Director-AIChE WIC 2024 Past ChairSince the seasonal dunking-on-lncRNAs is back, and I do 💕 lncRNAs, a 🧵 on what I think have been the sources of the main problems in the 15 years of the field so far:
A sad day Danny Kahneman, 1934-2024 Most people knew him as a thinker. I knew him as a person.
I spent like all of my 20s obsessed with trying to fix the loneliness problem - hosted tons of events, tried starting a company around it, etc. Main two takeaways 1) The fact that you can stay home and basically self-medicate with content in a way that feels not-quite-bored is…
For the best way to know what people care about, find out what they tend to exaggerate.
PRC2 is reported to bind RNA. Yet, genetic experiments have raised serious questions about their functional relevance. Our paper revisits the biochemical evidence supporting widespread PRC2-RNA interactions and finds that many of these do not occur in vivo.…
@YSPTSPS @ItaiYanai Good stories have a beginning and an end. That take the reader from a to b. It doesn’t matter how it happened. Assuming the data is legit. Stories are not about the narrator but the reader.
@ItaiYanai Respectfully disagree. Average reader doesn’t care what happened when, but they do care the story is rigorous and conveyed as simply and clearly as possible. We are not poets.
How can we make any change in the genome, regardless of size? Today, @Tome_bio announces the acquisition of Replace Therapeutics. Together, PASTE and Replace allow edits both big and small, paving the way for new gene and cell therapies. Excited to bring these to patients!
Thrilled to announce today that Tome has acquired Replace Therapeutics in a move that positions Tome to be the leader in gene integration and editing technologies. Tome now has the ability to make any sized edit, small or large, with completely distinct approaches and…
Just weeks after launching with $213 million, @Tome_bio has acquired a tiny startup called Replace Therapeutics for its gene editing tool that combines Cas9 and a DNA ligase to insert a piece of genetic code. Read more in my exclusive story for @endpts endpts.com/exclusive-tome…
Super thrilled to see @Tome_bio come out of stealth to translate the vision of programmable gene replacement as a new editing modality for genomic medicines and cell therapy. Started this company with @jgooten to solve challenges in the gene therapy and gene editing fields. 🧵👇
Tome Biosciences emerges from stealth with $200M+ Series B funding to advance genetic medicine with the ability to insert large DNA segments wherever they’re programmed to go. Read the press release here: bit.ly/3Njlyq0 #TomeBio #CRISPR #LastChapterofGenomicMedicine
Congrats! @omarabudayyeh @jgooten & @kavehdaneshvar
Update time! This startup, Tome Biosciences, officially launched today with $213 million in Series A and B funding. My story from last year below 👇
Thanks @embojournal for featuring our story on this year's final issue cover🤩! Read now how we evaluated different fatty acid's action on liver organoid models of Steatotic Liver Disease. #MASLD #NADLD
Final 2023 issue! Review: metabolic stress stimuli & hematopoietic stem cells Resource: how EVs & endogenous retroviruses affect dendritic cells SAP30BP1– CDK11 cofactor in splicing control lncRNA in plant shade avoidance Cover: @anjuhess Alan Mullen et al embopress.org/toc/14602075/2…
Our group is moving to The University of Chicago! @UChicago. Excited to expand our work on weather extremes, scientific ML, climate change & turbulence with amazing new colleagues in Geophysical Sciences @GeoSci_UChicago, Computational & Applied Math, AI+Science @DSI_UChicago ...
Regarding the egotistical naming of labs, I'll go one further: I still haven't gotten used to the idea of referring to me and the people I advise or mentor as a 'lab' or 'group'. Or 'team' 🤢. I just don't see it as some sort of collective enterprise or institution.
@iskander malat1 was put in the genome by the Engineers to serve as a nuclear localization marker, they forgot to take it out before releasing to the public
Our latest work on lncRNA TILAM in liver fibrosis is out as a preprint!🥳 Proud to have contributed work in human liver organoids to this exciting project. 💪
Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in hepatic stellate cells biorxiv.org/cgi/content/sh… #bioRxiv
Honored to be invited to the Wolf Prize Awarding Ceremony in Jerusalem. Congratulations to Prof. Chuan He and all the Wolf Prize recipients! Can’t imagine it has been 16 years since I started to look for enzymes that can dynamically regulate RNA modifications at UChicago.
Excited to share that we got 2 NRC New Beginnings grants awarded! First with @Richard_Marcott and Simon Drouin on lncRNAs in EMT and second with @dnachicken And Umar Iqbal on new mRNA-LNP therapy approach.
First time doing #STED microscopy on Nuclear Pore Complexes with NUP96 staining, absolutely stunting 😵💫
Minipreps! They're a fact of life. But if they don't bring you joy, you might want to try new tactics or treat yourself to some fun new toys! Our lab has done 2,625 minipreps so far. Let me share a few tidbits about our approach and our favorite pieces of equipment. 🧵 (1/n)