Chris Rands @c_rands
Bioinformatics, omics, biotech, data science, single cell, oncology @AstraZeneca. Views my own Cambridge, UK Joined January 2014-
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How can cell atlases of human tissues support drug target discovery? In a joint effort between @teichlab @sanofi and Ensocell we tested whether info on cell type specific expression from scRNA-seq is associated w targets of clinically successful drugs medrxiv.org/content/10.110…
NEWS🎉 Today X-Net launched recommendations to @UKRI_News to tackle barriers for #InterdisciplinaryResearch careers 👇we explain how these were developed with researchers, public & industry x-net.bio/report Collaboration among @mrc_hgu @MRC_WIMM @mrcppu @KavliOxford 1/12
Looking forward to speaking at the Festival of Genomics this afternoon about single cell omics data & analytics on behalf of AstraZeneca colleagues #FOG24
Looking forward to speaking at the Festival of Genomics this afternoon about single cell omics data & analytics on behalf of AstraZeneca colleagues #FOG24
I'd be delighted to sponsor a @MEResearchUK and @DaphneJacksonTr #MEcfs Fellowship in @EdinburghUni (closing data 4 March 2024). Please get in touch
Everything you ever wanted to know about the @illumina DRAGEN analysis workflow. Looks like a great prepub. 56 pages! "Comprehensive and accurate genome analysis at scale using DRAGEN accelerated algorithms" biorxiv.org/content/10.110…
In a world first, the UK medicines regulator has approved a therapy that uses CRISPR gene editing as a treatment for diseases go.nature.com/3QDtwuV
Exciting postdoctoral position at @EarlhamInst as part of a BBSRC research program to work in my group in close collaboration with @EI_single_cell on the application of long read sequencing to study single cell heterogeneity earlham.ac.uk/vacancy/postdo…
I am hiring a #Postdoc in #singlecell #omics #cellandgenetherapy @AstraZeneca linkedin.com/posts/kerry-sm…
From Jan 1, 2000, to Oct 31, 2022, FDA granted 573 oncology indication approvals for 206 distinct oncology products. Read more from a review by FDA authors: Trends in the approval of cancer therapies by the FDA in the twenty-first century. nature.com/articles/s4157…
Using a deep generative model, CellBender models and denoises droplet-based single-cell data and improves multiple downstream analyses. @broadinstitute @patrick_ellinor @gatk_dev nature.com/articles/s4159…
RIP Bram Moolenaar en.wikipedia.org/wiki/Bram_Mool…
Illumina CEO Francis deSouza resigns after battle with Icahn reut.rs/3NoZXNi
1. Excited to share our new paper in @Nature! With over 1000 tumors analyzed by scRNA-seq, we provide a systematic pan-cancer characterization of transcriptional intra-tumor heterogeneity (ITH) nature.com/articles/s4158…
Rosalind Franklin was no victim in how the DNA double helix was solved, say @matthewcobb and @nccomfort in their @Nature comment piece. Read the full article here: nature.com/articles/d4158…
Rosalind Franklin was no victim in how the DNA double helix was solved, say @matthewcobb and @nccomfort in their @Nature comment piece. Read the full article here: nature.com/articles/d4158…
The phenomenal teams from Google Research’s Brain and @DeepMind have made many of the seminal research advances that underpin modern AI, from Deep RL to Transformers. Now we’re joining forces as a single unit, Google DeepMind, which I’m thrilled to lead! dpmd.ai/announcing-goo…
Bacteria and cancer. For decades we didn’t believe there were bacteria in tumors. Now that’s all changed. They not only play a significant role but may be used to treat cancer erictopol.substack.com/p/the-fascinat…
Dig into how the biotech industry worries the mifepristone decision will affect R&D w @jmaxlevin on this week's ep of the Readout Loud! Plus: 🔹Moderna's flu update 🔹Dispatches from @DrCaliff_FDA 🔹@adamfeuerstein & @Jasonmmast's $SRPT reporting statnews.com/2023/04/13/pod…
Delighted our big DDD paper is now out describing more than a decade of work finding rare genetic disorders. Huge thanks to everyone involved – scientists, bioinformaticians, clinicians, genetic counsellors, research nurses, funders, patients & families. nejm.org/doi/full/10.10…
Our paper presenting @scverse_team - our multi-institution open-source software project to address storage and analysis needs of single-cell data - is now online in @NatureBiotech! nature.com/articles/s4158… & rdcu.be/c9yNV.
What is an exon??? New paper w/ @ewjwallace and @RNA_julie in @CellGenomics : cell.com/cell-genomics/… Cue 🧵1/8
Mick W@tson ↙️ @BioMickWatson
30K Followers 3K Following Bioinformatics | (meta) genomics | Data science. Some politics. Views are all my own and do not represent past, current or future employer.
Michael Eisen @mbeisen
77K Followers 15K Following I science & try to make science open. Tweets do not represent my employer's views, but are always correct. My conflicts of interest https://t.co/bZ7I9oSJe0.
Manolis Kellis @manoliskellis
25K Followers 4K Following Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL, @BroadInstitute
The Powrie Lab @powrie_lab
4K Followers 94 Following Powrie lab news and mucosal immunology content! Tweets by members of the Powrie lab, not necessarily representative of the lab as a whole
Earlham Institute @EarlhamInst
15K Followers 5K Following Earlham Institute (EI) is a hub of life science research, training, and innovation focused on understanding the natural world through the lens of genomics.
Chris Ponting 💙 @CGATist
4K Followers 144 Following Disease genomics & molecular mechanisms; ME/cfs: https://t.co/cBhrtLCi6M @ Edinburgh University. Views - my own. He/him.
SIB @ISBSIB
8K Followers 875 Following The SIB Swiss Institute of Bioinformatics is an internationally recognized non-profit organization, dedicated to biological and biomedical data science.
Teighshe @Teighshe15687
30 Followers 290 Following In the dull and boring world, there is also occasional luck. No cross, no crown.
Brianne Whitmoyer @WhitmoyBrian
49 Followers 5K Following
Iris Einspahr @IEinspahr97837
77 Followers 5K Following
Catriona Worner @WornerCatr26951
79 Followers 5K Following
Rebbeca Slemp @RebbecaSle68054
84 Followers 5K Following
Aubrey Fennessy @AubreyFenn77104
93 Followers 5K Following
Thomasina Zarnick @thomasi_zarni
19 Followers 2K Following Thomasina . 24 . Crazy Presale of crypto casino👇🐋
McDythea @DytheaMc63631
25 Followers 288 Following In the dull and boring world, there is also occasional luck. No cross, no crown.
Shirl Purter @PurterShir34703
84 Followers 5K Following
Alena Kluever @ale_klueve
46 Followers 5K Following
Theetyt @Theetyt18763
31 Followers 262 Following In the dull and boring world, there is also occasional luck. No cross, no crown.
Megan Kirkpatrick @MeganKirkp60199
82 Followers 5K Following
Arielle Grassano @grass_ariel
64 Followers 5K Following
Carisa Onezne @onez_car
47 Followers 5K Following
Mallie Colehour @ColehoMal
97 Followers 5K Following
Inara Shindledecker @ShindledeckIna
87 Followers 5K Following
Lily-mae Bodnar @BodnarMae12064
83 Followers 5K Following
Misha Vore @MishaVore66646
100 Followers 5K Following
Ronnie Braunschweige @r_braunschwei
59 Followers 5K Following
Lynsey Loudenslager @LynseyLoud16617
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Jeanice Morrisey @JeanicMorris
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Shala Nunes @NunesShala26531
80 Followers 5K Following
Andera Vandergriend @AnderaVand76015
11 Followers 3K Following
Adriana Herkel @a_herke
35 Followers 5K Following
Pearle Florin @pea_flo
33 Followers 4K Following
Alexandrina Vanhamme @AlexandriVanham
44 Followers 5K Following
Henrietta Ballensky @HenrietBallens
47 Followers 5K Following
Harper_Wilson @harper_wil36187
28 Followers 2K Following
Catharine Louvier @CathariLouvie
32 Followers 5K Following
Janis Baraby @BarabJani
42 Followers 5K Following
Rosette Sisomphou @SisomphoRosett
44 Followers 5K Following
Beverly Castronova @BeverlyCas84297
38 Followers 5K Following
Aila Micek @aila_mic
54 Followers 5K Following
Ashlyn Pridmore @ash_pridmo
47 Followers 5K Following
Mick W@tson ↙️ @BioMickWatson
30K Followers 3K Following Bioinformatics | (meta) genomics | Data science. Some politics. Views are all my own and do not represent past, current or future employer.
Michael Eisen @mbeisen
77K Followers 15K Following I science & try to make science open. Tweets do not represent my employer's views, but are always correct. My conflicts of interest https://t.co/bZ7I9oSJe0.
Veera Rajagopal @doctorveera
17K Followers 4K Following MBBS, MD, PhD | GWAS storyteller | Scientist at Regeneron | Human genetics & drug discovery in Neuroscience & Psychiatry | He/Him
Manolis Kellis @manoliskellis
25K Followers 4K Following Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL, @BroadInstitute
Aaron Quinlan @aaronquinlan
17K Followers 1K Following Genome mutation, software for genomic discovery. https://t.co/6GKjALLFfk Co-director, DELPHI Data Science Init.: https://t.co/8uWRcIzWRr
𝕐 (@[email protected].. @nomad421
8K Followers 939 Following Associate Professor of CS @ University of Maryland. Proud Rust advocate! I ♥ science & compiled, statically-typed programming languages! Views are my own.
The Powrie Lab @powrie_lab
4K Followers 94 Following Powrie lab news and mucosal immunology content! Tweets by members of the Powrie lab, not necessarily representative of the lab as a whole
Ewan Birney @ewanbirney
50K Followers 2K Following Deputy Director General of EMBL, Director of EMBL-EBI. I have an insatiable love of biology. @[email protected]. I also work with ONT, Dovetail + GeL.
Adam Phillippy @aphillippy
18K Followers 1K Following Goodbye Twitter 👋 You can now find me on bsky. I'll also try and post research updates more frequently on my lab homepage, linked below ⬇️
Earlham Institute @EarlhamInst
15K Followers 5K Following Earlham Institute (EI) is a hub of life science research, training, and innovation focused on understanding the natural world through the lens of genomics.
Genomics England @GenomicsEngland
30K Followers 2K Following We’re working to enable faster and deeper genomic research, to bring genomic healthcare to all who need it.
James Hadfield @coregenomics
7K Followers 2K Following Developing ctDNA strategy & Epigenomics methods at @astrazeneca. NGS & Dx expert and 'omics fan. Developer of @Enseqlopedia, ex-@CRUK_CI. Views are all mine.
Chris Ponting 💙 @CGATist
4K Followers 144 Following Disease genomics & molecular mechanisms; ME/cfs: https://t.co/cBhrtLCi6M @ Edinburgh University. Views - my own. He/him.
Fabian Theis @fabian_theis
29K Followers 446 Following Computational biologist @HelmholtzMunich, prof @TU_Muenchen & associate PI @sangerinstitute. Dad of 4 and mountain lover. Department news, see @CompHealthMuc
SIB @ISBSIB
8K Followers 875 Following The SIB Swiss Institute of Bioinformatics is an internationally recognized non-profit organization, dedicated to biological and biomedical data science.
Sir John Burn @CaPP3
5K Followers 1K Following Prof of Clinical Genetics Newcastle Uni. CI Capp3 – aspirin cancer prevent'n trial. Chair QuantuMDx Ltd Chair Newcastle Hospitals FT. tweets my own. He/him
The Festival of Genom.. @FoGenomics
5K Followers 4K Following The UK's largest Genomics event is coming to Boston MA on June 12 - 13th. The next Festival of Genomics & Biodata in London will be on 29th & 30th January 2025.
Yaniv Erlich 💔 @erlichya
27K Followers 734 Following CEO/co-founder of @eleventx 🧬 ➡️🚀 Selected Bio: @MyHeritage's CSO (acquired by Francisco Partners). Prof. of CS at @Columbia U PI at @WhiteheadInst of MIT ✡
Python Maps @PythonMaps
73K Followers 561 Following Mapping the world with Python. Geospatial data scientist who likes maps. Contact [email protected]
Retro Biosciences @RetroBio_
4K Followers 2 Following Aspiring to add 10 years to healthy human lifespan, starting with cellular reprogramming, autophagy, & plasma-inspired therapeutics.
Florian Markowetz @markowetzlab
4K Followers 2K Following Computational Oncology at Cambridge | chromosomal instability | genomes and images | selfish about reproducibility | all fox, no hedgehog
Bo Wang @BoWang87
8K Followers 2K Following Assistant Prof. CS,LMP @UofT; CIFAR AI Chair @VectorInst; Chief AI Scientist, @UHN; former PHD, CS @Stanford; opinions my own. #AI #healthcare #combio
Francesca Finotello @Francesca_Fin_
1K Followers 2K Following Assist. Prof. leading the Computational Biomedicine Group at @uniinnsbruck • Data scientist at @DiSC_uibk: precision medicine and cancer immunotherapy • Mother
Alex Colville @AlexJColville
3K Followers 432 Following General Partner at @age1vc extending healthy lifespan. PhD alum of @Thomas_Rando @stanfordmed
GenomeWeb @GenomeWeb
24K Followers 613 Following Highlighting the best of GenomeWeb's coverage of the genomics sector. Maintained by Bernadette Toner, CEO.
Alex Telford @Atelfo
4K Followers 308 Following Tweets about the biotech industry, science, progress, and innovation | building better software for biopharma @Convokebio, ex-LS consultant
kevin @kevinwuhoo
2K Followers 1K Following writing software @10xgenomics • move fast and make things • 🍕&🍫
Tim Cook @tim_cook
14.9M Followers 70 Following Apple CEO Auburn 🏀 🏈 Duke 🏀 National Parks 🏞️ “Life's most persistent and urgent question is, 'What are you doing for others?'” - MLK. he/him
Xi Chen @XiChenUoM
1K Followers 645 Following Single cell genomics. Junior PI @SUSTechSZ. BSc @PKU1898, PhD @OfficialUoM, Postdoc @emblebi and Senior Staff Scientist @sangerinstitute. @teichlab alumnus.
David Jenkins @dfjenkins3
1K Followers 421 Following Director of Computational Biology - Pharma R&D @TempusLabs / Ph.D Bioinformatics, BU 2019 / I match classrooms with scientists for @SkypeScientist
Genomics Cow @GenomicsCow
3K Followers 69 Following Original and probably disagreeable perspectives on genomics. Not sure when I'm joking and when I'm being serious. Opinions my own, not the herd’s.
Katalin Kariko @kkariko
70K Followers 262 Following I am a scientist, working on the therapeutic use of in vitro transcribed mRNA.
Jamie Blundell @jrblundell
1K Followers 755 Following Assoc. Professor University of Cambridge. UKRI Future Leaders Fellow. Evolution, cancer and T-cell receptors. Co-founder and CSO https://t.co/RNEbGwOYN9.
U.S. FDA @US_FDA
563K Followers 145 Following Our posts are FDA Approved! Privacy Policy - https://t.co/LbTJXYRXVP FDA Authentic Accounts - https://t.co/w2LNbzG7M0
FDA Oncology @FDAOncology
38K Followers 376 Following FDA Oncology Center of Excellence expedites medical product development to improve the lives of people with cancer.
Open Targets @OpenTargets
5K Followers 3K Following Public-private partnership using human genetics and genomics data for systematic drug target identification and prioritisation. https://t.co/Slg1a5QUO4
Omer Ali Bayraktar @bayraktar_lab
3K Followers 674 Following Group leader at @sangerinstitute Neural diversity, spatial transcriptomics, glia, GBM https://t.co/AGAGRUasuI…
ASCO @ASCO
147K Followers 2K Following Account of the American Society of Clinical Oncology & its affiliate the Association for Clinical Oncology. Assoc tweets labeled #ASCOAdvocacy. RTs ≠ endorse.
Jeff Bezos @JeffBezos
6.4M Followers 355 Following Amazon. Blue Origin. Washington Post. Bezos Earth Fund. Bezos Academy.
Nathan Vardi @nathanvardi
7K Followers 1K Following I am Managing Editor for Enterprise @MarketWatch. Author of For Blood And Money https://t.co/ZQNtNV4mNb
AutoGPT @Auto_GPT
12K Followers 5 Following Explore the new frontier of autonomous AI, dive into the fastest growing open source project on Github, and journey through the dynamic agent ecosystem!
SpaceX @SpaceX
34.5M Followers 113 Following SpaceX designs, manufactures and launches the world’s most advanced rockets and spacecraft
gokcen @gokcen
1K Followers 1K Following Pronounced (gok-chen). 60% water. Group leader @ Biology Research | AI Development (BRAID) Genentech
Caroline Wright @carolinefwright
976 Followers 525 Following Academic research scientist in human genetics and genomic medicine (https://t.co/0qv9wG8bXn); pianist; hiker & outdoors enthusiast
Simona Cristea @simocristea
7K Followers 495 Following Head of Data Science at Hale Center for Pancreatic Cancer | Group leader @DanaFarber @Harvard | We ❤️ genomics, evolution & LLMs | PhD @eth | 🇷🇴🇸🇪🇨🇭🇺🇸
Lukas Heumos @LukasHeumos
820 Followers 698 Following European PhD student @HelmholtzMunich in the groups of @fabian_theis and @schillerlab. Steering council @scverse_team. Research software engineer @laminlabs.
Y Combinator @ycombinator
1.3M Followers 336 Following We help founders make something people want. Subscribe to our newsletter: https://t.co/sjqjxxBeLc
Coffeezilla @coffeebreak_YT
574K Followers 2K Following Internet Detective Exposing Scams. Follower of Jesus. Support Investigative Journalism: https://t.co/ATpU5zUzUY
Internal Tech Emails @TechEmails
523K Followers 901 Following Internal tech industry emails that surface in public records. 🔍
Mammoth Biosciences @mammothbiosci
6K Followers 2K Following Improving lives by reading and writing the code of life.
Colossal Biosciences�.. @itiscolossal
13K Followers 664 Following The de-extinction company. #itiscolossal
tylershultz @TylerShultz_
6K Followers 37 Following Co-founder and CEO Flux Biosciences. Theranos Whistleblower
AGBT Meeting @agbt
6K Followers 3K Following AGBT is considered the preeminent genome science and technology meeting for top global scientists, researchers and innovators. #AGBTag
Professor Dame Sue Hi.. @CSOSue
11K Followers 8K Following I am the Chief Scientific Officer for England and the Senior Responsible Officer for Genomics in the NHS
Memorial Sloan Ketter.. @MSKCancerCenter
104K Followers 2K Following One of the world’s leading comprehensive cancer centers. To make an appointment: 877-871-9362
Edward Snowden @Snowden
5.8M Followers 1 Following I used to work for the government, but now I work for the public.
Brad Loncar @bradloncar
69K Followers 365 Following #Biotech, Founder of @BiotechTVHQ, KC native, @univmiami hurricane.🧬🙌
Prof. Nikolai Slavov @slavov_n
14K Followers 264 Following Mentor, scientist & engineer. Director of @ParallelSqTech. Having fun in @SlavovLab with single-cell proteomics & ribosomes. Organizer of @SCP_meeting
Peter Wang 🦋 @pwang
48K Followers 2K Following Chief AI & Co-founder @AnacondaInc; invented @pyscript_dev, @PyData @Bokeh @Datashader. Former physicist. A student of the human condition. bsky: @wang.social
"The New Genetics: Man into Superman" Time Magazine, April 19, 1971. 50¢
Out today for those who enjoy genome-wide CRISPR knockout and activation screens for insights into drug resistance in cancer nature.com/articles/s4200…
Our review paper on "Genome assembly in the telomere-to-telomere era" published online in @NatureRevGenet. It amazes me how much assembly has progressed in the past four years – often ~100X improvement in contiguity and base accuracy and with haplotypes and hard regions resolved!
Genome assembly in the telomere-to-telomere era go.nature.com/4aLqIED #Review by Heng Li @lh3lh3 & Richard Durbin @richard_durbin @DanaFarber @HarvardDBMI @Cambridge_Uni
We don't yet have a way to guide therapy decisions with single-cell omics. Taking one step forward to solve this, we developed a transfer learning method for patient stratification & resistance emergence to targeted therapies using sc-omics & validated in 3 trials. 🧵
Inspired by @lpachter and team's exploration of scRNA-seq pipelines, we face similar challenges in scATAC-seq, only magnified! After 5 years of tackling these inconsistencies with my advisor @JunhyongKim , Here is a summary (and some solutions😃) 1/n #Genomics #Bioinformatics
The choice of whether to use Seurat or Scanpy for single-cell RNA-seq analysis typically comes down to a preference of R vs. Python. But do they produce the same results? In biorxiv.org/content/10.110… w/ @Josephmrich et al. we take a close look. The results are 👀 1/🧵
Excited to share Nicheformer! Led by @Alejandro__TL & @AnnaCSchaar, Nicheformer is a foundation model for single-cell & spatial omics. Its innovation is going beyond disassociated analysis to capture & predict local tissue context at single-cell level. biorxiv.org/content/10.110…
The antibody–drug conjugate landscape bit.ly/3vKHoNB This new analysis investigates innovation in the clinical pipeline for antibody–drug conjugates across five design levers: target, payload mechanism of action, antibody, linker and conjugation method
@c_rands @lpachter @vitaliikl @maelouisewoods @satijalab @fabian_theis No and what is really complex about biology is there are MULTIPLE RIGHT answers, different UMAPs and clusters can highlight different true and important aspects of biology. Of course there could be bad, spurious nonsense answers, but also many correct and valuable answers
World's largest genetic study of ME offers hope to sufferers. Chris Ponting on @Channel4News on how #MEcfs is 20 years behind other diseases because society doesn’t take it seriously. @DecodeMEstudy trying to change this w PwME. youtu.be/3bPNjc4dRRs?si…
@lpachter I did not say the entire enterprise failed. I said the HCA / CZI failed in the specific task of an automated processing pipeline that works with a universal set of parameters to processes the data in a way that preserves biological integrity. Because that is a hard problem.
As my lab develops Seurat, I wanted to share some thoughts on the important Seurat and scanpy package selection preprint from @Josephmrich/@lpachter 🧵
Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9
Thrilled to share our latest discovery on a spliceosomal snRNA gene causing neurodevelopmental disorders: medrxiv.org/content/10.110… Thank you to everyone who contributed; it’s been a phenomenal effort to collaborate with clinicians and researchers for what would help many families!
🧵 (1/6) Two years ago, when I only started digging into the current state of aging research, I was much more optimistic about our progress. I read articles like Laura Deming's Longevity FAQ, which lists "95 things that make mice live longer", and thought: "Well, at least we have…
Let’s talk about proteins whose abundance generally does not correlate to the abundance of the transcripts that template them. Give examples. .
The choice of whether to use Seurat or Scanpy for single-cell RNA-seq analysis typically comes down to a preference of R vs. Python. But do they produce the same results? In biorxiv.org/content/10.110… w/ @Josephmrich et al. we take a close look. The results are 👀 1/🧵
What's a good way of organizing scRNA-seq data for training foundation models? Say you run 1k experiments and each measures counts for 1M cells with varying metadata and orthogonal data. Storing these data in one gigantic array isn’t exactly easy. We wondered whether it’s…
The authors highlight that UMAP/tSNE preserve neighborhoods and conclude: "If used properly, 2D (tSNE/UMAP) embeddings will continue to help charting the world of single-cell biology." @hippopedoid @JanLause biorxiv.org/content/10.110…
Here's the post, with plenty of additional context for the questions included atelfo.github.io/2024/04/01/bio…
🤯 The level of sophistication of the XZ attack is very impressive! I tried to make sense of the analysis in a single page (which was quite complicated)! I hope it helps to make sense of the information out there. Please treat the information "as is" while the analysis…
In a pair of @biorxivpreprint preprints just posted w/ @sinabooeshaghi and @agalvezmerchan, we describe algorithms for an open data Commons Cell Atlas and demonstrate how a Human Commons Cell Atlas can be used for discovery. biorxiv.org/content/10.110… biorxiv.org/content/10.110… 1/🧵
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