Adil Daud @ad1600
history, art, literature and clinical researcher immunotherapy esp melanoma cancer.ucsf.edu/people/daud_ad… San Francisco, CA Joined April 2009-
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Adil Daud retweeted
DART (NCI/SWOG S1609): comprehensive final results from dual checkpoint inhibition with CTLA-4 and PD-1 blockade in rare cancers - Final results (full access link below) thanks to all esp the patients involved in the 1st NCI rare tumor IO basket study! sciencedirect.com/science/articl…
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@NEJM Great news for one of the hardest cancers
Adil Daud retweeted
Congratulations @EileenMOReilly @MSKCancerCenter @MSK_DeptOfMed Brian Wolpin Ziv Wainberg and all colleagues on a long awaited and badly needed game changer in #pancreascancer
Adil Daud retweeted
The MRF is honored to host its annual MRF Breakthrough Consortium (MRFBC) meeting at the American Society of Clinical Oncology (ASCO), bringing together 33 centers of excellence in melanoma to collaborate, advance medical research and improve treatment options for #melanoma patients. Today, we recognize Richard Carvajal, MD @Northwell and Ryan Sullivan, MD @MassGeneral, pictured here alongside MRF CEO, Kyleigh LiPira and Board Chair, Doug Brodman, for their leadership as MRFBC Co-Chairs from 2021-2026. Thank you, Drs. Carvajal and Sullivan for your outstanding commitment to advancing melanoma research and providing hope for countless melanoma patients and their families. Stay tuned for more research highlights from #ASCO26
Adil Daud retweeted
Day 2 #PRIMO2026 is underway. Thank you to our co-chair @rachnatshroff for kicking off the day. @DrRaviSalgia opened our sessions w/ lung cancer presentations, setting the stage for a full day of insights. Up next: melanoma & sarcoma discussions & evolving role of AI in oncology
Excited to meet colleagues from Hawaii and discuss clinical trials !!
. @ad1600 Sharing the rationale behind neoadjuvant therapy in melanoma, reshaping how we think about treatment sequencing and outcomes. #PRIMO2026
Adil Daud retweeted
What if immune cells don't need to destroy a cell to learn from it? Max Krummel's talk at #AACRio26 quietly reframed how we think about myeloid cell surveillance. His team observed macrophages picking up tiny pinched-off vesicles from living cells — a trogocytosis-like "nibbling" — without killing them. The sampled material then traveled through a distinct intracellular pathway, bypassing the usual route to lysosomes. The striking finding: this live-sampling pathway drove efficient MHC class I presentation and CD8+ T cell stimulation — arguably better than classical phagocytosis. The implication? Live-cell sampling may be the default mode of immune surveillance, with phagocytosis as the exception. And tumors may hijack this very pathway to drive T cell exhaustion. It's the kind of fundamental biology that quietly reshapes everything downstream. 🔬 🔗 Read ACIR's full #AACRio26 special feature → bit.ly/4sjXuoL #CancerImmunology #Immunotherapy #AACR #MyeloidCells @MaxKrummel
Adil Daud retweeted
Online now: Commensal-myeloid crosstalk in neonatal skin regulates interleukin-1 signaling and cutaneous type 17 inflammation dlvr.it/TQdlRJ
Adil Daud retweeted
I'm excited to share a new study in @natmed , a fascinating study about how the contribution of B cells in cancer immunotherapy and how tracking these cells may inform whether the patients will do better or worse nature.com/articles/s4159…
Adil Daud retweeted
Wellness advice is everywhere—but is medicine missing the mark? This #UCSFMGR features Ezekiel J. Emanuel, MD, PhD, on what wellness really means and the six core behaviors that matter most for long-term health. Moderated by @AllisonRBond ▶️ youtu.be/zUiQ7CZq6UY
Adil Daud retweeted
Immunotherapy changed melanoma care—what’s next? This #UCSFMGR explores how it works and where the science is headed. With Adil Daud, MD @ad1600. Moderated by @AllisonRBond ▶️ youtu.be/XudZm9uHQ1Q
Adil Daud retweeted
Together with Emma Dann, we are thrilled to present a massive new Perturb-seq atlas of 22M primary CD4+ T cells, from 4 donors, across 3 timepoints – the result of a decade-long collaboration between the Marson (@MarsonLab) and Pritchard (@jkpritch) labs. 🧵👇
Adil Daud retweeted
Fascinating study! The effectiveness of Anti-PD-L2 in aged versus young mice raises intriguing questions about immunotherapy and age-related immune differences. What could be driving the IL-17 dependency in aged mice? And how might this inform therapeutic strategies for different age groups in humans? #Immunotherapy #Aging For more insights into such complex biomedical questions, consider exploring sciqst.com. It's a great resource for generating comprehensive biomedical reviews.
Adil Daud retweeted
Pauken, Sharpe et al. show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. hubs.la/Q03RrZ8N0 📘In cancer immunotherapy hubs.la/Q03RrW2T0 #SITC25
Adil Daud retweeted
Excited to share our paper on a dramatic case of cancer lineage plasticity: melanoma to rhabdomyosarcoma transformation during ICB. Always fun working w/ Ryan Sullivan, David Liu, Keith Flaherty, Peter Sorger, among others. @MGHCancerCenter @broadinstitute medrxiv.org/content/10.110…
Very compelling !!
@ad1600 Thanks! I had the sky robots make this chart to emphasize the biggest driver of survival signal:
Super interesting analysis @iskander -would love to have you elaborate some more
A few different people reached out to see if I believe the results of "SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade" (nature.com/articles/s4158…) Answer? Kinda. I think the paper conflates three hard to distinguish effects:
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