Candie Paulsen Lab @LabPaulsen
@CandieDandie's biochemistry research group @YaleMBB consisting of unique individuals united in our use of diverse approaches to study pain signaling. paulsenresearchlab.wordpress.com New Haven, CT Joined May 2020-
Tweets85
-
Followers262
-
Following410
-
Likes879
🧠Pain sensors need to switch on fast—and off just as quickly. In our new tour de force Nature Communications paper, we show that calmodulin plays a key role in shutting down the TRPA1 pain receptor - a finding that could guide new pain therapies. 📰 rdcu.be/eJcMK
We had a great time at BPS 2025– learned a lot and made great connections. Congrats to Paulsen Lab grad student Isabel Romov for winning a Student Research Achievement Award! We celebrated at Disneyland. ‘Til next year!
@CandieDandie @YaleMBB 6. 1. Our work also raises interesting questions about whether endogenous TRPA1 modifications can perturb the TRPA1:calmodulin interaction to influence channel regulation. So many exciting questions to ask!
Delighted to share the next story from the Paulsen lab! In a team effort led by @CandieDandie's first @YaleMBB grad student, Justin Sanders, we've uncovered a critical role for calmodulin in the TRPA1 pain receptor's calcium regulation. Check it out here: biorxiv.org/content/10.110…
@CandieDandie @YaleMBB 5. Together, our work suggests that calmodulin pre-associates with TRPA1 in cells to facilitate proper calcium regulation. Perhaps calmodulin is a TRPA1 auxiliary subunit?
@CandieDandie @YaleMBB 4. Using a combination of biochemical, biophysical, and structural approaches, we characterized the TRPA1 DCTCaMBE:calmodulin interaction and found that it is driven exclusively by the calmodulin C-lobe with tightest binding observed at basal calcium concentration.
@CandieDandie @YaleMBB 3. This effect could be partially rescued by increasing the extracellular calcium concentration, suggesting that calmodulin binding to the DCTCaMBE is part of a multi-step long-range allosteric mechanism to control TRPA1 inactivation.
@CandieDandie @YaleMBB 1. We identified a highly conserved calmodulin binding site in the TRPA1 distal, structurally unresolved, cytoplasmic C-terminus (the DCTCaMBE). Genetic or biochemical ablation of calmodulin binding to this site slowed TRPA1 calcium inactivation 10-to-20 fold.
1. Calcium regulation is the primary TRPA1 regulatory mechanism that keeps its activity in check to sustain acute pain signaling and prevent aberrant signaling. This regulation is biphasic with initial channel potentiation followed by inactivation. Mechanism is unclear.
One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. youtu.be/db1afWzokOU?si…
@JorgGrandl @NeuroCellPress Congratulations on the beautiful work!!!
History of ion channels by one of his authors. Fred Sigworth’s closing seminar at the GRC was simply beautiful
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/sh…
Scientists Discover a New Hormone that Can Build Strong Bones | UC San Francisco Thank you @LauraKurtzman for a great summary of team effort with @dr_ambrosi ucsf.edu/news/2024/07/4…
We are hiring! A postdoctoral position is available immediately!
@zubcevic_lejla @justan_onymous Congratulations!!!
We had the BEST time at the inaugural Gateway Ion Channel Symposium. All three Paulsen Lab @YaleMBB 2nd year grad students gave talks (2 or 10 min) and posters. Trainee-centric & welcoming first meeting of their graduate careers. Can’t wait for the next one!
Congratulations to Drs. Justin Sanders and Avnika Bali!! They are the first two graduate students from the Paulsen Lab to defend their theses and move on to the next stage of their careers. We are so proud of them, and we can’t wait to see what they do next!
Congratulations to @SusanBaserga, elected to the American Academy of Arts and Sciences @americanacad. Dr. Baserga joins a prestigious group of members recognized for their achievements in academia, industry, policy, research, and science. @SmilowCancer @YaleMed @YNHH @YaleMBB
Victoria Jones @Victori08154703
8 Followers 202 Following
𝒢𝓇𝒶𝒸𝑒�... @Grace_Lumina
67 Followers 3K Following Daddy's girl in Connecticut. Parents separated, brother gone, I' m here needing to be fucked. FREE LINK here. ⬇️ @Grace_Serenityy
GoddessAmeliaCarter @Eanoujoo532822
17 Followers 2K Following Work hard play harder Finding joy in the little things
Whuidip @Whuidip24501
32 Followers 2K Following
Eleni_#02 @Mouixa866568
1 Followers 138 Following The stock market is a device for transferring money from the impatient to the patient. - Warren Buffett https://t.co/2oYsh07Nvu
Shuangtao Ma, MD, DO @shuangtao
84 Followers 331 Following Resident @ClevelandClinic Former cardiovascular researcher @MSU_Medicine No medical advice. Views my own.
Sydney Edwards @syd_medwards
17 Followers 183 Following Fan of bacteria and graph theory enthusiast | currently designing proteins 🧪 @UNC_BCBP, previously researching Shigella 🧫 at @harvardmed
Leewam @Leewam0262145
49 Followers 3K Following
Swnewsaw @Swnewsaw4u9Sc
155 Followers 4K Following
Wenjie ZOU @zou_wenjie
11 Followers 368 Following
Andy Wolfe @andrewlwolfe
280 Followers 667 Following Cancer researcher at Hunter College of the City University of New York & Weill Cornell Medicine. Views are my own.
Trista @1L46pkU47xZnLH
74 Followers 7K Following
Sonya Neal @Neal_Lab
4K Followers 3K Following Associate Professor @UCSD| HHMI Freeman Hrabowski Scholar| Research on rhomboid proteins|First Gen & Black in STEM| Proud mom|co-founder of @bummp_ucsd
Theshew @TheshewOntWg8
17 Followers 666 Following
Eroson @Eroson687372
75 Followers 4K Following
Suiliang Xia @YanYang80603102
44 Followers 2K Following
Gabriela K. Popescu @PopStarLab
2K Followers 2K Following AAAS Board Member | Past President, Biophysical Society | Scientist and Professor | ExtraVagant Granny Find me at: https://t.co/mZKsWYUDZC
Yale Cancer Biology I... @CancerYale
606 Followers 199 Following Follow us for news about #YCBI faculty and trainees as well as our partners @YaleCancer and @YaleMed.
Society of General Ph... @sgpweb
1K Followers 639 Following A society with the mission to promote and disseminate knowledge and interest in the subject of general physiology.
Alireza Dolatshahi-Pi... @aldo369369369
14K Followers 5K Following Assoc. Prof at DTU Health (Denmark), CTO & co-founder OuroBionics, CEO & co-founder Cybosense, co-founder #TeamBioEngine.lCyborganicsl&lLivingMaterialsl
Yang Yang & Lab @YangYangPhD
605 Followers 784 Following Lab studies monogenic autism, epilepsy, pain, and dementia in mice/iPSC; fan of sodium channel #SCN2A; precision medicine; @Purdue University; ex-travel hacker
Axel R. Concepcion @AxelRConcepcio1
683 Followers 675 Following Assistant Professor @UChicagoBMB, studying ion channels in immunity. Opinions are my own.
Zoja Selimi @zojaselimi
216 Followers 329 Following MD PhD-Postdoc at nanoEP lab| patch-clamper | my speciality: single-channel recordings 😎
Sri Karthika Shanmuga... @sri__26
51 Followers 183 Following Postdoctoral researcher @ Columbia Medical
Paul Jenkins @jenkins_paul
3K Followers 2K Following Off to a place where the Sky is Blue. @pjenkinslab.bsky.social
Nancy @AFriestad74240
22 Followers 894 Following
The De La Cruz lab (Y... @DeLaCruzLabYale
2 Followers 20 Following Our lab is interested in understanding and quantifying the fundamental biophysical properties that ultimately determine the behavior of biological systems.
Dr. Geo (Michel Geova... @GeoSantiagoM
5K Followers 5K Following Asst. Prof. @UConnMCB @UConn 🔬🧬🏳️🌈 (He/él) Mexican, Indigenous, 1st gen #methane #microbiology #microbiome #astrobiology @ArchaeaBio @ArchaeaPowerHr
Karbstein Lab @KarbsteinL
584 Followers 95 Following We are excited about ribosome assembly, its regulation, quality control, and better understanding how these lead to human disease. *postdocs wanted!
Jack Zhang Lab @zhang_lab
1K Followers 753 Following Jack (Kai) Zhang Lab at Yale University Intracellular Transport, Cell Motility, Mitochondria, Cryo-EM/ET Methodology -- Cellular Structures, Life & Health
João Victor Gomes @jvic_gomes
104 Followers 182 Following PhD Candidate | Yale University. Ciência, Botafogo, café, cerveja e muita azia | 🇧🇷
Yong Xiong Lab @Xiongosome
466 Followers 96 Following We study host-viral interactions so our bodies can fight #coronaviruses and #HIV @Yale. RTs are not endorsements. FYI Yong doesn’t tweet, his students do!
JakeScience @JakeScienc8444
0 Followers 59 Following
ammara @ammara91708910
52 Followers 284 Following Passionate Researcher, Synthetic Biologist, A proud Mom with PhD.
Butterwick Lab @butterwicklab
171 Followers 102 Following Biologists studying how smell and taste receptors decipher the world @YaleMed Latest publication @Nature: https://t.co/haHC8Le4BB
Kabeche Lab @KabecheLab
234 Followers 61 Following The Kabeche Lab at Yale University is dedicated to uncovering the mechanisms that drive genome instability.
Dr. ᐯᗩᒪEᖇIE �... @ValerieJHorsley
5K Followers 4K Following Valerie Horsley, Ph.D.• Scientist & Educator @yale • Mom • activist Mastodon: @[email protected]
Gendron Lab @GendronLab
506 Followers 185 Following
Jacqueline Ehrlich @jacqueline_ehr
143 Followers 164 Following Cornell PhD Candidate in the KawateLab | #membraneprotein #cryoEM & #celegans devotee | midwesterner 🌽 do-er 🏋️♀️be-er🧘♀️auntie 🤱
Sarah Chan (Codd) @sarahkcodd
31 Followers 56 Following PhD candidate in the @KawateLab at @Cornell Studying #membraneproteins using #Celegans
Sonya @sonyahans
2K Followers 5K Following Research Scientist @FlatironInst | biological temperature sensors 🌡️ cryo-EM 🔬computational biophysics 👩🏼💻 https://t.co/5fO6ikXBZo
Quynh-Anh Nguyen @QuynhA_Nguyen
183 Followers 207 Following Asst. Professor, Dept. of Pharmacology and Vanderbilt Brain Institute, Vanderbilt Univ. NINDS K99/R00. Studying brain hyperexcitability https://t.co/zLUMjLljcv
Yujie Li @YujieLi_0727
10 Followers 198 Following
Urcino @urcino123
2 Followers 120 Following
Gabriela K. Popescu @PopStarLab
2K Followers 2K Following AAAS Board Member | Past President, Biophysical Society | Scientist and Professor | ExtraVagant Granny Find me at: https://t.co/mZKsWYUDZC
GWIS Mid-Michigan @GWISmidMI
291 Followers 453 Following The Mid-Michigan Chapter of Graduate Women In Science at Michigan State University! STEM, science communication, outreach, undergraduate mentoring and more!
Axel R. Concepcion @AxelRConcepcio1
683 Followers 675 Following Assistant Professor @UChicagoBMB, studying ion channels in immunity. Opinions are my own.
Stephanie Gantz @GantzStephanie
394 Followers 400 Following Electrophysiologist - Assistant professor at University of Iowa - RYT 200 yoga teacher
Zoja Selimi @zojaselimi
216 Followers 329 Following MD PhD-Postdoc at nanoEP lab| patch-clamper | my speciality: single-channel recordings 😎
Sri Karthika Shanmuga... @sri__26
51 Followers 183 Following Postdoctoral researcher @ Columbia Medical
Yang Yang & Lab @YangYangPhD
605 Followers 784 Following Lab studies monogenic autism, epilepsy, pain, and dementia in mice/iPSC; fan of sodium channel #SCN2A; precision medicine; @Purdue University; ex-travel hacker
Paul Jenkins @jenkins_paul
3K Followers 2K Following Off to a place where the Sky is Blue. @pjenkinslab.bsky.social
Dr. Geo (Michel Geova... @GeoSantiagoM
5K Followers 5K Following Asst. Prof. @UConnMCB @UConn 🔬🧬🏳️🌈 (He/él) Mexican, Indigenous, 1st gen #methane #microbiology #microbiome #astrobiology @ArchaeaBio @ArchaeaPowerHr
Jack Zhang Lab @zhang_lab
1K Followers 753 Following Jack (Kai) Zhang Lab at Yale University Intracellular Transport, Cell Motility, Mitochondria, Cryo-EM/ET Methodology -- Cellular Structures, Life & Health
Hannah Malcolm @dr_hmalcolm
170 Followers 271 Following Assistant Professor at U North Florida, studying bacterial mechanosensitive channels, bacterial patch clamp. All pop culture and reality TV tweets are my own
Membrane Protein PDB @MemProtPDB
2K Followers 10 Following Listing publications containing membrane protein structures. #MembraneProteins #PDB #transporter #ionchannel #GPRC #cryoEM #crystallography #NMR #cryoET
Dr. Sharona Gordon �... @ProfSharona
3K Followers 525 Following I am a membrane-protein physiologist committed to advancing the quality of science and the quality of life of scientists. Posts are my own opinion. she/her/hers
Gendron Lab @GendronLab
506 Followers 185 Following
Amtrak Northeast @AmtrakNECAlerts
105K Followers 8 Following Real-time service delay information affecting three or more trains in the Northeast Region from VA to ME.
Jerelle A Joseph @jerelleaj
3K Followers 813 Following Assistant Professor @EPrinceton | biomolecular condensates + computer simulations | (she/her)
Ismail Ahmed @iaahmed123
5K Followers 2K Following PI @UUNeurobiology We work at the intersection of chembio and neuroscience to study neuropeptide modulation of behavior and physiology. Views are my own.
E @ePerozo
144 Followers 1K Following
Yale BQBS @BqbsYale
94 Followers 85 Following The Yale University Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS) Graduate Track. [email protected]
Anatomic Incorporated @AnatomicTech
147 Followers 259 Following Not Your Average Neuron™ Rapid production of human induced pluripotent stem cell-derived nociceptors for research and therapeutic applications.
Vertex Pharmaceutical... @VertexPharma
70K Followers 83 Following The official channel for Vertex Pharmaceuticals. https://t.co/RRKBue0YQ9
Lindsay🧠 @neuro_melody
3K Followers 1K Following Neuro PhD Candidate in the Corder Lab @PennNGG👩🏾🔬| she/her 🇨🇲 | #BlackinNeuro #scicomm | Co-Editor @PennNeuroKnow
Cambam @Cambam
15K Followers 215 Following KEWLTOWN Resident. | 27 | @Twitch Partner | @YouTube Partner | | PhD Student at @Cambridge_Uni | 📧: [email protected] 🏳️🌈🇬🇧🇳🇱🌍
Shifra Lansky @ShifraLansky
436 Followers 229 Following Assistant Professor at Weizmann Institute of Science. Structure and Dynamics of Membrane Proteins. Cryo-EM, HS-AFM, MD simulations, X-ray Crystallography.
Yarimar Carrasquillo @YarCarLab
2K Followers 2K Following Principal Investigator at the NIH interested in understanding how the brain modulates pain. Proud Puerto Rican. My views and opinions are my own.
Mike O'Donnell @_MikeOD_
515 Followers 473 Following @mike-od.bsky.social We study the behavioral effects of commensal microbes on the worm, C. elegans @MCDB_Yale. Join me! (he/him)
tina kim @tinakim_neuro
3K Followers 447 Following bioengineer & neuroscientist | assistant professor @princeton | freeman hrabowski scholar @hhmi_science | molecular circuits for accessing neuronal ensembles
Andrew Glazer @amglazer
468 Followers 574 Following Assistant Professor at Vanderbilt Univ. Medical Center. Arrhythmia genetics, ion channels, high-throughput methods. https://t.co/SME2KRmfPt.
Dave Grattan @ProlactinGuy
1K Followers 553 Following Neuroendocrinologist, interested in the hormone prolactin and the hormone-induced adaptations of the maternal brain during pregnancy
Bio Balance, Inc. @bio1balance
822 Followers 2K Following The philosophy of Bio Balance is that accurate descriptions of drug-receptor interactions will lead to the development of better drugs. #biotech #pharmacology
Crina Nimigean @CrinaNimigean
1K Followers 696 Following Membrane protein biophysicist and structural biologist. Professor at Weill Cornell Medical College.
Swetha Murthy @MurthySE
320 Followers 156 Following
Berro Lab 🔬📏�... @BerroLab
759 Followers 673 Following Quantitative biology with a particular focus on endocytosis and the actin cytoskeleton @Yale Molecular Biophysics & Biochemistry, and Cell Biology departments
Research Outreach @ResOutreach
5K Followers 1K Following ⚠️This account isn’t being managed anymore. Follow @KargerPublisher for future updates.
ChimeraX (bsky: chime... @UCSFChimeraX
7K Followers 15 Following UCSF ChimeraX - software for visualizing biomolecules
BryanRoth @zenbrainest
18K Followers 591 Following James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
Yansheng Liu @Yanshen73854711
530 Followers 219 Following Associate Professor at Yale Proteomics and Mass Spectrometry
Wyoming Water Bear La... @boothbylab
255 Followers 119 Following Boothby lab - tardigrades - space - disordered proteins - biology in the wild
Henning Stahlberg @LabStahlberg
3K Followers 370 Following Cryo-EM, Parkinson‘s Disease, Membrane Protein Structure and Function, and Method Development
Rajender Motiani @MotianiRaj1
1K Followers 500 Following Calcium signaling aficionado with interests in Cancer Biology & Skin Pigmentation. Science & Sports Enthusiast Associate Prof & DBT/Wellcome Intermediate Fellow
𝘿𝙧. 𝘾𝙧�... @RogersLabUCD
11K Followers 3K Following Principal investigator of a cell and #DevBio research lab at UC Davis School of Vet. Med. Co-Editor In Chief of @Diff_Journal. Tweets are my own. #NeuralCrest
Lauren Jackson @lpjhalfpint1018
404 Followers 423 Following Jackson lab at Vanderbilt University. Focused on discovery science, mentoring, training, and learning.
Anne Carlson @carlson_lab
583 Followers 439 Following For all things related to ion channels and fertilization
Sergey Melnikov @SergeyVMelniko1
345 Followers 247 Following Group Leader @UniofNewcastle pushing our way into the unknown. An avid lover of hibernation and (ironically) coffee.
Harpreet Singh ਹਰ... @HSingh_OSU
658 Followers 436 Following Play the Game: Fascinated by Ion Channels and Transporters. All views are personal and there is no other accounts associated with me.Trends for United States
You might like
