Andrew Glazer @amglazer
Assistant Professor at Vanderbilt Univ. Medical Center. Arrhythmia genetics, ion channels, high-throughput methods. https://t.co/SME2KRmfPt. Nashville, TN Joined June 2010-
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Andrew Glazer retweeted
I am proud to share our paper using two complementary approaches to resolve variants of uncertain significance (VUS) in the gene TSC2. VUS are a barrier to achieving a precise genetic diagnosis for tuberous sclerosis complex and some cancers. 1/14 nature.com/articles/s4146…
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Andrew Glazer retweeted
Common African ancestry-enriched variants of uncertain significance associated with increased cardiomyopathy and arrhythmia risk, particularly in individuals with CV risk factors or HF. ahajrnls.org/4gcmFXC
Andrew Glazer retweeted
Today, we share a breakthrough on the planar unit distance problem, a famous open question first posed by Paul Erdős in 1946. For nearly 80 years, mathematicians believed the best possible solutions looked roughly like square grids. An OpenAI model has now disproved that belief, discovering an entirely new family of constructions that performs better. This marks the first time AI has autonomously solved a prominent open problem central to a field of mathematics.
Andrew Glazer retweeted
June 2024: The latest general-purpose LLMs could not count the r's in strawberry. July 2025: The latest general-purpose LLMs get gold in the International Math Olympiad. May 2026: The latest general-purpose LLM solve one of the "best-known questions in combinatorial geometry"
Andrew Glazer retweeted
Ventricular conduction is a marker for arrhythmic risk in SCN5A-E1784K overlap sodium channel disease academic.oup.com/europace/artic…
Vanderbilt's division of Genetic Medicine has an open faculty position: apply.interfolio.com/177945
A nice editorial about our recent SCN5A automated patch clamp paper. @ChaiAnn_Ng @VandenbergJamie academic.oup.com/eurheartj/adva…
Andrew Glazer retweeted
Biobank data shows SCN5A variant carriers have longer baseline QTc and greater sensitivity to QT-prolonging drugs. Findings support ancestry-informed pharmacogenetic risk stratification ahajrnls.org/3Yryv6e
Excited to share our preprint: Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk! We performed ~50,000 experimental measurements of KCNQ1 variants.
📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]
Andrew Glazer retweeted
Homemade Archimedes' screw test (yes, invented 2,300 years ago).
Andrew Glazer retweeted
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Andrew Glazer retweeted
Automated patch clamp data improve variant classification and penetrance stratification for SCN5A–Brugada syndrome. Read more in #EHJ @escardio @ESC_Journals #Brugadasyndrome academic.oup.com/eurheartj/adva…
This was a collaborative project led by @mjoneill95 and @joanne_gjm and co-supervised by me, @VandenbergJamie, and @ChaiAnn_Ng. Link: academic.oup.com/eurheartj/adva… [4/4]
Variants with severe loss-of-function had ~25% penetrance & 501x increased odds of BrS. Normal-function variants had lower risk. This work stratifies SCN5A variants into low-risk vs high-risk categories, aiding diagnosis & management for patients & families. [3/4]
Congrats to Matthew O'Neill for winning an American Heart Association Early Career award for our work on functional studies of SCN5A variants from patients with Brugada syndrome!
Andrew Glazer retweeted
Genomic variants in the LDL receptor are the big driver of atherosclerosis, but most were previously unclassified for their impact. Today @ScienceMagazine nearly all 17,000 variants (!) were assessed functionally, which markedly improves the diagnosis for familial high cholesterol. Some people have a normal LDL cholesterol level but increased risk of heart attack due to LDLR variants. science.org/doi/10.1126/sc…
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