Kamil Pabis @Aging_Scientist
Singapore based Aging Researcher. @vita_dao, longevity advocacy, progress studies, city planning, open science, AI, democracy & economics of SE asia. biogerontolgy.blogspot.co.at Joined January 2017-
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Sobbering perspective on agentic LLMs. Maybe not as good as people thought. aisnakeoil.com/p/ai-leaderboa…
"The importance of reaction norms in dietary restriction and ageing research" Simons & Dobson 2023 Very interesting work (and unpublished DGRP fly CR data) from the authors, hiding behind an opaque title. Might be interesting to you @kapahi_pankaj
"Do no harm" & "safety first" should be abandoned in medicine due to inadequate consideration of the harms of inaction, which can be substantial & also likely. A switch to decision theory or a similar form of optimization under uncertainty as overt guiding principle is overdue.
don't have a clear opinion on this but we should at least discuss over-regulation as a possible reason for ballooning costs of large construction projects and for Eroom's law.
don't have a clear opinion on this but we should at least discuss over-regulation as a possible reason for ballooning costs of large construction projects and for Eroom's law.
Great to see AI competitions with held out questions kaggle.com/competitions/a…
LLMs are useless if you are a domain expert, they say. Okay, here is Terrence Tao the best mathematician in the world who is including LLM tools in his workflows. "A lot of these technologies are very close to prime time..." youtube.com/watch?v=AayZuu…
We need to relax IRB approval
It really proves how successful AI is now that you can make a living out of claiming that AI is useless, dumb and unsuccessful.
Soon we will discover that mTOR not only regulates everything, it also senses every micro- and macronutrient possible - hence is regulated by everything. LARS, TARS2, SAMTOR, Sestrins, CASTOR1, what other madness will we uncover next?
Matt Kaeberlein @mkaeberlein
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25K Followers 1K Following My posts are strictly personal, not reflective of positions or policies of Insilico Medicine, which disclaims any responsibility for my individual statements.João Pedro de Magalh.. @jpsenescence
15K Followers 2K Following Scientist planning to live forever (so far so good!), professor decoding the genome @unibirmingham, geek, entrepreneur, speaker, writer, keen footballer.Andrew Steele @statto
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8 Followers 151 FollowingAgingdoc⭐David Barz.. @agingdoc1
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1K Followers 1K Following A community to help the production and promotion of longevity films and documentaries. Join: https://t.co/5QUZ0cKaxnPhilmann Neo @ImNotAlpharius
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22 Followers 24 FollowingJennifer Schleit, PhD.. @JennSchleit
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350 Followers 222 Following DeSci Asia: Building bridges, sharing knowledge and fostering growth for DeSci communities in Asia.College DAO @ GG20 �.. @collegedao_hub
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2K Followers 861 Following Provost’s Chair Prof & Director @TheN1Institute / @WeAreWisDM; Head, @bme_nus; National University of Singapore; Assoc Ed, @ACSNano; EdBoard, @npjDigitalMedOra Biomedical, Inc. @OraBiomedical
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75 Followers 181 Following 王鹤龄 | Ph.D. candidate at UiO | Researching mechanisms of Alzheimer's disease and microbiota related questions at @TheFangGroupUiO | MDS, DDS from JLUKristen Fortney @kpfortney
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8K Followers 2K Following Advancing science and technology for long-term, flourishing futures by creating community, promoting beneficial uses, and reducing potential misuse and harm.Jesse Poganik @jpoganik
361 Followers 295 Following Instructor in Medicine @harvardmed, @BrighamWomens, member of @gladyshev_lab, Executive Committee member @agingbiomarkersDr Chiara Herzog @chiara_herzog
793 Followers 1K Following researching epigenetics, ageing, and cancer prevention @uniinnsbruck/@ucl. Neuroscience PhD @EdinburghUni. she/herAlexander Anisimov @anisimov_123
113 Followers 320 Following Researching Alzheimer's disease and aging @TheFangGroupUiO | The new generation running & fitness app https://t.co/CfoTQlmuFf (the website is currently not working)How much lifespan would be added if humanity eliminated common cold? I’d wager that the number would be significant
A lot of people said they were worried about me until they read the full tweet. they are only worried if you are dying in the next 5 years. If its in the next 30 years - somehow its totally different. How do we change the mindset around this?
I turn 40 today and I want to share something I haven’t told anyone - I am dying. I was diagnosed with a terminal disease. I've been given just 14,000 days. But hope remains. My birthday wish? That we find a cure Aging is our enemy and we need to invest more resources in life…
@eperlste imagine curing every rare disease and still being worth less than a video game chip developer
@viemccoy They didn't see anything. They are just way too deep in the twitter sphere. GPT5 is already being shown to enterprise customers. And those people aren't freaking out. The only people freaking out are the twitter influencers who benefit from their own hype.
@Aging_Scientist @HousingSpock If you have prime quality agricultural land, optimal climate and no water scarcity, you might be able to produce enough for one person on a quarter acre of land. This would be a largely plant based diet with very occasional chicken.
@Aging_Scientist Go ahead and give it a try! I was just sharing the result of the few tests I had time to do myself today.
This image from the classic Weindruch and Walford "The Retardation of Aging and Disease by Dietary Restriction" comes from an experiment done in the 1980s. Anyone who wants to understand where the field has - and has not - advanced in the past 50 years should read this book. I…
@MattPachent @jburnmurdoch Groceries seem to be generally more expensive in the U.S. too.. also the one that surprised me is how much Americans pay for Internet and mobile phone packages.
@uk_biobank 3/n BMI below which an upturn in mortality was seen than was seen in the observational analysis /cont onlinelibrary.wiley.com/doi/epdf/10.10…
@uk_biobank 9/n For more on problems in MR see “Noodles, No Nulls and Numb Skulls: Threats to the future of Mendelian Randomization" NLMR abuts all three categories youtube.com/watch?v=jQmlba…
@Aging_Scientist @Joris_Deelen This is a known problem, I posted the original preprint before here: x.com/agingdoc1/stat… and media discussion here: x.com/agingdoc1/stat… Ecological data is intriguing and may inspire hypothesis but dirty, data from centenarian cohort data is far more reliable obs data.
Places claiming to be centenarian hotspots may just have bad data Adopting birth certificates appears to cut the lifespans of the very old economist.com/graphic-detail… @TheEconomist
@Aging_Scientist @agingdoc1 In the genetic studies we perform(ed) the far majority of individuals are from countries were the records are centrally kept, so this reduces the chance they were unreliable. This was something we really payed attention to.
@Aging_Scientist As of that time, Waymo had no accidents in LA because they were under 1 million miles, so the LA data alone is useless for comparison. But anyway (and this is purely robotic driving), Waymo does show a reduction compared to human drivers.
What's the best podcast in the AI space right now? I know Dwarkesh, Latent Space, and ThursdAI are all putting out good content. Anyone else
Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation "Our findings underscore a complex state of age- and tissue-specific metabolic homeostasis and raise questions not only about how much, and for how long, but at what age is NAD+…
Europe could so easily be the center of the world again, but we're choosing overregulation instead. Pic: euro/acc community cover picture.
I'm fascinated with the divide over protein reqs w/ longevity scientists recommending less than muscle-oriented scientists do. I'd love to hear critiques of this new paper associating lower protein in context of healthy diet with lower breast cancer: link.springer.com/article/10.100…
@JohnSpeakman4 @AnnaPanArt Same answer: with the job that you can keep working on once aging isn't robbing you of your physical and mental capacities. Plus even a very modest saving rate and conservative investing adds up when you increase your working life.
Lifespan doubled in the last 100 years. Nobody is complaining that it made their life less meaningful. Why do you think that if doubled lifespan again, it would make life less meaningful. 80 just happens to be an optimal number for meaningful life?