Richard Sprague @sprague
Technology. Personal Science. Microbiome. Quantified Self. #DeSci. China 中国 Japan 日本. Longevity. Linguistics. Heideggerian AI richardsprague.eth personalscience.com mercer island, washington Joined October 2007-
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@max_winderbaum @AITinkerers Grateful for the open source Chinese models that keep the frontier lab subsidy train going
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After all these years I finally cancelled my @WIRED subscription for good. Boring, repetitive content; reviews I don't trust. Such a shame, a shadow of its former self.
i'm back from Biohackers World NYC and, as I like to do after events, I used my conference-booth-report skill (proofbound.com/workshop/skills) to make a readable summary of all the photos I took. personalscience.com/docs/biohacker…
I'm reading way fewer books now. Blame Claude for that. open.substack.com/pub/personalsc…
@GeekTimmy @CoachDanGo Nice! lmk when you're ready to let others try it. I'm using HRVlogger but it's buggy and often disconnects. Meanwhile I download the raw data and use a skill: personalscience.com/p/personal-sci…
@CoachDanGo Yeah, serious self-trackers have known this for years. But occasionally a few non-obvious and actionable results slip through
You’ve been wearing a fitness tracker for years. Isn’t it time to make a thorough long-term analysis with actionable, non-obvious conclusions? open.substack.com/pub/personalsc…
@mike_lustgarten Same, plus a skill for my H10 HRV. Haven’t built more sophisticated skills yet; eg might be nice to hook directly into a pubmed MCP.
I'm using more than $100 worth of Anthropic tokens/day and it's still not enough to keep up with my personal science work. Here are a few tips to improve your Claude experience: open.substack.com/pub/personalsc…
Thanks, but that's a different Richard Sprague! The one you want is Richard P. Sprague, co-inventor of First Byte's SmoothTalker text-to-speech patent (US 4,692,941) — that's the engine behind Zug's voice. Coincidentally, I was doing speech research at SRI around then, but never worked on those games. Let me know if you find out more!
LLMs are fundamentally just “transformers” that convert one series of tokens/text into another. Meanwhile, we humans are very good at remembering stories and social relationships. Here’s a brilliant idea to “translate” the complicated facts about cell biology into memorable stories and characters. This could work for lots of things that are ordinarily hard to remember lesswrong.com/posts/BJ7AqXei…
Cancelled my @evernote account at last. I've been a paying member since 2009, but their $275/yr price change was too much for me. Claude helped me migrate all 43k notes to Obsidian. So long!
@WillManidis @hkanji Years ago, when I carefully measured such things, I calculated that the most reliable predictor of my retention for foreign vocabulary was the number of times I opened the (paper) dictionary to (re)look up the word. There just are no shortcuts.
Yup, I find Zipf characteristics in my own app and phone usage. Claude + ActivityWatch makes analysis like this trivial open.substack.com/pub/personalsc…
I used to read 50-100 books / year, but now I maybe read 5. AI, including “vibe-reading” is just a more productive use of my time. arnoldkling.substack.com/p/why-are-you-… @KlingBlog
@mkaeberlein Please continue your podcast!
I tested the physician-grade @EvidenceOpen AI-driven clinical chatbot against Claude. Yes, it's nice that OpenEvidence uses top journals but I concluded that Claude is better for personal scientists. personalscience.com/p/personal-sci…
I've known for years that I'll feel more rested all day when I wake up with a low resting heart rate (RHR), but how can I reliably get there? I've been feeding a ton of detailed information into Claude the last few weeks and to my surprise it found one important driver I hadn't considered: the amount of protein I ate the day before.
I'm not quite ready to bet on this possibility but IMHO those open models are awfully good
Hard to see how any of the ai providers have any kind of moat. Claude is as per usual down so I just switched to @grok and ran my query through it. The result was more than sufficient and I solved my problem while Dario fails to populate his data centers with sufficient numbers
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