Kamil Slowikowski @slowkow
Computational biologist at @MGH_RI. PhD @HarvardDBMI. I study genomics data to learn what the cells in our body are doing in health and disease. slowkow.com USA Joined December 2009-
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Interesting to look back now at the time when the first indoor CO2 limits were imposed by law. (in UK) In 1904 a ventilation standard of 1200 ppm CO2 was considered “much too lax” by the medical authorities (!) and they pleaded for a maximum of 900 ppm CO2 in working places. 1/3
Interesting to look back now at the time when the first indoor CO2 limits were imposed by law. (in UK) In 1904 a ventilation standard of 1200 ppm CO2 was considered “much too lax” by the medical authorities (!) and they pleaded for a maximum of 900 ppm CO2 in working places. 1/3 https://t.co/dn7uxzm0Fm
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
✨School Leaders & Clean Air Advocates✨ US Sec of Ed, @SecCardona, issued a letter recently (3/22/24) to all school leaders to address the chronic absenteeism crisis. YES!! He addresses the need to improve indoor air quality to improve attendance. www2.ed.gov/policy/gen/gui… 🧵
What a PERFFect day to share our new preprint! With @tsion_abay #BobStickels @MerilTakizawa @ChaligneRonan and @Satpathology, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n
A strong case for mandating indoor air quality in public buildings science.org/doi/10.1126/sc… @ScienceMagazine @lidiamorawska @j_g_allen and an impressive list of 40+ co-authors with expertise
Jeffrey Sachs: "A US-funded laboratory origin of Covid-19 would certainly constitute the most significant case of governmental gross negligence in history. The people of the world deserve transparency and factual answers on vital questions." commondreams.org/opinion/covid-…
The @WHO updated yesterday their laboratory biosafety guidance related to SARS-CoV-2. They downgraded (!) the biosafety level for ‘propagative work’ (virus culture, animal studies,…) from BSL-3 to BSL-2. Previous: iris.who.int/bitstream/hand… Updated: iris.who.int/bitstream/hand…
The @WHO updated yesterday their laboratory biosafety guidance related to SARS-CoV-2. They downgraded (!) the biosafety level for ‘propagative work’ (virus culture, animal studies,…) from BSL-3 to BSL-2. Previous: iris.who.int/bitstream/hand… Updated: iris.who.int/bitstream/hand… https://t.co/VW649QPWNR
Long-term, sustainable solutions to COVID: ➡️Develop nextgen/nasal vaccines that greatly reduce transmission ➡️Normalize masking & make respirators free ➡️Regulate indoor air quality ➡️Develop effective treatments for Long COVID ➡️Make healthcare free & guarantee paid sick leave
Democracy Now! just turned 28 years old. We're independent, ad-free and funded by our audience. Your donation today will get a match, doubling your impact! democracynow.org/donate/sp-2024…
Something I don't want to get lost is that the field is much better now at studying, visualizing, and discussing complex populations than it has ever been, and there are many resources to help do this effectively. A few suggestions below:
I’ve always wanted to visualize my own IMPACT tracks on the UCSC Genome Browser, to get immediate insight into cell type specific activity for SNPs or genes. IMPACT 707 is now fully integrated with the Genome Browser. Big thanks to @soumya_boston for mentorship creating IMPACT!
I’ve always wanted to visualize my own IMPACT tracks on the UCSC Genome Browser, to get immediate insight into cell type specific activity for SNPs or genes. IMPACT 707 is now fully integrated with the Genome Browser. Big thanks to @soumya_boston for mentorship creating IMPACT!
ggplot2 3.5.0 is on it's way to CRAN 🎉🎉🎉 This is a big one and is in large part the work of @TeunvandenBrand. The new features will be spread out over several blog posts, starting with this: tidyverse.org/blog/2024/02/g…
@BernieSanders With 1.2 million U.S. infections per day, that's an eventual 60,000+ new #LongCovid cases piling up. Per day. x.com/michael_hoerge…
@BernieSanders With 1.2 million U.S. infections per day, that's an eventual 60,000+ new #LongCovid cases piling up. Per day. x.com/michael_hoerge…
Million of Americans continue to suffer from long COVID, and too often many have their symptoms dismissed or ignored. We cannot allow this crisis to continue.
Sick School Air is Unfair. Kids returned to classrooms alongside a whole new way to get sick. The solution to US K-12 absenteeism is not to blame families or send kids to school sick; we must #DemandCleanAir Visit iaqadvocates.org/demandcleanair for details.
The CDC wants to stop telling people to isolate for five days when they are sick with COVID. This is a reckless, anti-public health policy that contravenes science, increases disease spread, and puts everyone at greater risk. 🧵
New pediatric paper: ➡️20% of COVID cases in the United States are in children ➡️current pediatric long Covid prevalence estimates are 10% to 20%, ➡️Long Covid is estimated to affect up to 5.8 million children, representing a significant community impact #LongCovid
Something notable from this chart comparing U.S. COVID wastewater levels by year, is that we've never seen levels this high at this time of the year! (indicated by the black line representing current levels, crossing the blue line representing Omicron levels in 2022)
THREAD. I'm going to keep talking about this because it's important. The media calls enhancing brutal repression "strengthening law enforcement efforts." Here, the New York Times uses that euphemism to describe the torture of solitary confinement. But it's worse.
The average German worker took TWENTY sick days last year; a new report finds that this lost productivity sent Germany into a recession. Why are we still pretending zero COVID mitigation is good for the economy? thegauntlet.news/p/germany-ente…
Ming "Tommy" Tang @tangming2005
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8K Followers 939 Following Associate Professor of CS @ University of Maryland. Proud Rust advocate! I ♥ science & compiled, statically-typed programming languages! Views are my own.dana_peer @dana_peer
13K Followers 164 FollowingCecilia Lindgren @ceclindgren
8K Followers 1K Following Director of Oxford Big Data Institute. Proud mom of 3. Co-chair of @icdabio. Wellcome Trust Investigator. Promoting equality in academia. Love 🦈. #🕷🕸💙Eric Fauman @Eric_Fauman
6K Followers 246 Following GWAS whisperer 'Nothing in biology makes sense except in the light of evolution' -Dobzhansky DMs open Executive Director, Integrative Biology @PfizerbioRxiv Bioinfo @biorxiv_bioinfo
15K Followers 0 FollowingDavid R. Liu @davidrliu
64K Followers 59 Following Professor at Harvard, Broad Institute, & HHMI. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1Zuguang Gu | 顾祖�.. @jokergoo_gu
3K Followers 131 Following R/Bioconductor package developer and old postdoc @DKFZ and @NCT_HD. I wrote #ComplexHeatmap, #circlize, and many other R/Bioc packages.Dmitry Kobak @hippopedoid
7K Followers 239 Following Researcher at Tübingen University. Manifold learning, contrastive learning, scRNAseq data. Excess mortality. Born but to die and reas'ning but to err.Science Magazine @ScienceMagazine
4.0M Followers 483 Following The world's leading outlet for cutting-edge research in all areas of science. Follow @NewsfromScience for stories from our news team.Richard McElreath �.. @rlmcelreath
46K Followers 2K Following Anthropologist @MPI_EVA_Leipzig - telling anyone who will listen that, if we are very careful and try very hard, we might not completely mislead ourselvesNational Students for.. @NationalSJP
25K Followers 520 Following Official account of National SJP, an independent, grassroots organization supporting 300+ SJP chapters. Retweets are not endorsements.Robert Mackey @RobertMackey
39K Followers 2K Following Reporter. Investigating human rights abuses, war crimes and violence against protesters @ForensicArchi. + 3,000 bylines @nytimes, @theintercept, @guardianJustine Tunney @JustineTunney
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2K Followers 5K Following Latin American. Gay (his/him). OCD. Sociologist. Postdoctoral Marie S.-Curie Fellow. Researching global social dissent against air transport and mass tourism.Karsten Suhre @ksuhre
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353 Followers 125 Following Solid state physicist (retired). Born at 309 ppm CO2.COVID Safety For Scho.. @CovidSafetyEd
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As we see police in dozens of cities beating philosophy professors, tackling economics scholars, body slamming Fox camera people, and putting chains on 100s of students singing songs and enjoying seder, it's important to see that these are not a few bad apples.
Interesting to look back now at the time when the first indoor CO2 limits were imposed by law. (in UK) In 1904 a ventilation standard of 1200 ppm CO2 was considered “much too lax” by the medical authorities (!) and they pleaded for a maximum of 900 ppm CO2 in working places. 1/3
It has become popular to use CO2 monitors to estimate risk. This is based upon the idea that the CO2 informs about how well a space is ventilated. From our study, the results show that the levels of the CO2 will also inform about how long the virus remains infectious in the air.
One of the primary functions of police is to violently crush progressive social movements. It's one of the reasons expanding the size and power of police is always authoritarian and is never an answer to inequality. *It is a key part of preserving inequality, in all its forms.*
Periodic reminder that using modularity maximization for network data analysis is virtually always a bad idea, in any context, and that superior inferential methods have existed for a long time. skewed.de/tiago/posts/mo…
Happy to share that our work on how small set of motifs and rules explain most human promoters is published in @ScienceMagazine I am very grateful for the chance to be part of a team of amazing scientists: Donghong Cai, Chenlai Shi,@JianXuLab,@zhou_jian science.org/doi/10.1126/sc…
Chimeric Origin of Eukaryotes from Asgard Archaea and Ancestral Giant Viruses biorxiv.org/content/10.110…
Hospital Infection Control Guidance for SARS by @WHO in 2003. In contrast to this pandemic, @WHO advised at the time: 👉Airborne precautions 👉“N95 mask as a minimum” (Retrieved via The Wayback Machine: web.archive.org/web/2003040322…) Why did @WHO “forget” this in 2020?
In early 2020, there was a sudden collective amnesia about airborne transmission of other coronaviruses among @WHO's IPC experts. We must uncover the causes of this mysterious "amnesia" so that it does not recur in the next pandemic.
And what does the fact that it is left to citizens to uncover and share such telling documents say about the current state of public health journalism? A good journalist should have brought this up at the beginning of 2020. Why didn't that happen?
Hospital Infection Control Guidance for SARS by @WHO in 2003. In contrast to this pandemic, @WHO advised at the time: 👉Airborne precautions 👉“N95 mask as a minimum” (Retrieved via The Wayback Machine: web.archive.org/web/2003040322…) Why did @WHO “forget” this in 2020?
Thank you @lpachter for kind words about GLM-PCA last week. I want to highlight some more recent alternative implementations people should also be aware of (full list here: github.com/willtownes/glm… ). Many of them run faster than the glmpca R package and are more memory efficient.
This thread is about alpha-gal syndrome (AGS) - meat allergy induced by tick bites. I’ve been living with AGS for >2 yrs. I hope this info will help those who suffer from this illness without knowing the cause. Please help bring awareness to #AGS (1/n) resident360.nejm.org/clinical-pearl…
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
“Every virus that we know of seems to have a different effect on the body long term.” NIH Director. SSPE is an example of a rare form of progressive brain inflammation caused by a persistent infection with the measles virus years after acute infection.
Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
So, seqspec has been published. This is a good opportunity to remind everybody that your count matrix, R object, h5ad etc are NOT your raw data. Raw data are fastq files which are only useful when you know the content of your reads. Then ... 1/7 academic.oup.com/bioinformatics…
Another study for @Marc_Veld and @ID_Denmark to share with their followers. Here, 42 out 46 patients had nucleocapsid protein (green specks) in their skeletal muscle up to 504 days later. 19 of which were asymptomatic healthy controls.
This is the cover of @Brain1878 today. Over 355.00 people were analyzed. How are we going to treat all these people with dementia? "We found a higher incidence of encephalopathy, dementia, seizure/epilepsy, brain fog, and myelitis within the acute phase from 7 days to 3 months…
Increased frequency and mortality in persons with neurological disorders during COVID-19 academic.oup.com/brain/article-… It is all in the head, no? #covid19 #longcovid
I keep an R package on GitHub with no code, with a DESCRIPTION that Imports the packages I always need. On any new R version, new VM, new laptop, I can `remotes::install("stephenturner/Tverse")` and get them all #rstats github.com/stephenturner/…
This is cool as hell
Can Turing patterns be engineered in synthetic biological populations? Yes: A recent paper by @imperialcollege Mark Isalan shows how to obtain regular and tunable Turing structures in growing colonies using @synbio: biorxiv.org/content/biorxi… @vdlorenzo_CNB