Kevin Esvelt @kesvelt
Sculpting evolution & safeguarding biotechnology, MIT Media Lab. sculptingevolution.org Cambridge, MA Joined February 2014-
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If you wouldn't throw out error bars when analyzing data, best account for experimental noise when training models. FLIGHTED makes this easy, notably changing model performance. Also, scaling doesn't currently seem to hold in bio: data is limiting, not # of parameters.
If you wouldn't throw out error bars when analyzing data, best account for experimental noise when training models. FLIGHTED makes this easy, notably changing model performance. Also, scaling doesn't currently seem to hold in bio: data is limiting, not # of parameters. https://t.co/VzEAdKTeN8
It's long past time for the complete DNA sequences of all constructs used in preprints and publications to be shared in full. (just not for potential pandemic viruses) Also, deposit @Addgene! Kudos to @thuronyi @erika_alden_d @barricklab journals.plos.org/plosbiology/ar…
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@vikramsundar @boqiangtu @lindseyguan @kesvelt Here’s some relevant prior work by @AmmarTareen1 you might want to cite. MAVE-NN is not Bayesian, but the overall approach has important similarities. genomebiology.biomedcentral.com/articles/10.11…
Clearly @kesvelt and the mRNA vaccine people. Who else?
@balajis Network state establishes the very power of AI to its people. Execution seems challenging but there has to be a breakeven to handle these kind of jolt. Sam, the face of OpenAI was not spared.
@kesvelt I absolutely support all that, and would rather we had started moonshot level investments into that after MERS already. The fact that not even COVID was enough of an impetus suggests nation states are less trustworthy than I imagined. Consider that accelerating AI adoption…
Anonymous or not, to me the bigger issue with NIH grant review is that it tends to reward incrementalism. The danger as researchers is that after a while, you may not just write grants that way, but actually start to think that way.
yeah thanks for saying it @geochurch and Juerg 🙌🙌 At least in synthetic biology and in our understanding of biology generally the rate of progress is insane since I started grad school 20 years ago. at @Ginkgo we are always 👀👀that we don't miss the next big shift.
George Church: Let's not "hallucinate a depressing decline in the face of remarkable progress" statnews.com/2023/02/01/dis…
@gregkoblentz P3CO reform can improve oversight within the US and that's an important step. But the problem of journals incentivizing GOFROC should be addressed, esp in light of BSL4s coming up in developing countries. @T_Inglesby @StevenSalzberg1 @mlipsitch @DavidRelman @kesvelt @jbloom_lab
“12 Monkeys” is a gem of a movie from the 1990’s Was re-watching it and was struck by how this scene matches up with @kesvelt’s article in @BulletinAtomic from November describing intentional biothreats Seems more realistic now than in 1995. Chilling #biosecurity #onehealth
If a terrorist released a virus equivalent to #Covid, which has taken 20 million lives worldwide, that person could kill more people than if they detonated a nuclear warhead in a dense city. How can we prevent this? @kesvelt has some ideas. bit.ly/3hLLeyw
@emre_mayo @kesvelt @R_H_Ebright Isn't that the point though? If they aren't insurable, they shouldn't exist.
This threat is what convinced even the most recalcitrant early genetic engineers at Asilomar that they needed to take biosecurity very seriously.
@jbloom_lab: "I would not be allowed to drive if my car accident could kill millions of people and cost trillions of dollars in economic losses." We need catastrophe liability (+required insurance) for acts that could kill >1m Americans, even indirectly. nytimes.com/2022/10/30/opi…
A cool story by @jdkstern13 about the quest to engineer a more perfect PPE. Featuring a surprising (to me) appearance by @kesvelt of CRISPR gene drive fame. theatlantic.com/science/archiv…
21/n ePACE overcomes many of the design, operation and infrastructural challenges of traditional PACE, and adds to a growing list of exciting automated directed evolution systems! (e.g. see the nice work from @kesvelt & co: nature.com/articles/s4159…)
As an example of longtermism in practice, I focus on the work of @kesvelt, who studies how to monitor wastewater for new pathogens and advance far-UVC lighting which could eradicate many airborne diseases.
@DukeEngineering @kesvelt @jaybradner At every level, my advisors set an example of what I hope to embody as a mentor-- kindness, fearlessness, and fierce support for their trainees, colleagues, and for science. To the future students and postdocs out there, I can't wait for the chance to work with you. 3/n…
@DukeEngineering My postdoc has been an absolute joy and I wouldn't be here without the support of my amazing postdoc, PhD, and undergrad mentors (@kesvelt, Jim Collins, Jerry Crabtree, @jaybradner). You have all supported, taught, and inspired me along the way 2/n…
I am thrilled to announce that I'll be joining the faculty of @DukeEngineering as an Assistant Professor of Biomedical Engineering in 2023! The Chory lab will be developing new therapies & tools to study gene regulation using robotic directed evolution. 1/n…
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