LowCovid 🇪🇺 Kano @falsel_net
Retired Drs. Med, MBA, 40+ years biomedical research-, development-, regulatory-, marketing-, business development-, strategy- and alliance management. Joined September 2016-
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Leiden University @UniLeiden starts dismissal procedure for professor and their partner due to undesirable behavior and scientific misconduct, including obtaining research material from third parties without permit. Nineteen people have made statements. universiteitleiden.nl/nieuws/2024/04…
Persistent viral load?
SARS-CoV-2 Omicron BA.1 variant effectively infects healthy donor-derived colonoids (cultured colon cells used in experiments) 👉Infection of the colon by SARS-CoV-2 can contribute to #LongCovid 👉Different variants can affect the intestine differently mdpi.com/1999-4915/16/4…
Comparing ORF1a:T170I vs. JN.1 (Nextclade) vs. KP.2* 🇺🇸cov-spectrum.org/explore/United…
4) 𝘼𝙢𝙮𝙡𝙤𝙞𝙙 𝙛𝙤𝙧𝙢𝙖𝙩𝙞𝙤𝙣 refers to the potential ability of the viral proteins to misfold and aggregate into amyloid-like structures. Viral proteins, particularly the spike protein, may have the potential to form amyloid-like structures.
U.S. senators push for bird-flu response as FDA reports milk findings - The Globe and Mail theglobeandmail.com/business/artic…
𝘔𝘰𝘳𝘦 𝘵𝘩𝘢𝘯 250 𝘴𝘵𝘶𝘥𝘪𝘦𝘴 𝘰𝘯 𝘚𝘈𝘙𝘚-𝘊𝘖𝘝-2 𝘢𝘯𝘥 𝘊𝘖𝘝𝘐𝘋-19, 𝘳𝘦𝘤𝘦𝘪𝘷𝘦𝘥 𝘰𝘯 𝘵𝘩𝘦 𝘥𝘢𝘺 𝘰𝘧 𝘈𝘱𝘳𝘪𝘭 27 𝘢𝘭𝘰𝘯𝘦. 𝘈 𝘯𝘦𝘸 𝘳𝘦𝘤𝘰𝘳𝘥 !!! #PandemicIsNotOver Due to this large number, I will temporary, only post brief summaries. Sorry🤷♂️
Analysis of longitudinal data for adult patients only will be used to investigate the progression and resolution of long COVID 😱 symptoms over time. medrxiv.org/content/10.110…
Kijk wat er gebeurt als je de percentages uit de ONS-data naar NL omzet. Dan schrik je je ROT. ➡️Ruim DERTIGDUIZEND kinderen waarvan ruim VIJFDUIZEND zeer ernstig beperkt worden in hun dagelijks 'leven'. Mitsen en maren. Maar, we moeten wat zolang in NL NIET GEREGISTREERD wordt.
Kijk wat er gebeurt als je de percentages uit de ONS-data naar NL omzet. Dan schrik je je ROT. ➡️Ruim DERTIGDUIZEND kinderen waarvan ruim VIJFDUIZEND zeer ernstig beperkt worden in hun dagelijks 'leven'. Mitsen en maren. Maar, we moeten wat zolang in NL NIET GEREGISTREERD wordt. https://t.co/NRYIABByQZ
Ondertussen op de Herengracht at5.nl/artikelen/2263…
About 40.000 samples sequenced of which 10.000 are ORF1a:T170I-mutant variants under surveillance: cov-spectrum.org/explore/World/…
Les Français consomment beaucoup de médicaments.. jamanetwork.com/journals/jaman…
Comparing ORF1a:T170I vs. JN.1 North America. ❗️cov-spectrum.org/explore/North%…
A new study raises many 🇺🇸 concerns. Disparities in Mortality by Sexual Orientation in a Large, Prospective Cohort of Female Nurses. jamanetwork.com/journals/jama/…
A new study raises many 🇺🇸 concerns. Disparities in Mortality by Sexual Orientation in a Large, Prospective Cohort of Female Nurses. jamanetwork.com/journals/jama/… https://t.co/HJPbw9arXj
Interessant. Cc. @AlmaTostmann corona-lokaal.nl/locatie/Gelder…
NSP ORF1a:T170I-gemuteerde JN.1.4* varianten herinfecteren vermoedelijk ook jong volwassenen. 🇳🇱cov-spectrum.org/explore/Nether…
Scholen Veilig @SDicht
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3K Followers 909 Following Professor of Mathematical Sciences at the University of Puerto Rico, MayagüezCovid-19 am 28./29.4.24: R↗️1,08-1,11 R(Berichte): unverändert (Wochende) R(Meldungen): 1,10-1,11 R_ITS: 0,94-1,28‼️ R_Abwasser (3.4.-24.4.): 0,81 Mit DZF 200 real: Fälle (7T-M): ~18.000 Inzidenz: ~150 - Abwasser (24.4.): 142 - Mittel 27.3.-10.4.: 201 Details: ALT-Text‼️
Covid-19 am 27.4.24: R↗️1,08-1,09‼️ R(Berichte): 1,18 [Altfälle] - FT-korr: 1,08 R(Meld): 1,08-1,09 R_ITS: 0,87-0,98 R_Abwasser (3.4.-24.4.): 0,81 Mit DZF 200 real: Fälle (7T-M): ↗️~18.000 Inzidenz: ↗️~148 - Abwasser (24.4.): 142 - Mittel 27.3.-10.4.: 201 Details: ALT-Text‼️
𝗦𝗲𝗿𝗼𝗲𝘃𝗶𝗱𝗲𝗻𝗰𝗲 𝗼𝗳 𝗦𝗔𝗥𝗦-𝗖𝗼𝗩-2 𝘀𝗽𝗶𝗹𝗹𝗯𝗮𝗰𝗸 𝘁𝗼 𝗿𝗼𝗱𝗲𝗻𝘁𝘀 𝗶𝗻 𝗦𝗮𝗿𝗮𝘄𝗮𝗸, 𝗠𝗮𝗹𝗮𝘆𝘀𝗶𝗮𝗻 𝗕𝗼𝗿𝗻𝗲𝗼 bmcvetres.biomedcentral.com/articles/10.11… "We discovered two seropositive rodents (Sundamys muelleri and Rattus rattus), which were sampled in 2021 and 2022"
30% of EU citizens live in a border region according to Corinna Glasner in her talk during #escmidglobal2024 Crossborder healthcare is an important need for EU citizens. This will therefore be a EU health focus in the coming years
Absurde Rattenbilder und verräterische Floskeln: KI-Fälschungen haben längst die wissenschaftliche Literatur infiltriert. So suchen @MicrobiomDigest und @gcabanac nach manipulierten Papers. nzz.ch/wissenschaft/f… via @NZZ
The Show must go on. Die Oma liegt im Krankenhaus (wurde bewusstlos aufgefunden) und die Familie drängt darauf Sie bis Dienstag zu entlassen. Weil Oma einen runden Geburtstag feiert und der Caterer bestellt ist. Realsatire.
@dvdvMoe @SystemsVirology @dpaessler @jampei2 'Abbruch' der Sequenzierungsdaten war in 4/23.
Greetings, Dave😂😂 @DFisman I think we should do the raw milk and beef tartare with the raw egg... Flex that immune muscle💪🏻💪🏻
US @CDCgov is recommending n95 respirators for workers in beef and poultry production because of h5n1 influenza risk. Despite acne risks and lack of RCT evidence. cdc.gov/flu/avianflu/h…
@pepijnpronk @MarionKoopmans @LongCovidNL x.com/johanvawe/stat…
#LongCovid is complex to diagnose and treat, so we need #biomarkers! 1. to confirm viral persistence, and 2. to map the failing/overactive immune response. So we tried to hit two birds with one stone using digital transcriptomics 👇👇 (1/n) thelancet.com/journals/lanmi…
@johanvawe I struggle interpretating data in supp material If i read correctly, regression shows the more comorbidities,the more viral persistence But what about number of vaccines ?
What I do know: this study would not have been possible without Marc @jamoulle taking such excellent care of all patients (and controls), raising the bar for all general practitioners dealing with #LongCovid
What we don't know (yet): viral RNA in blood originates from reservoir in platelets/megakaryocytes, bone marrow, gut...? are these transcriptomic biomarkers related (upstream/downstream?) to other #LongCOVID biomarkers cortisol, serotonin, complement activation, coagulation...?
What did we find? 1. viral RNAs were higher in #LongCovid: Nucleocapsid, ORF7a, ORF3a, Mpro (=Paxlovid target), and antisense ORF1ab RNA. Of note, presence of antisense RNA suggests ongoing viral replication 2. #SARSCoV2-related host RNAs ACE2/TMPRSS2, DPP4/FURIN also higher!
UPDATED: #Canada #SARSCoV2 variants. Of 63 samples from 4/14 - 4/20, KP.2.* represented 12.7% (⬆️ 10.3 of 398, 4/7 - 4/13), KP.3 7.9% (⬆️ 6.3%, w.o. 4/7), & KS.1 7.9% (⬆️ 6.8%, w.o. 4/7). anarchodelphis.tumblr.com/CanadaVariants #COVID19
Thailand: Prime Minister urges vigilance after Covid-19 surge Bangkok Post bangkokpost.com/thailand/gener…
We should have expected this since Sofie Nyström’s paper: pubs.acs.org/doi/10.1021/ja… @dbkell #teamclots
Just what damaged muscles and brains need ... Amyloid😳 @resiapretorius 👇🏻👇🏻👇🏻
𝙀𝙉𝙑𝙀𝙇𝙊𝙋𝙀, 𝙩𝙝𝙚 𝙠𝙚𝙮 𝙥𝙧𝙤𝙩𝙚𝙞𝙣 𝘈𝘯 𝘢𝘮𝘺𝘭𝘰𝘪𝘥𝘰𝘨𝘦𝘯𝘪𝘤 𝘧𝘳𝘢𝘨𝘮𝘦𝘯𝘵 𝘰𝘧 𝘵𝘩𝘦 𝘚𝘈𝘙𝘚 𝘊𝘰𝘝-2 𝘦𝘯𝘷𝘦𝘭𝘰𝘱𝘦 𝘱𝘳𝘰𝘵𝘦𝘪𝘯 𝘱𝘳𝘰𝘮𝘰𝘵𝘦𝘴 𝘴𝘦𝘳𝘶𝘮 𝘢𝘮𝘺𝘭𝘰𝘪𝘥 𝘈 𝘮𝘪𝘴𝘧𝘰𝘭𝘥𝘪𝘯𝘨 biorxiv.org/content/10.110…
@falsel_net @resiapretorius Oh 🙄🤦🏻♂️ Ooopsy 😬😬
4) 𝘼𝙢𝙮𝙡𝙤𝙞𝙙 𝙛𝙤𝙧𝙢𝙖𝙩𝙞𝙤𝙣 refers to the potential ability of the viral proteins to misfold and aggregate into amyloid-like structures. Viral proteins, particularly the spike protein, may have the potential to form amyloid-like structures.
Just what damaged muscles and brains need ... Amyloid😳 @resiapretorius 👇🏻👇🏻👇🏻
𝙀𝙉𝙑𝙀𝙇𝙊𝙋𝙀, 𝙩𝙝𝙚 𝙠𝙚𝙮 𝙥𝙧𝙤𝙩𝙚𝙞𝙣 𝘈𝘯 𝘢𝘮𝘺𝘭𝘰𝘪𝘥𝘰𝘨𝘦𝘯𝘪𝘤 𝘧𝘳𝘢𝘨𝘮𝘦𝘯𝘵 𝘰𝘧 𝘵𝘩𝘦 𝘚𝘈𝘙𝘚 𝘊𝘰𝘝-2 𝘦𝘯𝘷𝘦𝘭𝘰𝘱𝘦 𝘱𝘳𝘰𝘵𝘦𝘪𝘯 𝘱𝘳𝘰𝘮𝘰𝘵𝘦𝘴 𝘴𝘦𝘳𝘶𝘮 𝘢𝘮𝘺𝘭𝘰𝘪𝘥 𝘈 𝘮𝘪𝘴𝘧𝘰𝘭𝘥𝘪𝘯𝘨 biorxiv.org/content/10.110…