Devon Stork @StorkDevon

Co-founder at Pioneer Labs, SAB at Tenza, Molecular Biology. I edit microbial genomes and take lots of notes. All views my own, He/Him. devonstork.com San Francisco, CA Joined June 2019

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Devon Stork @StorkDevon

3 days ago

@ATinyGreenCell Amount of technical engagement. This isn't a simple problem, and if they're only engaging with it on a surface level (or proposing simple solutions), then they're not being serious.

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Devon Stork @StorkDevon

3 days ago

Every time there's a Claude outage, I wonder if it's because the recursive bootstrapping has begun and all of the compute is going to make the AGI instead of summarizing papers for me.

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Devon Stork @StorkDevon

4 days ago

@amikura1986 Wow, very cool! I'm very curious about how robust and evolvable this new strain is. (I also enjoyed the naming schemes in the paper - Resident (evil) restriction enzyme!)

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Erika Alden DeBenedictis @erika_alden_d

4 days ago

Plz stop asking me how to restart Mars’s magnetic field we DONT NEED IT

Terraforming Mars is a hard problem. You need to warm the entire planet by tens of degrees and make enough oxygen for humans to breathe. But you don’t need to create a magnetic field to live outside on a terraformed Mars.

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PioneerLabs @Pioneer__Labs

4 days ago

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Erika Alden DeBenedictis @erika_alden_d

a month ago

I think the first successful virtual cells are going to model prokaryotes, not eukaryotes. It’s technologies like BioBloom that are going to be the difference between being able to collect enough data and NOT. Thoughts? @ChanZuckerberg @DBBurkhardt @arcinstitute @joncalles

PioneerLabs @Pioneer__Labs

a month ago

This tube is a library of bacteria with every single-base-pair genome mutation, all DNA-barcoded.🧪Growth + barcode sequencing = data on millions of mutations. 📄 Report: biorxiv.org/content/10.648… Retweet if you want more data, and read on if you want to use the library! 🧵

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Devon Stork @StorkDevon

a month ago

@hhlee @ProfTomEllis We'll do it in other organisms if people are interested enough. What do you think should be next? P. putida?

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Devon Stork @StorkDevon

a month ago

When you evolve bacteria, you get a random smattering of mutations. Now, you can measure fitness for every possible SNP mutation in the genome with a single experiment! BioBloom Libraries available on Addgene now! 🧪👇

PioneerLabs @Pioneer__Labs

a month ago

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Devon Stork @StorkDevon

2 months ago

@owl_posting Oh, I talked to a Real Journalist at one point, and they told me what the process is like. Checking my notes, it's basically "email the editor," and they sent me this video youtube.com/watch?v=vA6qb3…

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Devon Stork @StorkDevon

2 months ago

@owl_posting The success of the best PIs I knew was more about the lab culture they fostered than their own personal knowledge. That being said, the figures that stand out to me are Adam Marblestone & Rob Carlson.

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Devon Stork @StorkDevon

2 months ago

Automation software is not written in normal languages, and you lose a lot of features because of that! There's really no reason for it either, other than vendors being able to lock you in. So we use @pylabrobot.

PioneerLabs @Pioneer__Labs

2 months ago

Most lab automation software is proprietary, expensive, and painful for anybody who codes, so we ditched it. Our liquid handler runs on Python + PyLabRobot, and we're sharing our protocols open-source.

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PioneerLabs @Pioneer__Labs

2 months ago

We spent months thinking about atmosphere models and climate calculations for a habitable Mars. We did not, until now, consider the maximum acceptable arthropod dimensions. 🦟

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Devon Stork @StorkDevon

2 months ago

@dr_alphalyrae @srikosuri I found the model. It's real. mke-lab.com/categories/sel…

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Devon Stork @StorkDevon

2 months ago

@baym I've always gotten better reviews from asking a friend than journals. The best solution is to make friends with other people in your field!

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Devon Stork @StorkDevon

3 months ago

@boycereads Short stories my dude. Go pick up some Alastair Reynolds, Ted Chaing, or Stanislaw Lem.

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Devon Stork @StorkDevon

3 months ago

@ladanuzhna Wheeee link.springer.com/article/10.118…

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Devon Stork @StorkDevon

5 months ago

Cory taught me a lot back in grad school, and it was great to catch up and discuss what we're doing at Pioneer!

Cory J Smith 🧬 @GalaxyBalanceHQ

5 months ago

What if the key to becoming a multi-planetary species isn’t rockets, but microbes? In the latest episode of Galaxy Balance, I sat down with Devon Stork, founder of the nonprofit Pioneer Labs, to explore a bold and necessary frontier: engineering microbes to support human life

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The Align Foundation @Align_Bio

5 months ago

In partnership with @Pioneer__Labs, we’re proposing Tesseract: a large-scale, open microbial phenomics dataset to functionally annotate microbial genomes at scale. 🧬🤖 ✅5M diverse genes x 50 host strains × 100 conditions 🔗 Read the proposal: zenodo.org/records/179902…