Manish Butte @ManishButte
Immunologist, E. Richard Stiehm Chair; Professor @UCLA; Division Chief @UCLAMCH; T cell aficionado; (he/him) [email protected] tcell.mimg.ucla.edu Los Angeles, CA Joined November 2011-
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Did u know your child’s doctor is paid 25% less than adult docs with the same yrs of training and debt? The way we fund care in this country is backwards, leading to a dwindling pool of med grads choosing pediatrics @bvincibmc and I propose a fix here: statnews.com/2024/04/02/too…
Wonderful paper, Dusan. Two q: (1) what's the story with the unaffected parent (P6)? (2) Since PMID 31354696, I've used high total STAT1 (not phospho) as a "cumulative" measure of elevated STAT1 activity. Is total STAT1 high in these patients?
Wonderful paper, Dusan. Two q: (1) what's the story with the unaffected parent (P6)? (2) Since PMID 31354696, I've used high total STAT1 (not phospho) as a "cumulative" measure of elevated STAT1 activity. Is total STAT1 high in these patients?
Congrats to the team! This could be a general approach to enhance the Long-term memory of T cell responses pubs.acs.org/doi/10.1021/ac…
Type-1 interferonopathies are treated with Jak inhibitors, but their non-selectivity hits multiple pathways & yields serious side effects. We treated a child with DNase2 deficiency with anifrolumab, which only blocks IFNAR: a new tx for #autoinflammation. authors.elsevier.com/a/1ihVW7tEbbQs…
#RareDiseaseDay alert. TODAY! Please rally your Congressfolk to support H.R.5539 (ORPHAN Cures Act) that protects development of #RareDisease therapies by fixing two sentences in the wording of the Inflation Reduction Act. congress.gov/bill/118th-con… A minor fix for a major win.
Tomorrow is #RareDiseaseDay. #UCLA Immunology and the California Center for Rare Disease will celebrate by screening the Jeffrey Modell movie "Do Something" in memory of the recent passing of Vicki Modell. 💔 You can learn about the movie here dosomethingdoc.com
UCLA Receives $4.6 Million Grant from The Warren Alpert Foundation to Launch Computational Biology/AI Training Program compmed.ucla.edu/news/184
#Coccidioidomycosis ranges from asymptomatic, to Valley fever, to life-threatening dissemination in a tiny few. We don't yet understand why the #immune system fails in these cases. We developed a categorization to consistently capture clinical outcomes: academic.oup.com/ofid/article/1…
Over a dozen groups worldwide have begun to explore the implications of Artificial Intelligence in #primaryimmunodeficiency. We held a conference last summer to launch this exploration, and wrote a review summarizing the meeting and the state of the field: jacionline.org/article/S0091-…
🎉Congrats to my lab's newly minted PhD Matthew Miller 🎓. His project endows cancer-fighting T cells with the metabolic ability to use a source of glucose that tumor cells cannot use. 🤯 #immunometabolism
Such sad news. I first met Vicki as a fellow on a harbor boat as a fellow. She has been a ceaseless advocate for our patients but also a cheerleader and inspiration for me. I will miss her kindness and generosity. Fair winds and following seas, Vicki.
Such sad news. I first met Vicki as a fellow on a harbor boat as a fellow. She has been a ceaseless advocate for our patients but also a cheerleader and inspiration for me. I will miss her kindness and generosity. Fair winds and following seas, Vicki.
Beautiful study (congrats!) from @TurveyLab of over 1000 kids with allergies linked to changes in their gut microbiome during infancy. Short chain fatty acids (butyrate) are protective, surprise surprise. Q: does breastfeeding mitigate impacts of early antibiotic exposure?
Beautiful study (congrats!) from @TurveyLab of over 1000 kids with allergies linked to changes in their gut microbiome during infancy. Short chain fatty acids (butyrate) are protective, surprise surprise. Q: does breastfeeding mitigate impacts of early antibiotic exposure?
Please congratulate my star @uclacaltechmstp student Eta Atolia who successfully defended her PhD thesis today. 🎉She's a star T-cell immunologist and a physician-scientist in the making. Eta developed a new way to make vaccines! Thanks to @gatesfoundation for $$ support.
Immunology fellows- Summer School time is here. Applications due soon. clinimmsoc.org/CIS/Meetings/2…
Congrats Ken for a great use of single cell seq to explain the coordinated movement of cells in wound healing. Does this help explain why some people make huge scars and some don't?
Congrats Ken for a great use of single cell seq to explain the coordinated movement of cells in wound healing. Does this help explain why some people make huge scars and some don't?
I'm excited to present about respiratory viruses in #primaryimmunodeficiency with my friend and Johns Hopkins star immunologist Dr. Antoine Azar.
I'm excited to present about respiratory viruses in #primaryimmunodeficiency with my friend and Johns Hopkins star immunologist Dr. Antoine Azar.
Our review on a new integrated physical and chemical theory of danger sensing by the immune system is now in print and on the cover of @NatRevImmunol . Excellent working again with the team and editors. @ZoeHXDu @ManishButte Wendy Liu J. Bartleson. nature.com/nri/volumes/23…
On this #RareDiseaseDay, the California Center for Rare Diseases at UCLA celebrates with a panel discussion by five patients and advocates. Noon today (pacific). uclahs.zoom.us/webinar/regist… @UCLAHealth @dgsomucla
UCLA researchers led by @ManishButte developed a biodegradable scaffold to implant near solid tumors that acts as a training boot camp for immune cells to fight cancer cells. (via @dailybruin) dailybruin.com/2023/01/25/ucl…
New research from the Butte lab is featured on the cover of Nature Biomedical Engineering! Researchers used a tiny implantable device to get rid of regulatory T cells within tumors in mouse models with promising results. Congratulations @ManishButte!
New research from the Butte lab is featured on the cover of Nature Biomedical Engineering! Researchers used a tiny implantable device to get rid of regulatory T cells within tumors in mouse models with promising results. Congratulations @ManishButte!
yoni יוני @Primary_Immune
41K Followers 27K Following Human being. Jew. Israeli. Primary Immunodeficiency patient. הודו לה׳ כי טוב כי לעולם חסדו #Immunology #raredisease #ISRAELCasanova Lab @casanova_lab
10K Followers 499 Following We're a research lab at Rockefeller University (NY) and Necker Hospital (Paris) studying human genetic and immunological determinants of infectious diseases.Stuart Tangye @stutangye
2K Followers 205 Following I work and live in Sydney, trying to unravel the complexities of the immune system. I also quite like going to the beach! Views are definitely my own!Jeffrey Modell Founda.. @Info4PI
4K Followers 3K Following JMF is a global nonprofit dedicated to #PrimaryImmunodeficiency Advocacy, Research, Education, Newborn Screening & Genetic Sequencing to #CurePI worldwide 🌎Turvey lab @TurveyLab
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706 Followers 5K Following ?She/Her Bisexual & Bi-romantic TBI, DV, & GSW survivor in recovery. Single mom of 3 kids & 2 fur babies. Spoonie ♿️☮️☯️♋️ BLM Keto Low-carb Pro-Love Pro-Equaljazzapple2020 @jazzapple2020
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22 Followers 95 FollowingMariko Bennett MD PhD.. @nachoriko
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23 Followers 290 Following She/They. Attempting to survive pandemic, amkd global environmental collapse. Disability/health Advocate, OT and proud 2SLGBTQ+ family.Suzanne Collins @Kuldeep34959586
3K Followers 4K Following Golf⛳️, Yoga🧘♀️, Shopping🛒, Travel🌊, Cooking🍳, Reading📚, Meditation🧸, Entertainment🎤HDMarhaeny @HMarhaeny
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40K Followers 2K FollowingGavin Preston, M.D. @GavinPrestonMD
89K Followers 98K Following Author of the upcoming book: "The Managed Care Blues: A doctor's journey, a broken system, real solutions." Retired physician. Willing to be wrong. Trumpeter.Rosa Whary @RosaWhary50123
47 Followers 5K FollowingAli Steuck @AliSteuck77273
53 Followers 5K FollowingGlennie Howie @howie_glen
41 Followers 5K Followingyoni יוני @Primary_Immune
41K Followers 27K Following Human being. Jew. Israeli. Primary Immunodeficiency patient. הודו לה׳ כי טוב כי לעולם חסדו #Immunology #raredisease #ISRAELCasanova Lab @casanova_lab
10K Followers 499 Following We're a research lab at Rockefeller University (NY) and Necker Hospital (Paris) studying human genetic and immunological determinants of infectious diseases.Stuart Tangye @stutangye
2K Followers 205 Following I work and live in Sydney, trying to unravel the complexities of the immune system. I also quite like going to the beach! Views are definitely my own!Jeffrey Modell Founda.. @Info4PI
4K Followers 3K Following JMF is a global nonprofit dedicated to #PrimaryImmunodeficiency Advocacy, Research, Education, Newborn Screening & Genetic Sequencing to #CurePI worldwide 🌎Turvey lab @TurveyLab
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727 Followers 479 Following Primary immunodeficiencies, hyper-IgE syndrome, papillomaviruses. Still a NK cell aficionados.BogunovicLab @BogunovicLab
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1K Followers 1K Following Auto- & Hyper-inflammation | MAS HLH | IL-18 | Down wit OPD | we❤️puns (see logo) | 🚲 evangelist | opinions my ownIPOPI @ipopi_info
3K Followers 1K Following IPOPI is the association of Primary Immunodeficiency national patient organisations. Improving awareness, access to early diagnosis and optimal treatments.ESID @ESIDsociety
3K Followers 402 Following European Society for #Immunodeficiencies | PID | Diagnosis-Treatment-Management | Foster Research-Cooperation-Education | Join us at #ESID2024 Meeting!Catherine Biggs @CatherineMBiggs
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43 Followers 260 Following ID PD @KernMedical. Assistant professor CS @dgsomucla UCLA/kern. Associate medical director @VFI_Research; she/her; coccidioidomycosisProfessor Oak @Prof_Oak_
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4K Followers 2K Following Dad/husband/son, allergist/immunologist, gardener (zone 9b), genealogist, smoker/griller. USC football fan. Livin' in the new world with an old soul.Matthew Miller @mattrambleson
87 Followers 292 Following molecular biologist at UCLA studying immunology, cancer, and metabolismDeepak Rao @Deepakarao
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8K Followers 514 Following Infectious disease MD. Medical Microbiologist. Clinician-Scientist (Inborn Errors of Immunity). Clinical section head (ID-Heme/Onc/Transplant). FellowCIS. FIDSAGates Foundation @gatesfoundation
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236 Followers 466 Following Postdoc at @UniofExeter. Former postdoc @sangerinstitute. Working on the integration of 'omics data into burden testing frameworks. @chundru.bsky.socialMing Li @MingLiLab
2K Followers 163 Following Member, Memorial Sloan Kettering Cancer Center Views expressed are not affiliated with my employer.Loes Olde Loohuis @loldeloo
785 Followers 600 Following Assistant Professor in psychiatry, genetics and compmed at UCLA; mom of three; lover of forests and mountains and rain and running; recovering logicianPharming Group NV @PharmingGroupNV
319 Followers 0 Following Pharming develops innovative protein replacement therapies and precision medicines for the treatment of rare diseases and unmet medical needs. HAE-GLO-2021-0008Ton Schumacher Lab @Schumacher_lab
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3K Followers 1K Following the Laboratory of Lymphatic Immunobiology - exploring the contribution of lymphatic transport to dermal and anti-tumor immunity @nyulangoneMarion Pepper @PepperMarion
759 Followers 385 Following Immunologist at the University of Washington.ASolmonson @ASolmonson
711 Followers 621 Following Assistant Professor @UTSWGreenCenter in the @SolmonsonLab studying Developmental Metabolism and Placenta Biology. Postdoc @RJDlab, PhD @UTAustinRoy Perlis @royperlis
1K Followers 710 Following Director, MGH CQH | HMS Professor | Psychiatrist | Dad. Probably not Batman. Opinions my own, not my institutions'.David Rosenthal, DO, .. @dwrosenthal
864 Followers 2K Following Father; Allergy/Immunology Physician & Researcher, specializing in HIV in Adolescents/Young adults, HIV prevention , Transgender Care & Primary ImmunodeficiencySara Tolaney @stolaney1
10K Followers 620 Following Chief, Division of Breast Oncology @DanaFarber Tennis fan Mother of two teenage girlsExcited to be speaking at #ESID2024 with @DrCindyMa & Prof. Jolles. Join the #ESID community dedicated to improving the lives of patients with #immunodeficiencies and #inbornerrors. Submit your #PID research by 7 May. #immunity #genetics #ingid #ipopi invt.io/1txbre1o7w5
A few yrs ago @MasatoOgishi @casanova_lab described 1st cases of human PD1 deficiency. Today, they follow up with 1st report of human PDL1-deficiency. Similar but different - IEI reveal unique roles of PD1, PDL1 and prob PDL2. Another terrific study 👏 rupress.org/jem/article/22…
It has been an immense privilege and honor to review with John MacMicking and Carl Nathan in @ScienceMagazine the past 40 years of IFN-gamma research, and reflect on its neglected and potential role as a medicine science.org/doi/epdf/10.11…
1/ New paper alert! We describe the first children with inherited PD-L1 deficiency, with neonatal-onset type 1 diabetes. We compared these children clinically and immunologically with previously described PD-1-deficient siblings. rupress.org/jem/article/22…
Excited to be part of a team that identified a rare family with a defect in PDL1 that has a strong link to type 1 diabetes and other immune dysregulation. rupress.org/jem/article/22…
Congratulations to Dr. Tejas Dhamaraj! He successfully defended his PhD this week and I couldn't be more proud of him and the work he's done on phage delivery. @stanfordimmuno @StanfordMed @stanfordID
We're excited to attend the Clinical Immunological Society annual meeting May 1-4 to connect with providers across the U.S. to discuss clinical immunology, primary immunodeficiency (PI) diagnosis, research, and treatment! Stop by and say hi!
Horesh, @BogunovicLab et al. suggest that individually rare JAK1 gain-of-function (GoF) variants may underlie an emerging syndrome with more common presentations of autoimmune and inflammatory disease (JAACD syndrome). hubs.la/Q02rwjK20 #HumanDiseaseGenetics #Autoimmunity
First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant, from @E_BernaldoQ, Correa-Rocha et al. @lab_lir: hubs.la/Q02sjjTk0 Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjxxk0
How to pick a problem. Today in @CellCellPress. 1/53 cell.com/cell/fulltext/…
@DrJenChen4kids I see that, but the -“-variant” part implies that this is not how asthma classically presents. But cough is a (or THE) major manifestation of asthma in children, hence my mantra of “albuterol [or now, ICS/formoterol] is his cough medicine.”
Congratulations to Sohan Talluri, a 3rd-year MIMG student, for being awarded the 2024 Goldwater Scholarship! To learn more about the Goldwater Scholarship and view the full list of recipients, visit goldwaterscholarship.gov.
Out today in @NatImmunol: MEF2C regulates NK cell effector functions through control of lipid metabolism by Li et al! Joey Li (@thejoeyli) is a PhD3 in the O’Sullivan lab. Congratulations!!! nature.com/articles/s4159…
📣 Calling all Immunologists and Primary Immunodeficiency patients 📣 We have a special video project planned for WPIW, and would love your participation from around the world! Let us know if you’d like more info and we’ll send you a DM!
I do not want free cookies or weekly zoom meditation or group coaching or appreciative alluser emails. I want internet that works, administrators who want to help me do my job, and hospital leadership that remembers our unique and sacred mission.
Put off looking at our most recent #NIH R01 score because...well...seemed like self-torture. Then courage. Then this miracle.😯 Can't wait to start this work to increase #equity in #colorectalcancer w/Beth Glenn (@GlennMallouk) & colleagues #WhenYouLeastExpectIt #Persevere #R01
Great match !
We are pleased to share that Michael Lenardo M.D., #genetics & molecular #immunology researcher & founder of the @NIAIDNews Clinical Genomics Program, has been appointed Chief Scientific Officer of Calico. Read more here: calicolabs.com/press/calico-a…
Thrilled to see our paper out today! Work led by @adamdesmith and @bloodgenes that unravels genetic mechanisms at an important risk locus for acute lymphoblastic leukemia in Hispanic/Latino children 🧬
A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children dlvr.it/T4dz3Z
Proud to build a new engine for drug discovery with The Column group and @carlcward @R_Schmidt_ & @StacieDodgson. Amazing momentum for the Site Therapeutics team gathering around this effort! linkedin.com/posts/the-colu…
Dr. Turveys research has made an incredible impact on patients and families across BC and globally. @TurveyLab your innovative work in precision medicine for clinical immunology has put UBC on the map as a leading center of excellence. Congratulations!!
Congratulations Dr. Stuart Turvey! Dr. Turvey is a recipient of a 2023 UBC Killam Research Prize for outstanding research and scholarly contributions in the category of Applied Science, Medicine and Sciences. bit.ly/4au8tTJ @TurveyLab @DrStevenPMiller @KylaHildebrand1