Ed Reznik @EdReznik
Developing computational approaches to studying metabolism in cancer, find our publications here: https://t.co/GU8zmkIItS componcmsk.org/reznik-lab/ New York, NY Joined October 2013-
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My professional goal is to do science that directly touches and improves the life of at least one cancer patient. If you want to participate in that adventure, come work with me and @ZiadBakouny as a postdoctoral fellow studying toxicity and adverse events in cancer therapy.
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Ed Reznik retweeted
RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) biorxiv.org/content/10.648…
Ed Reznik retweeted
Congrats @ZiadBakouny and @BraunMDPhD for this @kidneycan #KCRS26 award!
Ed Reznik retweeted
This study changed the way I think about cachexia. For a long time we have been looking for tumor-secreted factors that induce sickness and wasting. @ThalesPapaG now shows us that the "sickness signal" can be transmitted directly to the brain via sensory neurons. Congrats to the whole team. #CANCAN @CancerGrand @theNCI @CRUKresearch science.org/doi/10.1126/sc…
Ed Reznik retweeted
Anatomical dynamics define cancer cachexia subtypes and identify systemic inflammation as a marker of lethal wasting @EdReznik medrxiv.org/content/10.648…
Please RT: official post forthcoming, but for those currently hunting for postdocs, my group will have a fully funded position for an individual to lead our activities in computational analysis of radiographic data. If you have those skills and want to dream, please reach out.
Congratulations Ziad, watch out world
After 15 years of training, excited to be starting as a Genitourinary Oncologist and Instructor @MSKCancerCenter! Very thankful to my wife & daughter who have put up with me during my training, the fellowship program, and all my incredible mentors along the way! @MSK_DeptOfMed
Ed Reznik retweeted
Why do VEGFR-TKI + IO combinations produce impressive responses in ccRCC but often fail to achieve the long-term durability seen with dual checkpoint blockade? Check out our lab's latest in @Cancer_Cell led by the incredible Lyn Vuong! cell.com/cancer-cell/fu…
Ed Reznik retweeted
🚨 really pleased to post a new preprint from our lab, where we describe an ancient metabolic axis that controls mtDNA copy number and mitochondrial content; a mechanism we uncovered in human cells that stretches through evolution to control mtDNA in flies, yeast and even plants!
@iskander But tRNAs are typically not polyadenylated right? Not in your library
@iskander mtDNA encodes just 13 proteins that ultimately determine the most basic metabolic decision for a cell, to respire or ferment. i think that's as basic a feature of tumor biology as you're going to get.
@notSoJunkDNA @iskander yes, mtdna is polyadenylated
Ed Reznik retweeted
Thrilled to receive the Gerstner Physician Scholars’ grant! The grant will support our work for the next 3 years on mitochondrial DNA mutations in cancer. Very thankful for the mentorship from Craig Thompson, @EdReznik, @motzermd, @arihakimi and many others! @MSK_DeptOfMed
Thanks to the many, many people who helped and guided along the way, and to the funders, esp @psscra for their investment in this high-risk science before we had anything to tangible to show for it, and to @CancerGrand + CANCAN for supporting new ideas in cachexia science
Lots of implications from this, but the biggest one is that we firmly believe a framework like this could be used to pioneer a precision medicine trial for cancer cachexia, matching tx to subtype.
Very excited to report on our lab’s unexpected adventure into subtyping cancer cachexia by way of anatomy, where we study the evolution of the bodies (not the genomes!) of patients with cancer during profound weight loss. Led by Sonia Boscenco. medrxiv.org/content/10.648…
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