Darren Martin @DarrenM98230782
bio Joined May 2020-
Tweets972
-
Followers456
-
Following200
-
Likes2K
This intense thread from Ryan links mutation patterns during chronic SC2 infections to optimization of the complex inner workings of the micro-factories that coronaviruses use to both replicate their genomes and produce transcripts for gene expression. I learned so much from it.
This intense thread from Ryan links mutation patterns during chronic SC2 infections to optimization of the complex inner workings of the micro-factories that coronaviruses use to both replicate their genomes and produce transcripts for gene expression. I learned so much from it.
This is a really nice overview of SARS-CoV-2 evolution to-date. My only minor niggles are : 1) some animals might also have chronic infections; 2) important geographical contexts of VOC emergences glossed over; and 3) IMHO treatment played no role in VOC emergences(except alpha).
This is a really nice overview of SARS-CoV-2 evolution to-date. My only minor niggles are : 1) some animals might also have chronic infections; 2) important geographical contexts of VOC emergences glossed over; and 3) IMHO treatment played no role in VOC emergences(except alpha).
Here Ryan unpacks some of the really interesting features of the new BA.2.87 lineage
Here Ryan unpacks some of the really interesting features of the new BA.2.87 lineage
Yaaaayyyy plants. Although I wonder how much more impressive that plant stack must've been 5K years ago (before we destroyed >50% of the world's forests)
Yaaaayyyy plants. Although I wonder how much more impressive that plant stack must've been 5K years ago (before we destroyed >50% of the world's forests)
You can now run @hyphy_software entirely in your browser thanks to @emscripten, @observablehq and biowasm (@RobAboukhalil). Simple example in observablehq.com/@spond/hyphy-b…
Although antibody escape mutations get the most attention, for me the most interesting plotlines in the unfolding SARS-Cov-2 evolution story are those involving daring (and sometimes crazy) adaptive innovations. Ryan beautifully explores one of these subplots here.
Although antibody escape mutations get the most attention, for me the most interesting plotlines in the unfolding SARS-Cov-2 evolution story are those involving daring (and sometimes crazy) adaptive innovations. Ryan beautifully explores one of these subplots here.
A nicely written paper exploring how describing complex objects (like cells or mobile phones) in terms of 1) how many steps are needed to make one and 2) how many of the objects exist, might be used to quantify the amount of selection needed to explain their existence.
A nicely written paper exploring how describing complex objects (like cells or mobile phones) in terms of 1) how many steps are needed to make one and 2) how many of the objects exist, might be used to quantify the amount of selection needed to explain their existence.
I think this preprint, by @StuartTurville, is potentially one of the more important recent SARS-CoV-2 papers. It promises to unwrap some of the most mystifying aspects of Omicron surrounding cell entry, TMPRSS2 use, & reduced lung invasion/pneumonia. 1/48 x.com/stuartturville…
I think this preprint, by @StuartTurville, is potentially one of the more important recent SARS-CoV-2 papers. It promises to unwrap some of the most mystifying aspects of Omicron surrounding cell entry, TMPRSS2 use, & reduced lung invasion/pneumonia. 1/48 x.com/stuartturville…
Tulio de Oliveira @Tuliodna
61K Followers 654 Following Director of CERI (Centre for Epidemic Response & innovation) @StellenboschUni and KRISP (KZN Research Innovation & Sequencing Platform) @UKZN. Tweets my own.
Tom Peacock @PeacockFlu
51K Followers 1K Following Virologist. Viruses, Influenza, Coronaviruses and SARS-CoV-2. Typos are intenitonal. Fellow at @Pirbright_Inst and @ImperialInfect
Bloom Lab @jbloom_lab
48K Followers 1K Following Lab studying molecular evolution of proteins and viruses. Affiliated with @fredhutch @HHMINEWS @uwgenome. @jbloomlab@bsky
Marta Giovanetti @Mittenavoig
2K Followers 791 Following Virology, Genomic epidemiology, Data Science, Phylogenetics. Oswaldo Cruz Foundation #ScienceIsInAllThings. 🇮🇹🇪🇺🇧🇷
Spyros Lytras @SpyrosLytras
3K Followers 1K Following Evolutionary Virologist at the @SystemsVirology lab, University of Tokyo 🇯🇵 Molecular Evolution, Phylogenetics, Viral Genomics (he/him) 💻🔬🏳️🌈
T. Ryan Gregory @TRyanGregory
83K Followers 1K Following Professor of evolutionary biology. I would like there to be less death, pestilence, war, and famine. Assume sarcasm. No one could have foreseen this. He/him.
Houriiyah Tegally, Ph.. @houzhou
4K Followers 741 Following Pathogen Genomics, Genomic Epidemiology, Data Visualisation, Phylodynamics Head of Data Science, CERI, SU 👩🏾💻🦠🧬📈 @yale 2016. @imperialcollege 2018.
Aris Katzourakis @ArisKatzourakis
37K Followers 2K Following Paleovirology, cross-species transmissions, evolution, genomics, viruses, selfish genes. UCU NEC, Branch Hon Sec, Oxford Biol. Tweets mine, retweets not.
Ryan Hisner @LongDesertTrain
22K Followers 838 Following Teacher "Be ruthless with systems and be kind to people." Michael Brooks, 1983-2020
Theo Sanderson @theosanderson
14K Followers 1K Following Scientific researcher in pathogen genetics. Previously: @GoogleAI, @sangerinstitute 🧪 🤖 🖥️ @[email protected] / @theo.io on bluesky
VignuzziLab @VignuzziLab
16K Followers 9K Following viruses-evolution-Singapore-fitness! @idlabs_astar. #PrideInSTEM 🏳️🌈 #DiversityInSTEM 🇸🇬🇮🇹🇨🇦🇫🇷🇺🇸🇸🇦🇬🇧🇭🇺🇲🇾
Yunlong Richard Cao @yunlong_cao
19K Followers 412 Following Biochemistry & Immunology | Host Immune Response, Antibody Drug & Vaccine Design | PhD @Harvard | Assistant Professor at Peking University BIOPIC
Carla Nartuhi Mavian .. @nartuhi
395 Followers 1K Following Assistant Professor, Evolutionary virologist, Emerging Pathogens Institute, University of Florida
Federico Gueli 🏳�.. @siamosolocani
5K Followers 3K Following Quanto era bella la pace Brotherdog = a will of peace while seeking variants RT =not endorsment! If i must die, you must live to tell my story (Refat Alareer)
Arvind Varsani @Varsani_lab
2K Followers 1K Following Nomadic 'viral' scientist #virome #virus #virus_evolution #virology 🇰🇪 🇿🇦 🇳🇿
The Sato Lab (Kei Sat.. @SystemsVirology
20K Followers 2K Following 東京大学医科学研究所システムウイルス学分野教授 The Genotype to Phenotype Japan (G2P-Japan) Consortium主宰 一般社団法人G2P-Japan代表理事 週プレNEWSでコラム連載中→https://t.co/zLvSNcurTq
Marc Johnson @SolidEvidence
31K Followers 131 Following Molecular virologist, Professor, sewage sage and wastewater wizard.
Tom Wenseleers @TWenseleers
23K Followers 1K Following Professor @KU_Leuven - evolutionary biology, theoretical biology & biostatistics. Working with #insects, #microorganisms (incl. Covid) & #humans.
Ed Rybicki 🇿🇲�.. @edrybicki
5K Followers 245 Following A highly opinionated virologist who dabbles in molecular farming and vaccinology, science fiction and red wine. Sometimes all at once. 🇿🇦🇿🇲🚀🍷
Steven Weaver @stvnwvr
293 Followers 216 Following All about software development and biotech. Dick's Last Resort Downtown San Diego 2003 Jelly Donut Eating Contest Champion. San Diego born/raised. #firstgen
Kerem bikmaz @Bikmazkerem098
56 Followers 881 Following Başarı tesadüf değildir. Sıkı çalışma, azim, öğrenme, çalışma, fedakarlık ve hepsinden önemlisi, yaptığınız veya yapmayı öğrendiğiniz şeyi sevmektir.
Carole 😍 @CaroleKacie572
5 Followers 641 Following Sеductivе viхеn longing for infinitе erotiс advеnturеs
Dan @CpnpDan
110 Followers 2K Following
@restonvirus @restonvirus
470 Followers 500 Following Dead lab monkeys infected w/ a new Ebola strain in 1989 were hidden by government scientists in a car's trunk & driven from Reston, Virginia to Ft. Detrick, MD.
Louise Ward @wardnotabot
73 Followers 751 Following I left Twitter - I joined again - I left Twitter - I joined again - I left X - here I am again... 5th account from scratch 😫
Ralph Baric's Attorne.. @ProGof39474
222 Followers 93 Following Keeping gain of function safe for virologists
Chris de Z @ChrisDeZPhD
812 Followers 291 Following biochemist / immunologist, founder of diagnostics company, R&D infectious diseases, medical devices, environ. surveillance, analytics of everything
Finn Harvor @finn_harvor
1K Followers 5K Following Writer, artist, filmmaker, musician. Published in many lit mags; screened in Canada, UK, US, Ireland, Hong Kong, Greece, and S Korea. Own microhouse: BridgeText
Billy Bostickson 🏴.. @BillyBostickson
18K Followers 3K Following Billy Bostickson is your Friend PR Secretary Rage University Coordinator of DRASTIC at https://t.co/XnTqFxhoy4 https://t.co/YR3ygEuhO0
Carrie doesn’t cons.. @Cccsjb
6K Followers 6K Following Lib Dem LGBTQIA Insomniac INTJ Vaxd & maskd Stronger Together #Covid is Not Over #NoHate They’re/their/there #HandsOffOurBodies #GunOwnerforSafety 🇳🇮🇺🇦
Linda @218res1
263 Followers 2K Following
Euan Arnott @Nucleocapsoid
159 Followers 111 Following
AdrianGibbs1934 @AdrianJ44426152
437 Followers 730 Following Concerned crumbly. Biologist who works on the evolution of viruses. Photo 1954!
Cathal Seoighe @SeoigheCathal
712 Followers 503 Following
Ashleigh Hamilton @AshRHamilton
756 Followers 5K Following producer | director | curious | questioning | public health | 🐈⬛ lover | fan of anime |🇿🇼 🇬🇧 🇿🇦 🇺🇸| 🎥 INFINITE pictures | CBS, NBC, NYT, UN
Eric Manfredonia @EricManfre44006
68 Followers 5K Following
Lesa Simokat @LesaSimoka69680
49 Followers 5K Following
Nick Rose @Asinickle1
2K Followers 268 Following
Ariya Pavlikowski @pavlikowsk61068
66 Followers 5K Following
Patrick Shaw Stewart @PatrickSSte
2K Followers 2K Following DMs open. Our grandparents were right - put on your hat & gloves. See pinned tweet/our paper in Reviews in Medical Virology: https://t.co/pcRileGIxl
Kathline Braegelmann @KathlineB38646
39 Followers 5K Following
MJ Allen @MJnanostretch
4K Followers 672 Following Founder at Biometrology. Nanobiologist, scanning probe microscopist. Frmr research scientist: US Dept of Energy, Digital Instruments, Univ of Chicago faculty.
Still Addicted to Wor.. @LoeduBoisson
92 Followers 324 Following Covid virgin. In rehab for Wordle addiction. Watch too much TV. Personal account for stuff I can't say on my other account.
Franzi @Franzi325
0 Followers 2K Following
Melanie @MelanieCeolta
30 Followers 295 Following Forensic structural engineer, wife, mother, lover of dogs and travel.
Thesaint8x @Thesaint8x
943 Followers 3K Following Buying selling shares in India-my calling.I write articles on how to improve at chess-get paid for it.Fide rated. Play,study chess .Love books,movies.
not dead yet.. might .. @ABuermeyer
630 Followers 3K Following “There is some good in this world, and it’s worth fighting for.” #BLM, #DefundThePolice... find me in the lab, on the ultimate field, or in the wilderness
Dr Fabrício Campos @camposfabricios
826 Followers 2K Following Prof at Federal University of Rio Grande do Sul. MSc in Microbiology. PhD in Veterinary Science. I work with viruses using metagenomics and NGS.
Mel @oskaandme
782 Followers 2K Following
#MedicareForAll #Covi.. @NancyDr85866312
972 Followers 4K Following
COVIDSTRIKE! @covidstrike
515 Followers 895 Following COVID-related rants. Disability Justice. Fuck the fash. Black flag. DM or reply if I can improve access on my tweets/retweets. Bio pic ID: water and fire
Dionne Miles @Dionne_Miles
13 Followers 13 Following
sally 🕶 😷 🪰 .. @sejwatson
1K Followers 5K Following [email protected] https://t.co/nR3YAMvoL4 @[email protected] https://t.co/FRuzo2Fyp3
Jeeper Creeper @usapride22
57 Followers 411 Following Loving Husband and Father. Fisherman. Republican. American. ✊
Simone L. 🇺🇦 @dieselchen1978
588 Followers 2K Following Studium der EW & Soziologie (Schwerpunkt Soziale Arbeit), Hang zur Biologie & Interesse an Studien #noAfD #noQD Tweets in English/German @dieselchen.bsky.social
public Public Health .. @Intro2PH
518 Followers 806 Following b/c PH is offline! b/c HCW lost their moral 🧭! b/c it’s the age of narcism! b/c it’s an era of embracing Pandemics! b/c it’s Pandemicene!
Patricia Walsh @Trish000000
32 Followers 575 Following
Héctor Ruiz @HaRuiz75
25 Followers 203 Following
Judy Zellers @JudyJZellers
186 Followers 4K Following
Helena @awdx951
13 Followers 98 Following
Tulio de Oliveira @Tuliodna
61K Followers 654 Following Director of CERI (Centre for Epidemic Response & innovation) @StellenboschUni and KRISP (KZN Research Innovation & Sequencing Platform) @UKZN. Tweets my own.
Tom Peacock @PeacockFlu
51K Followers 1K Following Virologist. Viruses, Influenza, Coronaviruses and SARS-CoV-2. Typos are intenitonal. Fellow at @Pirbright_Inst and @ImperialInfect
Bloom Lab @jbloom_lab
48K Followers 1K Following Lab studying molecular evolution of proteins and viruses. Affiliated with @fredhutch @HHMINEWS @uwgenome. @jbloomlab@bsky
Dr Emma Hodcroft @firefoxx66
80K Followers 824 Following Die Virenjägerin! 🏹🧬 Co-developer of @nextstrain! Using phylogenetics, I study viruses. I like ✈️ & 🐈 @[email protected] @firefoxx66.bsky.social
Marta Giovanetti @Mittenavoig
2K Followers 791 Following Virology, Genomic epidemiology, Data Science, Phylogenetics. Oswaldo Cruz Foundation #ScienceIsInAllThings. 🇮🇹🇪🇺🇧🇷
Spyros Lytras @SpyrosLytras
3K Followers 1K Following Evolutionary Virologist at the @SystemsVirology lab, University of Tokyo 🇯🇵 Molecular Evolution, Phylogenetics, Viral Genomics (he/him) 💻🔬🏳️🌈
Houriiyah Tegally, Ph.. @houzhou
4K Followers 741 Following Pathogen Genomics, Genomic Epidemiology, Data Visualisation, Phylodynamics Head of Data Science, CERI, SU 👩🏾💻🦠🧬📈 @yale 2016. @imperialcollege 2018.
Aris Katzourakis @ArisKatzourakis
37K Followers 2K Following Paleovirology, cross-species transmissions, evolution, genomics, viruses, selfish genes. UCU NEC, Branch Hon Sec, Oxford Biol. Tweets mine, retweets not.
Ryan Hisner @LongDesertTrain
22K Followers 838 Following Teacher "Be ruthless with systems and be kind to people." Michael Brooks, 1983-2020
Theo Sanderson @theosanderson
14K Followers 1K Following Scientific researcher in pathogen genetics. Previously: @GoogleAI, @sangerinstitute 🧪 🤖 🖥️ @[email protected] / @theo.io on bluesky
Stuart Neil @stuartjdneil
16K Followers 1K Following Virologist. 🦠 HIV, EBOV, SARS2 and Flu interactions with their hosts. ‘Biodefense expert’ according to a hack
Marion Koopmans, publ.. @MarionKoopmans
86K Followers 3K Following https://t.co/x3zIbMPDg5 Head of Viroscience Department , WHO collaborating centre EID
Kai Kupferschmidt @kakape
150K Followers 2K Following @kakape.bsky.social science journalist. molecular biologist. curious. writer at @sciencemagazine part of @pandemiapodcast, all things #blue
Nick Loman @pathogenomenick
38K Followers 2K Following Professor of Microbial Genomics and Bioinformatics @unibirmingham, @MRCClimb, Sr. Genomics Adviser @UKHSA, CSO @microbesNG
Stephen Goldstein @stgoldst
8K Followers 2K Following Evolutionary virology postdoc @ Univ of Utah. Previously Penn Medicine. Coronaviruses and the Wasatch.
Virological Posts @virological_org
5K Followers 0 Following A bot tweeting new posts from the https://t.co/Na52gjaiN2 discussion forum for molecular evolution and epidemiology of viruses. Maintained by @noamross
UCT IDM @UCTIDM
2K Followers 198 Following The IDM was established in 2004 as a cross-faculty postgraduate research institute based within the University of Cape Town (UCT), South Africa.
Xavier Didelot @XavierDidelot
3K Followers 939 Following Professor of Statistical Epidemiology and Genomics at @warwickuni
Maria Van Kerkhove @mvankerkhove
119K Followers 597 Following Infectious Disease Epidemiologist; COVID-19 Technical Lead, Director ai Epidemic & Pandemic Preparedness & Prevention, WHO, WHE, Mom of 2. Opinions my own
Meaghan Kall @kallmemeg
62K Followers 2K Following Epidemiologist @UKHSA, mom, wife, . Born 🇺🇸 Migrated 🇬🇧. Tweet about HIV & COVID-19. #Nature10 scientist. 🏳️🌈 Personal account, obvs.
Cathal Seoighe @SeoigheCathal
712 Followers 503 Following
GIFT for Africa @GIFT_for_Africa
200 Followers 77 Following A South African-led international partnership to develop tools to improve management of sexually transmitted infections and bacterial vaginosis in women
lixingguang @lixingguang
857 Followers 1K Following I am an evolutionary virologist, focus on virus evolution, phylogenetics, and phylodynamics.
Adam Eyre-Walker @AdamEyreWalker
2K Followers 197 Following
Will Ratcliff @wc_ratcliff
8K Followers 2K Following Evolutionary biologist (Multicellularity & social evolution). Associate Prof. at Georgia Tech & Director @QBioS_GT PhD program.
Dionne Miles @Dionne_Miles
13 Followers 13 Following
Gnome "doing their da.. @annethegnome
26K Followers 1K Following gay-dhd&d ⚔ they/she ⚔ TTRPG creator, writer, mycophile, rabble rouser https://t.co/a0x0nr9PyX
Euan Arnott @Nucleocapsoid
159 Followers 111 Following
Tom Wenseleers @TWenseleers
23K Followers 1K Following Professor @KU_Leuven - evolutionary biology, theoretical biology & biostatistics. Working with #insects, #microorganisms (incl. Covid) & #humans.
Peter Miller @tgof137
1K Followers 241 Following
Joe Felsenstein @JFelsenstein
729 Followers 1 Following
San Emmanuel James, P.. @JSAN4CHRIST
638 Followers 1K Following Systems Analyst and Programmer, Bioinformatician, Data Scientist, Viral and Bacterial Research, Training and Capacity Building in Africa
Dave Moi @steg0s4urus
235 Followers 292 Following 🔬 Postdoctoral Researcher working at the @dbc_unil for the @DessimozLab | Bridging Borders | #Bioinformatics & #MachineLearning 🤖 |
People In A Film - a .. @PeopleInAFilm
110 Followers 99 Following Wire are the definitive post-punk band. Directors Malcolm Boyle and Graham Duff are making a feature documentary about them. The title is People In A Film.
Raj Rajnarayanan @RajlabN
17K Followers 702 Following Assistant Dean of Research and Associate Professor, NYITCOM at Arkansas State University | My Tweets are my own
JoeThornton @JoeThorntonLab
2K Followers 112 Following Evolution and biochemistry. Reconstructing ancestral proteins. "Training" scientists. UChicago faculty. Ambivalent about twitter.
Nana Amoako @ssyamoako
127 Followers 481 Following Bioinformatician | Data Scientists | Research Assistant | Machine Learning Enthusiast @ WACCBIP, Ghana
houter @houterkabouter
2K Followers 439 Following I'm an educated fool. Aspirant relativist. PhD klinische & epidemiologische virologie.
Derek Tshiabuila @DKTshiabuila
110 Followers 241 Following Master of Medical Science student Majoring in Virology in the discipline of Bioinformatics at KRISP UKN
Peter Jacobs @past_is_future
5K Followers 5K Following researching Pliocene and future climate and hoping to keep the former from becoming the latter.
Chuck Pfarrer | Indic.. @ChuckPfarrer
170K Followers 1K Following Former SEAL Team 6 Squadron Leader, Conflict Correspondent, Mriya Report host, NYT Best Selling author, Hollywood screenwriter, dad husband & epic snowboarder.
David Byrne's America.. @americanutopia
7K Followers 72 Following David Byrne's American Utopia played its final Broadway performance on April 3, 2022.
Craig Finn @steadycraig
26K Followers 1K Following Stay Positive. A LEGACY OF RENTALS available now. Order here: https://t.co/ZfRLoccyBc…
Dara Massicot @MassDara
77K Followers 569 Following Senior Fellow, Carnegie Endowment for International Peace, Russia and Eurasia Program, focusing on defense issues in Russia. Opinions mine RTs not endorsements.
[ Malcolm Gladwell ] @InsideGladwell
13K Followers 0 Following The latest Malcolm Gladwell news curated by the @inside team.
David Epstein @DavidEpstein
59K Followers 1K Following author RANGE and TheSportsGene. Ex-@ProPublica, @SInow. (pic is w/Frances Hesselbein). IG @davidepstein. RANGE WIDELY newsletter 👉 https://t.co/jIJNey9epd
regular steve albini @electricalWSOP
92K Followers 190 Following recording engineer who plays billiards and poker, and eats like a viking I reflexively block blue check accounts and promoted tweets @electricalwsop.bsky.social
The Sato Lab (Kei Sat.. @SystemsVirology
20K Followers 2K Following 東京大学医科学研究所システムウイルス学分野教授 The Genotype to Phenotype Japan (G2P-Japan) Consortium主宰 一般社団法人G2P-Japan代表理事 週プレNEWSでコラム連載中→https://t.co/zLvSNcurTq
Simon Frost @sdwfrost
3K Followers 3K Following Computational biologist, data scientist. Principal Data Scientist @Microsoft @DIOS_vax, Professor of Pathogen Dynamics @LSHTM
Joicymara Xavier @joicy_xavier
647 Followers 527 Following Dr in Bioinformatics, Assistant Professor at #UFVJM, Research Fellow at CERI, Administrative Director at Código X, and a dreamer. 🇧🇷🇿🇦
Yusasha Pillay @YusashaPillay31
108 Followers 119 Following 🇿🇦 Proudly South African 🎓 Medical Scientist 🐈 Cat Mom 🌏 Traveller 🏆 LFC
Peter Ellis @pjie2
2K Followers 746 Following Father, husband, scientist, singer. Prone to getting over-excited about nerdy stuff in public. He/him. @[email protected]
phoneswithchords @PhonesWithChrds
1K Followers 2K Following Collab album with @bensooy of @aplaceforowls is out!!! Also, check out @uhaveuntillunch
ChrisO_wiki @ChrisO_wiki
196K Followers 339 Following Independent military history author and researcher. Also at https://t.co/T008p5JDEr
Marc Meneghini @marc_meneghini
236 Followers 404 Following Former tennis prodigy wanna-be; now studying viruses in yeast.
Josette Schoenmakers @JosetteSchoenma
7K Followers 402 Following
nature @Nature
2.6M Followers 4K Following Research, News, and Commentary from Nature, the international journal of science. For daily science news, get Nature Briefing: https://t.co/wGmQlQ8a4D
Alexis Stamatakis @AlexisCompBio
2K Followers 358 Following ERA Chair @ICS_FORTH & Research Group Leader @HITStudies & Prof. @KITInformatik
Santiago F. Elena @SantiagoFElena
1K Followers 352 Following
Britt Koskella @bkoskella
7K Followers 2K Following Evo-ecologist studying interactions among phages, microbiomes, and plants. Tweets about science, teaching, gender issues. Mainly at https://t.co/6uSII7Tp5b
Sebastian Bonhoeffer @sbonhoeffer
1K Followers 215 Following infectious disease dynamics & director of Collegium Helveticum
Nels Elde @ElEarlyBird
5K Followers 1K Following Evolutionary genetics and cell biology. And co-host of This Week in Evolution #TWiEVO. And chicken-assisted gardening. #MacFellow @HHMINEWS
What a #powerhouse team @GIFT_for_Africa - exciting things happening in the lab #hardwork
Our GIFT samples have arrived at the lab! Tech officer, Nangamso Cawe and the dedicated research team are ready for action and now begin the rigorous task of preparing the vaginal swab samples. #Healthresearch #Womeninresearch #madeinAfrica #GIFT4Africa @EDCTP @MRCza @tiaorgza
So proud of our biorepository and deeply grateful for people like #YacoebGanief @UCT_Research @UCTHealthSci @UCTIDM news.uct.ac.za/news/research-…
@EvolvedBiofilm Thanks for sharing! We are VERY excited about this one : )
Congratulations to Prof. Valerie Mizrahi on being elected as an American Association for the Advancement of Science (AAAS) Fellow! Read more here- idm.uct.ac.za/articles/2024-…
I lean perhaps 3:1 toward a natural origin of COVID-19, but I am often disturbed by the arrogance and condescension of those who advocate it most strongly. The behavior intimates a lack of objectivity that undermines their case, if not scientifically then at least societally.
not shared. To formalize this I would say P(picking so many majority alteratives|ZW) ~= 1 but P(picking them|LL) ~= 0.15 or lower. This gives us a Bayes Factor of about 6 or 7 in favour of a natural origin of the restriction map. END. @mbw61567742 @VBruttel @ban_epp_gofroc
indicated that that region was closest to RpYN06, which shares the genotype of SARS2. There isn't a single case in which SARS2 happens to have a genotype that isn't shared by at least one other relative, even though n most cases, nearly half of the silent alternatives are...
she could have chosen from, but she happened to pick the majority one every time. There is about a 1.5% chance of getting that lucky. The one removed site (at 10444) that doesn't use the majority alternative is the one where the independent recombination analysis by Temmam...
Those alternatives all would have been silent and all would have involved changing a single nucleotide, unless there's a bug in my code (and please check any of these sites that you can be bothered to). I have marked with a * the ones that are actual BsaI/BsmBI sites...
Note also that SARS2 only has 5 BsaI/BsmBI restriction sites. This is an unusually low number. If the restriction map were engineered it's likely our engineer would have had to remove not just one site but at least 3 or so. In each case there are about 4 alternatives...
As you can see, some of the viruses lower down have GAGACG, which is a BsmBI site. In SARS2 that site has been removed, by replacing it GCGACG. 20 other viruses also have GCGACG. But an engineer would have had no reason to choose GCGACG over GCGATG, GTGACG, GAGACG or GGGACG...
in the Temmam paper) in 18/19 places SARS2 shares the *particular* silent alternative (to a BsaI/BsmBI recognition site) that it is has with the *majority* of related viruses that also don't have the site. Perhaps best explained with an example. Here is the first one...
of those alternatives that happens to be shared with a bunch of related viruses. She would just pick the first one she thought of that happened to be silent and used one mutation. Looking at the 29 close relatives CC used (which I think are the ones...
This contrasts with adding a site where you basically only have two alternatives for each kind of site (GGTCTC or GAGACC for BsaI, CGTCTC or GAGACG for BsmBI). The greater choice available allows us a better view into what happened. An engineer has no reason to pick one...
I've done another analysis on this which is a big win for a *natural* origin of SARS2's unusual restriction map. It is on similar lines to those done by Andersen and Crits-Cristoph, but we're focussing just on the RE sites that are apparently removed in...
Is SARS2 a reverse genetics system? I don't believe Bruttel et al have shown convincingly that it is. But has Crits-Christoph (CC) shown that it isn't? Where they see "hotspots of silent mutation", he sees "hotspots of recombination", pointing to a natural origin. How much...
SARS2 and ignoring the ones that were added. The point here is that if you are an engineer trying to remove a site, you want to do it with a single silent mutation, so as to minimize chances of disrupting the function. But in many cases there are multiple ways of doing that...
How do you define creativity? When asked, medicine laureate Susumu Tonegawa had an inspiring reply. Tonegawa was awarded the 1987 medicine prize "for his discovery of the genetic principle for generation of antibody diversity."
Dead Kennedys - Holiday in Cambodia
There's actually a lot more that I intended to include in this thread, but I've been flogging this horse for months, & I'm pretty sure it never had a pulse to begin with. I'm trying to write something vaguely proper out of this, so I'll save the rest for that. 120/END
All genomic data ramblers run into impassable walls that defy all attempts to burrow beneath, journey around, or catapult over, and whose enchantments only the wizards of the wet lab are capable of defeating. 119/120
Trends for United States
You might like
