Aging Highlights @AgingHighlights
Biology of #aging #science #longevity #lifespan #senescence 🧬🥼 Joined November 2016-
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Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver science.org/doi/10.1126/sc…
Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition nature.com/articles/s4358…
𝐎𝐩𝐨𝐫𝐭𝐮𝐧𝐢𝐝𝐚𝐝𝐞 𝐈𝐧𝐜𝐫𝐢́𝐯𝐞𝐥: 𝐃𝐮𝐚𝐬 𝐯𝐚𝐠𝐚𝐬 𝐝𝐨𝐜𝐞𝐧𝐭𝐞𝐬 𝐧𝐨 𝐧𝐨𝐬𝐬𝐨 𝐃𝐞𝐩𝐚𝐫𝐭𝐚𝐦𝐞𝐧𝐭𝐨! Mais informações sobre o Departamento: iq.usp.br/portaliqusp/?q…‐br/bioquimica/apresentacao Edital referente a este concurso: uspdigital.usp.br/gr/admissao
The complete manuscript cycle will take place on pubpub.org, where I will respond and revise according to public feedback. In addition, @RauchLab has kindly agreed to serve as editor. She will solicit/curate anonymous peer review that we will append to the manuscript
Brilliant gutsy experiment in challenging the current "publishing" model. Need to figure out how we can support & participate in such an effort. Maybe this is the trigger we all needed to start to move away from traditional peer review.
Brilliant gutsy experiment in challenging the current "publishing" model. Need to figure out how we can support & participate in such an effort. Maybe this is the trigger we all needed to start to move away from traditional peer review.
“We want to benefit from your work and the work of your colleagues for free, but don’t want the community to benefit from our work” 👏 well done @CellPressNews, thanks for demonstrating yet again that (most) publishers are predatory
“We want to benefit from your work and the work of your colleagues for free, but don’t want the community to benefit from our work” 👏 well done @CellPressNews, thanks for demonstrating yet again that (most) publishers are predatory
No particular shade on this editor but this is an anachronistic policy that makes the publisher look petulant, desperate, and painfully out of touch. It’s clear why this is the case but the clock is ticking on how long this can persist
No particular shade on this editor but this is an anachronistic policy that makes the publisher look petulant, desperate, and painfully out of touch. It’s clear why this is the case but the clock is ticking on how long this can persist
Epigenetic age oscillates during the day onlinelibrary.wiley.com/doi/10.1111/ac…
A paper in @NatureAging describes lipids that change with age across ten tissues in mice. Notably, bis(monoacylglycerol)phosphate accumulated with age, and this lipid also accumulated in muscle of older humans and was reduced with exercise. 🔒 go.nature.com/444uvud
🗞️Our April issue is out!🎉 Read about HSC aging, partial reprogramming in the mammalian brain, the STEP trial, ovarian aging and much more nature.com/nataging/volum…
I have created Bioicons - a library of 1632+ free, high quality science illustrations in vector format easily searchable and filterable specifically for the life science community. All icons are under permissive CC0 or CC BY license. ➡️ bioicons.com
What is it in young blood that may help modulate the aging process? It's still unsolved. A new @NatureAging report on small extracellular vesicles that favorably affects mitochondrial function @justsaysinmice
Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism nature.com/articles/s4358…
Targeting aging and age-related diseases with vaccines nature.com/articles/s4358…
Human skeletal muscle aging atlas nature.com/articles/s4358…
Cross-platform proteomics signatures of extreme old age biorxiv.org/content/10.110…
Harvard longevity scientist sparks furor with claim about reversing aging in dogs @MeganMolteni writes @statnews statnews.com/2024/03/05/dav… See my critical review of the study here. pubpeer.com/publications/0… [Spoiler alert: the supplement does NOT reverse aging in dogs]
Two new papers on aging indicate importance of lipid metabolism and the benefit of exercise nature.com/articles/s4358… nature.com/articles/s4358… @NatureAging
🎉 Proud to share our latest paper, in @NatureAging, in which we identified BMPs (the lipids, not the protein) as a class of aging lipids in mice and humans ⬇️ rdcu.be/dEx0f
A lipidome landscape of aging in mice #lipidome #aging nature.com/articles/s4358…
David Sinclair @davidasinclair
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Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition nature.com/articles/s4358…
Online now! Zhi Zhou at ShanghaiTech University and colleagues show that dysregulated phago-/auto- lysosomes in Sertoli cells are a key feature of late-onset hypogonadism (LOH), they can be targeted to alleviate LOH in mice. (rdcu.be/dFu4g) doi.org/10.1038/s43587…
But, we can move the needle slowly and deliberately in the right direction. Doing so requires bringing people together that are interested in de-risking these principles. So if you’re interested in trying things differently, I’d love to know! docs.google.com/forms/d/e/1FAI… (n/n).
The complete manuscript cycle will take place on pubpub.org, where I will respond and revise according to public feedback. In addition, @RauchLab has kindly agreed to serve as editor. She will solicit/curate anonymous peer review that we will append to the manuscript
I opted for PubPub for several reasons: it's a nonprofit with stable funding, completely free and open, enables public feedback directly within the manuscript, and its utility has been demonstrated by @ArcadiaScience.
You might ask: why not submit to a journal? We have too many talented scientists, and too precious little funding, to tolerate the current academic standard of publish-or-perish. We should build an impact-centric nonprofit research culture where we instead publish-and-persist.
Brilliant gutsy experiment in challenging the current "publishing" model. Need to figure out how we can support & participate in such an effort. Maybe this is the trigger we all needed to start to move away from traditional peer review.
The complete manuscript cycle will take place on pubpub.org, where I will respond and revise according to public feedback. In addition, @RauchLab has kindly agreed to serve as editor. She will solicit/curate anonymous peer review that we will append to the manuscript
@DrSalinasLab Just wanted to add that you can always revise your own preprint in your own way! add even more things you might not be able to add in the journal version due to their restrictions making the preprint _more_ valuable instead of just keeping it up-to-peer-review! 🙃
“We want to benefit from your work and the work of your colleagues for free, but don’t want the community to benefit from our work” 👏 well done @CellPressNews, thanks for demonstrating yet again that (most) publishers are predatory
@DrSalinasLab For Cell Press journals, we ask that you don't post the revised versions that reflect editorial work (e.g., revisions made after the peer review process, etc.).
No particular shade on this editor but this is an anachronistic policy that makes the publisher look petulant, desperate, and painfully out of touch. It’s clear why this is the case but the clock is ticking on how long this can persist
@DrSalinasLab For Cell Press journals, we ask that you don't post the revised versions that reflect editorial work (e.g., revisions made after the peer review process, etc.).
A paper in @NatureAging describes lipids that change with age across ten tissues in mice. Notably, bis(monoacylglycerol)phosphate accumulated with age, and this lipid also accumulated in muscle of older humans and was reduced with exercise. 🔒 go.nature.com/444uvud
🗞️Our April issue is out!🎉 Read about HSC aging, partial reprogramming in the mammalian brain, the STEP trial, ovarian aging and much more nature.com/nataging/volum…
"mathematics is not well funded...Grant[s] are tiny by comparison to biomedical sciences...this is why [we] sh[ied] away from APCs" ☝️APCs were never going to work in some disciplines without cross-subsidies. No-one can argue this was unforeseen scholarlykitchen.sspnet.org/2024/04/17/rob…
Online now! Xiaorui Chen, Yang Luo, Qing Zhu, Jingzi Zhang, Huan Huang et al. show that small extracellular vesicles derived from young plasma rejuvenate whole-body physiology in aged mice. (rdcu.be/dEZTc) doi.org/10.1038/s43587…
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𝐎𝐩𝐨𝐫𝐭𝐮𝐧𝐢𝐝𝐚𝐝𝐞 𝐈𝐧𝐜𝐫𝐢́𝐯𝐞𝐥: 𝐃𝐮𝐚𝐬 𝐯𝐚𝐠𝐚𝐬 𝐝𝐨𝐜𝐞𝐧𝐭𝐞𝐬 𝐧𝐨 𝐧𝐨𝐬𝐬𝐨 𝐃𝐞𝐩𝐚𝐫𝐭𝐚𝐦𝐞𝐧𝐭𝐨! Mais informações sobre o Departamento: iq.usp.br/portaliqusp/?q…‐br/bioquimica/apresentacao Edital referente a este concurso: uspdigital.usp.br/gr/admissao
That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.
What is it in young blood that may help modulate the aging process? It's still unsolved. A new @NatureAging report on small extracellular vesicles that favorably affects mitochondrial function @justsaysinmice
Online now! ✨Kedlian, Wang, Liu et al present the Muscle Aging Cell Atlas @teichlab @kedlian @KSaebParsy @bayraktar_lab @humancellatlas @sangerinstitute nature.com/articles/s4358… rdcu.be/dEMas