Hey there #Bioinformatics folks looking for a job, I have an academic PI friend looking to hire bioinfx talent to work on long read (@PacBio Iso-Seq) + other omics. International candidates welcome! no job req yet so for now DM me to be connected. RT appreciated ❤️
.@si_hardwick & team present single-nuclei isoform RNA sequencing (SnISOr-Seq). Their method enables investigation of cell-type-specific splicing patterns & improves understanding of isoform combinations in healthy tissue & in disease: bit.ly/3wNrFvi
Imagine you could sequence one molecule on @PacBio and @nanopore ... you could really tell all the differences on a single-molecule basis, where any discrepancy must be a mistake in one approach: genome.cshlp.org/content/early/…
Led by the incredible Alla M. & Andrey P. @genomeresearch
For the first time in the #covid pandemic, Australia now has more average daily cases than the US. Yet our average daily deaths is only 16, compared to 1,224 for the US 🤔
Amazing work led by postdocs Simon H, Wen H and grad student Anoushka J, with contributions by so many : nature.com/articles/s4158…
Get splicing info out of human brain. TSS-exon, exon-polyA and distant exon pairing rules are more cell-type specific. Adjacent exon pairs less so.
I am beyond thrilled to present our work on single-nuclei isoform sequencing (SnISOr-Seq), now out in Nature Biotech nature.com/articles/s4158…. Thread below ⬇️
Single-nuclei isoform RNA sequencing reveals combination patterns of transcript elements across human brain cell types biorxiv.org/cgi/content/sh…#bioRxiv
Our new work on single-nuclei isoform sequencing is available on biorxiv: biorxiv.org/content/10.110… Led by postdocs @si_hardwick & Wen Hu and PhDstudent @noush_joglekar but with contributions by many. Applied to human PFC and sc splicing, TSS, polyA sites and combination patterns.
Our new preprint is up! We develop and apply a new technique which enables single-nuclei, long-read RNA sequencing in human brain samples (or any frozen, archived, or hard-to-dissociate sample) @hagentilgnerbiorxiv.org/content/10.110…
255,964 #covid19 vaccine doses given yesterday in Australia. Scaled for population, this is the equivalent of ~3.4 million doses in the US, which they were hitting in late March. Not bad Australia, but we can still do much better!
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