saif @psyf01
Cofounder & CTO @ NiaHealth. Making longevity accessible. niahealth.co Toronto, Ontario Joined July 2016-
Tweets2K
-
Followers323
-
Following597
-
Likes56K
I really appreciate how consistently thoughtful Karri has been in posting. It shows in linear.
In grindmaxxing there are a couple of questions inside it. First question is that whether you should do it or not, and to what level. I don’t think there is one right answer because it is situational and plays into the dynamics of the market. Most startups the mode is either
Never noticed because composer 2.5 is THAT good
Opus 4.8 is a very strange model. Clearly Anthropic tried to improve honesty, which is commendable. However, the model's curiosity (already worse in 4.7) degraded further. Result is a judgmental personality + sycophancy + sooo much hedging. Basically the opposite of Opus 3.
Under appreciated
One of the best things you can do for aging parents is to constantly plan things 1-2 years out so they always have something to look forward to. Listen and Learn: youtube.com/watch?v=49Xnp6…
Gone through exact same pattern at Nia. Usually we use something off the shelf to ship fast, run into annoying problems, "k I'll make it myself" Only time we've been burnt bad is when we were convinced of the need to build in-house before the 'hack it together and get signal' phase Different scales and industry ofc, but same pattern! Almost have to "earn the right" to diy
This is fascinating
@morajabi Not really The only time we’ve regretted it is when we’ve done it without being first burned by an existing tool This is just the circle of vertical integration life
The only thing worse than a problem is a guy doing nothing but complaining about it
tort law exam ass case
NEW: Nebraska woman hospitalized after a dog in another vehicle accidentally fired a shotgun at her.
I gotta try this. Novel idea.
This is brilliant. 'I write a paragraph about why I should take a meeting.' If you should take the meeting it's easy to do, but if you start writing and you're like “I don’t want to do this,” then the meeting is a waste of time. "For the things that I think are really
Become the person who makes vague problems concrete, concrete problems tractable, and tractable problems solved.
The best career advice is still brutally simple: become useful in a way that is hard to fake.
delusionmaxx. always always always be optimistic. not gonna fucking make it otherwise.
"it's better to be an optimist and wrong than to be a pessimist and correct"
@scottastevenson I struggle with this one as an amateur builder. Assuming ypu don't have taste, the best thing you can do is ship more and observe. Which means you need to ship faster if you can sustainably do so. What am I missing?
Hard earned lessons
At every level of every profession there are two types of people: 1. Those who got there due to their craft 2. Those who got there due to social mimicry and manoevring Paradoxically, it gets *harder* to tell the difference the higher up you get, because the chameleons get so
“Being able to consistently suffer for long periods is arguably one of the deepest moats”
MrBeast: "If my mental health was a priority I wouldn't be as successful as I am" "I obviously never would have buried myself alive for seven days. There's a reason no one makes videos like me, not even close. Because no one wants to live the life I live" "There were months I'm
Many people just give up when their context window gets overwhelmed. If you can handle large amounts of information coming at you from many directions, it’s actually very rare to be able to deal with that well. You need to wire your brain to do one of two things: 1. Compress context to fit in your window constantly (lossless) 2. Filter and use lossy compression constantly, enabling you to discard a lot of information These are skills that impact the core of how you think and process information. They can be learned but it takes a lot of practice.
This advice is generally right, but for any individual founder the timing of a launch depends on their market: its maturity, dynamics, risk tolerance, and frankly, noise. Today it’s easy to make a professional-looking MVP quickly with AI. That also means people have less time, interest or patience for trying 100 different half-formed products. You need to launch with a point of view. Something that resonates. Then build enough product to prove that point. Where that bar is depends entirely on the company and category. When it’s the last time you’re seen Snap type company being crated? Snap was founded in 2011 when mobile was really taking off. I’d wager most of consumer apps are form that era and we actually hav seen very many attempts but very few breakthroughs.
Michael Seibel, Managing Director at Y Combinator, on why shipping a crappy product in under a month beats building a perfect one for a year: Michael starts with a simple challenge: "Do you remember the day Snapchat launched? Do you remember the day Instagram launched? Do you
jerica @jerica_kuah
312 Followers 237 Following founder @ jlrobotics | building autonomous underwater robots for subsea infrastructure 🐠
نوف | Nouf @Nouf0633
69K Followers 59K Following أسأل الله أن لا يحرمني ولا يحرمكم :رزقه ، وتوفيقه ، ورحمته ، ومغفرته ، ورضوانه ،وجنته ، وصحبة نبيه ﷺ ،...
Nancy W @HandanMoglu
17 Followers 772 Following emotional jukebox & follow back machine 🎶 100% follow back
Rehoboth Adam. @reowrites00
511 Followers 418 Following Ghostwriter/ I help AI and SaaS founders execute distribution faster/ helped took a biz → 7 figures. https://t.co/QSAVKUVdYE
Camilla @SpheraTimes
2K Followers 1K Following https://t.co/DsGtkvpMfY turn service vendors into enterprise partners. 40+ clients, Est. 2023. Partner & business development @Durindal_US
Muskan Bhardwaj @bhardwajmskn
819 Followers 2K Following Sports 🏸| Travel 🛫 | Fashion 👜 💌 : Email for Work Inquiries 📍 🇨🇦
Shea Balish @SheaBalish
793 Followers 3K Following Once introduced as “defender of the null hypothesis”. Building: @curv_ai Writing: @deepdebates
Bigyan Karki @bgyankarki
782 Followers 3K Following Building world's first agentic workspace @thedriveAI Past: @UAlberta @AmiiThinks
Takeshi @Takeshi49812797
0 Followers 36 Following
sahand @sahand_io
120 Followers 147 Following CEO at @pingram_io | Trigger-Ready Messaging Stack (Emails, SMS, Voice)
Raza News Pulse @MohdR88491
62 Followers 218 Following Allah सबसे बड़ा है 👆🏻Love my India 🇮🇳सारे जहाँ से अच्छा हिन्दोस्ताँ हमारा हम बुलबुलें हैं इस की ये गुलसिताँ हमारा🇮🇳
irfan sharif @irfansharifm
473 Followers 585 Following father figure. previously @modal, @cockroachdb
malliha @Mallihafatima
45 Followers 748 Following
Ralph Sadowski @RalphSadowski
149 Followers 826 Following - dad first. Nerd second. - love tech & creative destruction - building something new 🚀 - publishing mental models weekly.
turja🕺 @tchowd_
2K Followers 925 Following building - https://t.co/idxLhCkmk1 @ycombinator @535toronto alum 🇨🇦
shane ☯︎ @shanebarakat_
1K Followers 618 Following co-founder @polarityco prev. shopify, uwaterloo | 🇨🇦
Elmo Hills @ElmoHills50154
124 Followers 5K Following
Dhruv Bhatia | Bootst... @north_star_says
2K Followers 1K Following Product Leader, 2x Founder Building AI Agents and SaaS tools💪
Ted Nyman @tnm
6K Followers 553 Following computers at openai. prev ceo at cased, cto github, eng banksimple. https://t.co/ppNMfi1g3i. "sf’s guardian angel"-ken jennings
Kallie Haag @HaagKallie61314
128 Followers 5K Following
- - @yingyangwins
4K Followers 3K Following
Oliva Teichmiller @OTeichmill52384
2 Followers 83 Following
salehdigital @saleh_digital
2K Followers 1K Following design guy @falcongx_ • prev @roblox @teamguilded
Wilson Ler @LerWilson
406 Followers 415 Following Founder @ jlrobotics | Engineer at heart, building autonomous underwater drones for subsea infra 🌊
Eric Angelo @ricangelooo
4K Followers 4K Following Designer - Running @calyptuswork Clients include @polyester @zellifyapp @tryprofound @zipper_trade @robinmarketsxyz @typedreamhq & more
Adam Hassan @adamislucky
3K Followers 1K Following Angel investor. SMB operator. B2B and public sector sales, strategy, and operations. There is no Adam Fund.
Eric Muellejans @EricMuellejans
291 Followers 617 Following HealthTech By Day // Community Catalyst by Night (he/il/他) Building in the 🧠 Analytics space
denzell @cdxker
905 Followers 785 Following chief shipping officer @mintlify (prev Trieve acq. W24).
Daryna Kulya @darynakulya
5K Followers 1K Following Co-Founder @gowithquo (fka OpenPhone) 🇺🇦🇨🇦 in SF. Sharing my company building journey - https://t.co/FEUfv8ogmY
Arvind @arvinddotdev
267 Followers 580 Following 22 | ai engineer @mudstack (a16z) | contributor adding features @kubernetes oss | busy shipping projects and reading papers | agents are cool, ig?
Andrew D'Souza @andrewdsouza
15K Followers 8K Following founder / mad scientist @boardyai | founder @getclearco
Kyriakos Eleftheriou @kyriakosel
3K Followers 474 Following Weight lifter, ex-Special Forces and CEO @TerraAPI
Chris Thomson @chris24
2K Followers 1K Following developer at @workwithpage / previously @wealthsimple @shopify @uwaterloo
faizan khan @faizan10114
873 Followers 3K Following https://t.co/JhJCxe3bHV (agent facing docs on auto-pilot) 24/7 support https://t.co/hGdYjU2sdK @sirdocsalot
BD Hoang @BDHoang_
970 Followers 4K Following Working 5-9 to quit my 9-5. 9-5: Finance @ FAANG 5-9: Vibe Coding with AI. Run an AI Accounting Firm. Husband. Dad. Cooking something new (launching in May'26)
Robert Scoble @Scobleizer
585K Followers 50K Following San Francisco/Silicon Valley AI | Robots, holodecks, BCIs, analysis of new things | Ex-Microsoft, Rackspace, Fast Company | Wrote eight books about the future.
SheilaAlice @AWBuW0Bj59ocODc
3 Followers 205 Following
jerica @jerica_kuah
312 Followers 237 Following founder @ jlrobotics | building autonomous underwater robots for subsea infrastructure 🐠
Counsel Health @CounselHealth
725 Followers 16 Following The modern front door to healthcare. AI meets real doctors for instant, personalized, and safe medical guidance—anytime, anywhere.
Socket @SocketSecurity
21K Followers 5K Following Socket is the #1 software supply chain security platform. Next-gen SCA + SBOM + 0-day prevention. LOVED BY DEVELOPERS. 👀 @npm_malware
Refero @referodesign
4K Followers 190 Following Design research for humans and AI. Real product screens, flows, and patterns to help teams and AI make better design decisions.
Mike Bespalov @bbssppllvv
13K Followers 463 Following Making AI design not suck. Founder of @referodesign (250K+ users). Ex- @clerk
npj Digital Medicine @npjDigitalMed
4K Followers 1K Following Open access @NaturePortfolio journal for the #DigitalMedicine community, publishing research, reviews & comments. Tag us & tweet your work with @npjDigitalMed.
Dr. Ribu Thomas PT, D... @Ribu18
204 Followers 685 Following 🔥 Anaplastic Thyroid Cancer Survivor | 🏃♂️ Physical Therapist | 👨👧👦 Father || ⛳ Late to Golf, Suck At It!
Frontier Systems @CS153Systems
4K Followers 13 Following Field notes from the people building the future.
Maziyar PANAHI @MaziyarPanahi
18K Followers 331 Following Building @OpenMed_AI · 3,500+ open-source medical models · #1 on HuggingFace Daily Papers · Shipping OpenMed Agent today: Terminal-native AI for Healthcare
OpenMed @OpenMed_AI
5K Followers 7 Following Open-Source AI Agents for Healthcare & Life Sciences · Now shipping OpenMed Agent: Terminal-native AI for Healthcare
Daniel Lemire @lemire
36K Followers 2K Following Software performance expert. Ranked in the top 2% of scientists globally (Stanford/Elsevier 2025) and among GitHub's top 1000 developers. Father, husband.
vittorio @IterIntellectus
201K Followers 2K Following practice expert “unique online personality” former TPOT thinker (exiled) professional shitpoaster @SpaceX don't take me seriously
Andrea D. Huberwoman,... @thegenesisbl0ck
35K Followers 2K Following ZKPs. Crypto Maxi. Esoteric & Existential. Biohacker. Accelerated. Milfmaxxing.
Paul Bakaus @pbakaus
17K Followers 782 Following Renaissance geek (creativity × culture × tech). Product engineer before it was cool. Made @impeccable_ai, @radiant_shaders, @jqueryui | x-@google, @zynga
Matt Biilmann @biilmann
13K Followers 4K Following CEO and Co-founder of Netlify. Builder of things, coiner of terms.
Saurabh Suri @surim0n
4K Followers 1K Following helping people build ai native companies @redbricklabs_ @buildfutureto
Worklayer @worklayer
305 Followers 1 Following Make any agent (Codex, Claude, Hermes, etc.) faster and cheaper to use. Worklayer is an SSO App vault that lets your agents run all your apps in code-mode.
sahand @sahand_io
120 Followers 147 Following CEO at @pingram_io | Trigger-Ready Messaging Stack (Emails, SMS, Voice)
NUS @NUSingapore
69K Followers 100 Following The National University of Singapore is Asia’s leading university with a global approach in education, research and service. (RT, links and likes ≠ endorsement)
Akiff Premjee, MD @akiffpremjee
2K Followers 2K Following Internal Medicine physician interested in healthcare, technology, and creative pursuits. Ex-data @oscarhealth and @dropbox
Sam Rawal, MD @samarthrawal
2K Followers 222 Following MD + Computer Science, working on Clinical AI. Internal Med Resident @MayoClinic. // MD @ILLINOISmed; CS @ASU.
gluestack @gluestack
4K Followers 53 Following Tailwind / NativeWind Components & Patterns for React & React Native: https://t.co/4m2Q05tUw8 • "shadcn of React Native" - anonymous • Built with ❤️ by @geekyants
Sazabi @sazabi
681 Followers 1 Following The AI-native observability platform for fast-moving engineering teams. 🌐 https://t.co/b024pkd0uo ⭐️ https://t.co/9e5v3a98Kj 🎥 https://t.co/F2pMKibeL7
Bento @Bento
5K Followers 366 Following Meet the email sending platform for modern teams. Streamline campaigns, automations, and customer journeys with less effort.
David Senra @davidsenra
123K Followers 101 Following Conversations with the greatest living founders.
Stitch by Google @stitchbygoogle
161K Followers 6 Following Stitch by @GoogleLabs turns your ideas into beautiful interface designs, powered by some of the latest Gemini models. Try free of charge.
Karri Saarinen @karrisaarinen
88K Followers 1K Following ceo of @linear 🇫🇮🇺🇸 previously: @coinbase @airbnb, YC alumni
Malte Ubl @cramforce
48K Followers 905 Following Self-driving infrastructure @Vercel CTO. Immigrant 🇺🇸/🇩🇪/acc
Lenny Rachitsky @lennysan
368K Followers 3K Following Deeply researched product, growth, and career advice
Descript @descript
31K Followers 245 Following If you can edit text, you can make videos, podcasts, and clips. And Descript's AI makes it fast and easy.
turja🕺 @tchowd_
2K Followers 925 Following building - https://t.co/idxLhCkmk1 @ycombinator @535toronto alum 🇨🇦
Oasis @oasishealthapp
69K Followers 61 Following The world’s trusted health layer. Science-backed lab testing revealing what’s actually healthy
irfan sharif @irfansharifm
473 Followers 585 Following father figure. previously @modal, @cockroachdb
Patrick McKenzie @patio11
195K Followers 807 Following I work for the Internet and am an advisor to @stripe. These are my personal opinions unless otherwise noted.
Delve @getdelve
6K Followers 51 Following Compliance in days, security that lasts. AI-native compliance trusted by 500+ of the fastest-growing companies.
Olive Song @olive_jy_song
1K Followers 140 Following I study RL & Evals @MiniMax_AI · Alum @NYU_Courant · Dig deep; Collaborate openly; Make things happen.
Lucy Hargreaves @lucyhargreaves4
6K Followers 2K Following canada should be the richest country in the world. i write about what's stopping it. ceo @build_canada · @canada_spends
shane ☯︎ @shanebarakat_
1K Followers 618 Following co-founder @polarityco prev. shopify, uwaterloo | 🇨🇦
Every 📧 @every
51K Followers 82 Following The only subscription you need to stay at the edge of AI. Ideas and apps: @TrySpiral @CoraComputer @SparkleApp @usemonologue
Bob Kallonen @BobKallonen
155 Followers 555 Following



































