Owen Hale @owenmicro
Grad student in @megbehri's lab studying the ecology, evolution, and health impacts of the human microbiome. GT alum 🐝 owenfhale.github.io Nashville, TN Joined April 2022-
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The Behringer Lab at Vanderbilt is looking to hire a research assistant! A great position for trainees interested in microbiology, evolution, & genetics while gaining experience in anaerobic cell culture, experimental evolution, & genome editing. Details at quote tweet below! ⬇️
The Behringer Lab at Vanderbilt is looking to hire a research assistant! A great position for trainees interested in microbiology, evolution, & genetics while gaining experience in anaerobic cell culture, experimental evolution, & genome editing. Details at quote tweet below! ⬇️ https://t.co/fv5jZH9gve
Hot off the presses! 📰📰 E. coli evolution in repeated 100-day Feast/Famine cycles is out in @CurrentBiology! We see high mutational order, extreme parallelism (nucleotide level!), & early mutations can ⬆️ fitness simultaneously for growth & survival! doi.org/10.1016/j.cub.…
Preprint Alert! 🚨🚨🚨 Exciting collaboration between my group, @MarcBoudvillain’s group and @bpbratton! From populations experimentally evolved to extreme feast/famine cycles, we find pH-sensing rho alleles that confer pH-dependent plasticity in transcription termination!
Preprint Alert! 🚨🚨🚨 Exciting collaboration between my group, @MarcBoudvillain’s group and @bpbratton! From populations experimentally evolved to extreme feast/famine cycles, we find pH-sensing rho alleles that confer pH-dependent plasticity in transcription termination! https://t.co/ibjjEISWlH
Honored that our work was awarded the Zuckerkandl Prize by @JMolEvo. This was a terrific effort by Postdoc @sb_worthan and former undergraduate Robby McCarthy! A must read for anyone who performs lab cell culture, is interested in plasticity, or collects fitness measurements!
Honored that our work was awarded the Zuckerkandl Prize by @JMolEvo. This was a terrific effort by Postdoc @sb_worthan and former undergraduate Robby McCarthy! A must read for anyone who performs lab cell culture, is interested in plasticity, or collects fitness measurements!
Good Morning! I’m excited to share our study in #mbio led by PhD candidate @StarlCone investigating 6mA evolution in E. coli! 🥳🧫🧬 Carl developed an R package (CoMMA) for differential methylation analysis of 6mA, so you can analyze differential 6mA too! journals.asm.org/doi/10.1128/mb…
August is already off to a strong start for the lab! Great presentations by postdoc @sb_worthan and Ph.D student @owenmicro at their respective GRCs! 🙌 Awesome poster by summer undergrad Briana Harness! 👏🧫🩺 Now, a ESI-MIRA NOA to start the fall semester!! 💪🥳🥳
Great day at the @VI4Research Symposium. Oven Hale (@owenmicro), a Ph. D. Student in our lab, got to share his research conducting mutation studies in Lactic Acid Bacteria.
👇Check out our most recent paper!
New #preprint from our lab! Here, PhD student @StarlCone has developed an R package (CoMMA) to annotate and identify differential 6mA methylation in microbes from Nanopore data. With CoMMA he observes relaxed selection on 6mA in Exp. evolved E.coli clones without mismatch repair.
New #preprint from our lab! Here, PhD student @StarlCone has developed an R package (CoMMA) to annotate and identify differential 6mA methylation in microbes from Nanopore data. With CoMMA he observes relaxed selection on 6mA in Exp. evolved E.coli clones without mismatch repair. https://t.co/3c7ZNfhHM0
Happy to share that a preprint is up for my 1st 1st-author publication! I wrote an R package for analyzing 6mA methylation in bacteria with Nanopore data. 6mA is dynamic! Less methylation around promoters, breakdown in 6mA over time w/o MMR. All the hits inside the paper!
Happy to share that a preprint is up for my 1st 1st-author publication! I wrote an R package for analyzing 6mA methylation in bacteria with Nanopore data. 6mA is dynamic! Less methylation around promoters, breakdown in 6mA over time w/o MMR. All the hits inside the paper!
Congrats to prof Donegan @rebeccadonegan @Barnard_Chem for the nice work showing that heme scavenged by the pathogen M. Tuberculosis is not nearly as bioavailable as heme that the bug makes. Her work suggests targeting heme synthesis may be an effective strategy to combat TB
Congrats to prof Donegan @rebeccadonegan @Barnard_Chem for the nice work showing that heme scavenged by the pathogen M. Tuberculosis is not nearly as bioavailable as heme that the bug makes. Her work suggests targeting heme synthesis may be an effective strategy to combat TB
New paper alert! @AReddiLab and colleagues describe differential use of exogenous and endogenous heme by M. tuberculosis in this offering. journals.asm.org/doi/pdf/10.112…
I am so proud to have the first major report of our #rUTI #metagenomics studies of the postmenopausal #urobiome published today in @CellRepMed #OpenAccess. Here's a quick summary of what we found in this @NIDDKgov and @WelchFoundation funded study. 1/7 cell.com/cell-reports-m…
So happy to finally make a thorough post about our new study with @wchoEvo, Complex Ecotype Dynamics Evolve in Response to Fluctuating Resources in @mbiojournal! (1/n) doi.org/10.1128/mbio.0…
So proud of @StarlCone! Did an amazing job at his quals today and is now a PhD candidate!!! Big day for the Behringer lab, our first grad student is now our first candidate! More good things to come! @VUGradSchool @VU_ASM @VandyBioGrad
4) We are also welcoming a new graduate student to the group, Owen Hale (@owenmicro)! Owen’s interests are metagenomics, evolution, and the microbiome. So stay tuned for great things from him!
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First paper of my postdoc out now in @PNASNews! 🧵 doi.org/10.1073/pnas.2…
BIG DAY
How stable are bacterial genomes as they adapt to an environment? My collaboration with @anuraglimdi, @EvolSys, @RELenski, and @ten_olivier exploring this over 50,000 generations of evolution is out today! 1/ science.org/doi/10.1126/sc…
We're excited to announce the winner of the 2023 Zuckerkandl prize, given to the top paper in JME in the calendar year: “Case Studies in Microbial Fitness: Seemingly Subtle Changes Can Have Major Effects on Phenotypic Outcomes”, by @sb_worthan, Robert McCarthy, and @megbehri!
We have the 3x National Champion Women’s Bowling Team, thank you very much. 😤
Vandy catching an absolute heater on their day off. 🥵
Great year for the Behringer Lab: Three pubs led by or featuring postdoc, grad, & undergrad researchers. Graduated 4 amazing undergrads who helped open the lab. Awesome talks & posters by @sb_worthan & @owenmicro at their GRCs, & a MIRA to fund our science! Onward to 2024! 🧫
Cracking up over my groups submission for the BioSci Department Lab Door Decorating Contest. They did the E. coli K-12 Days of Christmas and it looks great! Ph.D. Student William McLaughlin is a cartoonist and he did all the E. coli on our tree! 🎄🧫🧪🎅🏻
The @Isala_UAntwerp project’s empowered new insights into the vaginal microbiome and women’s health @NatureMicrobiol - @S_Ahannach @S_Wittouck @thiesgehrmann @ERC_Research, @FWOVlaanderen funding nature.com/articles/s4156…
My review “Targeting hedgehog-driven mechanisms of drug-resistant cancer” is officially published! My first publication ever 🤸♀️ @JulieRhoadesLab frontiersin.org/articles/10.33…
Good Morning! I’m excited to share our study in #mbio led by PhD candidate @StarlCone investigating 6mA evolution in E. coli! 🥳🧫🧬 Carl developed an R package (CoMMA) for differential methylation analysis of 6mA, so you can analyze differential 6mA too! journals.asm.org/doi/10.1128/mb…
Me leading the seminar speaker to their next meeting in Medical Center North:
Excited to announce my very first preprint, representing my first project as a @RokasLab postdoc! Explainer thread below 🧵 biorxiv.org/content/10.110…
Byndloss and @Wenhan_Zhu1 labs celebrating TWO papers being accepted the same week! Congrats Luisella + Ryan (paper #1 from Zhu lab) and @catie_shelton (paper #2 from Byndloss lab). Stay tuned for some for some cool #microbiome papers coming out soon. 😊
First paper from the lab and also an amazing paper from the @Mari_Byndloss lab! It is so wonderful to have amazing collaborators like @Mari_Byndloss @EricSkaar @EricCMartens1 @ChazinWalter @ZhongyueY ! Stay tuned for more details!
Byndloss and @Wenhan_Zhu1 labs celebrating TWO papers being accepted the same week! Congrats Luisella + Ryan (paper #1 from Zhu lab) and @catie_shelton (paper #2 from Byndloss lab). Stay tuned for some for some cool #microbiome papers coming out soon. 😊
The Mike lab’s first research article is out in @mSphereJ! journals.asm.org/doi/10.1128/ms… This was a great team effort with @microbioSaroj and @RingBrooke leading the way. #klebclub #newPI
bonus picture with Beauregard the Alaskan brown bear
I am immensely honored to be part of the 2023 cohort! Thank you @pewtrusts for this incredible opportunity to advance the research we are passionate about, and grateful for the amazing support from @VI4Research @VUMCResearch @EricSkaar @Mari_Byndloss.
🎉Congrats to our 2023 biomedical scholars and fellows! These 37 early-career scientists are embarking on innovative research projects in neuroscience, microbiology, cancer research, and more. pew.org/3X1DwAU
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