canhumansbeoptimised @optimizehuman

@QuoteJung Most work isn’t meant to be noticed. If it holds, it doesn’t need noise. Recognition is rare because understanding is rare.

@joeroganhq That would be an awesome job for the Boring Company... tunneling under the Giza pyramids? 🚀@elonmusk

🧠 A 2024 study found that 25-30g of creatine (roughly 0.35g/kg body weight) counteracts 21 (even up to 36) hours of sleep deprivation, boosting cognitive processing speed and memory by acting as an emergency brain energy buffer. This challenges the assumption that sleep is the only way to recover brain energy, suggesting metabolic supplementation can directly replenish ATP and override fatigue-related cognitive decline. 🗂️Mechanisms of Action: 📑Rapid ATP Regeneration: When the brain is sleep-deprived, it runs out of ATP (Adenosine Triphosphate - the primary energy currency needed for neurons to function). Creatine donations of phosphate groups regenerate ATP, which sustains neuronal function and improves cognitive speed and working memory, even when the brain is under severe metabolic stress. 📑Rapid Brain Uptake: While it was previously thought that creatine takes weeks to affect the brain, new research shows that single, high-dose of creatine can significantly increase brain creatine levels within hours. 📑Mitigating Metabolic Dysfunction: Studies shows that a single 25-30g dose can completely negate cognitive deficits, such as slowed reaction time and reduced executive function, caused by 21-36 hours of sleep deprivation. 📑Buffer for Mental Fatigue: Creatine acts as an “energy safety net”, supporting brain energy metabolism and reducing the mental fog, poor focus, and reduced processing speed that accompany fatigue. 📑Results: “Better than rested performance”. The research indicates that this high-dose strategy can not only reverse the negative effects of poor sleep, but in some cases, make individuals perform better than they would have without the supplement and with proper sleep, including improved memory, faster processing and better focus. PMID: 38418482

@dr_ericberg Removing urgency. Doing fewer things. At a steady pace. Whether I felt like it or not. Most improvements came from what I stopped reacting to, not what I added.

@QuoteJung Epictetus said we have two ears and one mouth for a reason. Judgment is fast. Understanding takes effort.

🧠 What Two Hours of Silence Can Do to Your Brain Will Shock You… You won’t believe this—but the quietest moments of your day could be secretly building a stronger, sharper brain. Scientists gave mice just two hours of silence every day, and something incredible happened: their memory center—the hippocampus—started growing new brain cells. Not music. Not white noise. Just silence. After a week, the mice in silence had more lasting brain growth than any that listened to music or other sounds. Imagine what this could mean if humans took even a few minutes every day to truly unplug. Sometimes, the most powerful “soundtrack” isn’t a song at all. It’s the stillness you’ve been ignoring. The moments when the world goes quiet might be doing more for your brain than you ever thought possible. 🔥 Could the secret to a sharper mind really be… nothing at all?

@dr_ericberg Quiet movement or deliberate stillness. A walk without audio. A few minutes without input.

@dr_ericberg 100%. Protein keeps blood sugar stable, no spike and crash like you get with carbs alone. Makes a huge difference for sustained energy.

@davidasinclair This is huge for aging research. Biomarker endpoints mean we can finally iterate quickly on longevity interventions instead of waiting 50 years for results. The science is accelerating.

@QuoteJung Imagination is not escape from reality. It is rehearsal for it. Without play, thought hardens too early, and nothing new can take shape.

@Rainmaker1973 The number matters less than the insight. Perception isn’t five inputs added together. It’s a continuous negotiation between body, brain, and environment. We don’t experience the world as it is, but as a coordinated construction. And this is amazing.

Think you only have five senses? This study says you may have 33. We all grew up believing humans have just five senses: sight, hearing, smell, taste, and touch. But modern neuroscience reveals a much richer reality, suggesting that we actually possess between 22 and 33 interacting senses that constantly collaborate to shape our perception of the world. Beyond the classic five, we rely on proprioception to know the position of our limbs and body in space, the vestibular system to maintain balance and orientation, and interoception to monitor internal states such as hunger, thirst, heartbeat, or the urge to breathe. We also experience a sense of agency—the feeling that we are the ones initiating our own actions—and a sense of body ownership, the conviction that our limbs and body belong to us. Both of these can be disrupted after strokes or in certain neurological conditions. Even the traditional senses are more complex than they appear. Touch actually includes separate channels for pain, temperature, itch, pressure, and vibration, while taste is largely a composite experience created by combining true taste (sweet, salty, sour, bitter, umami) with smell and touch to produce what we perceive as flavor. Because our senses are so deeply interconnected, input from one can profoundly influence another. For example, the scent of shampoo can make hair feel silkier, and added aromas in low-fat yogurt can trick the brain into perceiving it as creamier without any extra fat. In noisy airplane cabins, background engine noise suppresses sweet, salty, and sour tastes while enhancing savory umami flavors, which is why tomato juice and other umami-rich foods often taste surprisingly good at altitude. During takeoff or climb, the vestibular system signals that the body is tilting backward, causing the cabin to visually appear slanted even though it remains level. These cross-sensory illusions and interactions—explored in cutting-edge research and interactive exhibits like “Senses Unwrapped”—demonstrate that human perception is not a simple sum of five independent channels, but a rich, dynamic negotiation among dozens of senses working together. [Smith, B. (2026). You Don’t Have Just Five Senses – New Research Suggests Humans May Have up to 33. SciTechDaily (January 18, 2026)]

After writing about silence, I noticed something simple. Silence does not announce itself. It does not arrive with fanfare, insight, or sudden relief. Most days, it passes almost unnoticed. A few minutes without input. A pause before replying. A decision made with one notch less urgency. Nothing dramatic changes on the surface. No fireworks. No epiphany montage. But something subtle does shift. The mind stops performing for an audience of one. Attention stops splintering in a dozen directions. What remains feels ordinary… yet strangely steadier. Silence does not “improve” life in the productivity-hack sense. It does not add features or optimize output. It quietly restores proportion. The small becomes small again. The urgent reveals itself as merely loud. The important remembers its own weight. And that—over months, not moments—may be enough. What small silences have you let in lately? Even five minutes count.

@Rainmaker1973 An amazing signal. Rare. Most compounds never touch aging pathways at all. This one does at the cellular and organism level. Still worth paying attention to.

Psilocybin made human cells live 50% longer. A new study has uncovered surprising anti-aging potential in psilocin—the active metabolite produced when the body breaks down psilocybin, the psychoactive compound found in magic mushrooms. In laboratory experiments, researchers exposed two human cell lines (skin fibroblasts and fetal lung fibroblasts) to a 100 μM concentration of psilocin. The results were striking: lung cells took 57% longer to reach replicative senescence (the point at which cells permanently stop dividing and accumulate damage), while skin fibroblasts extended their replicative lifespan by 51%. These findings suggest psilocin may slow fundamental cellular aging processes, possibly by lowering oxidative stress, enhancing DNA-repair pathways, supporting mitochondrial health, or dampening chronic inflammation—mechanisms that overlap with those targeted by leading experimental longevity drugs. The benefits extended beyond cell culture. In aged female mice (19 months old at the start, equivalent to approximately 60–65 human years), a single monthly dose of psilocybin dramatically improved outcomes. After 10 months of treatment, 80% of the psilocybin-treated animals remained alive, compared with only 50% of untreated controls. Treated mice also displayed markedly fewer visible signs of aging, including reduced fur loss and graying. This research marks the first direct demonstration that psilocybin/psilocin can influence biological aging itself, rather than solely producing psychological effects. The authors emphasize that the study used relatively conservative dosing and are now advocating for follow-up work with higher or more frequent administration, detailed assessments of immune, metabolic, and cognitive function, and investigations into whether the extended lifespan corresponds to genuine improvements in healthspan and quality of life. ["Psilocybin treatment extends cellular lifespan and improves survival of aged mice." npj Aging, 2025]

I believe that Camus is not calling for noise or defiance for its own sake. He is pointing to an inner freedom that cannot be granted or taken away. When a person governs their values, judgments, and actions, they no longer move in step with an unfree world. That quiet refusal is the rebellion.

@DeepPsycho_HQ Solitude isn’t about being above others. It’s about learning to stand without them.