Jen Carole, Justice Advocate @jcarole

Jared Kushner, childhood family friend of Israeli Prime Minister Benjamin Netanyahu, Marries Donald Trump's daughter and now he gets to sabotage peace talks with Israel's enemies. Pretty convenient if you ask me!

You now what did have a cut in it that was caused by some sort of ‘vandalism’? The rotor blade of the rental helicopter carrying Trump’s casino executives back from a press conference he summoned them to in NYC in 1989. They all died and mystery was never solved.

These are bribes. The Trump administration has been selling pardons. This is, by far, the most corrupt administration ever.

FactPost @factpostnews

10 hours ago

Trump's DOJ has killed a criminal investigation into Trump's pardon of David Gentile, a private equity executive convicted in a $1.6 billion fraud scheme. Gentile had discussed making payments of over $2.5 million to Trump allies to help facilitate the pardon.

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🚨 DETAILS: Karmelo Anthony has hired a powerful legal team to appeal his murder conviction tmz.com/2026/06/22/kar…

Epstein 2.0

@OlenaRohoza So who is gonna fall out of a window now?

DC Circuit will REHEAR EN BANC the case involving Judge Boasberg's attempt to investigate possible criminal contempt by DOJ and DHS in sending 137 Venezuelans to CECOT in apparent violation of his order. Oral argument 9/29. storage.courtlistener.com/recap/gov.usco…

If adults ever get power again, Tulsi Gabbard must be charged for espionage, fraud, perjury & possibly treason. Her ENTIRE CAREER has been a fraud. Every oath she took, every document she signed, everything was a lie. The media figured it out too late—but justice must be done.

Jim Stewartson, Decelerationist 🇨🇦🇺🇦🇺🇸 @jimstewartson

a day ago

Cult leader Chris Butler to Tulsi Gabbard: “no one gives a shit what you think…” This is a great story, timed perfectly so that it doesn’t matter. Who knew? 😒 washingtonpost.com/investigations…

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@LordOfSatyrs @maniaUFO 👏🏼 👏🏼 👏🏼 👏🏼 👏🏼

@maniaUFO Look muggles. Get back to work. Nothing to see here.

OOF: The plaintiffs who unsuccessfully sued trying to stop Trump from renovating the Reflecting Pool have just uncorked a scathing update to the judge "This is the foreseeable result of defendants’ decision to bypass the consultative process required by law and which must occur before the government can alter our nation’s most sacred spaces" "It should go without saying, Congress required agencies to consult with experts and public before making changes to historic properties for a reason. The public is now witnessing what happens when, instead, agencies barrel ahead with ill-conceived plans in a hasty manner to meet an arbitrary deadline imposed by the White House"

Women are using AI to put burkas on men and I'm rolling. Muslim men in the comments, not so much.

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I am deeply alarmed by the detention of Sama Safi in an Israeli prison. Sama, a 20-year-old Palestinian American student, was taken from her home in the middle of the night and continues to be held without charges. This is part of a disturbing pattern of the Israeli government denying Palestinians their basic due process rights, often at risk to their health and safety. The United States has a responsibility to protect its citizens abroad, and we must hold our allies to basic standards of equal justice under the law. I am urging Secretary Rubio and the Trump Administration to use every diplomatic tool available to bring Sama home safely.

Texas has begun setting a $50 limit on Gasoline purchases due to the Hormuz crisis. Gas is nearing $5 a gallon.

How will Ireland cope with this heatwave 😂

I'm a cardiologist. NPR reported this morning on something that could save more lives than any drug I've ever prescribed. One blood test. One vial. Screening for 50 different cancers simultaneously. It's called Galleri. And the FDA could approve it later this year. Right now, we routinely screen for exactly five cancers in the United States — breast, colon, cervical, prostate, and lung. Each requires its own separate scan or exam. For the rest — pancreatic cancer, ovarian cancer, liver cancer, esophageal cancer, gastric cancer, and dozens more — we have no routine screening at all. We find them when symptoms appear. By then, most are Stage 3 or 4. By then, for many patients, it's too late. Pancreatic cancer has a 12% five-year survival rate — because we almost always catch it late. Ovarian cancer: 50%. Liver cancer: 21%. These numbers aren't medical failures. They're detection failures. The treatments exist. We just find the disease after the window for those treatments has closed. Galleri changes the math entirely. Here's how it works. Every tumor — no matter where it is in your body — sheds tiny fragments of DNA into your bloodstream as cancer cells die and divide. These fragments carry specific methylation patterns — chemical signatures that are unique to cancer cells and different from the DNA your healthy cells release. Galleri captures these fragments from a standard blood draw and reads their methylation patterns using next-generation sequencing and AI-driven analysis. The AI doesn't just detect whether cancer is present. It predicts where it's coming from — which organ, which tissue type — with over 90% accuracy in studies. One vial of blood tells your doctor: there's a cancer signal, and it's likely originating in your pancreas, or your lung, or your liver. Your physician then orders targeted follow-up imaging to confirm or rule out the finding. Galleri isn't a diagnosis. It's a precision compass that tells your doctor exactly where to look. The data is building fast. GRAIL has now sold over 475,000 Galleri tests commercially under a special FDA designation. The NHS-Galleri trial — the largest randomized controlled trial of any multi-cancer detection test in history — enrolled over 142,000 people aged 50-77 in England. The primary endpoint — an overall reduction in late-stage cancers — was not met. But by the third year of annual screening, they found a 26% reduction in Stage IV cancers in key deadly types including pancreatic, liver, lung, and gastric. The test detected four times more cancers overall when added to standard screening — catching cancers that would otherwise have been found late or not at all. The U.S. Pathfinder 2 study — 25,490 participants — showed similar positive signals and forms the basis of the FDA submission filed in January 2026. Congress has already acted. The Nancy Gardner Sewell Medicare Multi-Cancer Early Detection Screening Coverage Act passed in February. If the FDA approves Galleri, Medicare will begin covering one test per year starting in 2028. The current retail price is $950. Exact Sciences' competing test Cancerguard is $659. These prices will fall dramatically once FDA approval triggers insurance coverage and competition scales. As a cardiologist, let me tell you why this matters far beyond oncology. Cancer is now the number one killer of Americans over 50. Not heart disease. Cancer. And the patients I lose to cancer are often the same patients whose hearts I saved — patients who survived their cardiac event, optimized their metabolic health, and then received a late-stage cancer diagnosis that nobody screened for because no screening tool existed. I've written on this platform about GLP-1 drugs reducing cancer metastasis by up to 50%. About personalized mRNA cancer vaccines cutting recurrence by 49%. About inflammation as the common root of heart disease and cancer. About AI detecting disease years before symptoms. Galleri is the missing piece that connects all of it. Detect the cancer early — with a blood test. Confirm it with AI-enhanced imaging. Treat it with personalized mRNA vaccines, targeted therapy, and GLP-1 drugs that may slow progression. Monitor response with liquid biopsy in real time. That's not five separate breakthroughs. That's one integrated system of cancer prevention and treatment that didn't exist five years ago — and could be standard of care within five more. The shift from reactive to proactive medicine — from "we found it too late" to "we caught it in time" — has been the central theme of everything I've written on this platform. Preventive cardiology. Advanced lipid testing. Inflammation detection. AI imaging. Gene editing. Galleri applies the same principle to cancer. And it could save more lives than all of them combined. One blood test. Fifty cancers. FDA decision expected this year. Prevention is the new cure. And the science just took its biggest step yet. open.substack.com/pub/afshine/p/…

@MurphMixer_X @MoMohler BAZINGA

Pete Hegseth can ignore the experts. He can ignore the history. He can ignore the generals who mandated this shot through Democratic AND Republican administrations. But the flu doesn't read his memos. And it just sent the bill. P.S. One trainee is dead. The cause is still under review. The timing is not.

JUST IN: Judge rules Workday must face claims that its AI hiring tools discriminated against disabled applicants, Black job seekers, women, & people over 40.

Today I signed an Executive Order for every worker exposed to extreme heat on the job. It requires multilingual heat safety guidance for workers, a review of construction site heat safety practices, and heat illness prevention plans at every mayoral agency. Extreme heat is a worker safety issue. The workers who build our skyline, staff our airports, stock our warehouses, and deliver our packages, keep this city running.  This executive order will ensure they come home safe at the end of every shift.

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