Dirk Paul @dirk_paul
Integrative Genomics, Precision Medicine, Complex Diseases, Drug Discovery @AstraZeneca @Cambridge_Uni | Parkrunner | Views my own Cambridge, England Joined October 2011-
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In a new paper in @NatureGenet, scientists from MRC Epidemiology Unity, University of Cambridge, report a new obesity gene--BSN (nature.com/articles/s4158…). Loss of function mutation in BSN causes an extreme form of obesity that is reminiscent of the weight gain associated with…
Among patients with obesity-related heart failure with preserved ejection fraction & type 2 diabetes, semaglutide produced greater reductions in symptoms, physical limitations & body weight than placebo at 1 year. Full STEP-HFpEF DM trial results: nej.md/3TPKpUC #ACC24
Five steps to connect genetic risk variants to disease go.nature.com/4an9gGC
Rare gene variants identified by @ZhaoDylan and @The_MRC colleagues have the largest impacts on obesity risk discovered to date. The BSN & APBA1 variants are among the first for which increased risk of obesity isn't observed until adulthood. mrc-epid.cam.ac.uk/blog/2024/04/0… 🧵(1/6)
📣Latest from the lab: Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities medrxiv.org/content/10.110… Led by Doug Loesch with @dirk_paul, Abhishek Nag and an excellent team @AstraZeneca
Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities medrxiv.org/cgi/content/sh… #medRxiv
Awesome work by Doug Loesch (AZ postdoc) who led this analysis of the proteomic correlates of (partitioned) polygenic risk of T2D as well as their association with cardiometabolic outcomes in the EXSCEL and DECLARE-TIMI trials! x.com/dirk_paul/stat… 👉medrxiv.org/content/10.110…
Awesome work by Doug Loesch (AZ postdoc) who led this analysis of the proteomic correlates of (partitioned) polygenic risk of T2D as well as their association with cardiometabolic outcomes in the EXSCEL and DECLARE-TIMI trials! x.com/dirk_paul/stat… 👉medrxiv.org/content/10.110… https://t.co/fX0xLqWIwg
Learn about our proteo-genomic analysis of type 2 diabetes (medrxiv.org/content/10.110…) and check out the data portal (tinyurl.com/4chyetsr). Awesome industry-academic collaboration with @minouye271 @CAMBRIDGE_CEU.
📣Out today in Nature. Savita Karthikeyan, Adam Butterworth's large-scale study reveals genetic determinant of metabolome. 136K participants, 9K genetic associations and new insights into understanding of the genetic regulation of lipoproteins. nature.com/articles/s4158…
Join the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at Broad Institute on Tuesday, March 19 for the Variant to Function Symposium. Attend in-person at Broad, or virtually. More info: broad.io/v2f
An important paper on polygenic risk scores was published @NatureMedicine today nature.com/articles/s4159… and I wrote a Ground Truths post about it (see profile for link)
Interested in a PhD studying multimorbidity using multi-omics data? Studying @CAMBRIDGE_CEU @HLRI_Cambridge with an internship @AstraZeneca across the road? Then this MRC iCASE studentship is for you (due: March 4): jobs.cam.ac.uk/job/45195/! DMs open for any questions!
Interested in a PhD studying multimorbidity using multi-omics data? Studying @CAMBRIDGE_CEU @HLRI_Cambridge with an internship @AstraZeneca across the road? Then this MRC iCASE studentship is for you (due: March 4): jobs.cam.ac.uk/job/45195/! DMs open for any questions!
A concise overview of several key publications in the @jclinicalinvest that helped build the story of GLP-1 science @the_asci #Diabetes #T2D #obesity #heartdisease #kidney #Parkinsonsdisease #weightloss #islets jci.org/articles/view/…
Interesting to see 23andme's special interest in one of the T2D protective genes previously identified in the UK Biobank exome analysis. MAP3K15 is an X-linked gene encoding a mitogen-activated protein kinase. Loss of function variants in MAP3K15 were found to be associated…
The wait is over! @FinnGen_FI DF10 (N= 412,181) GWAS results and summary statistics are now freely available! You can browse the results with our web browser and/or download them. More info: finngen.fi/en/access_resu… #OpenScience #genomics
Excited to share our newly published paper rdcu.be/dtI4s on the interplay of monogenic and polygenic risk in CKD. Joint analysis of @uk_biobank and @AllofUsResearch by @atlasmaths shows that polygenic risk alters the penetrance of kidney disease in ADPKD and COL4A-AN!
When I thought I was done with the GWAS stories of 2023 and I should wrap up, @StephenORahilly dropped yet another great paper from his team. How can I resist? It's storytelling time. In this hot-off-the-press Nature paper, @DrFejzo et al. uncover an absolutely fascinating…
When I thought I was done with the GWAS stories of 2023 and I should wrap up, @StephenORahilly dropped yet another great paper from his team. How can I resist? It's storytelling time. In this hot-off-the-press Nature paper, @DrFejzo et al. uncover an absolutely fascinating… https://t.co/qX4UZMJqJk
I'm hiring! We are looking for a post-doc to work on an @NIH_CommonFund funded project exploring convergent mechanisms in neurodevelopment disease! jobs.bcm.edu/job/Houston-Po…
@yang_i_li Summary statistics are now available on Zenodo: zenodo.org/records/103544…, and future links will be added to the portal: intervalrna.org.uk/downloads/
US regulators approve two gene therapies for sickle cell disease theguardian.com/us-news/2023/d…
Adam Butterworth @aidanbutty
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2K Followers 955 Following @[email protected] Group leader at @MRC_LMS, Hon. Senior Lecturer at @ImperialCollege. Opinions / views my own.Mark McCarthy @markmccarthyoxf
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239 Followers 482 Following PhD Candidate @PrecisionMedPhD @EdinburghUni | statistical genetics | dermatogenetics | https://t.co/cs4Bm7SmCcSi Fang @sifang1678
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269 Followers 1K Following Medical Doctor & Scientist | Co-founder @PheironInc | Data and evidence in healthcare | via @ChariteBerlin, @berlinnovation, @UniFAUYajie Zhao, 赵亚杰 @ZhaoDylan
500 Followers 2K Following MRC Postdoctoral Fellow at @MRC_Epid & Warwick MORSE 1st Hons➡️Oxford OMMS ➡️Cambridge PhD & Human Geneticist🧬/ Photographer📷/Cat Enthusiast🐱Omid S. Alavijeh @OAlavijeh
169 Followers 426 Following Currently: @AstraZeneca Research Fellow (Translational Science) Recent @The_MRC Doctoral Fellow @renalgenomics Academic Renal Trainee #bioinformatics #genomicsKubilay Kınoğlu,MD/.. @Kubilayknoglu
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382 Followers 551 Following Cardiology Registrar - South London | Former @theBHF Clinical Research Training Fellow, Barts Heart Centre & UCLMary-Ellen Lynall @MLynall
1K Followers 2K Following Cellular immunity in psychiatry | co-chair, PGC Functional Genomics workgroup | Clinical Lecturer, Univerity of CambridgeAmar Marthi @AmarMarthi
409 Followers 1K Following UK renal registrar, currently Epidemiology PhD student UNC-Chapel Hill.Kyriaki Michailidou @KyrMichailidou
817 Followers 2K Following Genetic epidemiology and biostatistics @NeuroGeneticsCy, mom, views are my ownGuoqiang Yi @GuoqiangYi
101 Followers 2K FollowingCecilia Salvoro @CeciliaSalvoro
19 Followers 116 Following Geneticist, I believe in the power of science and education. Unstoppable traveller, passionate reader and food lover.Lizzy Hass @Lizzyhaas_12
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60 Followers 288 Following UK Health Security Agency @UKHSA Research and scientific impact 👩👩👦👦🩺 Patient and Public Involvement and Engagement (PPIE) 🤝 She/her Views my ownEPSRC CMAC @EPSRC_CMAC
1K Followers 644 Following World Leading Centre for Medicines Manufacturing Research, Skills, Facilities and Translation.Yaning 亚凝 (she/he.. @nerdfighterwu
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933 Followers 614 Following Assistant Professor at Boston Children's Hospital, Harvard Medical School. She/her.David A Knowles (@dav.. @david_a_knowles
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1 Followers 58 FollowingMichael Sweeting @michaelsweeting
490 Followers 355 Following Biostatistician. @AstraZeneca. Honorary Fellow @uniofleicester. Enjoy walking in hills and following English cricket. All views, political & otherwise, my own.Moresapien @moresapien
297 Followers 315 Following Our mission is to enable curious individuals on their path to deeper self-knowledge and inner wisdom. Tools, workshops and guides. A little wiser, everyday.Kiki, PhD @kiki_omics
757 Followers 2K Following she/they Postdoc at @HumanGeneticsOx & @UniofOxford studying the immune system | Previously at @sangerinstitute & @Cambridge_Uni | Autistic | MexicanaMeike Bartels @Meike_Bartels
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537 Followers 1K Following MRF Fellow/Stem cells/cardiovascular/stroke scientistCRYPTO Kameleon @kameleon_CRYPTO
373 Followers 3K Following JESUS CHRIST 1st! MULTI-FACETED. BLENDING IN. CAUTIOUSLY OPTIMISTIC. NEVER ANY FINANCIAL ADVICE! do your own research! #onlyfrens (X)'s GET RICH OR DIE TRYIN!Adam Butterworth @aidanbutty
2K Followers 2K Following Professor of Molecular Epidemiology @CAMBRIDGE_CEU @Cambridge_Uni. Tweeting in a personal capacity.Mike Inouye @minouye271
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6K Followers 246 Following GWAS whisperer 'Nothing in biology makes sense except in the light of evolution' -Dobzhansky DMs open Executive Director, Integrative Biology @PfizerCharlotte Summers @charlot_summers
17K Followers 6K Following Director of @hlri_Cambridge & Professor of Intensive Care @Cambridge_Uni; Fellow @selwyn1882 Tweets represent only my personal views.Jeffrey Barrett @jcbarret
22K Followers 505 Following Chief Scientific Officer, Nightingale Health. Formerly led the Covid-19 genomics initiative @sangerinstitute.Stephen Burgess @stevesphd
2K Followers 253 Following Medical statistician, work with genetic data to disentangle causation from correlation. Author of book on Mendelian randomization.BHF Cardiovascular Ep.. @CAMBRIDGE_CEU
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53K Followers 74 Following The original Cambridge Diary. 5,000 continuous daily pictures of #cambridge New book 'Town & Gown' available now at https://t.co/JmfzBlMROLVPD Heart & Lung Rese.. @HLRI_Cambridge
612 Followers 755 Following Official Twitter feed of the Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge. #HLRIUK Biobank @uk_biobank
21K Followers 1K Following A large-scale biomedical database and research resource, that can be accessed globally by approved researchers, to enable scientific discoveries.Nicole Soranzo @nicolesoranzo
4K Followers 3K Following Human geneticist. Senior group leader at @sangerinstitute and @cambridge_uni, Head of Genomics @humantechnopoleCarl Anderson @anderson_carl
3K Followers 990 Following Head of Human Genetics and Senior Group Leader (Genomics of Inflammation and Immunity) at Wellcome Sanger Institute. A particular focus on IBD. #firstgenMark McCarthy @markmccarthyoxf
6K Followers 1K Following Using human genetics to advance knowledge & find new therapies. Otherwise: Liverpool FC, cricket, cinema, seafood, travel. Now at Genentech but views mine.Sam Lambert @iamslambert
587 Followers 804 Following 🇨🇦 in UK. Assistant Prof studying polygenic scores & multimorbidity @Cambridge_Uni/@PGSCatalog /@ChurchillCol. PhD studying TFs @UofT. Views are my own.Marie-Pierre @MP_Dube
189 Followers 293 Following Genetic epidemiologist at the Montreal Heart Institute.Inside Precision Medi.. @Inside_PM
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1K Followers 795 Following Genomics, drug development, bioinformatics, equity & diversity 🧬 💊 | Senior Director of Genome Analytics at AstraZeneca | Views my ownEuropean Society of H.. @eshgsociety
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841 Followers 793 Following Neuroscience, genetics, biomarkers & drug discovery. 🇮🇪European Society of C.. @ESCardioNews
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540 Followers 831 Following Assistant Professor @PennMedicine | Investigator @DeptVetAffairs Million Veteran Program (MVP) | Queen of Supplementary TablesEuropean Society of C.. @escardio
145K Followers 2K Following European Society of Cardiology. Join us also on @ESC_Journals @ESCAdvocacy @ESCardioNews @ESC_President. #ESCCongress #ESCGuidelines #ESCTVToday #ESCDigitalEleanor @eleanorwheeler
96 Followers 173 FollowingRobert Scott @robert_a_scott
431 Followers 356 Following Human Genetics at GSK. Opinions my own, but mostly kept to myself.Health Data Research .. @HDR_UK
13K Followers 3K Following As the UK's national institute for health data science, our mission is to unite the UK’s health data to enable discoveries that improve people’s lives.Emanuele @Di_Angelantonio
476 Followers 201 Following Clinician scientist, Professor @Cambridge_uni, Director @DonorHealthBTRU, @CAMBRIDGE_CEU, Director Health Data Science @humantechnopoleNIHR BioResource @NIHRBioResource
2K Followers 2K Following National panel of 250,000+ volunteers, each consented to take part in experimental research and early phase clinical trials based on genotype and/or phenotype.Nature Cardiovascular.. @NatureCVR
7K Followers 996 Following Online-only Nature Research journal that publishes basic, translational, clinical and public health research in cardiac, vascular and blood biology.Olivier Govaere @OGovaere
390 Followers 437 Following Tenure Track Professor in the field of Hepatology @KU_Leuven focusing on multi-omics, NAFLD, immunometabolism and liver regeneration.Google Health @GoogleHealth
28K Followers 81 Following Official Google Health news and updates on how we’re progressing our mission to help billions of people be healthier.John Andrew Todd @ProfJohnATodd
1K Followers 107 FollowingRegeneron Genetics Ce.. @RegeneronDNA
2K Followers 194 Following Official channel for Regeneron Genetics Center. Science-Obsessed. Human-Inspired.CureGN @CureGn
1K Followers 625 Following CureGN is a multi-center longitudinal cohort study of children and adults with glomerular disease (MCD, FSGS, membranous, IgAN/IgAV) sponsored by @NIDDKgovVincent Wong @VWSWong
829 Followers 267 FollowingMelina Claussnitzer, .. @MelinaClaussnit
1K Followers 651 Following Associate Director @novonordiskfond Center for Genomic Mechanisms of Disease & Institute Member @broadinstitute; Faculty @MGH @HarvardMed @CGM_MGHKrzysztof Kiryluk @kirylukk
1K Followers 525 Following Medicine, Genetics, Statistics, Nephrology, Kidney Disease, Columbia University. My posts represent my own views and not those of Columbia University.Alex Tokolyi @AlexTokolyi
127 Followers 178 Following Medical genomics PhD student @SangerInstitute @Cambridge_Uni from 🇦🇺Nature Reviews Cardio.. @NatRevCardiol
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156 Followers 243 Following Senior Director, Head of Data Science and AI. Research and Early Development, Cardiovascular, Renal and Metabolism. AstraZeneca, Cambridge (UK)Gundula Povysil @GPovysil
85 Followers 133 Following MD turned Bioinformatician, Computational Postdoc at Columbia University working on Human GeneticsTIMI Study Group @TIMIStudyGroup
4K Followers 326 Following Providing the latest news and research from the TIMI Study Group, an ARO affiliated with Brigham and Women’s Hospital and Harvard Medical School.FinnGen @FinnGen_FI
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3K Followers 621 Following Chief of Cardiology @MGHHeartHealth, Director, CV Disease Initiative @broadinstitute, CV research mixed w weekend projects around the houseJason Tarkin @Jmtarkin
252 Followers 244 Following Wellcome Clinical Research Career Development Fellow & Hon Consultant Cardiologist @Cambridge_Uni | Jnr Research Fellow @Catz_Cambridge | BSCI/BSCCT committeeMichele @MikeVacca1979
324 Followers 452 Following Associate Professor, Interdisciplinary Dept Medicine, @unibait ; Principal Investigator, Liver Metabolism and NAFLD Lab, @Inst_of_HepQuentin M. Anstee @QAnstee
1K Followers 367 Following Professor of Experimental Hepatology & Consultant Hepatologist: NAFLD/MASLD Treatment | Biomarkers | Pathogenesis | GeneticsEndpoints News @endpts
29K Followers 68 Following The biopharma world is here. Get the industry’s most comprehensive daily news reports at https://t.co/qpcDlbaOSxProf Sir Menelas Pang.. @MenePangalos
4K Followers 445 Following Drug discoverer & science lover. Dad and amateur photographer. Passionate about turning science into medicine in a an ever increasing digital age.Tregouet David-Alexan.. @TregouetBPH
332 Followers 186 Following 'Success is the ability to go from one failure to another with no loss of enthusiasm'. W. CBenoit Arsenault @ArsenaultBenoit
6K Followers 1K Following Professor, Department of Medicine @universitelaval Cardiometabolic diseases prevention researcher @IUCPQ Les voies métaboliques sur YouTube Co-président @sqlnm_First DavLab PhD thesis added to the shelf. Great work @AlexTokolyi!
3️⃣ Emile Cairess 4️⃣ Mahamed Mahamed Incredible effort from the British duo in the #LondonMarathon! #BBCMarathon
Out now! Together with members of our Exec & Science Leadership Team @emblebi @sangerinstitute @GSK @genentech @pfizer @bmsnews @sanofi we share our perspective on how @OpenTargets we use human genetics & genomics for drug target ID & prioritisation: annualreviews.org/content/journa…
The largest genome-wide association study for type 2 diabetes so far, which included several ancestry groups, led to the identification of eight clusters of genetic risk variants go.nature.com/3xzZ27i
FinnGen Scientific Director, @FIMM_UH Research Director Aarno Palotie has been named Docent of the Year in 2024 at the University of Helsinki. Warm congratulations! helsinki.fi/en/news/univer…
In a new paper in @NatureGenet, scientists from MRC Epidemiology Unity, University of Cambridge, report a new obesity gene--BSN (nature.com/articles/s4158…). Loss of function mutation in BSN causes an extreme form of obesity that is reminiscent of the weight gain associated with…
READY to add my 5K #AACR24 Thanks @OmniscopeAI for supporting Cancer Research #IOmeetsAI
worth a listen. But be prepared to feel down at the idea most of us will never be able to explain complex science as well as @StephenORahilly . I am claiming 0.0001% of the credit as the person who plucked the "computer scientist", now Prof @jrbperry, from an MSc course in 2006.
Listen to Professor Stephen O'Rahilly @StephenORahilly discuss on @BBCr4today the implications of the discovery by a team of @The_MRC and @ASTRAZENECAUK scientists of new gene varients that are strongly associated with adult-onset obesity. bbc.co.uk/sounds/play/m0… (starts 54:18)
Five steps to connect genetic risk variants to disease go.nature.com/4an9gGC
👇Our new findings out in @NatureGenet today, where we report 2 new genes linked to adult-onset obesity. In particular, variation in Bassoon results in the largest effect on body-weight seen at the population level to date! #genetics #obesity #obesityisnotachoice
Rare gene variants identified by @ZhaoDylan and @The_MRC colleagues have the largest impacts on obesity risk discovered to date. The BSN & APBA1 variants are among the first for which increased risk of obesity isn't observed until adulthood. mrc-epid.cam.ac.uk/blog/2024/04/0… 🧵(1/6)
Rare gene variants identified by @ZhaoDylan and @The_MRC colleagues have the largest impacts on obesity risk discovered to date. The BSN & APBA1 variants are among the first for which increased risk of obesity isn't observed until adulthood. mrc-epid.cam.ac.uk/blog/2024/04/0… 🧵(1/6)
Exome-wide association study of venous thromboembolism in the UK Biobank (14,723 cases and 334,315 controls). He, Wu, Yang, Guo, Deng, et al. Nat Comm nature.com/articles/s4146…
Happy to share that I have been promoted to Associate Professor @UniTartuCS. Very grateful to my team and collaborators who have made this possible!
The Cambridge Men have won The 169th Men’s Gemini Boat Race by a margin of 3 1/2 boat lengths, in a time of 18 minutes & 56 seconds. #TheBoatRace2024 @CUBCsquad @Cambridge_Uni @Gemini
🚣 What an incredible day for rowing it's been! There were bold moves and so many exciting moments, with many pushing themselves to the edge (Matt Edge is OK!)(Thread)🧵
Very excited to finally see our study of global RNA stability in Salmonella out today in @PNASNews, where we use Bayesian statistical modeling to show bacterial transcripts have subminute half-lives, far shorter than previously thought. pnas.org/doi/10.1073/pn… 1/n
Why do Latino children have the highest risk for childhood leukemia in the US? We identify one cause for this in a paper out in @CellGenomics today, led by @adamdesmith, @LWahlster, @SoYoungJeon_Eli, @fulong_yu, @CharlestonCWKC, & colleagues: cell.com/cell-genomics/…
The frustrating thing to me about the quote from this article is that the columnist knows, and the Conservatives know, and Labour knows, that Brexit was an awful economic and geopolitical error. This was obvious in my view in 2016 and it’s ten times more obvious now, for the…
"Our economic model is bust. Being a services superpower is not enough" Nick Timothy, strong Brexit proponent, concludes in the Telegraph there's a rise of regional protectionism but then doesn't join the dots to the only country outside that protectionism because of Brexit.
Just out @NatureAging👉 Integration of polygenic and gut metagenomic risk prediction for common diseases. nature.com/articles/s4358… Excellent work by Yang Liu, @sritchie73 @phylogeo and co! Also see our recent review cell.com/trends/microbi…