James @basedsystems

@anshulkundaje I know a guy who figured out how to generate the structures dataset without crystals. So, there will be much larger datasets in a bit of time

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James @basedsystems

4 weeks ago

putting this tweet on the wall in the office

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James @basedsystems

4 weeks ago

downtown livermore feels a little like Palo Alto with shittier cars

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James @basedsystems

a month ago

@SashaGusevPosts will be a lot of this. probably need a way for centralized domain expertise to reach out to the datasets and pick at them live as like a service

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If you're building real things—as an engineer, entrepreneur, technician—consider having more children earlier than you thought. Your children will have the irreplaceable inspiring experience of growing up with parents who do things and make things. More👇

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James @basedsystems

a month ago

in the future the large companies will have been started in group chats

Jon Erlichman @JonErlichman

a month ago

First offices of 6 companies worth a combined $21 trillion.

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undefined behavior @undebeha

a month ago

i think trump is working on some strange generalization of the collatz conjecture

unusual_whales @unusual_whales

a month ago

Trump: These are tough questions. They say take a number, any number. I say ok, 99. Multiply it by 9. Divide it by 3. Add 4293. Divide by 2. Subtract 93. Divide by 9. What is your answer? I got it right. It was actually more complex than that.

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Jared Duker Lichtman @jdlichtman

a month ago

Update on Erdős Problem 1196: In joint work, we refined and adapted the proof method from GPT-5.4 Pro to give proofs of several additional problems. This includes another 60 year old conjecture by Erdős, Sárközy, and Szemerédi. A proof is valued not just by the problem it solves, but by what new avenues it opens up. This is perhaps one of the first examples of an AI-generated proof having downstream impacts, which we are still exploring. We are announcing the result today at the Future of Mathematics Symposium (see links below)

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James @basedsystems

a month ago

when the kids are destroying the house but also leaving you alone so you gotta decide if you’re gonna get up and do something about it

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James @basedsystems

a month ago

@bazarovturg also, we rip apart how the standard software works because we need to optimize for correctness in our services. often you dig in and find missing knobs or broken / complex code

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James @basedsystems

a month ago

@bazarovturg we use it to run various internal services. better to just write a new, efficient one that integrates with the rest of our stuff

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James @basedsystems

a month ago

We wrote our own hyper-efficient version of the STAR aligner. Typically it costs around $35 in cloud compute to process 30k cells with Cell Ranger. Ours costs so little that we don't charge for it. Also ours works with nanopore. If you prefer pseudoalignments, then you can run it in pseudoalignment mode -- obviously we don't charge for that too. All results instantly integrated with our other tools. As soon as a run finishes you can open alignments or expression matrices in our viewers without moving anything. Let me know if you want to try it!