Arthur Etchells @asketch
Love learning, building and hard challenges. Grew an eCommerce AI company from 0 to 8-figure ARR. Building what's next. arthuretchells.com San Francisco, CA Joined January 2010-
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🧵 Important from FDA today -- a new, broad initiative to improve clinical trial efficiency with aim of maintaining 🇺🇸 biomedical edge over 🇨🇳. Reform entails a long series of small changes that, taken together, tilt the playing field back in US favor. This is a key start...
@_heyglassy @PlanetScale Congrats @_heyglassy!!
Happy Father’s Day
Doesn’t seem catastrophic for a savvy founder… just find a 409a firm that will account for the blended entry. If those entries are on the same day at different prices for the same security, the only reasonable practice is to account for price on a blended basis.
I’m an AI researcher turned brain tumor patient, and recently I used the models to crack my mystery fatigue faster than my PCP could. I believe everyone can do the same with their own symptoms. Here’s how:
Prices are high because they aren’t high enough?
Half of all families live in child care deserts. How did we get here? It’s Econ 101: Prices are high because lots of families need care, but there’s nowhere near enough child care providers. And there aren’t enough providers, because we’re not paying them enough.
Between 1982 and 2020, the number of the 100 richest Americans who got rich from inheritance decreased from 60 to 27. And yet on the left they think the mid 20th century was the good old days, because economic inequality was lower then. paulgraham.com/richnow.html
Will never not surprise me that all the professional networks - alphasight, GLG, etc - entirely missed business opportunity for expert data labeling. The lesson to me: Businesses often miss opportunities their existing customer base.
@_pierre_barre How is it different from S3 files?
i've heard parents talk about there being a last time they hold their kids, feed them their supper or change a diaper. it strikes me that there is a last time most of us use a terminal directly.
one might say this is my most load-bearing alias ``` alias yolo='claude --dangerously-skip-permissions --remote-control' ```
TIL espresso increases cholesterol, pour over does not
In 2019, there were about 150,000 people working in autism therapy. Six years later, there were 654,000—more than the number of people who work in mining and logging, or telecommunications, or at the US Postal Service.
@mitchellh I reached the same realization before completing my PPL. Sure I can get this piece of paper that says I’m a pilot, but to feel good about flying loved ones means several hundred more hours and several dozen hours a year (at least) to stay at the top of my game.
@garybernhardt I believe Cursor mirrors (or did at one point) your codebase to turbopuffer. Their head of product mentioned a 1% ab win for this approach in a talk. I suspect the silent part is it’s not about better results, but rather token efficiency.
The new White House policy requiring green card applicants to apply from outside the US is a capricious attack on legal immigration. It will hurt families, leave us with fewer doctors, teachers and scientists, and hurt American competitiveness in AI.
Eli Lilly released retatrutide Phase 3 data yesterday. 28% weight loss in 80 weeks. The most powerful obesity drug that’s ever been tested. And today the cancer signal drops. 12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%. Cancer joins a list that already includes heart disease (SELECT, 20% MACE reduction), kidney failure (FLOW, 24% slower decline), sleep apnea (SURMOUNT-OSA, FDA-approved), addiction (BMJ, 600K veterans, 18-25% reduction across substances), and liver disease (86% fat clearance). Tumors express GLP-1 receptors. Activate them and NF-kB drops, apoptosis rises. The drug isn’t just shrinking fat. It’s talking directly to the cancer. One drug class. Designed for blood sugar. The biology keeps finding uses the designers didn’t predict.
The world’s most popular weight-loss and diabetes drugs are linked to a powerful new possible benefit: better outcomes for cancer patients. on.wsj.com/3RBfcXO
They say the fantastic future of our childhood dreams never came, but I'm tickled with joy that Claude can take the wheel to request replacements for stolen Amazon packages!
Rhianne @RhianneJjK6
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Michael Fanous @michaelfanous1
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Jason Freedman @jasonfreedman
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Yaroslav Bulatov @yaroslavvb
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Pierce Alexander Lilh... @PierceLilholt
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bronknysh54241 @bronknysh549415
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Adam May @A_May_MD
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Michael Fanous @michaelfanous1
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Michelle Zatlyn @zatlyn
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JF @NA
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Noam Brown @polynoamial
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Thariq @trq212
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Emily Sloan-Pace, nee... @shakespeareprof
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Helen Toner @hlntnr
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Volkan Gurses @bvolkangurses
359 Followers 339 Following PhD in electrical engineering and physics @Caltech and visiting researcher @NVIDIA studying the fundamental physical limits of technologies
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Abhinav Sharma @abhinavsharma
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Gavin Morrice @morriceGavin
582 Followers 574 Following Classically trained rubyist. Leading conversations about OOP. Chow-hound. Professional toddler negotiator.
Effy Zhang @effyyzhang
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Reiner Pope @reinerpope
19K Followers 459 Following CEO and founder, @MatXComputing, developing high throughput chips tailored for LLMs
Oliver @olvrgln
3K Followers 1K Following when I was a boy I heard God’s voice. now I build b2b saas @ https://t.co/us8mCfGrFf
Fonzi AI @FonziAI
609 Followers 8 Following Where great engineers find their next chapter. Text us if you're interested in exploring who's hiring! https://t.co/C0tMWvbXpu
Soleio @soleio
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Jake @earthtojake_
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nadav @NadavAHollander
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Yohei @yoheinakajima
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Arram @arram
13K Followers 998 Following I make beautiful things. Art, Meditation, Writing, Angel Investing Personal site: https://t.co/pdxEHdr6Ip Substack: https://t.co/QPLJSCt5uo
Kenan Saleh @kenanhsaleh
5K Followers 1K Following Investment Partner @a16z. Previously: GM @Lyft, Founder @HaloCars (acq by Lyft), @Penn @Wharton
Ethan Jagoda @EthanJagoda
625 Followers 891 Following Building @kiloforgeai | Explorer of life | prev @ucberkeley
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Bella @nazzari
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seb (recruiter arc) @hiiinternet
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Danh Trang @danh_trang
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kyt @kyttenjanae
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