Andrew Gallimore @alieninsect
Tokyo. Computational neurobiologist, chemical pharmacologist, writer interested in psychedelics, especially DMT. Reality Switch Technologies OUT NOW alieninsect.net Musashino-shi, Tokyo Joined April 2015-
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My new book is now available! Interviews with Duncan Trussell, Hamilton Morris, Graham Hancock, Andrew Gallimore and others! innertraditions.com/books/psychede…
“I console myself with the thought that nothing very interesting happens in well-lighted places.” — Don DeLillo
"There are these beings of immense intelligence with whom we've been communicating for centuries..." "You're hallucinating." "They are part of our tribe and as real as you and I..." "You're hallucinating." "But if you use this technology we've developed you can see and…
I always wonder about this bar whenever I walk past. But I will never go in there, because I’m almost 100% certain that the reality won’t match what’s in my head. 🥛🤏
A trip report from Stephen Szára's very first DMT study in 1956, from an unpublished manuscript: "The dimensions are strange... This whole world is frightfully realistic... This is the true color and shape of things. Dangerous game; it would be so easy not to return... I am…
Gotta love Herzog's perspective on life... “The trees are in misery, the birds are in misery — I don’t think they sing, they just screech in pain… The harmony of overwhelming and collective murder."
Gotta love Herzog's perspective on life... “The trees are in misery, the birds are in misery — I don’t think they sing, they just screech in pain… The harmony of overwhelming and collective murder."
Robert E. Brown of the Neo-American Church's classic 1968 psilocin synthesis... Spot the problem (apart from his archaic spelling of psilocin)...
Salvinorin is always conveniently forgotten in these attempts to define what is and isn’t a psychedelic by pointing to the 5HT2A receptor.
Salvinorin is always conveniently forgotten in these attempts to define what is and isn’t a psychedelic by pointing to the 5HT2A receptor.
5-MeO-DMT Factory Reset... "5-MeO-DMT in the complete resolution of the consequences of chronic, severe sexual abuse in early childhood" Pre-print: researchgate.net/publication/37…
花見時間🌸
88,888 words later, feels done. [If my editor makes me cut the allusion to a US President’s drug habit and/or the section about “the rasping squeals of dying sheep”🐑, might be fewer.]
There are no Machine Elves in the unconscious. (Art: Paul Robertson)
Moon won. Landslide. I’m a dew boy but the world has chosen. I made them choose.
Moon won. Landslide. I’m a dew boy but the world has chosen. I made them choose. https://t.co/LoeinFQDxw
Salvinorin A & B found in the common garden & houseplant Coleus scutellarioides ‘Electric lime’. Levels much lower than Salvia divinorum, but can be increased by feeding a readily-available rooting hormone, NAA. Would need about 12g of fresh leaves for a 200ug dose.
“You can find solace for all things by looking at the moon. Someone once declared that there is nothing more delightful than the moon, while another disagreed, claiming that dew is the most moving — a charming debate.” — Urabe Kenkō (卜部 兼好, 1283–1350)
“It is a most wonderful comfort to sit alone beneath a lamp, book spread before you, and commune with someone from the past whom you have never met.” — Kenkō (兼好), 1283-1350 The banalisation of the world continues, one soulless “optimised morning routine” shell of a man at a…
https://t.co/TFhbd4liV4
The Church of the Sacred Synthesis' (Psilomethoxin) "defamation" case petition is looking for, in damages,...... One MIIIIIIILLION dollars... 🤔 (they don't have the emoji I want to use, but you know what I'm going for here) -- served against 20 employees of USONA (for…
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7K Followers 4K Following ディマ・クリスティアン 准教授 早稲田大学 @remmid |トランジションデザイン|地域イノベーション|ドーナツ経済の実験者|transition design|community innovations|new commons|alternative practices from post-growth JapanSome like to see AI as offering new fertile possibilities. Perhaps it does in some fields, but taken as a whole it seems to me the further growth of the desert. Or put another way, the transformation of the metaphysical landscape from scrub to true desert.
Yet it’s fair to say the Eighties felt barren in comparison to the Forties. The desert has been growing for a long time.
Robot Dog with flamethrower: youtube.com/watch?v=rj9JSk…
Good morning from a grey and rainy Tokyo. Mainly in the office today. Perfect weather for it. :-) Whatever you're doing, wishing you as happy, productive and positive a day as possible. Here's some of the little wonders of nature for us all to marvel at. Luv&peace ❤️🙌
@alieninsect Yup... takes lots of $$$ to sort all this madness out.
Serotonin is non-lipophilic so cannot reach the intracellular 5-HT2A receptors responsible for neuroplastic effect? DMT is lipophilic so doesn't need to compete with serotonin intracellularly? A guess... pubmed.ncbi.nlm.nih.gov/36795823/
@RCarhartHarris @dmt_quest @drdluke @Graham__Hancock What does comparing absolute concentrations really tell us though? Ki of 5HT and dopamine across their receptor subtypes are in the low nM range... DMT?? 5HT2A: 65nM; Sigma-1 -- micromolar range. Which receptors is it actually going to tickle if it has an endogenous role?
Participants reported boundary dissolution & changes in their perceptions of self, leading them to experience nature & non-human beings as having spiritual or human-like agency. tandfonline.com/doi/full/10.10…
My new book is now available! Interviews with Duncan Trussell, Hamilton Morris, Graham Hancock, Andrew Gallimore and others! innertraditions.com/books/psychede…
@wurst_martin @JonesDanny Gee thanks! As it happens I'm on a call with @alieninsect right now, LOL. I think our episodes pair very well as somewhat parallel forays into Weirdness...
How can we account for the diverse profile of subjective and therapeutic effects which psychedelics seem to induce? In a new preprint (link below), we present theoretical and empirical evidence which point to the need to look beyond just the 5-HT2a receptor. A thread 🧵... 1/12
@alieninsect A side trivia: the largest ayahuasca religion in Brazil (UDV) has its temples lighted with strong with cold-white (blueish) fluorescent bulbs. Mood of the sessions is awful just because of the sterile, strong lighting but no one seems to care.
@alieninsect This looks like an appropriate moment to publish our paper in which we interviewed Stephen Szára - realitysandwich.com/dmt-research-f…
@alieninsect the arrogance of modern intellectuals towards metaphysical experiences is bewildering. but science and ancient knowledge seem to be converging (thanks to scientists like you) so i'm hopeful for the future
@alieninsect Great post. The ungratefulness knows no bounds. Human civilisation is built on the shoulders of drug users.
"There are these beings of immense intelligence with whom we've been communicating for centuries..." "You're hallucinating." "They are part of our tribe and as real as you and I..." "You're hallucinating." "But if you use this technology we've developed you can see and…
@alieninsect A "hallucination" is something that is completely random. Akin to when you're high on anesthethics after a surgery and you start seeing things that aren't there. Psychedelic visions are of a completely different nature because they are consistent even among different people.
@alieninsect This hits hard, if you know you know 🤷🏼♂️🤷🏼♂️
@alieninsect @AtiqYomin Fascinating, I’ll have a read. Although I think I’ll stick to vicarious DMT experience. I’d fear I’d lose my mind 😬
@alieninsect haha fair. Thanks for all your output, i quoted you many times in my psychology-thesis about nn-dmt. Such a shame that there is barely any work on dmt in the german spoken world despite DMT is just like germans: orderly and intense :-))