Kevin Mitchell @WiringTheBrain
Neurogeneticist interested in genes, brains, and minds. Author of INNATE (2018), FREE AGENTS (2023). https://t.co/PdgAxi6myV wiringthebrain.blogspot.com Dublin Joined June 2011-
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Neurotweeps! I'm looking for papers showing that switching task demands drives neural representations or manifolds to become orthogonal to each other. Can't remember where I saw it...
@Timothy0Leary All cellular processes are noisy They’ve just *evolved* with this noise to make “optimal”, nay “efficient” use of the noise towards effectively implementing precise functions Our job is to identify how such evolutionary convergence of noise and precision manifest across scales
@jbimaknee to save energy! Reliability costs ATP. This book makes a comprehensive case imo mitpress.mit.edu/9780262534680/…
Biden: “Of course, age is an issue. I’m a grown man, and I’m running against a six-year-old.”
“400,000 years for the carbon cycle to fully remove current emissions” "get emissions down to zero, warming will stop but the world will not cool down for centuries to millennia" Hence we burden our descendants with ten-thousand generation thermo-toxin sublationmedia.com/the-lefts-clim…
“400,000 years for the carbon cycle to fully remove current emissions” "get emissions down to zero, warming will stop but the world will not cool down for centuries to millennia" Hence we burden our descendants with ten-thousand generation thermo-toxin sublationmedia.com/the-lefts-clim…
I reread 'Saving Normal' to see if still current- pleased it is. Only thing I'd add if writing now is malignant effect of seductive social media algorithms on mental health of girls/women. Explains rapidly raised rates eating,anxiety,depressive disorders & suicide. #BanTikTok
I reread 'Saving Normal' to see if still current- pleased it is. Only thing I'd add if writing now is malignant effect of seductive social media algorithms on mental health of girls/women. Explains rapidly raised rates eating,anxiety,depressive disorders & suicide. #BanTikTok
@WiringTheBrain I have questions about the logistics. Do they all get changed together into their chino’s and shields, and if so where? Or do they all split up and go home separately and awkwardly ?
They should be arrested just on aesthetic grounds.
They should be arrested just on aesthetic grounds.
columbia university:
The Dissenter now has a website! Check it out. thedissenter.net In-depth interviews with leading academics on #psychology, #philosophy, #anthropology, #neuroscience, #economics, #biology, and more.
Marr has computation, algorithm, and mechanism. Tinbergen got evo, devo, goal, and mechanism. But whats the name for "I just fit something and great R2. Many papers do it. It does not fit into Marr nor Tinbergen. How is it called? Nihilism?
Are neurons noisy? Let’s come at this a different way: How can neurons do computations in the presence of variability? Our recent sequence filtering effect is a computation occurring even when single neurons are noisy. Each frame of a visual sequence is represented in ctx by 1/
Are neurons noisy? Let’s come at this a different way: How can neurons do computations in the presence of variability? Our recent sequence filtering effect is a computation occurring even when single neurons are noisy. Each frame of a visual sequence is represented in ctx by 1/ https://t.co/4PcQ38yzha
@CianaDeveau Because this all relies on population patterns of firing rate changes, this sequence filtering can occur in the presence of variability. (Neurons are in this case near-Poisson, in some sense the highest var possible: see O’Rawe et al 2023 where we measured opto responses,)
@CianaDeveau Because this all relies on population patterns of firing rate changes, this sequence filtering can occur in the presence of variability. (Neurons are in this case near-Poisson, in some sense the highest var possible: see O’Rawe et al 2023 where we measured opto responses,)
@WiringTheBrain 1/I totally agree, these are reliable and important data to understand autism, which is a sensible problem for many of us. It looks like the field of genetics is advancing to provide specific answers on genetic causes of autism and other neurodevelopmental conditions
When you think of a beautifully designed suit, all the elements—the fabric, details, silhouette—have to work together in harmony. You can't stick random things on like Mr. Potato Head. Otherwise, you wind up with weird stuff that doesn't make sense.
white blood cells crawling between red blood cells
Elad Schneidman in his Ph.D. thesis with Idan Segev showed that stochasticity of Na+ channels contributed considerable variability to spike generator& explained M&S results. Basic intuition: ~50 channels open@threshold, fluctuations +/- sqrt(50) ~15%. direct.mit.edu/neco/article-a…
A pet peeve: Mainen & Sejnowski 1995 is constantly quoted as saying spike generation is reliable, not a source of variability. It did not show that at all. It showed reliability for very large voltage fluctuations - which might mean driving well above threshold (wasn't clear) 1/
A pet peeve: Mainen & Sejnowski 1995 is constantly quoted as saying spike generation is reliable, not a source of variability. It did not show that at all. It showed reliability for very large voltage fluctuations - which might mean driving well above threshold (wasn't clear) 1/
Luiz Pessoa @PessoaBrain
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7K Followers 196 Following Assistant Professor of Psychology and Data Science @ NYU. Co-Director of the NYU Minds, Brains, and Machines Initiative.@WiringTheBrain ugh... more Revolutionary War reenactors? Don't let them near the tea warehouse, ok?
Hey @WiringTheBrain you’re in Toulouse thx to @ChiasmaParis ✨💫🤗 @RECtlse
@WiringTheBrain You know they’re “perfectly fine people“ by their masks.
@Timothy0Leary for larger brains, neural networks form interacting high dimensional dynamical systems, and can generically be expected to exhibit chaotic behavior - that is the usual way "noise" is generated in classical systems (+ injected stochasticity at the cellular/synaptic level).
@cian_neuro @WiringTheBrain @jbimaknee yes, and it could also be that the code is so degenerate (ie many population spiking patterns lead to the same computational outcome) that neurons appear unreliable when their collective computation really isn't. Deneve et al beautifully illustrated this: journals.plos.org/ploscompbiol/a…
I'm tired of explaining why this won't work
Now You know - How Neuralink Works 🧠 Credit @zackdfilms
@aylwyn_scally @WiringTheBrain True. But I *never* do that, of course. In my experience it’s generally someone asking about something I am going to say later, in my own good time, thankyou very much.
Someone should sequence his MC4R…any volunteers to take the mouth swab?
This bear, affectionately named ‘Fat Albert’ by locals in Katovik, Alaska, is thought to weigh a whole 200 kilograms heavier than he should be at 453 kg (1,000 lbs). It could be the ‘fattest polar bear alive'.
@WiringTheBrain @theAliceRoberts @AdamRutherford my exact first thought - he looks constipated and desperately trying to poo
@WiringTheBrain Maybe I’m shallow, but I’d expect an alleged “master race” to be a bit better looking.
@WiringTheBrain I never thought it would be possible to make chinos whiter, but here we are.
@matthewcobb @WiringTheBrain Often the speaker assumes everyone understands something, and I'd rather someone piped up then than have the audience baffled for the rest of the talk.
@HistedLab @WiringTheBrain No idea if this is relevant but artificial neural networks actually train better when fed a small amount of random noise/data. (My suspicion is that it helps to avoid training to local minima).
@WiringTheBrain @aylwyn_scally Though it appears they went in for the “interrupt the speaker with a question on the first slide” mode which I hate. Shut up and listen, it’s my talk, not yours. if it’s important, ask me at the end. Plus it encourages gob-offs, which I guess made up most of the Helmholtz Club…
@WiringTheBrain @aylwyn_scally They wouldn’t only discuss one thing, normally. And on average there were only about 20 ppl there, from across Southern California. More here: sciencedirect.com/science/articl…
I'm pretty sure I see some police
White supremacists are now marching in Charleston, West Virginia. With no police in sight.
Very excited. A book with Van Gogh's co-mentions of other artists on the cover. Expected release: October 2024. I think it will be heavy enough to make an effective doorstop.
@WiringTheBrain I’m increasingly seeing comments like “[Trait with very high h2] is actually to do with microbiome/metabolism” and it annoys me very much