Mark Histed @HistedLab
Neuroscientist. We aim to understd brain networks and brain wiring, using lasers & neuro AI. Prev: policy for @democracypolicy. Personal views. Not a lab acct. linktr.ee/markhisted Washington, DC Joined May 2013-
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Yep. Check out our 2014 paper on this: papers.nips.cc/paper_files/pa…
Local minima are rare in high dimensions because a strict local minimum has to curve upward in every direction, so all Hessian eigenvalues must be positive. In a D-dimensional toy model where eigenvalue signs are independent, that’s a 2^(-D) event. In GOE-like random matrix
"This isn’t how the sciences work, and it’s basically a dagger aimed at the sciences and medical research" That's right
"...in which the fed gov't funds sciences and medical research. Instead, it makes the entire apparatus into a kind of political patronage system, with any researcher liable to be immediately cut off if they offend the current occupant of the White House." talkingpointsmemo.com/edblog/surveyi…
TPM covers the presidentialization of science agencies. This is what Natalie Aviles and I have been on about: the unitary executive logic of SCOTUS/P2025 is not compatible with good science. "[the OMB rule] purports to end the system which Congress created..." 1/
Hopefully this moves the needle and encourages the pharma industry to speak up. I have heard from several sources that pharma execs know exactly what’s going on and what the damage will be, but they can justify inaction because the effects won’t hit their stock prices soon.
“The damage inflicted over the past 16 months is prologue. The OMB’s proposal for overhauling U.S. government grantmaking would explicitly subordinate expert peer review to political gatekeepers and make ideological alignment with the administration a prerequisite for funding.”
“As the admin moves from cutting budgets and attacking elite universities to dismantling the foundations of the US research enterprise, pharma CEOs have remained silent. Their silence is a choice.” biocentury.com/article/659615
Governments in personalist states don’t work. And moreover civil servants in the US took an oath to the Constitution— that is, to American democracy. If one party chooses to shred the Constitution, that is also not the fault of civil servants.
And civil servants should not bend their values. They should not give up their commitments to democracy.
I deeply believe in a non-partisan civil service. But civil servants must also be pro-democracy and anti-fascism. If that runs at odds with the choices of the political parties today, that is not the fault of civil servants.
and if any one is wrong we can accept it. In contrast, some big clinical trials maximize rigor at high cost. A great science ecosystem has a mix of different approaches. #metascience
High-risk, high rigor, and low cost in science are tradeoffs: for any line of research we generally get to choose just two. For some emerging fields, we want to throw a lot of high-risk and low-cost darts …
So we choose a reasonable rigor std, do our best to peer review, & accept some errors, worked out by followup work. (There are many issues w/ glam journals, over-selling, favoring huge labs—etc. But this 'some are wrong' issue is just the nature of reality.) /end
This framework is well-worked out in theory—we must choose an error criterion ("wrong"), which comes w/ a cost in time/$. This isn't ex it (need a cost term), bt same idea, fm David Heeger's notes. Type 1/2 errors, sensitivity/specificity: same idea. cns.nyu.edu/~david/handout…
A good number of papers in Science and Nature are wrong... and that's not a bad thing. (What's something everyone in your field knows but people outside the field don't?) 1/
Going to start calling myself a Lincoln liberal.
Kording Lab 🦖 @KordingLab
63K Followers 3K Following Konrad kording, @Penn Prof, deep learning, brains, #causality, rigor, https://t.co/tTJW05RRfa, https://t.co/qf7ZHxjaK1, Transdisciplinary optimist, Dad, Loves outdoors, 🦖
Kay M Tye PhD @kaymtye
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Kanaka Rajan @KanakaRajanPhD
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Luiz Pessoa @PessoaBrain
49K Followers 1K Following Neuroscientist interested in cognitive-emotional brain Author of The Entangled Brain (MIT Press); The Cogitive-Emotional Brain Neuroscience & Philosophy Salon
Nicole C Rust, PhD @NicoleCRust
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Tony Zador @TonyZador
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Earl K. Miller @MillerLabMIT
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Jess Cardin @jess_cardin
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Prof Aman Saleem @Aman_sal
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David Schoppik @schoppik
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Dan Levenstein @dlevenstein
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David Sussillo @SussilloDavid
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Tim Kietzmann @TimKietzmann
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Alex Kwan 關進晞 @kwanalexc
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Adrienne Fairhall @alfairhall
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James V @james_mtc
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137 Followers 256 Following Never the wrong time to do the right thing
mianini 🌸 @miasweety17an5y
9 Followers 383 Following blonde and dangerously lovable, but make it blonde
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Maria Robles @RBioceutics
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Molly @outlinedtextbox
96 Followers 143 Following BS in Astrophysics (- + + +). I like bifurcations, PDEs, cosmology, black holes, and mathematical neuroscience. I have a tuxedo cat named Bean. Tartans '26
z @betaokumura
301 Followers 4K Following a dog in human’s clothing | interested in math + informatics + chemistry (sometimes even philosophy) | no hate but curiosity really killed the cat 😉
Warren W. Pettine @WarrenWPettine
78 Followers 152 Following Academic/founder. As much skiing as humanly possible.
CrystalPan @crystalpann
81 Followers 283 Following PhD candidate in Rumbaugh lab at Scripps Research, first gen, cyclist, she/her, and BLA BLA BLA
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Paul @Paul08889112017
22 Followers 806 Following
José Vergara de la F... @PP_borre
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Ash Paul @pash22
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Fine Yahtzee @FineYahtze60428
25 Followers 147 Following
RapOmena @MosheTre
414 Followers 5K Following m-pepe inadai confirmed pale https://t.co/JjsC20Bdq8. all black utadhani mi ni msudi. subreme leader of jabascript. dean of kenyan hip-hop and sheng studies.
Xavier Olleros @xolleros
513 Followers 6K Following Retired business school professor (ESG-UQAM) Co-editor, Research Handbook on Digital Transformations (2016)
Wieger Scheurer @wiegerscheurer
57 Followers 161 Following PhD candidate at the Predictive Brain Lab, Donders Centre for Cognitive Neuroimaging. Neuro-AI & Intuitive Physics to study prediction. 🟦 wiegerscheurer.bsky
Daisy @Daisy83ci
28 Followers 663 Following 🌷 Sweet, sassy, and a little sparkly ✨ | Chasing dreams & adorable pups 🐶 | Smiles guaranteed 😘
Aditya Vaidya @_avaidya
258 Followers 649 Following PhD student at @HuthLab. Interested in language, computers, and the brain. No thoughts about memes.
James Hyman @JamesMHyman
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Jonathan Crock @JonathanCrock
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Daniel Whiteson @DanielWhiteson
9K Followers 5K Following Particle physics and ML (https://t.co/1MlHzNHDNB). Co-creator @DandKUniverse pod and @ElinorWonders TV. New book: "Do Aliens Speak Physics?" out Nov 4!
Olivia H. Scharfman @OliviaHelenS
4K Followers 3K Following Biosecurity & Biotechnology @IFP. Formerly: Co-founder @ LincSwitch Tx, Principal @ SALT Fund, Biophysics @Yale, Chairman @SEDSusa, @XPRIZE.
coco🇨🇦ouaouaron... @cocoz62277008
196 Followers 578 Following Compassion,Truth & Facts matter. That's another way of saying Science matters. It's easy to deny, but we're safest when confronting reality.2e.
Zoidzorg @zoidzorg
54 Followers 2K Following
David Z. Morris @davidzmorris
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Aaron Simpson @AaronSimps93991
17 Followers 103 Following
Tommi Moilanen @TommiMoilanen2
147 Followers 8K Following
José Luis de la Fuen... @jlfuenteoc1
11K Followers 6K Following Opinions —not scientific verdicts— on energy, and what life taught me. Dr. Ingeniero Industrial, UPM. MSc, Stanford. https://t.co/stLIZja773
Venkatesh Srinivas @signal_vs_noise
389 Followers 2K Following Engineer @google; Co-Founder https://t.co/3uTe3XDLgx; occasional climate & philanthropy
Perry @kosh516
281 Followers 4K Following
toe_of_frege @eye_of_newton
16 Followers 1K Following
buy my IPO, not the O... @mcnultydigital
393 Followers 7K Following Believe in yourself so much you do Dario-level things! Jade Wang Sucks! ✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️✝️
T.Theodorus Ibrahim @theodorus5
466 Followers 4K Following
Louis @Louis9687221579
71 Followers 3K Following Mainline Economics | Idea page | ramblings of a schizo
Kording Lab 🦖 @KordingLab
63K Followers 3K Following Konrad kording, @Penn Prof, deep learning, brains, #causality, rigor, https://t.co/tTJW05RRfa, https://t.co/qf7ZHxjaK1, Transdisciplinary optimist, Dad, Loves outdoors, 🦖
Kay M Tye PhD @kaymtye
34K Followers 865 Following Mom. Neuroscientist. She/Her. BLM. https://t.co/sN3wqA9sHH https://t.co/GgqdGIyJwi
Kanaka Rajan @KanakaRajanPhD
14K Followers 2K Following Associate Professor at Harvard & Kempner Institute. Applying computational frameworks & ML to decode multi-scale neural processes. Marathoner. Rescue dog mom.
Luiz Pessoa @PessoaBrain
49K Followers 1K Following Neuroscientist interested in cognitive-emotional brain Author of The Entangled Brain (MIT Press); The Cogitive-Emotional Brain Neuroscience & Philosophy Salon
bioRxiv Neuroscience @biorxiv_neursci
62K Followers 0 Following
Spencer LaVere Smith @Labrigger
4K Followers 3 Following prof at UC Santa Barbara. https://t.co/nj3RtLGy3K Neuroscience, neuroengineering, and computation. Optics, imaging, circuitry. Sharing notes at https://t.co/NhYOb5zygg
Nicole C Rust, PhD @NicoleCRust
9K Followers 815 Following Professor @Penn. Mood and memory scientist. Book: Elusive Cures (Spring 2025). https://t.co/Luxotpp5wJ
Tony Zador @TonyZador
12K Followers 2K Following Neuroscientist at CSHL. Interests: neuroAI, molecular connectomics, & cortical circuits underlying decisions. Co-founder of Cosyne and NAISys meetings.
Ardem Patapoutian @ardemp
51K Followers 263 Following @scrippsresearch Professor. @HHMINEWS Investigator. @NobelPrize 2021. Research: touch & other forms of pressure sensing. Find me at @ardemp.bskyverified.social
Earl K. Miller @MillerLabMIT
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Yann LeCun @ylecun
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Jess Cardin @jess_cardin
5K Followers 605 Following Systems neuroscientist / Cortical circuits researcher / Associate Prof in Neuroscience at Yale School of Medicine
Mackenzie Weygandt Ma... @TrackingActions
22K Followers 54 Following merging adaptive motor control & machine learning | Prof @EPFL | 🐭@deeplabcut 🦓@cebraAI | @ELLISforEurope Scholar | @Harvard Alum | https://t.co/FakcYoDAC3
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David Schoppik @schoppik
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Marina Picciotto @MarinaP63
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Randy Bruno @TheBrunoCortex
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69K Followers 3K Following accelerating science for a healthier world
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Rajini Rao @madamscientist
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Yasmine El-Shamayleh @ElShamayleh
904 Followers 460 Following Assistant Professor of Neuroscience @Columbia @ZuckermanBrain, investigating how the world takes shape in the brain.
Scott Linderman @scott_linderman
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Diana Valencia @Valencia_planet
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David Bessis @davidbessis
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Sam Haselby @samhaselby
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Anshul Kundaje @anshulkundaje
31K Followers 3K Following Federally funded academic research is the innovation engine of the US economy. Reform is welcome. Destruction will have long term consequences.
Drug Monkey @drugmonkeyblog
9K Followers 194 Following
Rui Costa @ruimcosta
7K Followers 546 Following The wanderer. The clown. The chairman. President and CEO, Allen Institute. Opinions are my own.
Tim Röhn @Tim_Roehn
128K Followers 7K Following Senior Editor @AxelSpringerGRN | POLITICO, BILD, Business Insider, WELT, Onet, Fakt | Reported from 40+ countries I [email protected]
Isaac Chotiner @IChotiner
109K Followers 1K Following New Yorker staff writer and Houston Rockets fan; formerly a staff writer at Slate and senior editor at The New Republic.
Sean Piantadosi @PiantadosiSean
825 Followers 861 Following Incoming Assistant Professor in @UCIneurobio. Currently @mbruchas lab (Post-doc) and formerly Ahmari lab in @NeuroatPitt (PhD) Not the evil twin @ptpiantadosi
Talia Ringer 🕊🪬 @TaliaRinger
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Lisa Desjardins @LisaDNews
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steve blank @sgblank
218K Followers 492 Following Customer Development & Secret History, Teaching at Stanford
Rahul Dave @rahuldave
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Samantha Ramirez @Sam_RamirezQ
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Marshall Steinbaum �... @Econ_Marshall
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Sam Liccardo @sliccardo
35K Followers 2K Following Official: @repliccardo. US Rep for CA 16th District. Former Mayor of San José. Despite being 60% water, I’m a big eater. @kohl_garcia's Husband. He/Him.
Maria Curi @m_ccuri
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Meghan Mott @mmottDC
192 Followers 517 Following Scientist, Boy Mom, Professional Staff @SenateApprops / @PattyMurray / @tammybaldwin
Carson Chow @ccc1685
140 Followers 170 Following Applied mathematics, biology, computational neuroscience
Mike White @genologos
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Vigi Katlowitz @Vigi_Katlowitz
225 Followers 120 Following Aspiring husband, father, neurosurgeon scientist, cyborg.
David Brennan, MD @DavidNBrennan
522 Followers 246 Following Internal Medicine physician @mayoclinic. Obesity & Metabolic Health. Founder and Medical Director, Mayo Clinic Weight Management Program.
Alexander Harris @dr_alexharris
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LoogerLab @LoogerL
5K Followers 5K Following NOT CHECKING THIS CESSPOOL OF HATE. EMAIL ME. ENEMY WITHIN @UCSD
Jocelyn Kaiser @jocelynkaiser
1K Followers 71 Following I'm a reporter covering NIH and biomedical research policy for Science magazine.
Siyuan (Steven) Wang @SStevenWang
4K Followers 1K Following Image-based spatial multi-omics. Associate Professor at Yale. NIH Director's New Innovator Awardee. MIT Technology Review 35 Innovators Under 35.
Dr. Michele A. Basso @MicheleABasso1
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Jakob Voigts @jvoigts
2K Followers 373 Following Neuroscientist | Group leader @voigtslab @HHMIJanelia | @OpenEphys | @[email protected] | @jvoigts.bsky.social
TimHahn @TheRealTimHahn1
463 Followers 433 Following Heisenberg Professor for Machine Learning. Tech enthusiast. Livin' the dream. Views are my own.
Sheena Yoon 🌱 @SheenaYoon
2K Followers 3K Following Labor, Race, Justice & Equity, and Place 📚 PhD Candidate @EconUofU Prev: @OJPNIJ⚖️ @ILO, @WorldBank, @AU_Economics. 🛠 #Rstats 🗺️ #SpatialJustice
Zac Hill @zdch
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The Transmitter @_TheTransmitter
5K Followers 336 Following Dedicated to helping neuroscientists stay current and build connections. Subscribe to receive the latest news and perspectives on neuroscience: https://t.co/UUx8iyTIJW
Peter Hogg @neuro_Pete
283 Followers 675 Following Neuroscientist! Lover of brains 🧠 microscopes 🔬 and coffee ☕ Harvard Postdoc UBC PhD
Prof. Cleiton Lopes A... @NeuroCleiton
814 Followers 2K Following Associate Professor - Depto. Physiology and Biophysics (UFMG). Interested in the mechanisms of memory formation during sleep.
Michele Avissar-Whiti... @maw_tweets
861 Followers 737 Following Director, Open Science Strategy at HHMI | talk to me about preprints | tweets are mine 🥑🎼🧬🤓🎤
Ubadah Sabbagh @neubadah
11K Followers 279 Following neuroscientist by training, biotech guy @arcadiascience and open science guy @asterainstitute• syrian immigrant • former @mit @virginia_tech • الأمل موهبة
Tyler Black, MD @tylerblack32
55K Followers 4K Following Suicidologist, emergency psychiatrist, pharmacologist, data geek. 🫘 Debunking misinformation rather easily. Views expressed are my own opinions. He/him (😊)
Duncan Mearns @duncan_mearns
346 Followers 301 Following Postdoc @PrincetonNeuro @MurthyLab Evolutionary biologist in training, disciple of the connectome, computational neuroethologist & systems neuroscientist.
Tomás Ryan @TJRyan_77
13K Followers 6K Following Neuroscientist at @tcddublin| P.I. of @RyanLabTCD| Find me on Bluesky: https://t.co/d8vNyJILXu
Tolmachev Pavel @TolmachevPavel2
123 Followers 129 Following Researcher in Computational Neuroscience @PrincetonNeuro with focus on neural representations, recurrent neural networks and reinforcement learning
Rebecca Seal @lab_seal
896 Followers 539 Following Basic Research & Therapeutics Laboratory focused on delineating neural circuits for Persistent Pain and Parkinson's Disease. @US_ASP @Pitt_brain @Painresforum
Marco Capogrosso @MCapogrosso
3K Followers 2K Following Assistant Prof @PittNeurosurg & @RNELabs #Neuroscience #Neurotech #Paralysis Founder of @ReachNeuro. What I love most of Science? my friends! 💙 Opinions my own
Todd Lencz @ToddLencz
727 Followers 2K Following Researching causes and treatments for serious mental illness. All opinions are strictly my own, and not of my employers. RT does not mean endorsement.



















