Mark Histed @HistedLab
Neuroscientist. We aim to understd brain networks and brain wiring, using lasers & neuro AI. Prev: policy for @democracypolicy. Personal views. Not a lab acct. linktr.ee/markhisted Washington, DC Joined May 2013-
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Mark Histed retweeted
Yep. Check out our 2014 paper on this: papers.nips.cc/paper_files/pa…
Local minima are rare in high dimensions because a strict local minimum has to curve upward in every direction, so all Hessian eigenvalues must be positive. In a D-dimensional toy model where eigenvalue signs are independent, that’s a 2^(-D) event. In GOE-like random matrix
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"This isn’t how the sciences work, and it’s basically a dagger aimed at the sciences and medical research" That's right
"...in which the fed gov't funds sciences and medical research. Instead, it makes the entire apparatus into a kind of political patronage system, with any researcher liable to be immediately cut off if they offend the current occupant of the White House." talkingpointsmemo.com/edblog/surveyi…
TPM covers the presidentialization of science agencies. This is what Natalie Aviles and I have been on about: the unitary executive logic of SCOTUS/P2025 is not compatible with good science. "[the OMB rule] purports to end the system which Congress created..." 1/
Hopefully this moves the needle and encourages the pharma industry to speak up. I have heard from several sources that pharma execs know exactly what’s going on and what the damage will be, but they can justify inaction because the effects won’t hit their stock prices soon.
“The damage inflicted over the past 16 months is prologue. The OMB’s proposal for overhauling U.S. government grantmaking would explicitly subordinate expert peer review to political gatekeepers and make ideological alignment with the administration a prerequisite for funding.”
“As the admin moves from cutting budgets and attacking elite universities to dismantling the foundations of the US research enterprise, pharma CEOs have remained silent. Their silence is a choice.” biocentury.com/article/659615
Governments in personalist states don’t work. And moreover civil servants in the US took an oath to the Constitution— that is, to American democracy. If one party chooses to shred the Constitution, that is also not the fault of civil servants.
And civil servants should not bend their values. They should not give up their commitments to democracy.
I deeply believe in a non-partisan civil service. But civil servants must also be pro-democracy and anti-fascism. If that runs at odds with the choices of the political parties today, that is not the fault of civil servants.
and if any one is wrong we can accept it. In contrast, some big clinical trials maximize rigor at high cost. A great science ecosystem has a mix of different approaches. #metascience
High-risk, high rigor, and low cost in science are tradeoffs: for any line of research we generally get to choose just two. For some emerging fields, we want to throw a lot of high-risk and low-cost darts …
So we choose a reasonable rigor std, do our best to peer review, & accept some errors, worked out by followup work. (There are many issues w/ glam journals, over-selling, favoring huge labs—etc. But this 'some are wrong' issue is just the nature of reality.) /end
This framework is well-worked out in theory—we must choose an error criterion ("wrong"), which comes w/ a cost in time/$. This isn't ex it (need a cost term), bt same idea, fm David Heeger's notes. Type 1/2 errors, sensitivity/specificity: same idea. cns.nyu.edu/~david/handout…
A good number of papers in Science and Nature are wrong... and that's not a bad thing. (What's something everyone in your field knows but people outside the field don't?) 1/
Going to start calling myself a Lincoln liberal.
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