Vern Dolinsky @VernDolinsky
Professor and Co-lead of DREAM, the #Diabetes Theme @DREAM_diabetes at the Children's Hospital Research Institute of Manitoba @CHRIManitoba dreamdiabetesresearch.com Winnipeg, MB Joined September 2013-
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Vern Dolinsky retweeted
Home alone. Remote work can adversely influence mental health. A new study @ScienceMagazine science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…
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Vern Dolinsky retweeted
A new Hormone Cell Atlas maps where hormones are made and received across 47 human tissues using 14 million single cells. The resource reveals unexpected hormone-producing cells, endocrine feedback networks, and new insights into metabolic and endocrine disease. #Endocrinology #SingleCell #PrecisionMedicine science.org/doi/10.1126/sc…
Retrospective cohort study: Detection of young-onset type 2 #diabetes using deep learning across primary and secondary care: Nationwide study from Denmark (n=16828 youth-onset T2D population) @TheLancet thelancet.com/journals/landi…
Vern Dolinsky retweeted
The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer. ✓ out the new Ground Truths (link in profile)
REVIEW: #Metabolic syndrome and #kidney dysfunction: emerging molecular and cellular mechanisms at the metabolic–renal interface #mitochondria @FrontEndocrinol frontiersin.org/journals/endoc…
REVIEW: #Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for #diabetes onlinelibrary.wiley.com/doi/10.1111/17…
REVIEW: #Heart Failure in Type 1 vs. Type 2 #diabetes Shared Pathways, Distinct Challenges onlinelibrary.wiley.com/doi/10.1155/jd…
REVIEW: #Proteomics of the #heart @physiolrev journals.physiology.org/doi/full/10.11…
Functional validation of a non-canonical HNF1B splice-site variant in MODY5 #diabetes @FrontEndocrinol frontiersin.org/journals/endoc…
Check out this interesting paper @DREAM_diabetes @DREAM_trainees #diabetes
@Inserm Progressive HNF1A-MODY pathophysiology revealed by a translational mouse model: doi.org/10.1172/jci.in…
Maternal #obesity alters adipogenic potential and #mitochondrial maximal respiration in infant mesenchymal stem cells #DOHaD @FrontEndocrinol frontiersin.org/journals/endoc…
Vern Dolinsky retweeted
🚨Excited to share our single-cell multi-omic atlas of #stemcell islet differentiation that predicts cell fate decisions and identifies causal regulators of lineage specification. You can start browsing the data now 👉 synbioelab.com/islettwin Preprint 👉 biorxiv.org/content/10.648…
Vern Dolinsky retweeted
1. Our main biomedical funding body is telling Canadian PIs its review system is collapsing. 50% increase in applications (attributed to AI but really due to PIs dealing w/ is essentially a lottery). PIs declining to review due to fatigue from turning down so much awesome science
@mrlakin13 @JCI_insight Nice paper congrats
Vern Dolinsky retweeted
The fascinating biology of targeting nuclear receptor ligands to GLP-1 receptor + cells continues, with the latest chapter studying GLP-1 E2 in NOD mice, with or without low dose aCD3 @DiabetologiaJnl link.springer.com/article/10.100…
Vern Dolinsky retweeted
Blood NAD+ may not be the aging biomarker many hoped for. Across 7 human cohorts, whole-blood NAD+ levels stayed remarkably stable with age and lifestyle changes—shifting mainly with nicotinamide riboside supplementation. #Aging #NAD #Longevity nature.com/articles/s4225…
Vern Dolinsky retweeted
From earlier this week: A landmark in cardiac metabolism: doi.org/10.1172/JCI202… Jay D. Horton & team @UTSWMedCenter find unrestrained fat oxidation in heart cells deplete cardiolipins that are needed for mitochondrial energy, triggering heart failure in mice and revealing a potential metabolic target. The figure shows decreased heart function in cardiac-specific ACC1/ACC2 double KO (dHKO) mice. #CardiacMetabolism #HeartFailure
Vern Dolinsky retweeted
New advances in understanding the wide range in human islet cell heterogeneity and secretory phenotypes from the Integrated Islet Distribution Program (IIDP). The abundance of δ cells showed the strongest association with insulin secretion and #T2D nature.com/articles/s4146…
Vern Dolinsky retweeted
Timing matters 🕒 For type 2 diabetes, afternoon/evening exercise boosts insulin sensitivity & glycemic control, while morning workouts may raise blood sugar. Later workouts are also linked to lower cortisol, less inflammation & better oxidative capacity. #Diabetes #ExerciseScience @WuTsaiAlliance sciencedirect.com/science/articl…
Vern Dolinsky retweeted
After Hungary, Putin and Trump’s overlapping influence operations have a new target. And this time it’s Canada. My latest… olgalautman.substack.com/p/putin-and-tr…
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