Teif Lab @TeifLab
Teif lab at @uni_of_essex. We work on nucleosomes, chromatin, TFbinding, CTCF, cfDNA. Find us at 🐘 and 🦋. [email protected]; [email protected] generegulation.org University of Essex, UK Joined March 2019-
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Nucleosome aficionados! Our new review "Nucleosome spacing across cell types, diseases, and ages" is out in NAR: academic.oup.com/nar/article/54… A huge effort to pull together what we’ve learned about nucleosome spacing in many systems. Enjoy! #nucleosomics #nucleosome #chromatin #cfDNA
Congratulations to Negin Behboodi on successfully passing your PhD viva! We are so proud of you! Keep an eye out for Negin's upcoming big papers! And thank you to the kind examiners @mikhailspivakov and @amarcobio!
Some refs on nucleosome-mediated cooperativity in TF binding: ▶️Concept suggested by Polach & Widom, 1996: sciencedirect.com/science/articl… ▶️Our first single-bp resolution model, 2010: cell.com/biophysj/fullt… ▶️Its application to TFs at enhancers, 2011: iopscience.iop.org/article/10.108…
Congratulations to Amishasingh Beeharry for successfully passing the MSD viva! You are the best, Amisha! Thank you very much to the examiners, Abdenour Soufi and Toni Marco!
@SylvanBacaLab @jberchuck @manoliskellis Congratulations on your preprint! You may be also interested in this one: x.com/TeifLab/status…
Great to see that this preprint used our software NucTools to calculate NRL, and reached conclusions confirming our previous paper, which reported effect of linker histones H1 on cfDNA fragmentation patterns and nucleosome spacing in cancer tissues/cfDNA link.springer.com/article/10.118…
Great to see that this preprint used our software NucTools to calculate NRL, and reached conclusions confirming our previous paper, which reported effect of linker histones H1 on cfDNA fragmentation patterns and nucleosome spacing in cancer tissues/cfDNA link.springer.com/article/10.118…
Excited to share our latest preprint by Alexis Yang and Gary Lee, in collab with the @jberchuck lab: biorxiv.org/content/10.110…. We found that transcription of enhancers (a mark of activation) causes distinct fragmentation patterns in #cfDNA.
Happy to announce that our department (School of Life Sciences at the University of Essex) is upgraded to number 6th out of 91 UK universities in the subject area Biology according to the Guardian University Guide 2026. theguardian.com/education/ng-i…
Very happy to contribute to this CTCF-nucleosome paper by @ElenaPugachev12 &Co. Exciting science and a cool journal cover!
Excited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/53… It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate CTCF’s constant struggle in shaping the 3D genome architecture.
Excited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/53… It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate CTCF’s constant struggle in shaping the 3D genome architecture.
NHS announced that it will start offering first liquid biopsy tests for diagnostics of lung and breast cancer; also planning expansion to pancreatic and gallbladder cancers england.nhs.uk/2025/05/nhs-fi…
We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and more jobs.ac.uk/job/DMK060/sen…. Apply by 21st April 2025!
Very happy to contribute to this paper about cfDNA in SCLC, led by the team of Anish Thomas. It's already online in Genome Medicine: Takahashi et al., Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor genomemedicine.biomedcentral.com/articles/10.11…
Early detection of #PancreaticCancer saves lives. @TeifLab @EssexLifeSci are using cutting-edge technology to measure fragments of tumour DNA in the blood. This "liquid biopsy" could provide an accurate & affordable new test for pancreatic cancer: bit.ly/3F3vXF1
2nd time at #FOG2025 (1st time presenting!), it never disappoints!✨ Great talks, groundbreaking research and good times with old&new friends Huge thanks to everyone who stopped by my poster, truly grateful for the interest & discussions Already looking forward to next year!🙌
So excited for the festival and this great opportunity to present my research 😄
We're pleased to share that @isabella_ciu (PhD Student, University of Essex) will be sharing her research in the #FOG2025 Poster Zone! Register now: hubs.la/Q032Q75f0
@vitaliikl @StevenSalzberg1 @DaveJuergens The paper actually says they use ATAC-seq as input. It's not just from sequence
Low quality picture but… Had to show the matching glasses 🤭🤓
Interestingly, the BBC coverage attributed this success to NHS testing vans stationed in busy areas where any person can walk-in without referral. Probably technological genomics developments also contributed to this improvement, in any case these are set to help going forward
Encouraging news to start the new year: NHS reports 2.7% improvement in early cancer diagnostics in comparison to pre-pandemic levels. An estimated additional 7,000 patients diagnosed at an early stage.
Latest NHS data shows that the proportion of patients being diagnosed with cancer at an early stage in England has risen to its highest ever level. Find out more about the latest data. ➡️ england.nhs.uk/2025/01/early-…
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