Rafael Moliner @RafaelMoliner
Biochemist by formation. Neuroscientist by vocation. Human by nature. Adventurer of the mind, and always eager to walk the world! 🧠 PhD candidate @helsinkiuni medium.com/neurolands Helsinki, Finland Joined March 2017-
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Time finlandês com a escalação luxuosa de 3 brasileiros coloca os receptores de tirosina cinase no jogo dos psicodélicos. @MarceloNLeite escreve pra Folha. Inclui um breve comentário meu sobre os achados. Parabéns novamente aos autores! www1.folha.uol.com.br/blogs/virada-p…
Uso clínico do LSD e psilocina ainda é restrito pelos efeitos colaterais e a necessidade de acompanhamento profissional devido ao seu potencial alucinógeno; pesquisa traz novos dados para o desenho de medicamentos que possam contornar essas limitações jornal.usp.br/ciencias/em-en…
Opening the fridge is difficult when there’s a dragon guarding it 24/7 🐉 🌈 🍄
Rafael Moliner, experto en psicodélicos: "En 10 años podremos ver su uso terapéutico en humanos" elespanol.com/ciencia/salud/…
The week's news in psychedelics: New study suggests TrkB receptor is key to psychedelics’ antidepressant effects, U.S. Patent board upholds COMPASS COMP360 patents, and Rhode Island bill advances themicrodose.substack.com/p/new-study-su…
Some tweets should come with a disclosure of conflicts of interest attached!
IPN director @DEOlsonLab comments on a recent study from the group of @castren_eero about #psychedelics binding to TrkB inverse.com/health/lsd-mag…
I have been asked many times how it could be mechanistically possible to have benefits from psilocybin without 5HT2A/psychedelic effects (as shown in our case report ajp.psychiatryonline.org/doi/10.1176/ap…) This well done study shows a very plausible mechanism with direct BDNF effects
I have been asked many times how it could be mechanistically possible to have benefits from psilocybin without 5HT2A/psychedelic effects (as shown in our case report ajp.psychiatryonline.org/doi/10.1176/ap…) This well done study shows a very plausible mechanism with direct BDNF effects
Los efectos positivos de las drogas psicodélicas, como la plasticidad neuronal, y los negativos, como las alucinaciones, se podrían separar para crear antidepresivos, según un estudio en el que participa el @IBV_CSIC . ➡️bit.ly/3Cmz99P
summary of current #psychedelic twitter
Great coverage of our paper, thank you @cathleenogrady!
Great coverage of our paper, thank you @cathleenogrady!
The #psychedelics LSD and psilocin directly bind to the BDNF receptor, TrkB, and this is required for effects on #antidepressant-like behavior in mice New from @castren_eero @RafaelMoliner @p_casarotto @UH_Neuro @HkiBrainMind nature.com/articles/s4159…
Please check our latest paper nature.com/articles/s4159…. LSD and psilocin are high-affinity ligands of TrkB, sensitizing TrkB to BDNF, promoting plasticity, but not hallucinations. Huge thanks to all the co-authors, especially @RafaelMoliner, @p_casarotto and Ilpo Vattulainen.
Yiwei Hua @yiwei_hua
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27 Followers 245 FollowingLeor Roseman @LeorRoseman
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120 Followers 357 Following Postdoctoral researcher - University of California, Davis@zenbrainest @RafaelMoliner @CassianoDiniz3 Thanks so much @zenbrainest ! Probably me, but I also can't find where you used a 2A antagonist in this paper. I see where yall blocked Kalrin with Karlrin int, but I don't see where you blocked 2A. I also don't see it in the methods or SI methods. Is there another paper?
@CassianoDiniz3 @RafaelMoliner @zenbrainest 💯 they certainly did not
@sequencemyneuro @RafaelMoliner @zenbrainest nor did they exclude any possibility that the TrkB-dependent effects of LSD and PSI are cortex-dependent.
@sequencemyneuro @RafaelMoliner @zenbrainest Fair skepticism is only good. I'm sure all authors want other groups trying to replicate the findings. We have an additional puzzle, that's Science!! But the fact is, none of that data by itself says that the TrkB-dependent effects of LSD and PSI happen only in the hippocampus.
@RafaelMoliner @CassianoDiniz3 @zenbrainest Dont get me wrong, I love this work. Just trying to keep it real. Yall keep saying "no data that restricts to the cortex". True, but yall also didn't specifically show that cortical plasticity is TrkB dependent in vivo, so people are skeptical bc others have.
@RafaelMoliner @CassianoDiniz3 @zenbrainest Totally agree with your overall point, but I don't agree with the 1st statement. We do not know the neurological mechanisms of antidepressant effects yet. It could be that HPC plasticity/neurogenesis is sufficient for the FST. Some good studies suggest this.
Time finlandês com a escalação luxuosa de 3 brasileiros coloca os receptores de tirosina cinase no jogo dos psicodélicos. @MarceloNLeite escreve pra Folha. Inclui um breve comentário meu sobre os achados. Parabéns novamente aos autores! www1.folha.uol.com.br/blogs/virada-p…
Thank you @sats_brsf for this wonderful recognition 🙏🏻 I am truly honored. Thank you also to all past and present group members with whom we’ve accomplished all this.
Neuroscience Finland / BRSF Award Ceremony Neuroscientist of the year: Professor Iiris Hovatta! @sats_brsf @helsinkiuni @hovatta #codedtoconnect @NeurocenterFI @HkiBrainMind
@zenbrainest Just to make it clearer, no data in last week's Nature Neuroscience paper restricts the 5HT2a-independent/TrkB dependent effects of LSD and PSI to only the hippocampus. Multiple times and for independent experiments, both hippocampal and cortical neurons were used.
Uso clínico do LSD e psilocina ainda é restrito pelos efeitos colaterais e a necessidade de acompanhamento profissional devido ao seu potencial alucinógeno; pesquisa traz novos dados para o desenho de medicamentos que possam contornar essas limitações jornal.usp.br/ciencias/em-en…
New study found that #psychedelics like LSD & psilocin promote plasticity by directly binding TrKB receptors with much higher affinity than traditional antidepressants. TrkB is the receptor for BDNF, a very important protein in brain development, neuron growth, and plasticity.
@RafaelMoliner @LeorRoseman Cell type-specific and regional differences in receptor transcript variants, 2nd messenger pathway, etc may play a role. Unstressed HPC doesn't have very high 2A levels, but cortex does. Not saying trkB isn't req. in cortex 4 plasticity, but it might be more complex there..
Its really fun that the TrkB paper shows that LSD's plastogenic effect is 5-HT2a independant. The beloved receptor can now be left for those who want to trip. Now go make some TrkB agonists please. nature.com/articles/s4159…
Researchers have identified a mechanism with which psychedelic drugs could produce effects similar to those of antidepressants, but potentially without adverse hallucinogenic effects. @HiLIFE_helsinki @UH_Neuro @castren_eero @helsinkiuni Read more: 👇 helsinki.fi/en/news/brain/…
Earlier this week the psychedelic science world blew tf up with something called 'TrkB.' Completely ignited. Shards of LSD everywhere – it’s wild, but it could be more wild than you think… (1/19)
Rafael Moliner, experto en psicodélicos: "En 10 años podremos ver su uso terapéutico en humanos" elespanol.com/ciencia/salud/…
The week's news in psychedelics: New study suggests TrkB receptor is key to psychedelics’ antidepressant effects, U.S. Patent board upholds COMPASS COMP360 patents, and Rhode Island bill advances themicrodose.substack.com/p/new-study-su…