Grant Glatfelter @gcglatfelter
DDRU - pharmacology, drug discovery, NPS, psychedelics, circadian biology. Views are my own - RTs & follows 🚫= endorsement. scholar.google.com/citations?hl=e… Baltimore, MD Joined February 2019-
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New @NIH_NCCIH study launching: Psilocybin and Affective Function in Chronic Low Back Pain and Depression (CLBP+D). Me & @p_fi are Co-PIs. CLPB+D is among the leading causes of disability in the US. Now recruiting! Please spread the word and/or send ideas for study recruitment.
Spread the word on this new study! @JHPsychedelics
Spread the word on this new study! @JHPsychedelics
It’s insane how this man can speak with confidence on topics he clearly knows absolutely nothing about to his legions of followers. This is just straight up misinformation.
It’s insane how this man can speak with confidence on topics he clearly knows absolutely nothing about to his legions of followers. This is just straight up misinformation.
From someone who has studied this field for over 2 decades, I can comfortably say that virtually everything said here is inaccurate. It is incredibly disturbing to me that someone claiming to be a scientist can talk with such authority on something they clearly know nothing about
From someone who has studied this field for over 2 decades, I can comfortably say that virtually everything said here is inaccurate. It is incredibly disturbing to me that someone claiming to be a scientist can talk with such authority on something they clearly know nothing about
@hubermanlab Holy fucking shit, it is actually disturbing how inaccurate the overwhelming majority of what is said here is. Like I have to believe that you have legitimately just made this stuff up. There is literally no research that has ever been done that could be cited to support this.
The @JHPsychedelics Journal Club is seeking presenters. This is a fantastic opportunity to present original research/ideas on psychedelics and related fields to our group (likeminded in their curiosity but diverse in their backgrounds). Please message if interested!
@Marthevdp After the break we continue with Michael Baumann @DDRU_pubs @NIDAnews, talking on the activity, reinforcing (self-administration) and cardiovascular effects of fentanyl analogs differing in alkyl chain length. 4/n
EXTREMELY excited to announce my first JHU lab-based #kratom 🌿study is officially recruiting! Check out the the flyer or click this screening link to learn more! 👇 tinyurl.com/kratomstudy (and please RT widely!).
EXTREMELY excited to announce my first JHU lab-based #kratom 🌿study is officially recruiting! Check out the the flyer or click this screening link to learn more! 👇 tinyurl.com/kratomstudy (and please RT widely!).
Please watch and share our PSA on psychedelic risks and adverse events. It is important to have an evidence-based perspective on the risk/benefit profile of psychedelics: youtube.com/watch?v=xUS2I8…
"CYB210010 represents a new tool molecule for investigating the therapeutic potential of 5-HT2 receptor activation." pubs.acs.org/doi/10.1021/ac… #psychedelics #pharmacology
Brief interview with DDRU Director Mike Baumann re our work with #NPS - check it out! go.nih.gov/J9T7A2W
Interested in getting involved with psychedelic science while getting research experience and training? Consider applying to our Research Program Coordinator position studying the effects of psilocybin for chronic low back pain and depression! A great post-undergraduate and…
We are thrilled to announce that Dr. Albert Garcia-Romeu (@AlChemical77) has been appointed as Associate Director of the CPCR and the Susan Hill Ward Professor in Psychedelics and Consciousness. Dr. Garcia-Romeu is a respected and beloved colleague both in the CPCR and the…
A really nice synopsis of our recently published study in #ACSPharmacolTranslSci on #lisuride vs #LSD from Derek Lowe for "In The Pipeline" 😎 science.org/content/blog-p… @ACSBioMed
Had an amazing time at #ISRP2024 this past weekend - don't miss the next one. Hands down the best #psychedelic science meeting I've been to. So great to catch up with everyone! 📸 thanks to A. Sherwood
@zenbrainest As you may have read (or not), the Discussion does try to be quite nuanced, comparing our findings to lit., pointing out where our data match or are in apparent discrepancy w. literature, also very explicitly mentioning limitations of our assays. Anyway, thanks for the input. 3/3
@zenbrainest @DR_WANG_SIBCB @john_mccorvy I don't agree there is a 'contradiction'. Contradiction would be if the same systems would have been used, yielding a different result. Here, I'd refer to 'an apparent discrepancy', which, indeed, may be related to using other methodologies. Neither is necessarily 'wrong', imo.
@zenbrainest @gcglatfelter Not entirely sure what is meant with "problems with equilibrium" and why bias evaluation with assays in which assay 1 & 2 even use different receptor constructs (tagged/non-tagged) or different levels of detection (recruitment vs downstream) would offer a better, 'unbiased' view.
@zenbrainest Thanks for sharing & checking out our work. We do see a preference for arrestin in our assay context - @christophestove & co conducted cellular assays for this. Be sure to read the discussion in the paper about the discrepancies noted here & the subtleties of these assays!
#psychedelics A new paper pubs.acs.org/doi/10.1021/ac… suggests lisuride is arrestin biased--these results are contradicted by results from my lab as well as two independent labs--@DR_WANG_SIBCB @john_mccorvy
Alaina Jaster, PhD @JasterAlaina
3K Followers 616 Following PhD in PharmTox. Psychedelic Scientist. Communicator via @psychedbrainsci , available for freelance writing/consulting. Queer, She/Her. Opinions all my own 🤡Alex Kwan 關進晞 @kwanalexc
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29K Followers 663 Following Tokyo. Computational neurobiologist, chemical pharmacologist, writer interested in psychedelics, especially DMT. Reality Switch Technologies OUT NOWRobin Carhart-Harris @RCarhartHarris
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3K Followers 616 Following PhD in PharmTox. Psychedelic Scientist. Communicator via @psychedbrainsci , available for freelance writing/consulting. Queer, She/Her. Opinions all my own 🤡Alex Kwan 關進晞 @kwanalexc
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38 Followers 147 Following Neuropharmaceutics synthetic chemist, psychedelic scientist, associate research scientist @Columbia @Chemcolumbia @sameslabMatthew Aragón @amazing__matt
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How it started / How it’s going @WackerLab @SamesLab
Wow--amazing paper from @WackerLab on #psychedelics in @Nature ! Structural pharmacology and therapeutic potential of 5-methoxytryptamines nature.com/articles/s4158…
GABAergic and not serotonergic effects (pix is from my talk).
@SteveTransform FYI: The psychoactive ingredients of Psilocybe species and Amanita muscaria have vastly different mode of actions / pharmacology. They are (probably) sought after for their distinct effects. Complement not substitute each other. Prohibition -whatever that is- is irrelevant here.
Spread the word on this new study! @JHPsychedelics
New @NIH_NCCIH study launching: Psilocybin and Affective Function in Chronic Low Back Pain and Depression (CLBP+D). Me & @p_fi are Co-PIs. CLPB+D is among the leading causes of disability in the US. Now recruiting! Please spread the word and/or send ideas for study recruitment.
It’s insane how this man can speak with confidence on topics he clearly knows absolutely nothing about to his legions of followers. This is just straight up misinformation.
How Marijuana Affects the Brain & Body
From someone who has studied this field for over 2 decades, I can comfortably say that virtually everything said here is inaccurate. It is incredibly disturbing to me that someone claiming to be a scientist can talk with such authority on something they clearly know nothing about
How Marijuana Affects the Brain & Body
Heres a crux am curious what people think. I have been openly critical of his approach to sci comm and so do not want to legitimize his podcast or him, but also having the opportunity on his platform to go through the problems with what he has said is the only way to correct it.
@canna_brain Would you like to come discuss your stance on cannabis research and use etc. We include references and I consult/ed with colleagues here at Stanford Med and elsewhere prior to this and other episodes but given your post, I would love to have a discussion for people to learn from…
The @JHPsychedelics Journal Club is seeking presenters. This is a fantastic opportunity to present original research/ideas on psychedelics and related fields to our group (likeminded in their curiosity but diverse in their backgrounds). Please message if interested!
I'm so thrilled to have celebrated @FredBarrettPhD's installation as the Oliver Lee McCabe III Professorship today. As Dr. Shih noted "Fred represents the best of us" and I agree wholeheartedly. Congratulations Fred!
@Marthevdp Last presenter of our mini-symposium on new synthetic opioids is @bruno_de_geest @UGent_Pharma, talking on a new lipid nanoparticle-based fentanyl vaccine, demonstrated to induce protection against fentanyl (and analogue) effects. 6/6
@EMCDDA Next up is @Marthevdp, talking on part of her PhD work, and more particularly the application potential of our in-house developed split-nanoluciferase assays, with a special focus on nitazene-type synthetic opioids. 3/n
@Marthevdp We continue the in vivo evaluation of new synthetic opioids, with Matteo Marti from the University of Ferrara, talking on the cardiorespiratory effects (bradycardia, bradypnea & respiratory depression) of fentanyl analogs and of the combination fentanyl - xylazine. 5/n
@Marthevdp After the break we continue with Michael Baumann @DDRU_pubs @NIDAnews, talking on the activity, reinforcing (self-administration) and cardiovascular effects of fentanyl analogs differing in alkyl chain length. 4/n
Next up is Michael Evans-Brown from the @EMCDDA, talking on the new synthetic opioid market in Europe, with the recent emergence of non-fentanyl-related opioids, in particular the #nitazenes. More drugs, more seizures, more intoxications, more deaths. Preparedness = 🔑. 2/n
Mini-symposium on new synthetic opioids now ongoing at the Faculty Room of @ugent_Pharma @ugent. First on is Meritxell Canals @MeritxellCanal5, talking on mu opioid receptor signaling, with a key focus on G protein bias (or the lack thereof) & the biased view on ligand bias. 1/n
Notice how most fictional super-villains have a PhD? The fact that no one has questioned the plausibility of this occurrence is concerning 😂😭😂😭
New pub from the lab! We measured molecular rhythms in D1/D2/astrocytes individually in the mouse NAc and find surprising differences in timing of gene expression and D1 neuron specific sex differences. Check it out: nature.com/articles/s4138…